Comparison of influenza disease burden in older populations of Hong Kong and Brisbane: the impact of influenza and pneumococcal vaccination
Identifieur interne : 000478 ( Pmc/Checkpoint ); précédent : 000477; suivant : 000479Comparison of influenza disease burden in older populations of Hong Kong and Brisbane: the impact of influenza and pneumococcal vaccination
Auteurs : Lin Yang ; King Pan Chan ; Chit Ming Wong ; Susan Shui Seng Chiu ; Ricardo J. Soares Magalhaes [Australie] ; Thuan Quoc Thach ; Joseph Syrial Malik Peiris ; Archie C. A. Clements [Australie] ; Wenbiao Hu [Australie]Source :
- BMC Infectious Diseases [ 1471-2334 ] ; 2019.
Abstract
Influenza and pneumococcal vaccine uptake in the older population aged 65 years or over of Hong Kong dramatically increased since the 2003 SARS outbreak. This study is aimed to evaluate the impact of increased coverage of influenza and pneumococcal vaccines by comparing the change of disease burden in the older population of Hong Kong, with the burden in the older population of Brisbane with relatively high vaccine coverage in the past fifteen years.
Time series segmented regression models were applied to weekly numbers of cause-specific mortality or hospitalization of Hong Kong and Brisbane. Annual excess rates of mortality or hospitalization associated with influenza in the older population were estimated for the pre-SARS (reference period), post-SARS and post-pandemic period, respectively. The rate ratios (RRs) between these periods were also calculated to assess the relative change of disease burden.
Compared to the pre-SARS period, excess rates of mortality associated with influenza during the post-SARS period in Hong Kong decreased for cardiorespiratory diseases (RR = 0.90, 95% CI 0.80, 1.01), stroke (RR = 0.74, 95% CI 0.50, 1.09), and ischemic heart diseases (RR = 0.45, 95% CI 0.34, 0.58). The corresponding RRs in Brisbane were 0.79 (95% CI 0.54, 1.15), 0.33 (0.13, 0.80), and 1.09 (0.62, 1.90), respectively. Only the mortality of ischemic heart diseases showed a greater reduction in Hong Kong than in Brisbane. During the post-pandemic period, excess rates of all-cause mortality increased in Hong Kong, but to a lesser extent than in Brisbane (RR = 1.41 vs 2.39).
A relative decrease (or less of an increase) of influenza disease burden was observed in the older population of Hong Kong after increased coverage of influenza and pneumococcal vaccines in this population, as compared to those of Brisbane where vaccination rates remained stable. The lack of significant findings in some disease categories highlights the challenges of evaluating the benefits of vaccination at the population level.
The online version of this article (10.1186/s12879-019-3735-7) contains supplementary material, which is available to authorized users.
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DOI: 10.1186/s12879-019-3735-7
PubMed: 30764779
PubMed Central: 6376732
Affiliations:
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A." last="Clements">Archie C. A. Clements</name><affiliation wicri:level="1"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 7477</institution-id><institution-id institution-id-type="GRID">grid.1001.0</institution-id><institution>Research School of Population Health,</institution><institution>The Australian National University,</institution></institution-wrap>Canberra, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Canberra</wicri:regionArea></affiliation></author><author><name sortKey="Hu, Wenbiao" sort="Hu, Wenbiao" uniqKey="Hu W" first="Wenbiao" last="Hu">Wenbiao Hu</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000000089150953</institution-id><institution-id institution-id-type="GRID">grid.1024.7</institution-id><institution>School of Public Health and Social Work,</institution><institution>Queensland University of Technology,</institution></institution-wrap>Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Brisbane</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">30764779</idno><idno type="pmc">6376732</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376732</idno><idno type="RBID">PMC:6376732</idno><idno type="doi">10.1186/s12879-019-3735-7</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000307</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000307</idno><idno type="wicri:Area/Pmc/Curation">000307</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000307</idno><idno type="wicri:Area/Pmc/Checkpoint">000478</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000478</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Comparison of influenza disease burden in older populations of Hong Kong and Brisbane: the impact of influenza and pneumococcal vaccination</title><author><name sortKey="Yang, Lin" sort="Yang, Lin" uniqKey="Yang L" first="Lin" last="Yang">Lin Yang</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1764 6123</institution-id><institution-id institution-id-type="GRID">grid.16890.36</institution-id><institution>GH515, School of Nursing,</institution><institution>The Hong Kong Polytechnic University,</institution></institution-wrap>Hung Hom, Hong Kong, Hong Kong, Special Administrative Region of China</nlm:aff><wicri:noCountry code="subfield">Special Administrative Region of China</wicri:noCountry></affiliation></author><author><name sortKey="Chan, King Pan" sort="Chan, King Pan" uniqKey="Chan K" first="King Pan" last="Chan">King Pan Chan</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000000121742757</institution-id><institution-id institution-id-type="GRID">grid.194645.b</institution-id><institution>School of Public Health,</institution><institution>The University of Hong Kong,</institution></institution-wrap>Hong Kong, Hong Kong, Special Administrative Region of China</nlm:aff><wicri:noCountry code="subfield">Special Administrative Region of China</wicri:noCountry></affiliation></author><author><name sortKey="Wong, Chit Ming" sort="Wong, Chit Ming" uniqKey="Wong C" first="Chit Ming" last="Wong">Chit Ming Wong</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000000121742757</institution-id><institution-id institution-id-type="GRID">grid.194645.b</institution-id><institution>School of Public Health,</institution><institution>The University of Hong Kong,</institution></institution-wrap>Hong Kong, Hong Kong, Special Administrative Region of China</nlm:aff><wicri:noCountry code="subfield">Special Administrative Region of China</wicri:noCountry></affiliation></author><author><name sortKey="Chiu, Susan Shui Seng" sort="Chiu, Susan Shui Seng" uniqKey="Chiu S" first="Susan Shui Seng" last="Chiu">Susan Shui Seng Chiu</name><affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000000121742757</institution-id><institution-id institution-id-type="GRID">grid.194645.b</institution-id><institution>Department of Pediatrics and Adolescent Medicine,</institution><institution>The University of Hong Kong,</institution></institution-wrap>Hong Kong, Hong Kong, Special Administrative Region of China</nlm:aff><wicri:noCountry code="subfield">Special Administrative Region of China</wicri:noCountry></affiliation></author><author><name sortKey="Magalhaes, Ricardo J Soares" sort="Magalhaes, Ricardo J Soares" uniqKey="Magalhaes R" first="Ricardo J. Soares" last="Magalhaes">Ricardo J. Soares Magalhaes</name><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9320 7537</institution-id><institution-id institution-id-type="GRID">grid.1003.2</institution-id><institution>School of Veterinary Science,</institution><institution>University of Queensland,</institution></institution-wrap>Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Thach, Thuan Quoc" sort="Thach, Thuan Quoc" uniqKey="Thach T" first="Thuan Quoc" last="Thach">Thuan Quoc Thach</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000000121742757</institution-id><institution-id institution-id-type="GRID">grid.194645.b</institution-id><institution>School of Public Health,</institution><institution>The University of Hong Kong,</institution></institution-wrap>Hong Kong, Hong Kong, Special Administrative Region of China</nlm:aff><wicri:noCountry code="subfield">Special Administrative Region of China</wicri:noCountry></affiliation></author><author><name sortKey="Peiris, Joseph Syrial Malik" sort="Peiris, Joseph Syrial Malik" uniqKey="Peiris J" first="Joseph Syrial Malik" last="Peiris">Joseph Syrial Malik Peiris</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000000121742757</institution-id><institution-id institution-id-type="GRID">grid.194645.b</institution-id><institution>School of Public Health,</institution><institution>The University of Hong Kong,</institution></institution-wrap>Hong Kong, Hong Kong, Special Administrative Region of China</nlm:aff><wicri:noCountry code="subfield">Special Administrative Region of China</wicri:noCountry></affiliation></author><author><name sortKey="Clements, Archie C A" sort="Clements, Archie C A" uniqKey="Clements A" first="Archie C. A." last="Clements">Archie C. A. Clements</name><affiliation wicri:level="1"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 7477</institution-id><institution-id institution-id-type="GRID">grid.1001.0</institution-id><institution>Research School of Population Health,</institution><institution>The Australian National University,</institution></institution-wrap>Canberra, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Canberra</wicri:regionArea></affiliation></author><author><name sortKey="Hu, Wenbiao" sort="Hu, Wenbiao" uniqKey="Hu W" first="Wenbiao" last="Hu">Wenbiao Hu</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000000089150953</institution-id><institution-id institution-id-type="GRID">grid.1024.7</institution-id><institution>School of Public Health and Social Work,</institution><institution>Queensland University of Technology,</institution></institution-wrap>Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Brisbane</wicri:regionArea></affiliation></author></analytic><series><title level="j">BMC Infectious Diseases</title><idno type="eISSN">1471-2334</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p id="Par1">Influenza and pneumococcal vaccine uptake in the older population aged 65 years or over of Hong Kong dramatically increased since the 2003 SARS outbreak. This study is aimed to evaluate the impact of increased coverage of influenza and pneumococcal vaccines by comparing the change of disease burden in the older population of Hong Kong, with the burden in the older population of Brisbane with relatively high vaccine coverage in the past fifteen years.</p></sec><sec><title>Methods</title><p id="Par2">Time series segmented regression models were applied to weekly numbers of cause-specific mortality or hospitalization of Hong Kong and Brisbane. Annual excess rates of mortality or hospitalization associated with influenza in the older population were estimated for the pre-SARS (reference period), post-SARS and post-pandemic period, respectively. The rate ratios (RRs) between these periods were also calculated to assess the relative change of disease burden.</p></sec><sec><title>Results</title><p id="Par3">Compared to the pre-SARS period, excess rates of mortality associated with influenza during the post-SARS period in Hong Kong decreased for cardiorespiratory diseases (RR = 0.90, 95% CI 0.80, 1.01), stroke (RR = 0.74, 95% CI 0.50, 1.09), and ischemic heart diseases (RR = 0.45, 95% CI 0.34, 0.58). The corresponding RRs in Brisbane were 0.79 (95% CI 0.54, 1.15), 0.33 (0.13, 0.80), and 1.09 (0.62, 1.90), respectively. Only the mortality of ischemic heart diseases showed a greater reduction in Hong Kong than in Brisbane. During the post-pandemic period, excess rates of all-cause mortality increased in Hong Kong, but to a lesser extent than in Brisbane (RR = 1.41 vs 2.39).</p></sec><sec><title>Conclusion</title><p id="Par4">A relative decrease (or less of an increase) of influenza disease burden was observed in the older population of Hong Kong after increased coverage of influenza and pneumococcal vaccines in this population, as compared to those of Brisbane where vaccination rates remained stable. The lack of significant findings in some disease categories highlights the challenges of evaluating the benefits of vaccination at the population level.</p></sec><sec><title>Electronic supplementary material</title><p>The online version of this article (10.1186/s12879-019-3735-7) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Glezen, Wp" uniqKey="Glezen W">WP Glezen</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Jefferson, T" uniqKey="Jefferson T">T Jefferson</name></author><author><name sortKey="Smith, S" uniqKey="Smith S">S Smith</name></author><author><name sortKey="Demicheli, V" uniqKey="Demicheli V">V Demicheli</name></author><author><name sortKey="Harnden, A" uniqKey="Harnden A">A Harnden</name></author><author><name sortKey="Rivetti, A" uniqKey="Rivetti A">A 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<front><journal-meta><journal-id journal-id-type="nlm-ta">BMC Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">BMC Infect. Dis</journal-id><journal-title-group><journal-title>BMC Infectious Diseases</journal-title></journal-title-group><issn pub-type="epub">1471-2334</issn><publisher><publisher-name>BioMed Central</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">30764779</article-id><article-id pub-id-type="pmc">6376732</article-id><article-id pub-id-type="publisher-id">3735</article-id><article-id pub-id-type="doi">10.1186/s12879-019-3735-7</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Comparison of influenza disease burden in older populations of Hong Kong and Brisbane: the impact of influenza and pneumococcal vaccination</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-5964-3233</contrib-id><name><surname>Yang</surname><given-names>Lin</given-names></name><address><phone>(852)27666398</phone><email>l.yang@polyu.edu.hk</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Chan</surname><given-names>King Pan</given-names></name><address><email>kpchanaa@hku.hk</email></address><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Wong</surname><given-names>Chit Ming</given-names></name><address><email>hrmrwcm@hku.hk</email></address><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Chiu</surname><given-names>Susan Shui Seng</given-names></name><address><email>ssschiu@hku.hk</email></address><xref ref-type="aff" rid="Aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Magalhaes</surname><given-names>Ricardo J. Soares</given-names></name><address><email>r.magalhaes@uq.edu.au</email></address><xref ref-type="aff" rid="Aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Thach</surname><given-names>Thuan Quoc</given-names></name><address><email>tqt@hku.hk</email></address><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Peiris</surname><given-names>Joseph Syrial Malik</given-names></name><address><email>malik@hku.hk</email></address><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Clements</surname><given-names>Archie C. A.</given-names></name><address><email>director.rsph@anu.edu.au</email></address><xref ref-type="aff" rid="Aff6">6</xref></contrib><contrib contrib-type="author"><name><surname>Hu</surname><given-names>Wenbiao</given-names></name><address><email>w2.hu@qut.edu.au</email></address><xref ref-type="aff" rid="Aff2">2</xref></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1764 6123</institution-id><institution-id institution-id-type="GRID">grid.16890.36</institution-id><institution>GH515, School of Nursing,</institution><institution>The Hong Kong Polytechnic University,</institution></institution-wrap>Hung Hom, Hong Kong, Hong Kong, Special Administrative Region of China</aff><aff id="Aff2"><label>2</label><institution-wrap><institution-id institution-id-type="ISNI">0000000089150953</institution-id><institution-id institution-id-type="GRID">grid.1024.7</institution-id><institution>School of Public Health and Social Work,</institution><institution>Queensland University of Technology,</institution></institution-wrap>Brisbane, Australia</aff><aff id="Aff3"><label>3</label><institution-wrap><institution-id institution-id-type="ISNI">0000000121742757</institution-id><institution-id institution-id-type="GRID">grid.194645.b</institution-id><institution>School of Public Health,</institution><institution>The University of Hong Kong,</institution></institution-wrap>Hong Kong, Hong Kong, Special Administrative Region of China</aff><aff id="Aff4"><label>4</label><institution-wrap><institution-id institution-id-type="ISNI">0000000121742757</institution-id><institution-id institution-id-type="GRID">grid.194645.b</institution-id><institution>Department of Pediatrics and Adolescent Medicine,</institution><institution>The University of Hong Kong,</institution></institution-wrap>Hong Kong, Hong Kong, Special Administrative Region of China</aff><aff id="Aff5"><label>5</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9320 7537</institution-id><institution-id institution-id-type="GRID">grid.1003.2</institution-id><institution>School of Veterinary Science,</institution><institution>University of Queensland,</institution></institution-wrap>Brisbane, Australia</aff><aff id="Aff6"><label>6</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 7477</institution-id><institution-id institution-id-type="GRID">grid.1001.0</institution-id><institution>Research School of Population Health,</institution><institution>The Australian National University,</institution></institution-wrap>Canberra, Australia</aff></contrib-group><pub-date pub-type="epub"><day>14</day><month>2</month><year>2019</year></pub-date><pub-date pub-type="pmc-release"><day>14</day><month>2</month><year>2019</year></pub-date><pub-date pub-type="collection"><year>2019</year></pub-date><volume>19</volume><elocation-id>162</elocation-id><history><date date-type="received"><day>19</day><month>6</month><year>2018</year></date><date date-type="accepted"><day>21</day><month>1</month><year>2019</year></date></history><permissions><copyright-statement>© The Author(s). 2019</copyright-statement><license license-type="OpenAccess"><license-p><bold>Open Access</bold>This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>) applies to the data made available in this article, unless otherwise stated.</license-p></license></permissions><abstract id="Abs1"><sec><title>Background</title><p id="Par1">Influenza and pneumococcal vaccine uptake in the older population aged 65 years or over of Hong Kong dramatically increased since the 2003 SARS outbreak. This study is aimed to evaluate the impact of increased coverage of influenza and pneumococcal vaccines by comparing the change of disease burden in the older population of Hong Kong, with the burden in the older population of Brisbane with relatively high vaccine coverage in the past fifteen years.</p></sec><sec><title>Methods</title><p id="Par2">Time series segmented regression models were applied to weekly numbers of cause-specific mortality or hospitalization of Hong Kong and Brisbane. Annual excess rates of mortality or hospitalization associated with influenza in the older population were estimated for the pre-SARS (reference period), post-SARS and post-pandemic period, respectively. The rate ratios (RRs) between these periods were also calculated to assess the relative change of disease burden.</p></sec><sec><title>Results</title><p id="Par3">Compared to the pre-SARS period, excess rates of mortality associated with influenza during the post-SARS period in Hong Kong decreased for cardiorespiratory diseases (RR = 0.90, 95% CI 0.80, 1.01), stroke (RR = 0.74, 95% CI 0.50, 1.09), and ischemic heart diseases (RR = 0.45, 95% CI 0.34, 0.58). The corresponding RRs in Brisbane were 0.79 (95% CI 0.54, 1.15), 0.33 (0.13, 0.80), and 1.09 (0.62, 1.90), respectively. Only the mortality of ischemic heart diseases showed a greater reduction in Hong Kong than in Brisbane. During the post-pandemic period, excess rates of all-cause mortality increased in Hong Kong, but to a lesser extent than in Brisbane (RR = 1.41 vs 2.39).</p></sec><sec><title>Conclusion</title><p id="Par4">A relative decrease (or less of an increase) of influenza disease burden was observed in the older population of Hong Kong after increased coverage of influenza and pneumococcal vaccines in this population, as compared to those of Brisbane where vaccination rates remained stable. The lack of significant findings in some disease categories highlights the challenges of evaluating the benefits of vaccination at the population level.</p></sec><sec><title>Electronic supplementary material</title><p>The online version of this article (10.1186/s12879-019-3735-7) contains supplementary material, which is available to authorized users.</p></sec></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>Influenza</kwd><kwd>Disease burden</kwd><kwd>Mortality</kwd><kwd>Morbidity</kwd><kwd>Elderly</kwd><kwd>Vaccine</kwd></kwd-group><funding-group><award-group><funding-source><institution-wrap><institution-id institution-id-type="FundRef">http://dx.doi.org/10.13039/501100005847</institution-id><institution>Health and Medical Research Fund</institution></institution-wrap></funding-source><award-id>13121282</award-id><principal-award-recipient><name><surname>Yang</surname><given-names>Lin</given-names></name></principal-award-recipient></award-group></funding-group><funding-group><award-group><funding-source><institution-wrap><institution-id institution-id-type="FundRef">http://dx.doi.org/10.13039/501100004377</institution-id><institution>Hong Kong Polytechnic University</institution></institution-wrap></funding-source><award-id>G-UADY</award-id><principal-award-recipient><name><surname>Yang</surname><given-names>Lin</given-names></name></principal-award-recipient></award-group></funding-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s) 2019</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list><country><li>Australie</li></country></list><tree><noCountry><name sortKey="Chan, King Pan" sort="Chan, King Pan" uniqKey="Chan K" first="King Pan" last="Chan">King Pan Chan</name><name sortKey="Chiu, Susan Shui Seng" sort="Chiu, Susan Shui Seng" uniqKey="Chiu S" first="Susan Shui Seng" last="Chiu">Susan Shui Seng Chiu</name><name sortKey="Peiris, Joseph Syrial Malik" sort="Peiris, Joseph Syrial Malik" uniqKey="Peiris J" first="Joseph Syrial Malik" last="Peiris">Joseph Syrial Malik Peiris</name><name sortKey="Thach, Thuan Quoc" sort="Thach, Thuan Quoc" uniqKey="Thach T" first="Thuan Quoc" last="Thach">Thuan Quoc Thach</name><name sortKey="Wong, Chit Ming" sort="Wong, Chit Ming" uniqKey="Wong C" first="Chit Ming" last="Wong">Chit Ming Wong</name><name sortKey="Yang, Lin" sort="Yang, Lin" uniqKey="Yang L" first="Lin" last="Yang">Lin Yang</name></noCountry><country name="Australie"><noRegion><name sortKey="Magalhaes, Ricardo J Soares" sort="Magalhaes, Ricardo J Soares" uniqKey="Magalhaes R" first="Ricardo J. Soares" last="Magalhaes">Ricardo J. Soares Magalhaes</name></noRegion><name sortKey="Clements, Archie C A" sort="Clements, Archie C A" uniqKey="Clements A" first="Archie C. A." last="Clements">Archie C. A. Clements</name><name sortKey="Hu, Wenbiao" sort="Hu, Wenbiao" uniqKey="Hu W" first="Wenbiao" last="Hu">Wenbiao Hu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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