Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study
Identifieur interne : 000325 ( Pmc/Checkpoint ); précédent : 000324; suivant : 000326Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study
Auteurs : Nan Yu [République populaire de Chine] ; Wei Li [République populaire de Chine] ; Qingling Kang [République populaire de Chine] ; Zhi Xiong [République populaire de Chine] ; Shaoshuai Wang [République populaire de Chine] ; Xingguang Lin [République populaire de Chine] ; Yanyan Liu [République populaire de Chine] ; Juan Xiao [République populaire de Chine] ; Haiyi Liu [République populaire de Chine] ; Dongrui Deng [République populaire de Chine] ; Suhua Chen [République populaire de Chine] ; Wanjiang Zeng [République populaire de Chine] ; Ling Feng [République populaire de Chine] ; Jianli Wu [République populaire de Chine]Source :
- The Lancet. Infectious Diseases [ 1473-3099 ] ; 2020.
Abstract
In December, 2019, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China. The number of affected pregnant women is increasing, but scarce information is available about the clinical features of COVID-19 in pregnancy. This study aimed to clarify the clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19.
In this retrospective, single-centre study, we included all pregnant women with COVID-19 who were admitted to Tongji Hospital in Wuhan, China. Clinical features, treatments, and maternal and fetal outcomes were assessed.
Seven patients, admitted to Tongji Hospital from Jan 1, to Feb 8, 2020, were included in our study. The mean age of the patients was 32 years (range 29–34 years) and the mean gestational age was 39 weeks plus 1 day (range 37 weeks to 41 weeks plus 2 days). Clinical manifestations were fever (six [86%] patients), cough (one [14%] patient), shortness of breath (one [14%] patient), and diarrhoea (one [14%] patient). All the patients had caesarean section within 3 days of clinical presentation with an average gestational age of 39 weeks plus 2 days. The final date of follow-up was Feb 12, 2020. The outcomes of the pregnant women and neonates were good. Three neonates were tested for SARS-CoV-2 and one neonate was infected with SARS-CoV-2 36 h after birth.
The maternal, fetal, and neonatal outcomes of patients who were infected in late pregnancy appeared very good, and these outcomes were achieved with intensive, active management that might be the best practice in the absence of more robust data. The clinical characteristics of these patients with COVID-19 during pregnancy were similar to those of non-pregnant adults with COVID-19 that have been reported in the literature.
National Natural Science Foundation of China, Hubei Provincial Natural Science Foundation of China.
Url:
DOI: 10.1016/S1473-3099(20)30176-6
PubMed: 32220284
PubMed Central: 7158904
Affiliations:
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sortKey="Liu, Yanyan" sort="Liu, Yanyan" uniqKey="Liu Y" first="Yanyan" last="Liu">Yanyan Liu</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Xiao, Juan" sort="Xiao, Juan" uniqKey="Xiao J" first="Juan" last="Xiao">Juan Xiao</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Haiyi" sort="Liu, Haiyi" uniqKey="Liu H" first="Haiyi" last="Liu">Haiyi Liu</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Deng, Dongrui" sort="Deng, Dongrui" uniqKey="Deng D" first="Dongrui" last="Deng">Dongrui 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xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Kang, Qingling" sort="Kang, Qingling" uniqKey="Kang Q" first="Qingling" last="Kang">Qingling Kang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Xiong, Zhi" sort="Xiong, Zhi" uniqKey="Xiong Z" first="Zhi" last="Xiong">Zhi Xiong</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Shaoshuai" sort="Wang, Shaoshuai" uniqKey="Wang S" first="Shaoshuai" last="Wang">Shaoshuai Wang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Xingguang" sort="Lin, Xingguang" uniqKey="Lin X" first="Xingguang" last="Lin">Xingguang Lin</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Yanyan" sort="Liu, Yanyan" uniqKey="Liu Y" first="Yanyan" last="Liu">Yanyan Liu</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Xiao, Juan" sort="Xiao, Juan" uniqKey="Xiao J" first="Juan" last="Xiao">Juan Xiao</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Haiyi" sort="Liu, Haiyi" uniqKey="Liu H" first="Haiyi" last="Liu">Haiyi Liu</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Deng, Dongrui" sort="Deng, Dongrui" uniqKey="Deng D" first="Dongrui" last="Deng">Dongrui Deng</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Suhua" sort="Chen, Suhua" uniqKey="Chen S" first="Suhua" last="Chen">Suhua Chen</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Zeng, Wanjiang" sort="Zeng, Wanjiang" uniqKey="Zeng W" first="Wanjiang" last="Zeng">Wanjiang Zeng</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Feng, Ling" sort="Feng, Ling" uniqKey="Feng L" first="Ling" last="Feng">Ling Feng</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Jianli" sort="Wu, Jianli" uniqKey="Wu J" first="Jianli" last="Wu">Jianli Wu</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author></analytic><series><title level="j">The Lancet. Infectious Diseases</title><idno type="ISSN">1473-3099</idno><idno type="eISSN">1474-4457</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><sec><title>Background</title><p>In December, 2019, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China. The number of affected pregnant women is increasing, but scarce information is available about the clinical features of COVID-19 in pregnancy. This study aimed to clarify the clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19.</p></sec><sec><title>Methods</title><p>In this retrospective, single-centre study, we included all pregnant women with COVID-19 who were admitted to Tongji Hospital in Wuhan, China. Clinical features, treatments, and maternal and fetal outcomes were assessed.</p></sec><sec><title>Findings</title><p>Seven patients, admitted to Tongji Hospital from Jan 1, to Feb 8, 2020, were included in our study. The mean age of the patients was 32 years (range 29–34 years) and the mean gestational age was 39 weeks plus 1 day (range 37 weeks to 41 weeks plus 2 days). Clinical manifestations were fever (six [86%] patients), cough (one [14%] patient), shortness of breath (one [14%] patient), and diarrhoea (one [14%] patient). All the patients had caesarean section within 3 days of clinical presentation with an average gestational age of 39 weeks plus 2 days. The final date of follow-up was Feb 12, 2020. The outcomes of the pregnant women and neonates were good. Three neonates were tested for SARS-CoV-2 and one neonate was infected with SARS-CoV-2 36 h after birth.</p></sec><sec><title>Interpretation</title><p>The maternal, fetal, and neonatal outcomes of patients who were infected in late pregnancy appeared very good, and these outcomes were achieved with intensive, active management that might be the best practice in the absence of more robust data. The clinical characteristics of these patients with COVID-19 during pregnancy were similar to those of non-pregnant adults with COVID-19 that have been reported in the literature.</p></sec><sec><title>Funding</title><p>National Natural Science Foundation of China, Hubei Provincial Natural Science Foundation of China.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Lu, H" uniqKey="Lu H">H Lu</name></author><author><name sortKey="Stratton, Cw" uniqKey="Stratton C">CW Stratton</name></author><author><name sortKey="Tang, Y W" uniqKey="Tang Y">Y-W Tang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hui, Dsi" uniqKey="Hui D">DSI Hui</name></author><author><name sortKey="Azhar, Ei" uniqKey="Azhar E">EI Azhar</name></author><author><name sortKey="Madani, Ta" uniqKey="Madani T">TA Madani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, C" uniqKey="Huang C">C Huang</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Li, X" uniqKey="Li X">X Li</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Huijun, C" uniqKey="Huijun C">C Huijun</name></author><author><name sortKey="Juanjuan, G" uniqKey="Juanjuan G">G Juanjuan</name></author><author><name sortKey="Chen, W" uniqKey="Chen W">W Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xu, Xt" uniqKey="Xu X">XT Xu</name></author><author><name sortKey="Chen, P" uniqKey="Chen P">P Chen</name></author><author><name sortKey="Wang, Jf" uniqKey="Wang J">JF Wang</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Chan, Jf" uniqKey="Chan J">JF Chan</name></author><author><name sortKey="Yuan, S" uniqKey="Yuan S">S Yuan</name></author><author><name sortKey="Kok, Kh" uniqKey="Kok K">KH Kok</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tegethoff, M" uniqKey="Tegethoff M">M Tegethoff</name></author><author><name sortKey="Pryce, C" uniqKey="Pryce C">C Pryce</name></author><author><name sortKey="Meinlschmidt, G" uniqKey="Meinlschmidt G">G Meinlschmidt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, N" uniqKey="Chen N">N Chen</name></author><author><name sortKey="Zhou, M" uniqKey="Zhou M">M Zhou</name></author><author><name sortKey="Dong, X" uniqKey="Dong X">X Dong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, R" uniqKey="Lu R">R Lu</name></author><author><name sortKey="Zhao, X" uniqKey="Zhao X">X Zhao</name></author><author><name sortKey="Li, J" uniqKey="Li J">J Li</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Wong, Sf" uniqKey="Wong S">SF Wong</name></author><author><name sortKey="Chow, Km" uniqKey="Chow K">KM Chow</name></author><author><name sortKey="Leung, Tn" uniqKey="Leung T">TN Leung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guan, W J" uniqKey="Guan W">W-J Guan</name></author><author><name sortKey="Ni, Z Y" uniqKey="Ni Z">Z-Y Ni</name></author><author><name sortKey="Hu, Y" uniqKey="Hu Y">Y Hu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shek, Cc" uniqKey="Shek C">CC Shek</name></author><author><name sortKey="Ng, Pc" uniqKey="Ng P">PC Ng</name></author><author><name sortKey="Fung, Gp" uniqKey="Fung G">GP Fung</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Lancet Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">Lancet Infect Dis</journal-id><journal-title-group><journal-title>The Lancet. Infectious Diseases</journal-title></journal-title-group><issn pub-type="ppub">1473-3099</issn><issn pub-type="epub">1474-4457</issn><publisher><publisher-name>Elsevier Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">32220284</article-id><article-id pub-id-type="pmc">7158904</article-id><article-id pub-id-type="publisher-id">S1473-3099(20)30176-6</article-id><article-id pub-id-type="doi">10.1016/S1473-3099(20)30176-6</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study</article-title></title-group><contrib-group><contrib contrib-type="author" id="au10"><name><surname>Yu</surname><given-names>Nan</given-names></name><degrees>PhD</degrees><xref rid="aff1" ref-type="aff">a</xref><xref rid="fn1" ref-type="fn">†</xref></contrib><contrib contrib-type="author" id="au20"><name><surname>Li</surname><given-names>Wei</given-names></name><degrees>PhD</degrees><xref rid="aff1" ref-type="aff">a</xref><xref rid="fn1" ref-type="fn">†</xref></contrib><contrib contrib-type="author" id="au30"><name><surname>Kang</surname><given-names>Qingling</given-names></name><degrees>PhD</degrees><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au40"><name><surname>Xiong</surname><given-names>Zhi</given-names></name><degrees>PhD</degrees><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au50"><name><surname>Wang</surname><given-names>Shaoshuai</given-names></name><degrees>PhD</degrees><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au60"><name><surname>Lin</surname><given-names>Xingguang</given-names></name><degrees>PhD</degrees><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au70"><name><surname>Liu</surname><given-names>Yanyan</given-names></name><degrees>PhD</degrees><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au80"><name><surname>Xiao</surname><given-names>Juan</given-names></name><degrees>PhD</degrees><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au90"><name><surname>Liu</surname><given-names>Haiyi</given-names></name><degrees>PhD</degrees><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au100"><name><surname>Deng</surname><given-names>Dongrui</given-names></name><degrees>Prof</degrees><degrees>PhD</degrees><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au110"><name><surname>Chen</surname><given-names>Suhua</given-names></name><degrees>Prof</degrees><degrees>PhD</degrees><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au120"><name><surname>Zeng</surname><given-names>Wanjiang</given-names></name><degrees>Prof</degrees><degrees>PhD</degrees><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au130"><name><surname>Feng</surname><given-names>Ling</given-names></name><degrees>Prof</degrees><degrees>PhD</degrees><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au140"><name><surname>Wu</surname><given-names>Jianli</given-names></name><degrees>PhD</degrees><email>jianliwu_tj@163.com</email><xref rid="aff1" ref-type="aff">a</xref><xref rid="cor1" ref-type="corresp">*</xref></contrib></contrib-group><aff id="aff1"><label>a</label>Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China</aff><author-notes><corresp id="cor1"><label>*</label>Correspondence to: Dr Jianli Wu, Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China <email>jianliwu_tj@163.com</email></corresp><fn id="fn1"><label>†</label><p id="cenpara10">Joint first authors</p></fn></author-notes><pub-date pub-type="pmc-release"><day>24</day><month>3</month><year>2020</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="epub"><day>24</day><month>3</month><year>2020</year></pub-date><permissions><copyright-statement>© 2020 Elsevier Ltd. All rights reserved.</copyright-statement><copyright-year>2020</copyright-year><copyright-holder>Elsevier Ltd</copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><related-article related-article-type="article-reference" id="d32e307" ext-link-type="doi" xlink:href="10.1016/S1473-3099(20)30191-2"></related-article><abstract id="ceab10"><title>Summary</title><sec><title>Background</title><p>In December, 2019, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China. The number of affected pregnant women is increasing, but scarce information is available about the clinical features of COVID-19 in pregnancy. This study aimed to clarify the clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19.</p></sec><sec><title>Methods</title><p>In this retrospective, single-centre study, we included all pregnant women with COVID-19 who were admitted to Tongji Hospital in Wuhan, China. Clinical features, treatments, and maternal and fetal outcomes were assessed.</p></sec><sec><title>Findings</title><p>Seven patients, admitted to Tongji Hospital from Jan 1, to Feb 8, 2020, were included in our study. The mean age of the patients was 32 years (range 29–34 years) and the mean gestational age was 39 weeks plus 1 day (range 37 weeks to 41 weeks plus 2 days). Clinical manifestations were fever (six [86%] patients), cough (one [14%] patient), shortness of breath (one [14%] patient), and diarrhoea (one [14%] patient). All the patients had caesarean section within 3 days of clinical presentation with an average gestational age of 39 weeks plus 2 days. The final date of follow-up was Feb 12, 2020. The outcomes of the pregnant women and neonates were good. Three neonates were tested for SARS-CoV-2 and one neonate was infected with SARS-CoV-2 36 h after birth.</p></sec><sec><title>Interpretation</title><p>The maternal, fetal, and neonatal outcomes of patients who were infected in late pregnancy appeared very good, and these outcomes were achieved with intensive, active management that might be the best practice in the absence of more robust data. The clinical characteristics of these patients with COVID-19 during pregnancy were similar to those of non-pregnant adults with COVID-19 that have been reported in the literature.</p></sec><sec><title>Funding</title><p>National Natural Science Foundation of China, Hubei Provincial Natural Science Foundation of China.</p></sec></abstract></article-meta></front></pmc><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Yu, Nan" sort="Yu, Nan" uniqKey="Yu N" first="Nan" last="Yu">Nan Yu</name></noRegion><name sortKey="Chen, Suhua" sort="Chen, Suhua" uniqKey="Chen S" first="Suhua" last="Chen">Suhua Chen</name><name sortKey="Deng, Dongrui" sort="Deng, Dongrui" uniqKey="Deng D" first="Dongrui" last="Deng">Dongrui Deng</name><name sortKey="Feng, Ling" sort="Feng, Ling" uniqKey="Feng L" first="Ling" last="Feng">Ling Feng</name><name sortKey="Kang, Qingling" sort="Kang, Qingling" uniqKey="Kang Q" first="Qingling" last="Kang">Qingling Kang</name><name sortKey="Li, Wei" sort="Li, Wei" uniqKey="Li W" first="Wei" last="Li">Wei Li</name><name sortKey="Lin, Xingguang" sort="Lin, Xingguang" uniqKey="Lin X" first="Xingguang" last="Lin">Xingguang Lin</name><name sortKey="Liu, Haiyi" sort="Liu, Haiyi" uniqKey="Liu H" first="Haiyi" last="Liu">Haiyi Liu</name><name sortKey="Liu, Yanyan" sort="Liu, Yanyan" uniqKey="Liu Y" first="Yanyan" last="Liu">Yanyan Liu</name><name sortKey="Wang, Shaoshuai" sort="Wang, Shaoshuai" uniqKey="Wang S" first="Shaoshuai" last="Wang">Shaoshuai Wang</name><name sortKey="Wu, Jianli" sort="Wu, Jianli" uniqKey="Wu J" first="Jianli" last="Wu">Jianli Wu</name><name sortKey="Xiao, Juan" sort="Xiao, Juan" uniqKey="Xiao J" first="Juan" last="Xiao">Juan Xiao</name><name sortKey="Xiong, Zhi" sort="Xiong, Zhi" uniqKey="Xiong Z" first="Zhi" last="Xiong">Zhi Xiong</name><name sortKey="Zeng, Wanjiang" sort="Zeng, Wanjiang" uniqKey="Zeng W" first="Wanjiang" last="Zeng">Wanjiang Zeng</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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