Mechano-genomic regulation of coronaviruses and its interplay with ageing
Identifieur interne : 000183 ( Pmc/Checkpoint ); précédent : 000182; suivant : 000184Mechano-genomic regulation of coronaviruses and its interplay with ageing
Auteurs : Caroline Uhler [Suisse] ; G. V. Shivashankar [Suisse]Source :
- Nature Reviews. Molecular Cell Biology [ 1471-0072 ] ; 2020.
Abstract
Coronaviruses employ various nuclear signalling mechanisms for their propagation. Here we link replication of coronaviruses, including SARS-CoV-2, the coronavirus disease 2019 (COVID-19)-causing virus, with cytoskeleton-dependent signalling and 3D genome organization. This link could provide novel insights into the high coronavirus pathogenicity in certain cellular states, particularly those associated with ageing.
Url:
DOI: 10.1038/s41580-020-0242-z
PubMed: 31676888
PubMed Central: 7115351
Affiliations:
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Shivashankar</name><affiliation wicri:level="4"><nlm:aff id="Aff2">Department of Health Sciences & Technology (D-HEST), ETH Zurich, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Health Sciences & Technology (D-HEST), ETH Zurich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName><orgName type="university">École polytechnique fédérale de Zurich</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1090 7501</institution-id><institution-id institution-id-type="GRID">grid.5991.4</institution-id><institution>Paul Scherrer Institute,</institution></institution-wrap>Villigen, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Villigen</wicri:regionArea></affiliation></author></analytic><series><title level="j">Nature Reviews. Molecular Cell Biology</title><idno type="ISSN">1471-0072</idno><idno type="eISSN">1471-0080</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">Coronaviruses employ various nuclear signalling mechanisms for their propagation. Here we link replication of coronaviruses, including SARS-CoV-2, the coronavirus disease 2019 (COVID-19)-causing virus, with cytoskeleton-dependent signalling and 3D genome organization. This link could provide novel insights into the high coronavirus pathogenicity in certain cellular states, particularly those associated with ageing.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name></author><author><name sortKey="Van Doremalen, N" uniqKey="Van Doremalen N">N van Doremalen</name></author><author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D Falzarano</name></author><author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Poppe, M" uniqKey="Poppe M">M Poppe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Uhler, C" uniqKey="Uhler C">C Uhler</name></author><author><name sortKey="Shivashankar, Gv" uniqKey="Shivashankar G">GV Shivashankar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Discher, De" uniqKey="Discher D">DE Discher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jain, N" uniqKey="Jain N">N Jain</name></author><author><name sortKey="Iyer, Kv" uniqKey="Iyer K">KV Iyer</name></author><author><name sortKey="Kumar, A" uniqKey="Kumar A">A Kumar</name></author><author><name sortKey="Shivashankar, Gv" uniqKey="Shivashankar G">GV Shivashankar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Nagarajan, M" uniqKey="Nagarajan M">M Nagarajan</name></author><author><name sortKey="Uhler, C" uniqKey="Uhler C">C Uhler</name></author><author><name sortKey="Shivashankar, Gv" uniqKey="Shivashankar G">GV Shivashankar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Damodaran, K" uniqKey="Damodaran K">K Damodaran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mitra, A" uniqKey="Mitra A">A Mitra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Uhler, C" uniqKey="Uhler C">C Uhler</name></author><author><name sortKey="Shivashankar, Gv" uniqKey="Shivashankar G">GV Shivashankar</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="brief-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Nat Rev Mol Cell Biol</journal-id><journal-id journal-id-type="iso-abbrev">Nat. Rev. Mol. Cell Biol</journal-id><journal-title-group><journal-title>Nature Reviews. Molecular Cell Biology</journal-title></journal-title-group><issn pub-type="ppub">1471-0072</issn><issn pub-type="epub">1471-0080</issn><publisher><publisher-name>Nature Publishing Group UK</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31676888</article-id><article-id pub-id-type="pmc">7115351</article-id><article-id pub-id-type="publisher-id">242</article-id><article-id pub-id-type="doi">10.1038/s41580-020-0242-z</article-id><article-categories><subj-group subj-group-type="heading"><subject>Comment</subject></subj-group></article-categories><title-group><article-title>Mechano-genomic regulation of coronaviruses and its interplay with ageing</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Uhler</surname><given-names>Caroline</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0003-0954-4496</contrib-id><name><surname>Shivashankar</surname><given-names>G. V.</given-names></name><address><email>gshivasha@ethz.ch</email></address><xref ref-type="aff" rid="Aff2">2</xref><xref ref-type="aff" rid="Aff3">3</xref></contrib><aff id="Aff1"><label>1</label>Department of Biosystems Science & Engineering (D-BSSE), ETH Zurich, Switzerland</aff><aff id="Aff2"><label>2</label>Department of Health Sciences & Technology (D-HEST), ETH Zurich, Switzerland</aff><aff id="Aff3"><label>3</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1090 7501</institution-id><institution-id institution-id-type="GRID">grid.5991.4</institution-id><institution>Paul Scherrer Institute,</institution></institution-wrap>Villigen, Switzerland</aff></contrib-group><pub-date pub-type="epub"><day>2</day><month>4</month><year>2020</year></pub-date><fpage>1</fpage><lpage>2</lpage><permissions><copyright-statement>© Springer Nature Limited 2020</copyright-statement><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p></license></permissions><abstract id="Abs1" abstract-type="Standfirst"><p id="Par1">Coronaviruses employ various nuclear signalling mechanisms for their propagation. Here we link replication of coronaviruses, including SARS-CoV-2, the coronavirus disease 2019 (COVID-19)-causing virus, with cytoskeleton-dependent signalling and 3D genome organization. This link could provide novel insights into the high coronavirus pathogenicity in certain cellular states, particularly those associated with ageing.</p></abstract><abstract id="Abs2" abstract-type="web-summary"><p id="Par2">Shivashankar and Uhler propose a link between cell mechano-genomics and coronavirus replication with implications for understanding the pathogenicity of SARS-CoV-2.</p></abstract><kwd-group kwd-group-type="npg-subject"><title>Subject terms</title><kwd>Nuclear organization</kwd><kwd>Mechanisms of disease</kwd><kwd>Ageing</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Suisse</li></country><region><li>Canton de Zurich</li></region><settlement><li>Zurich</li></settlement><orgName><li>École polytechnique fédérale de Zurich</li></orgName></list><tree><country name="Suisse"><region name="Canton de Zurich"><name sortKey="Uhler, Caroline" sort="Uhler, Caroline" uniqKey="Uhler C" first="Caroline" last="Uhler">Caroline Uhler</name></region><name sortKey="Shivashankar, G V" sort="Shivashankar, G V" uniqKey="Shivashankar G" first="G. V." last="Shivashankar">G. V. Shivashankar</name><name sortKey="Shivashankar, G V" sort="Shivashankar, G V" uniqKey="Shivashankar G" first="G. V." last="Shivashankar">G. V. Shivashankar</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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