Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents
Identifieur interne : 000153 ( Pmc/Checkpoint ); précédent : 000152; suivant : 000154Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents
Auteurs : G. Kampf [Allemagne] ; D. Todt [Allemagne] ; S. Pfaender [Allemagne] ; E. Steinmann [Allemagne]Source :
- The Journal of Hospital Infection [ 0195-6701 ] ; 2020.
Abstract
Currently, the emergence of a novel human coronavirus, SARS-CoV-2, has become a global health concern causing severe respiratory tract infections in humans. Human-to-human transmissions have been described with incubation times between 2-10 days, facilitating its spread via droplets, contaminated hands or surfaces. We therefore reviewed the literature on all available information about the persistence of human and veterinary coronaviruses on inanimate surfaces as well as inactivation strategies with biocidal agents used for chemical disinfection, e.g. in healthcare facilities. The analysis of 22 studies reveals that human coronaviruses such as Severe Acute Respiratory Syndrome (SARS) coronavirus, Middle East Respiratory Syndrome (MERS) coronavirus or endemic human coronaviruses (HCoV) can persist on inanimate surfaces like metal, glass or plastic for up to 9 days, but can be efficiently inactivated by surface disinfection procedures with 62–71% ethanol, 0.5% hydrogen peroxide or 0.1% sodium hypochlorite within 1 minute. Other biocidal agents such as 0.05–0.2% benzalkonium chloride or 0.02% chlorhexidine digluconate are less effective. As no specific therapies are available for SARS-CoV-2, early containment and prevention of further spread will be crucial to stop the ongoing outbreak and to control this novel infectious thread.
Url:
DOI: 10.1016/j.jhin.2020.01.022
PubMed: 32035997
PubMed Central: 7132493
Affiliations:
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Todt</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Molecular and Medical Virology, Ruhr University Bochum, Universitätsstrasse 50, 44801 Bochum, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Molecular and Medical Virology, Ruhr University Bochum, Universitätsstrasse 50, 44801 Bochum</wicri:regionArea><wicri:noRegion>44801 Bochum</wicri:noRegion><wicri:noRegion>44801 Bochum</wicri:noRegion><wicri:noRegion>44801 Bochum</wicri:noRegion></affiliation></author><author><name sortKey="Pfaender, S" sort="Pfaender, S" uniqKey="Pfaender S" first="S." last="Pfaender">S. Pfaender</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Molecular and Medical Virology, Ruhr University Bochum, Universitätsstrasse 50, 44801 Bochum, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Molecular and Medical Virology, Ruhr University Bochum, Universitätsstrasse 50, 44801 Bochum</wicri:regionArea><wicri:noRegion>44801 Bochum</wicri:noRegion><wicri:noRegion>44801 Bochum</wicri:noRegion><wicri:noRegion>44801 Bochum</wicri:noRegion></affiliation></author><author><name sortKey="Steinmann, E" sort="Steinmann, E" uniqKey="Steinmann E" first="E." last="Steinmann">E. Steinmann</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Molecular and Medical Virology, Ruhr University Bochum, Universitätsstrasse 50, 44801 Bochum, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Molecular and Medical Virology, Ruhr University Bochum, Universitätsstrasse 50, 44801 Bochum</wicri:regionArea><wicri:noRegion>44801 Bochum</wicri:noRegion><wicri:noRegion>44801 Bochum</wicri:noRegion><wicri:noRegion>44801 Bochum</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32035997</idno><idno type="pmc">7132493</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132493</idno><idno type="RBID">PMC:7132493</idno><idno type="doi">10.1016/j.jhin.2020.01.022</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">001830</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001830</idno><idno type="wicri:Area/Pmc/Curation">001830</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001830</idno><idno type="wicri:Area/Pmc/Checkpoint">000153</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000153</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents</title><author><name sortKey="Kampf, G" sort="Kampf, G" uniqKey="Kampf G" first="G." last="Kampf">G. Kampf</name><affiliation wicri:level="1"><nlm:aff id="aff1">University Medicine Greifswald, Institute for Hygiene and Environmental Medicine, Ferdinand-Sauerbruch-Straße, 17475 Greifswald, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Medicine Greifswald, Institute for Hygiene and Environmental Medicine, Ferdinand-Sauerbruch-Straße, 17475 Greifswald</wicri:regionArea><wicri:noRegion>17475 Greifswald</wicri:noRegion><wicri:noRegion>17475 Greifswald</wicri:noRegion><wicri:noRegion>17475 Greifswald</wicri:noRegion></affiliation></author><author><name sortKey="Todt, D" sort="Todt, D" uniqKey="Todt D" first="D." last="Todt">D. Todt</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Molecular and Medical Virology, Ruhr University Bochum, Universitätsstrasse 50, 44801 Bochum, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Molecular and Medical Virology, Ruhr University Bochum, Universitätsstrasse 50, 44801 Bochum</wicri:regionArea><wicri:noRegion>44801 Bochum</wicri:noRegion><wicri:noRegion>44801 Bochum</wicri:noRegion><wicri:noRegion>44801 Bochum</wicri:noRegion></affiliation></author><author><name sortKey="Pfaender, S" sort="Pfaender, S" uniqKey="Pfaender S" first="S." last="Pfaender">S. Pfaender</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Molecular and Medical Virology, Ruhr University Bochum, Universitätsstrasse 50, 44801 Bochum, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Molecular and Medical Virology, Ruhr University Bochum, Universitätsstrasse 50, 44801 Bochum</wicri:regionArea><wicri:noRegion>44801 Bochum</wicri:noRegion><wicri:noRegion>44801 Bochum</wicri:noRegion><wicri:noRegion>44801 Bochum</wicri:noRegion></affiliation></author><author><name sortKey="Steinmann, E" sort="Steinmann, E" uniqKey="Steinmann E" first="E." last="Steinmann">E. Steinmann</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Molecular and Medical Virology, Ruhr University Bochum, Universitätsstrasse 50, 44801 Bochum, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Molecular and Medical Virology, Ruhr University Bochum, Universitätsstrasse 50, 44801 Bochum</wicri:regionArea><wicri:noRegion>44801 Bochum</wicri:noRegion><wicri:noRegion>44801 Bochum</wicri:noRegion><wicri:noRegion>44801 Bochum</wicri:noRegion></affiliation></author></analytic><series><title level="j">The Journal of Hospital Infection</title><idno type="ISSN">0195-6701</idno><idno type="eISSN">1532-2939</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><p>Currently, the emergence of a novel human coronavirus, SARS-CoV-2, has become a global health concern causing severe respiratory tract infections in humans. Human-to-human transmissions have been described with incubation times between 2-10 days, facilitating its spread via droplets, contaminated hands or surfaces. We therefore reviewed the literature on all available information about the persistence of human and veterinary coronaviruses on inanimate surfaces as well as inactivation strategies with biocidal agents used for chemical disinfection, e.g. in healthcare facilities. The analysis of 22 studies reveals that human coronaviruses such as Severe Acute Respiratory Syndrome (SARS) coronavirus, Middle East Respiratory Syndrome (MERS) coronavirus or endemic human coronaviruses (HCoV) can persist on inanimate surfaces like metal, glass or plastic for up to 9 days, but can be efficiently inactivated by surface disinfection procedures with 62–71% ethanol, 0.5% hydrogen peroxide or 0.1% sodium hypochlorite within 1 minute. Other biocidal agents such as 0.05–0.2% benzalkonium chloride or 0.02% chlorhexidine digluconate are less effective. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Hosp Infect</journal-id><journal-id journal-id-type="iso-abbrev">J. Hosp. Infect</journal-id><journal-title-group><journal-title>The Journal of Hospital Infection</journal-title></journal-title-group><issn pub-type="ppub">0195-6701</issn><issn pub-type="epub">1532-2939</issn><publisher><publisher-name>The Healthcare Infection Society. Published by Elsevier Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">32035997</article-id><article-id pub-id-type="pmc">7132493</article-id><article-id pub-id-type="publisher-id">S0195-6701(20)30046-3</article-id><article-id pub-id-type="doi">10.1016/j.jhin.2020.01.022</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents</article-title></title-group><contrib-group><contrib contrib-type="author" id="au1"><name><surname>Kampf</surname><given-names>G.</given-names></name><email>guenter.kampf@uni-greifswald.de</email><xref rid="aff1" ref-type="aff">a</xref><xref rid="cor1" ref-type="corresp">∗</xref></contrib><contrib contrib-type="author" id="au2"><name><surname>Todt</surname><given-names>D.</given-names></name><xref rid="aff2" ref-type="aff">b</xref></contrib><contrib contrib-type="author" id="au3"><name><surname>Pfaender</surname><given-names>S.</given-names></name><xref rid="aff2" ref-type="aff">b</xref></contrib><contrib contrib-type="author" id="au4"><name><surname>Steinmann</surname><given-names>E.</given-names></name><xref rid="aff2" ref-type="aff">b</xref></contrib></contrib-group><aff id="aff1"><label>a</label>University Medicine Greifswald, Institute for Hygiene and Environmental Medicine, Ferdinand-Sauerbruch-Straße, 17475 Greifswald, Germany</aff><aff id="aff2"><label>b</label>Department of Molecular and Medical Virology, Ruhr University Bochum, Universitätsstrasse 50, 44801 Bochum, Germany</aff><author-notes><corresp id="cor1"><label>∗</label>Corresponding author. <email>guenter.kampf@uni-greifswald.de</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>6</day><month>2</month><year>2020</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>3</month><year>2020</year></pub-date><pub-date pub-type="epub"><day>6</day><month>2</month><year>2020</year></pub-date><volume>104</volume><issue>3</issue><fpage>246</fpage><lpage>251</lpage><history><date date-type="received"><day>31</day><month>1</month><year>2020</year></date><date date-type="accepted"><day>31</day><month>1</month><year>2020</year></date></history><permissions><copyright-statement>© 2020 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.</copyright-statement><copyright-year>2020</copyright-year><copyright-holder>The Healthcare Infection Society</copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract id="abs0010"><title>Summary</title><p>Currently, the emergence of a novel human coronavirus, SARS-CoV-2, has become a global health concern causing severe respiratory tract infections in humans. Human-to-human transmissions have been described with incubation times between 2-10 days, facilitating its spread via droplets, contaminated hands or surfaces. We therefore reviewed the literature on all available information about the persistence of human and veterinary coronaviruses on inanimate surfaces as well as inactivation strategies with biocidal agents used for chemical disinfection, e.g. in healthcare facilities. The analysis of 22 studies reveals that human coronaviruses such as Severe Acute Respiratory Syndrome (SARS) coronavirus, Middle East Respiratory Syndrome (MERS) coronavirus or endemic human coronaviruses (HCoV) can persist on inanimate surfaces like metal, glass or plastic for up to 9 days, but can be efficiently inactivated by surface disinfection procedures with 62–71% ethanol, 0.5% hydrogen peroxide or 0.1% sodium hypochlorite within 1 minute. Other biocidal agents such as 0.05–0.2% benzalkonium chloride or 0.02% chlorhexidine digluconate are less effective. As no specific therapies are available for SARS-CoV-2, early containment and prevention of further spread will be crucial to stop the ongoing outbreak and to control this novel infectious thread.</p></abstract><kwd-group id="kwrds0010"><title>Keywords</title><kwd>Coronavirus</kwd><kwd>Persistence</kwd><kwd>Inanimate surfaces</kwd><kwd>Chemical inactivation</kwd><kwd>Biocidal agents</kwd><kwd>Disinfection</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Allemagne</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Kampf, G" sort="Kampf, G" uniqKey="Kampf G" first="G." last="Kampf">G. Kampf</name></noRegion><name sortKey="Pfaender, S" sort="Pfaender, S" uniqKey="Pfaender S" first="S." last="Pfaender">S. Pfaender</name><name sortKey="Steinmann, E" sort="Steinmann, E" uniqKey="Steinmann E" first="E." last="Steinmann">E. Steinmann</name><name sortKey="Todt, D" sort="Todt, D" uniqKey="Todt D" first="D." last="Todt">D. Todt</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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