SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients
Identifieur interne : 000086 ( Pmc/Checkpoint ); précédent : 000085; suivant : 000087SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients
Auteurs : Lirong ZouSource :
- The New England Journal of Medicine [ 0028-4793 ] ; 2020.
Url:
DOI: 10.1056/NEJMc2001737
PubMed: 32074444
PubMed Central: 7121626
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients</title><author><name sortKey="Zou, Lirong" sort="Zou, Lirong" uniqKey="Zou L" first="Lirong" last="Zou">Lirong Zou</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32074444</idno><idno type="pmc">7121626</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121626</idno><idno type="RBID">PMC:7121626</idno><idno type="doi">10.1056/NEJMc2001737</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000B26</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000B26</idno><idno type="wicri:Area/Pmc/Curation">000B26</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000B26</idno><idno type="wicri:Area/Pmc/Checkpoint">000086</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000086</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients</title><author><name sortKey="Zou, Lirong" sort="Zou, Lirong" uniqKey="Zou L" first="Lirong" last="Zou">Lirong Zou</name></author></analytic><series><title level="j">The New England Journal of Medicine</title><idno type="ISSN">0028-4793</idno><idno type="eISSN">1533-4406</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="letter"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">N Engl J Med</journal-id><journal-id journal-id-type="iso-abbrev">N. Engl. J. Med</journal-id><journal-id journal-id-type="publisher-id">nejm</journal-id><journal-title-group><journal-title>The New England Journal of Medicine</journal-title></journal-title-group><issn pub-type="ppub">0028-4793</issn><issn pub-type="epub">1533-4406</issn><publisher><publisher-name>Massachusetts Medical Society</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">32074444</article-id><article-id pub-id-type="pmc">7121626</article-id><article-id pub-id-type="doi">10.1056/NEJMc2001737</article-id><article-id pub-id-type="publisher-id">NJ202003193821219</article-id><article-categories><subj-group subj-group-type="heading"><subject>Correspondence</subject></subj-group></article-categories><title-group><article-title>SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Zou</surname><given-names>Lirong</given-names></name><degrees>M.Sc.</degrees></contrib><aff>Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China</aff></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Ruan</surname><given-names>Feng</given-names></name><degrees>M.Med.</degrees></contrib><aff>Zhuhai Center for Disease Control and Prevention, Zhuhai, China</aff></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Huang</surname><given-names>Mingxing</given-names></name><degrees>Ph.D.</degrees></contrib><aff>Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, China</aff></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Liang</surname><given-names>Lijun</given-names></name><degrees>Ph.D.</degrees></contrib><aff>Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China</aff></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Huang</surname><given-names>Huitao</given-names></name><degrees>B.Sc.</degrees></contrib><aff>Zhuhai Center for Disease Control and Prevention, Zhuhai, China</aff></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Hong</surname><given-names>Zhongsi</given-names></name><degrees>M.D.</degrees></contrib><aff>Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, China</aff></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Yu</surname><given-names>Jianxiang</given-names></name><degrees>B.Sc.</degrees></contrib><contrib contrib-type="author"><name><surname>Kang</surname><given-names>Min</given-names></name><degrees>M.Sc.</degrees></contrib><contrib contrib-type="author"><name><surname>Song</surname><given-names>Yingchao</given-names></name><degrees>B.Sc.</degrees></contrib><aff>Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China</aff></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Xia</surname><given-names>Jinyu</given-names></name><degrees>M.D.</degrees></contrib><aff>Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, China</aff></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Guo</surname><given-names>Qianfang</given-names></name><degrees>M.Sc.</degrees></contrib><contrib contrib-type="author"><name><surname>Song</surname><given-names>Tie</given-names></name><degrees>M.Sc.</degrees></contrib><contrib contrib-type="author"><name><surname>He</surname><given-names>Jianfeng</given-names></name><degrees>B.Sc.</degrees></contrib><aff>Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China</aff></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Yen</surname><given-names>Hui-Ling</given-names></name><degrees>Ph.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Peiris</surname><given-names>Malik</given-names></name><degrees>Ph.D.</degrees></contrib><aff>University of Hong Kong, Hong Kong, China</aff></contrib-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Wu</surname><given-names>Jie</given-names></name><degrees>Ph.D.</degrees></contrib><aff>Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China<email xlink:href="771276998@qq.com">771276998@qq.com</email></aff></contrib-group><pub-date pub-type="ppub"><day>19</day><month>3</month><year>2020</year></pub-date><volume>382</volume><issue>12</issue><fpage>1177</fpage><lpage>1179</lpage><permissions><copyright-statement>Copyright © 2020 Massachusetts Medical Society. All rights reserved.</copyright-statement><copyright-year>2020</copyright-year><copyright-holder>Massachusetts Medical Society</copyright-holder><license specific-use="PMC_Covid-19"><license-p>This article is made available via the PMC Open Access Subset for unrestricted re-use, except commercial resale, and analyses in any form or by any means with acknowledgment of the original source. These permissions are granted for the duration of the Covid-19 pandemic or until revoked in writing. Upon expiration of these permissions, PMC is granted a license to make this article available via PMC and Europe PMC, subject to existing copyright protections.</license-p></license></permissions><self-uri content-type="pdf" xlink:href="NEJMc2001737.pdf"></self-uri><kwd-group kwd-group-type="nejm-topics"><nested-kwd><compound-kwd><compound-kwd-part content-type="code">18</compound-kwd-part><compound-kwd-part content-type="keyword">Infectious Disease</compound-kwd-part></compound-kwd><nested-kwd><compound-kwd><compound-kwd-part content-type="code">18_1</compound-kwd-part><compound-kwd-part content-type="keyword">Infectious Disease General</compound-kwd-part></compound-kwd><compound-kwd><compound-kwd-part content-type="code">18_6</compound-kwd-part><compound-kwd-part content-type="keyword">Viral Infections</compound-kwd-part></compound-kwd><compound-kwd><compound-kwd-part content-type="code">18_9</compound-kwd-part><compound-kwd-part content-type="keyword">Global Health</compound-kwd-part></compound-kwd></nested-kwd></nested-kwd></kwd-group></article-meta></front><floats-group><fig id="f1" orientation="portrait" position="float"><label>Figure 1</label><caption><title>Viral Load Detected in Nasal and Throat Swabs Obtained from Patients Infected with SARS-CoV-2.</title><p>Panel A shows cycle threshold (Ct) values of Orf1b on reverse-transcriptase–polymerase-chain-reaction (RT-PCR) assay that were detected in nasal swabs obtained from 14 patients with imported cases and 3 patients with secondary cases, and Panel B shows the Ct values in throat swabs. Patient Z did not have clinical symptoms and is not included in the figure. Patients with imported cases who had severe illness (Patients E, I, and P) are labeled in red, patients with imported cases who had mild-to-moderate illness are labeled in black, and patients with secondary cases (Patients D, H, and L) are labeled in blue. A linear mixed-effects model was used to test the Ct values from nasal and throat swabs among severe as compared with mild-to-moderate imported cases, which allowed for within-patient correlation and a time trend of Ct change. The mean Ct values in nasal and throat swabs obtained from patients with severe cases were lower by 2.8 (95% confidence interval [CI], −2.4 to 8.0) and 2.5 (95% CI, −0.8 to 5.7), respectively, than the values in swabs obtained from patients with mild-to-moderate cases. Panel C shows the aggregated Ct values of Orf1b on RT-PCR assay in 14 patients with imported cases and 3 patients with secondary cases, according to day after symptom onset. Ct values are inversely related to viral RNA copy number, with Ct values of 30.76, 27.67, 24.56, and 21.48 corresponding to 1.5×10<sup>4</sup>, 1.5×10<sup>5</sup>, 1.5×10<sup>6</sup>, and 1.5×10<sup>7</sup> copies per milliliter. Negative samples are denoted with a Ct of 40, which was the limit of detection.</p></caption><graphic xlink:href="NEJMc2001737_f1"></graphic></fig></floats-group></pmc><affiliations><list></list><tree><noCountry><name sortKey="Zou, Lirong" sort="Zou, Lirong" uniqKey="Zou L" first="Lirong" last="Zou">Lirong Zou</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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