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The enlightenment from two cases of asymptomatic infection with SARS-CoV-2: is it safe after 14 days of isolation?

Identifieur interne : 000035 ( Pmc/Checkpoint ); précédent : 000034; suivant : 000036

The enlightenment from two cases of asymptomatic infection with SARS-CoV-2: is it safe after 14 days of isolation?

Auteurs : Zhi-Qun Mao [République populaire de Chine] ; Ren Wan [République populaire de Chine] ; Li-Yi He [République populaire de Chine] ; Yue-Chun Hu [République populaire de Chine] ; Wei Chen [République populaire de Chine]

Source :

RBID : PMC:7128755

Abstract

Highlights

There may be virus carriers in asymptomatic population.

After 14 days of isolation, asymptomatic infection may still carry the virus.

Asymptomatic infection present a new challenge to home isolation.


Url:
DOI: 10.1016/j.ijid.2020.03.041
PubMed: 32251796
PubMed Central: 7128755


Affiliations:


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PMC:7128755

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<journal-id journal-id-type="iso-abbrev">Int. J. Infect. Dis</journal-id>
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<journal-title>International Journal of Infectious Diseases</journal-title>
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<contrib contrib-type="author" id="aut0005">
<name>
<surname>Mao</surname>
<given-names>Zhi-Qun</given-names>
</name>
<xref rid="aff0005" ref-type="aff">a</xref>
</contrib>
<contrib contrib-type="author" id="aut0010">
<name>
<surname>Wan</surname>
<given-names>Ren</given-names>
</name>
<email>wanrenradiology@163.com</email>
<xref rid="aff0005" ref-type="aff">a</xref>
<xref rid="cor0005" ref-type="corresp"></xref>
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<surname>He</surname>
<given-names>Li-Yi</given-names>
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<xref rid="aff0005" ref-type="aff">a</xref>
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<name>
<surname>Hu</surname>
<given-names>Yue-Chun</given-names>
</name>
<xref rid="aff0010" ref-type="aff">b</xref>
</contrib>
<contrib contrib-type="author" id="aut0025">
<name>
<surname>Chen</surname>
<given-names>Wei</given-names>
</name>
<xref rid="aff0015" ref-type="aff">c</xref>
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<label>a</label>
Department of Radiology, Hunan Provincial People’s Hospital(the First Affiliate Hospital of Hunan Normal University), Changsha, 410005, Hunan Province, China</aff>
<aff id="aff0010">
<label>b</label>
Department of Radiology, The center hospital of Loudi city, Loudi, 417000, Hunan Province, China</aff>
<aff id="aff0015">
<label>c</label>
The Academician workstation of Loudi Central Hospital, Loudi, 417000, Hunan Province, China</aff>
<author-notes>
<corresp id="cor0005">
<label></label>
Corresponding author at: Department of Radiology, Hunan Provincial People’s Hospital(the First Affiliate Hospital of Hunan Normal University), No.61 JieFangXi Road, Changsha, 410005, Hunan Province, China.
<email>wanrenradiology@163.com</email>
</corresp>
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<pub-date pub-type="pmc-release">
<day>3</day>
<month>4</month>
<year>2020</year>
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<pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
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<day>3</day>
<month>4</month>
<year>2020</year>
</pub-date>
<elocation-id></elocation-id>
<history>
<date date-type="received">
<day>28</day>
<month>2</month>
<year>2020</year>
</date>
<date date-type="rev-recd">
<day>14</day>
<month>3</month>
<year>2020</year>
</date>
<date date-type="accepted">
<day>17</day>
<month>3</month>
<year>2020</year>
</date>
</history>
<permissions>
<copyright-statement>© 2020 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.</copyright-statement>
<copyright-year>2020</copyright-year>
<copyright-holder></copyright-holder>
<license>
<license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p>
</license>
</permissions>
<abstract abstract-type="author-highlights" id="abs0005">
<title>Highlights</title>
<p>
<list list-type="simple" id="lis0005">
<list-item id="lsti0005">
<label></label>
<p id="par0005">There may be virus carriers in asymptomatic population.</p>
</list-item>
<list-item id="lsti0010">
<label></label>
<p id="par0010">After 14 days of isolation, asymptomatic infection may still carry the virus.</p>
</list-item>
<list-item id="lsti0015">
<label></label>
<p id="par0015">Asymptomatic infection present a new challenge to home isolation.</p>
</list-item>
</list>
</p>
</abstract>
<abstract id="abs0010">
<p>From 78 laboratory-confirmed cases, we found 2 asymptomatic infections. One patient was discharged within 14 days after treatment. Another patient was discharged 25 days after treatment, and his TR-PCR test was still positive on the 15th day. We found that there may be virus carriers in asymptomatic population with epidemiological contact history. After 14 days of isolation, asymptomatic infection may still carry the virus, which means the risk of transmission and present a new challenge to home isolation.</p>
</abstract>
<kwd-group id="kwd0005">
<title>Keywords</title>
<kwd>Novel coronavirus (SARS-CoV-2)</kwd>
<kwd>Asymptomatic infection</kwd>
<kwd>home isolation</kwd>
</kwd-group>
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<name sortKey="Wan, Ren" sort="Wan, Ren" uniqKey="Wan R" first="Ren" last="Wan">Ren Wan</name>
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