SrasV1, PascalFrancis, Curation, bibRecord, 000984

Evaluation of SSYA10-001 as a Replication Inhibitor of Severe Acute Respiratory Syndrome, Mouse Hepatitis, and Middle East Respiratory Syndrome Coronaviruses

Identifieur interne : 000984 ( PascalFrancis/Curation ); précédent : 000983; suivant : 000985

Evaluation of SSYA10-001 as a Replication Inhibitor of Severe Acute Respiratory Syndrome, Mouse Hepatitis, and Middle East Respiratory Syndrome Coronaviruses

Auteurs : Adeyemi O. Adedeji [États-Unis] ; Kamalendra Singh [États-Unis] ; Ademola Kassim [États-Unis] ; Christopher M. Coleman [États-Unis] ; Ruth Elliott [États-Unis] ; Susan R. Weiss [États-Unis] ; Matthew B. Frieman [États-Unis] ; Stefan G. Sarafianos [États-Unis]

Source :

Antimicrobial agents and chemotherapy [ 0066-4804 ] ; 2014.

RBID : Pascal:14-0220026

Descripteurs français

Pascal (Inist)
- Evaluation, Réplication, Inhibiteur, Syndrome respiratoire aigu sévère, Animal, Souris, Hépatite, Syndrome respiratoire du Moyen-Orient.

English descriptors

KwdEn :
- Animal, Evaluation, Hepatitis, Inhibitor, Middle East respiratory syndrome, Mouse, Replication, Severe acute respiratory syndrome.

Abstract

We have previously shown that SSYA10-001 blocks severe acute respiratory syndrome coronavirus (SARS-CoV) replication by inhibiting SARS-CoV helicase (nsp13). Here, we show that SSYA10-001 also inhibits replication of two other coronaviruses, mouse hepatitis virus (MHV) and Middle Eastern respiratory syndrome coronavirus (MERS-CoV). A putative binding pocket for SSYA10-001 was identified and shown to be similar in SARS-CoV, MERS-CoV, and MHV helicases. These studies show that it is possible to target multiple coronaviruses through broad-spectrum inhibitors.

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A03		`1`		`@0 Antimicrob. agents chemother.`
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A08	`01`	`1`	`ENG`	`@1 Evaluation of SSYA10-001 as a Replication Inhibitor of Severe Acute Respiratory Syndrome, Mouse Hepatitis, and Middle East Respiratory Syndrome Coronaviruses`
A11	`01`	`1`		`@1 ADEDEJI (Adeyemi O.)`
A11	`02`	`1`		`@1 SINGH (Kamalendra)`
A11	`03`	`1`		`@1 KASSIM (Ademola)`
A11	`04`	`1`		`@1 COLEMAN (Christopher M.)`
A11	`05`	`1`		`@1 ELLIOTT (Ruth)`
A11	`06`	`1`		`@1 WEISS (Susan R.)`
A11	`07`	`1`		`@1 FRIEMAN (Matthew B.)`
A11	`08`	`1`		`@1 SARAFIANOS (Stefan G.)`
A14	`01`			`@1 Christopher Bond Life Sciences Center, University of Missouri @2 Columbia, Missouri @3 USA @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 8 aut.`
A14	`02`			`@1 Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine @2 Columbia, Missouri @3 USA @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 8 aut.`
A14	`03`			`@1 Department of Microbiology & Immunology, University of Maryland School of Medicine @2 Baltimore, Maryland @3 USA @Z 4 aut. @Z 7 aut.`
A14	`04`			`@1 Department of Microbiology, University of Pennsylvania School of Medicine @2 Philadelphia, Pennsylvania @3 USA @Z 5 aut. @Z 6 aut.`
A14	`05`			`@1 Department of Biochemistry, University of Missouri @2 Columbia, Missouri @3 USA @Z 8 aut.`
A20				`@1 4894-4898`
A21				`@1 2014`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 13334 @5 354000504837190750`
A44				`@0 0000 @1 © 2014 INIST-CNRS. All rights reserved.`
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C01	`01`		`ENG`	@0 We have previously shown that SSYA10-001 blocks severe acute respiratory syndrome coronavirus (SARS-CoV) replication by inhibiting SARS-CoV helicase (nsp13). Here, we show that SSYA10-001 also inhibits replication of two other coronaviruses, mouse hepatitis virus (MHV) and Middle Eastern respiratory syndrome coronavirus (MERS-CoV). A putative binding pocket for SSYA10-001 was identified and shown to be similar in SARS-CoV, MERS-CoV, and MHV helicases. These studies show that it is possible to target multiple coronaviruses through broad-spectrum inhibitors.
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C03	`01`	`X`	`SPA`	`@0 Evaluación @5 01`
C03	`02`	`X`	`FRE`	`@0 Réplication @5 02`
C03	`02`	`X`	`ENG`	`@0 Replication @5 02`
C03	`02`	`X`	`SPA`	`@0 Replicación @5 02`
C03	`03`	`X`	`FRE`	`@0 Inhibiteur @5 03`
C03	`03`	`X`	`ENG`	`@0 Inhibitor @5 03`
C03	`03`	`X`	`SPA`	`@0 Inhibidor @5 03`
C03	`04`	`X`	`FRE`	`@0 Syndrome respiratoire aigu sévère @2 NM @5 04`
C03	`04`	`X`	`ENG`	`@0 Severe acute respiratory syndrome @2 NM @5 04`
C03	`04`	`X`	`SPA`	`@0 Síndrome respiratorio agudo severo @2 NM @5 04`
C03	`05`	`X`	`FRE`	`@0 Animal @5 05`
C03	`05`	`X`	`ENG`	`@0 Animal @5 05`
C03	`05`	`X`	`SPA`	`@0 Animal @5 05`
C03	`06`	`X`	`FRE`	`@0 Souris @5 06`
C03	`06`	`X`	`ENG`	`@0 Mouse @5 06`
C03	`06`	`X`	`SPA`	`@0 Ratón @5 06`
C03	`07`	`X`	`FRE`	`@0 Hépatite @5 07`
C03	`07`	`X`	`ENG`	`@0 Hepatitis @5 07`
C03	`07`	`X`	`SPA`	`@0 Hepatitis @5 07`
C03	`08`	`X`	`FRE`	`@0 Syndrome respiratoire du Moyen-Orient @4 CD @5 96`
C03	`08`	`X`	`ENG`	`@0 Middle East respiratory syndrome @4 CD @5 96`
C07	`01`	`X`	`FRE`	`@0 Virose`
C07	`01`	`X`	`ENG`	`@0 Viral disease`
C07	`01`	`X`	`SPA`	`@0 Virosis`
C07	`02`	`X`	`FRE`	`@0 Infection`
C07	`02`	`X`	`ENG`	`@0 Infection`
C07	`02`	`X`	`SPA`	`@0 Infección`
C07	`03`	`X`	`FRE`	`@0 Rodentia @2 NS`
C07	`03`	`X`	`ENG`	`@0 Rodentia @2 NS`
C07	`03`	`X`	`SPA`	`@0 Rodentia @2 NS`
C07	`04`	`X`	`FRE`	`@0 Mammalia @2 NS`
C07	`04`	`X`	`ENG`	`@0 Mammalia @2 NS`
C07	`04`	`X`	`SPA`	`@0 Mammalia @2 NS`
C07	`05`	`X`	`FRE`	`@0 Vertebrata @2 NS`
C07	`05`	`X`	`ENG`	`@0 Vertebrata @2 NS`
C07	`05`	`X`	`SPA`	`@0 Vertebrata @2 NS`
C07	`06`	`X`	`FRE`	`@0 Pathologie de l'appareil respiratoire @5 37`
C07	`06`	`X`	`ENG`	`@0 Respiratory disease @5 37`
C07	`06`	`X`	`SPA`	`@0 Aparato respiratorio patología @5 37`
C07	`07`	`X`	`FRE`	`@0 Pathologie des poumons @5 38`
C07	`07`	`X`	`ENG`	`@0 Lung disease @5 38`
C07	`07`	`X`	`SPA`	`@0 Pulmón patología @5 38`
C07	`08`	`X`	`FRE`	`@0 Pathologie de l'appareil digestif @5 40`
C07	`08`	`X`	`ENG`	`@0 Digestive diseases @5 40`
C07	`08`	`X`	`SPA`	`@0 Aparato digestivo patología @5 40`
C07	`09`	`X`	`FRE`	`@0 Pathologie du foie @5 41`
C07	`09`	`X`	`ENG`	`@0 Hepatic disease @5 41`
C07	`09`	`X`	`SPA`	`@0 Hígado patología @5 41`
N21				`@1 265`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Links toward previous steps (curation, corpus...)

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Pascal:14-0220026

Le document en format XML

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<author><name sortKey="Sarafianos, Stefan G" sort="Sarafianos, Stefan G" uniqKey="Sarafianos S" first="Stefan G." last="Sarafianos">Stefan G. Sarafianos</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term>
<term>Evaluation</term>
<term>Hepatitis</term>
<term>Inhibitor</term>
<term>Middle East respiratory syndrome</term>
<term>Mouse</term>
<term>Replication</term>
<term>Severe acute respiratory syndrome</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Evaluation</term>
<term>Réplication</term>
<term>Inhibiteur</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Animal</term>
<term>Souris</term>
<term>Hépatite</term>
<term>Syndrome respiratoire du Moyen-Orient</term>
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<front><div type="abstract" xml:lang="en">We have previously shown that SSYA10-001 blocks severe acute respiratory syndrome coronavirus (SARS-CoV) replication by inhibiting SARS-CoV helicase (nsp13). Here, we show that SSYA10-001 also inhibits replication of two other coronaviruses, mouse hepatitis virus (MHV) and Middle Eastern respiratory syndrome coronavirus (MERS-CoV). A putative binding pocket for SSYA10-001 was identified and shown to be similar in SARS-CoV, MERS-CoV, and MHV helicases. These studies show that it is possible to target multiple coronaviruses through broad-spectrum inhibitors.</div>
</front>
</TEI>
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</fA01>
<fA02 i1="01"><s0>AACHAX</s0>
</fA02>
<fA03 i2="1"><s0>Antimicrob. agents chemother.</s0>
</fA03>
<fA05><s2>58</s2>
</fA05>
<fA06><s2>8</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Evaluation of SSYA10-001 as a Replication Inhibitor of Severe Acute Respiratory Syndrome, Mouse Hepatitis, and Middle East Respiratory Syndrome Coronaviruses</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>ADEDEJI (Adeyemi O.)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>SINGH (Kamalendra)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>KASSIM (Ademola)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>COLEMAN (Christopher M.)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>ELLIOTT (Ruth)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>WEISS (Susan R.)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>FRIEMAN (Matthew B.)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>SARAFIANOS (Stefan G.)</s1>
</fA11>
<fA14 i1="01"><s1>Christopher Bond Life Sciences Center, University of Missouri</s1>
<s2>Columbia, Missouri</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine</s1>
<s2>Columbia, Missouri</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Department of Microbiology & Immunology, University of Maryland School of Medicine</s1>
<s2>Baltimore, Maryland</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Department of Microbiology, University of Pennsylvania School of Medicine</s1>
<s2>Philadelphia, Pennsylvania</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Department of Biochemistry, University of Missouri</s1>
<s2>Columbia, Missouri</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
</fA14>
<fA20><s1>4894-4898</s1>
</fA20>
<fA21><s1>2014</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>13334</s2>
<s5>354000504837190750</s5>
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<fA44><s0>0000</s0>
<s1>© 2014 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>12 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>14-0220026</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Antimicrobial agents and chemotherapy</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>We have previously shown that SSYA10-001 blocks severe acute respiratory syndrome coronavirus (SARS-CoV) replication by inhibiting SARS-CoV helicase (nsp13). Here, we show that SSYA10-001 also inhibits replication of two other coronaviruses, mouse hepatitis virus (MHV) and Middle Eastern respiratory syndrome coronavirus (MERS-CoV). A putative binding pocket for SSYA10-001 was identified and shown to be similar in SARS-CoV, MERS-CoV, and MHV helicases. These studies show that it is possible to target multiple coronaviruses through broad-spectrum inhibitors.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B02S</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B05C02C</s0>
</fC02>
<fC02 i1="03" i2="X"><s0>002B13C03</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Evaluation</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Evaluation</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Evaluación</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Réplication</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Replication</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Replicación</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Inhibiteur</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Inhibitor</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Inhibidor</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Syndrome respiratoire aigu sévère</s0>
<s2>NM</s2>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Severe acute respiratory syndrome</s0>
<s2>NM</s2>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Síndrome respiratorio agudo severo</s0>
<s2>NM</s2>
<s5>04</s5>
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<fC03 i1="05" i2="X" l="FRE"><s0>Animal</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Animal</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Animal</s0>
<s5>05</s5>
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<fC03 i1="06" i2="X" l="FRE"><s0>Souris</s0>
<s5>06</s5>
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<fC03 i1="06" i2="X" l="SPA"><s0>Ratón</s0>
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<fC03 i1="07" i2="X" l="FRE"><s0>Hépatite</s0>
<s5>07</s5>
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<fC03 i1="07" i2="X" l="ENG"><s0>Hepatitis</s0>
<s5>07</s5>
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<fC03 i1="07" i2="X" l="SPA"><s0>Hepatitis</s0>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Syndrome respiratoire du Moyen-Orient</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Middle East respiratory syndrome</s0>
<s4>CD</s4>
<s5>96</s5>
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<fC07 i1="01" i2="X" l="FRE"><s0>Virose</s0>
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<fC07 i1="01" i2="X" l="ENG"><s0>Viral disease</s0>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Virosis</s0>
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<fC07 i1="02" i2="X" l="FRE"><s0>Infection</s0>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Infection</s0>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Infección</s0>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Rodentia</s0>
<s2>NS</s2>
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<fC07 i1="04" i2="X" l="FRE"><s0>Mammalia</s0>
<s2>NS</s2>
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<fC07 i1="04" i2="X" l="ENG"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Pathologie de l'appareil respiratoire</s0>
<s5>37</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>37</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Pathologie des poumons</s0>
<s5>38</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Lung disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Pulmón patología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Pathologie de l'appareil digestif</s0>
<s5>40</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Digestive diseases</s0>
<s5>40</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Aparato digestivo patología</s0>
<s5>40</s5>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Pathologie du foie</s0>
<s5>41</s5>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Hepatic disease</s0>
<s5>41</s5>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Hígado patología</s0>
<s5>41</s5>
</fC07>
<fN21><s1>265</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
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Evaluation of SSYA10-001 as a Replication Inhibitor of Severe Acute Respiratory Syndrome, Mouse Hepatitis, and Middle East Respiratory Syndrome Coronaviruses

Evaluation of SSYA10-001 as a Replication Inhibitor of Severe Acute Respiratory Syndrome, Mouse Hepatitis, and Middle East Respiratory Syndrome Coronaviruses

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