SrasV1, PascalFrancis, Curation, bibRecord, 000906

Houttuynia cordata blocks HSV infection through inhibition of NF-κB activation

Identifieur interne : 000906 ( PascalFrancis/Curation ); précédent : 000905; suivant : 000907

Houttuynia cordata blocks HSV infection through inhibition of NF-κB activation

Auteurs : XIAOQING CHEN [République populaire de Chine] ; ZHONGXIA WANG [République populaire de Chine] ; ZIYING YANG [République populaire de Chine] ; JINGJING WANG [République populaire de Chine] ; YUNXIA XU [République populaire de Chine] ; Ren-Xiang Tan [République populaire de Chine] ; ERGUANG LI [République populaire de Chine]

Source :

Antiviral research [ 0166-3542 ] ; 2011.

RBID : Pascal:12-0002118

Descripteurs français

Pascal (Inist)
- Herpesvirus hominis, Infection, Inhibition, Facteur transcription NFκB, Evaluation performance, Flavonoïde, Antiviral.

English descriptors

KwdEn :
- Antiviral, Flavonoid, Herpesvirus hominis, Infection, Inhibition, Performance evaluation, Transcription factor NFκB.

Abstract

Houttuynia cordata Thunb. is a medicinal plant widely used in folk medicine in several Asian countries. It has been reported that a water extract of H. cordata exhibits activity against herpes simplex virus (HSV) and the virus of severe acute respiratory syndrome (SARS), although the mechanisms are not fully understood yet. Previous studies have demonstrated absolute requirement of NF-κB activation for efficient replication of HSV-1 and HSV-2 and inhibition of NF-κB activation has been shown to suppress HSV infection. Here we show that a hot water extract of H. cordata (HCWE) inhibits HSV-2 infection through inhibition of NF-κB activation. The IC50 was estimated at 50 μg/ml of lyophilized HCWE powder. At 150 and 450 μg/ml, HCWE blocked infectious HSV-2 production by more than 3 and 4 logs, respectively. The inhibitory activity was concomitant with an inhibition of NF-κB activation by HSV-2 infection. Although activation of NF-κB and Erk MAPK has been implicated for HSV replication and growth, HCWE showed no effect on HSV-2-induced Erk activation. Furthermore, we show that treatment with quercetin, quercitrin or isoquercitrin, major water extractable flavonoids from H. cordata, significantly blocked HSV-2 infection. These results together demonstrated that H. cordata blocks HSV-2 infection through inhibition of NF-κB activation.

A01	`01`	`1`		`@0 0166-3542`
A02	`01`			`@0 ARSRDR`
A03		`1`		`@0 Antivir. res.`
A05				`@2 92`
A06				`@2 2`
A08	`01`	`1`	`ENG`	`@1 Houttuynia cordata blocks HSV infection through inhibition of NF-κB activation`
A11	`01`	`1`		`@1 XIAOQING CHEN`
A11	`02`	`1`		`@1 ZHONGXIA WANG`
A11	`03`	`1`		`@1 ZIYING YANG`
A11	`04`	`1`		`@1 JINGJING WANG`
A11	`05`	`1`		`@1 YUNXIA XU`
A11	`06`	`1`		`@1 TAN (Ren-Xiang)`
A11	`07`	`1`		`@1 ERGUANG LI`
A14	`01`			`@1 State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, 22 Hankou Road @2 Nanjing, Jiangsu Province 210093 @3 CHN @Z 1 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut. @Z 7 aut.`
A14	`02`			`@1 School of Medicine, Nanjing University, 22 Hankou Road @2 Nanjing, Jiangsu Province 210093 @3 CHN @Z 1 aut. @Z 2 aut. @Z 4 aut. @Z 7 aut.`
A14	`03`			`@1 College of Life Science, Nanjing University, 22 Hankou Road @2 Nanjing, Jiangsu Province 210093 @3 CHN @Z 1 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut.`
A20				`@1 341-345`
A21				`@1 2011`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 18839 @5 354000507853860230`
A44				`@0 0000 @1 © 2012 INIST-CNRS. All rights reserved.`
A45				`@0 3/4 p.`
A47	`01`	`1`		`@0 12-0002118`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Antiviral research`
A66	`01`			`@0 GBR`
C01	`01`		`ENG`	@0 Houttuynia cordata Thunb. is a medicinal plant widely used in folk medicine in several Asian countries. It has been reported that a water extract of H. cordata exhibits activity against herpes simplex virus (HSV) and the virus of severe acute respiratory syndrome (SARS), although the mechanisms are not fully understood yet. Previous studies have demonstrated absolute requirement of NF-κB activation for efficient replication of HSV-1 and HSV-2 and inhibition of NF-κB activation has been shown to suppress HSV infection. Here we show that a hot water extract of H. cordata (HCWE) inhibits HSV-2 infection through inhibition of NF-κB activation. The IC50 was estimated at 50 μg/ml of lyophilized HCWE powder. At 150 and 450 μg/ml, HCWE blocked infectious HSV-2 production by more than 3 and 4 logs, respectively. The inhibitory activity was concomitant with an inhibition of NF-κB activation by HSV-2 infection. Although activation of NF-κB and Erk MAPK has been implicated for HSV replication and growth, HCWE showed no effect on HSV-2-induced Erk activation. Furthermore, we show that treatment with quercetin, quercitrin or isoquercitrin, major water extractable flavonoids from H. cordata, significantly blocked HSV-2 infection. These results together demonstrated that H. cordata blocks HSV-2 infection through inhibition of NF-κB activation.
C02	`01`	`X`		`@0 002B02S05`
C03	`01`	`X`	`FRE`	`@0 Herpesvirus hominis @2 NW @5 01`
C03	`01`	`X`	`ENG`	`@0 Herpesvirus hominis @2 NW @5 01`
C03	`01`	`X`	`SPA`	`@0 Herpesvirus hominis @2 NW @5 01`
C03	`02`	`X`	`FRE`	`@0 Infection @5 02`
C03	`02`	`X`	`ENG`	`@0 Infection @5 02`
C03	`02`	`X`	`SPA`	`@0 Infección @5 02`
C03	`03`	`X`	`FRE`	`@0 Inhibition @5 03`
C03	`03`	`X`	`ENG`	`@0 Inhibition @5 03`
C03	`03`	`X`	`SPA`	`@0 Inhibición @5 03`
C03	`04`	`X`	`FRE`	`@0 Facteur transcription NFκB @5 04`
C03	`04`	`X`	`ENG`	`@0 Transcription factor NFκB @5 04`
C03	`04`	`X`	`SPA`	`@0 Factor transcripción NFκB @5 04`
C03	`05`	`X`	`FRE`	`@0 Evaluation performance @5 05`
C03	`05`	`X`	`ENG`	`@0 Performance evaluation @5 05`
C03	`05`	`X`	`SPA`	`@0 Evaluación prestación @5 05`
C03	`06`	`X`	`FRE`	`@0 Flavonoïde @5 06`
C03	`06`	`X`	`ENG`	`@0 Flavonoid @5 06`
C03	`06`	`X`	`SPA`	`@0 Flavonoide @5 06`
C03	`07`	`X`	`FRE`	`@0 Antiviral @5 07`
C03	`07`	`X`	`ENG`	`@0 Antiviral @5 07`
C03	`07`	`X`	`SPA`	`@0 Antiviral @5 07`
C07	`01`	`X`	`FRE`	`@0 Alphaherpesvirinae @2 NW`
C07	`01`	`X`	`ENG`	`@0 Alphaherpesvirinae @2 NW`
C07	`01`	`X`	`SPA`	`@0 Alphaherpesvirinae @2 NW`
C07	`02`	`X`	`FRE`	`@0 Herpesviridae @2 NW`
C07	`02`	`X`	`ENG`	`@0 Herpesviridae @2 NW`
C07	`02`	`X`	`SPA`	`@0 Herpesviridae @2 NW`
C07	`03`	`X`	`FRE`	`@0 Virus @2 NW`
C07	`03`	`X`	`ENG`	`@0 Virus @2 NW`
C07	`03`	`X`	`SPA`	`@0 Virus @2 NW`
C07	`04`	`X`	`FRE`	`@0 Régulation @5 37`
C07	`04`	`X`	`ENG`	`@0 Regulation(control) @5 37`
C07	`04`	`X`	`SPA`	`@0 Regulación @5 37`
C07	`05`	`X`	`FRE`	`@0 Polyphénol @5 38`
C07	`05`	`X`	`ENG`	`@0 Polyphenol @5 38`
C07	`05`	`X`	`SPA`	`@0 Polifenol @5 38`
C07	`06`	`X`	`FRE`	`@0 Phénols @2 FX @5 39`
C07	`06`	`X`	`ENG`	`@0 Phenols @2 FX @5 39`
C07	`06`	`X`	`SPA`	`@0 Fenoles @2 FX @5 39`
N21				`@1 002`

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Pascal:12-0002118

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Houttuynia cordata blocks HSV infection through inhibition of NF-κB activation</title>
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<author><name sortKey="Jingjing Wang" sort="Jingjing Wang" uniqKey="Jingjing Wang" last="Jingjing Wang">JINGJING WANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, 22 Hankou Road</s1>
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<author><name sortKey="Yunxia Xu" sort="Yunxia Xu" uniqKey="Yunxia Xu" last="Yunxia Xu">YUNXIA XU</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, 22 Hankou Road</s1>
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<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
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<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Tan, Ren Xiang" sort="Tan, Ren Xiang" uniqKey="Tan R" first="Ren-Xiang" last="Tan">Ren-Xiang Tan</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, 22 Hankou Road</s1>
<s2>Nanjing, Jiangsu Province 210093</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
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<country>République populaire de Chine</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>College of Life Science, Nanjing University, 22 Hankou Road</s1>
<s2>Nanjing, Jiangsu Province 210093</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
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<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Erguang Li" sort="Erguang Li" uniqKey="Erguang Li" last="Erguang Li">ERGUANG LI</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, 22 Hankou Road</s1>
<s2>Nanjing, Jiangsu Province 210093</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>School of Medicine, Nanjing University, 22 Hankou Road</s1>
<s2>Nanjing, Jiangsu Province 210093</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Antiviral research</title>
<title level="j" type="abbreviated">Antivir. res.</title>
<idno type="ISSN">0166-3542</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Antiviral research</title>
<title level="j" type="abbreviated">Antivir. res.</title>
<idno type="ISSN">0166-3542</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral</term>
<term>Flavonoid</term>
<term>Herpesvirus hominis</term>
<term>Infection</term>
<term>Inhibition</term>
<term>Performance evaluation</term>
<term>Transcription factor NFκB</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Herpesvirus hominis</term>
<term>Infection</term>
<term>Inhibition</term>
<term>Facteur transcription NFκB</term>
<term>Evaluation performance</term>
<term>Flavonoïde</term>
<term>Antiviral</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Houttuynia cordata Thunb. is a medicinal plant widely used in folk medicine in several Asian countries. It has been reported that a water extract of H. cordata exhibits activity against herpes simplex virus (HSV) and the virus of severe acute respiratory syndrome (SARS), although the mechanisms are not fully understood yet. Previous studies have demonstrated absolute requirement of NF-κB activation for efficient replication of HSV-1 and HSV-2 and inhibition of NF-κB activation has been shown to suppress HSV infection. Here we show that a hot water extract of H. cordata (HCWE) inhibits HSV-2 infection through inhibition of NF-κB activation. The IC50 was estimated at 50 μg/ml of lyophilized HCWE powder. At 150 and 450 μg/ml, HCWE blocked infectious HSV-2 production by more than 3 and 4 logs, respectively. The inhibitory activity was concomitant with an inhibition of NF-κB activation by HSV-2 infection. Although activation of NF-κB and Erk MAPK has been implicated for HSV replication and growth, HCWE showed no effect on HSV-2-induced Erk activation. Furthermore, we show that treatment with quercetin, quercitrin or isoquercitrin, major water extractable flavonoids from H. cordata, significantly blocked HSV-2 infection. These results together demonstrated that H. cordata blocks HSV-2 infection through inhibition of NF-κB activation.</div>
</front>
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<fA08 i1="01" i2="1" l="ENG"><s1>Houttuynia cordata blocks HSV infection through inhibition of NF-κB activation</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>XIAOQING CHEN</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>ZHONGXIA WANG</s1>
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<fA11 i1="03" i2="1"><s1>ZIYING YANG</s1>
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<fA11 i1="04" i2="1"><s1>JINGJING WANG</s1>
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<fA11 i1="07" i2="1"><s1>ERGUANG LI</s1>
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<fA14 i1="01"><s1>State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, 22 Hankou Road</s1>
<s2>Nanjing, Jiangsu Province 210093</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
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<fA14 i1="02"><s1>School of Medicine, Nanjing University, 22 Hankou Road</s1>
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<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
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<fA14 i1="03"><s1>College of Life Science, Nanjing University, 22 Hankou Road</s1>
<s2>Nanjing, Jiangsu Province 210093</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
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<fC01 i1="01" l="ENG"><s0>Houttuynia cordata Thunb. is a medicinal plant widely used in folk medicine in several Asian countries. It has been reported that a water extract of H. cordata exhibits activity against herpes simplex virus (HSV) and the virus of severe acute respiratory syndrome (SARS), although the mechanisms are not fully understood yet. Previous studies have demonstrated absolute requirement of NF-κB activation for efficient replication of HSV-1 and HSV-2 and inhibition of NF-κB activation has been shown to suppress HSV infection. Here we show that a hot water extract of H. cordata (HCWE) inhibits HSV-2 infection through inhibition of NF-κB activation. The IC50 was estimated at 50 μg/ml of lyophilized HCWE powder. At 150 and 450 μg/ml, HCWE blocked infectious HSV-2 production by more than 3 and 4 logs, respectively. The inhibitory activity was concomitant with an inhibition of NF-κB activation by HSV-2 infection. Although activation of NF-κB and Erk MAPK has been implicated for HSV replication and growth, HCWE showed no effect on HSV-2-induced Erk activation. Furthermore, we show that treatment with quercetin, quercitrin or isoquercitrin, major water extractable flavonoids from H. cordata, significantly blocked HSV-2 infection. These results together demonstrated that H. cordata blocks HSV-2 infection through inhibition of NF-κB activation.</s0>
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<fC03 i1="01" i2="X" l="FRE"><s0>Herpesvirus hominis</s0>
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<s5>01</s5>
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<fC03 i1="01" i2="X" l="ENG"><s0>Herpesvirus hominis</s0>
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<s5>03</s5>
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<s5>03</s5>
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<s5>04</s5>
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<s5>04</s5>
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<s5>04</s5>
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<s5>07</s5>
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<s5>07</s5>
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<fC07 i1="01" i2="X" l="FRE"><s0>Alphaherpesvirinae</s0>
<s2>NW</s2>
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<fC07 i1="01" i2="X" l="ENG"><s0>Alphaherpesvirinae</s0>
<s2>NW</s2>
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<fC07 i1="01" i2="X" l="SPA"><s0>Alphaherpesvirinae</s0>
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<s2>NW</s2>
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<s2>NW</s2>
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<fC07 i1="02" i2="X" l="SPA"><s0>Herpesviridae</s0>
<s2>NW</s2>
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<fC07 i1="03" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
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<s2>NW</s2>
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<fC07 i1="03" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
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<fC07 i1="04" i2="X" l="FRE"><s0>Régulation</s0>
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<s5>37</s5>
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<s5>38</s5>
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<fC07 i1="05" i2="X" l="ENG"><s0>Polyphenol</s0>
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<fC07 i1="05" i2="X" l="SPA"><s0>Polifenol</s0>
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<s2>FX</s2>
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<s2>FX</s2>
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<s2>FX</s2>
<s5>39</s5>
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<fN21><s1>002</s1>
</fN21>
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Houttuynia cordata blocks HSV infection through inhibition of NF-κB activation

Houttuynia cordata blocks HSV infection through inhibition of NF-κB activation

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