SrasV1, PascalFrancis, Curation, bibRecord, 000803

Rhesus Theta-Defensin Prevents Death in a Mouse Model of Severe Acute Respiratory Syndrome Coronavirus Pulmonary Disease

Identifieur interne : 000803 ( PascalFrancis/Curation ); précédent : 000802; suivant : 000804

Rhesus Theta-Defensin Prevents Death in a Mouse Model of Severe Acute Respiratory Syndrome Coronavirus Pulmonary Disease

Auteurs : Christine L. Wohlford-Lenane [États-Unis] ; David K. Meyerholz [États-Unis] ; Stanley Perlman [États-Unis] ; HAIXIA ZHOU [États-Unis] ; Dat Tran [États-Unis] ; Michael E. Selsted [États-Unis] ; Paul B. Jr Mccray [États-Unis]

Source :

Journal of virology [ 0022-538X ] ; 2009.

RBID : Pascal:09-0437544

Descripteurs français

Pascal (Inist)
- Coronavirus, Antimicrobien, Défensine, Mort, Modèle animal, Syndrome respiratoire aigu sévère.
Wicri :
- topic : Mort.

English descriptors

KwdEn :
- Animal model, Antimicrobial agent, Coronavirus, Death, Defensin, Severe acute respiratory syndrome.

Abstract

We evaluated the efficacy of rhesus theta-defensin 1 (RTD-1), a novel cyclic antimicrobial peptide, as a prophylactic antiviral in a mouse model of severe acute respiratory syndrome (SARS) coronavirus (CoV) lung disease. BALB/c mice exposed to a mouse-adapted strain of SARS-CoV demonstrated 100% survival and modest reductions in lung pathology without reductions in virus titer when treated with two intranasal doses of RTD-1, while mortality in untreated mice was ˜75%. RTD-1-treated, SARS-CoV-infected mice displayed altered lung tissue cytokine responses 2 and 4 days postinfection compared to those of untreated animals, suggesting that one possible mechanism of action for RTD-1 is immunomodulatory.

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A11	`01`	`1`		`@1 WOHLFORD-LENANE (Christine L.)`
A11	`02`	`1`		`@1 MEYERHOLZ (David K.)`
A11	`03`	`1`		`@1 PERLMAN (Stanley)`
A11	`04`	`1`		`@1 HAIXIA ZHOU`
A11	`05`	`1`		`@1 TRAN (Dat)`
A11	`06`	`1`		`@1 SELSTED (Michael E.)`
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A14	`03`			`@1 Department of Internal Medicine, Carver College of Medicine, University of Iowa @2 Iowa City, Iowa 52242 @3 USA @Z 7 aut.`
A14	`04`			`@1 Department of Microbiology, Carver College of Medicine, University of Iowa @2 Iowa City, Iowa 52242 @3 USA @Z 3 aut. @Z 4 aut. @Z 7 aut.`
A14	`05`			`@1 Department of Pathology and Laboratory Medicine, University of California Irvine @2 Irvine, California 92697 @3 USA @Z 5 aut. @Z 6 aut.`
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C01	`01`		`ENG`	@0 We evaluated the efficacy of rhesus theta-defensin 1 (RTD-1), a novel cyclic antimicrobial peptide, as a prophylactic antiviral in a mouse model of severe acute respiratory syndrome (SARS) coronavirus (CoV) lung disease. BALB/c mice exposed to a mouse-adapted strain of SARS-CoV demonstrated 100% survival and modest reductions in lung pathology without reductions in virus titer when treated with two intranasal doses of RTD-1, while mortality in untreated mice was ˜75%. RTD-1-treated, SARS-CoV-infected mice displayed altered lung tissue cytokine responses 2 and 4 days postinfection compared to those of untreated animals, suggesting that one possible mechanism of action for RTD-1 is immunomodulatory.
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C03	`03`	`X`	`FRE`	`@0 Défensine @5 06`
C03	`03`	`X`	`ENG`	`@0 Defensin @5 06`
C03	`03`	`X`	`SPA`	`@0 Defensina @5 06`
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C07	`02`	`X`	`FRE`	`@0 Nidovirales @2 NW`
C07	`02`	`X`	`ENG`	`@0 Nidovirales @2 NW`
C07	`02`	`X`	`SPA`	`@0 Nidovirales @2 NW`
C07	`03`	`X`	`FRE`	`@0 Virus @2 NW`
C07	`03`	`X`	`ENG`	`@0 Virus @2 NW`
C07	`03`	`X`	`SPA`	`@0 Virus @2 NW`
C07	`04`	`X`	`FRE`	`@0 Peptide @5 13`
C07	`04`	`X`	`ENG`	`@0 Peptides @5 13`
C07	`04`	`X`	`SPA`	`@0 Péptido @5 13`
C07	`05`	`X`	`FRE`	`@0 Virose`
C07	`05`	`X`	`ENG`	`@0 Viral disease`
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C07	`08`	`X`	`FRE`	`@0 Pathologie des poumons @5 17`
C07	`08`	`X`	`ENG`	`@0 Lung disease @5 17`
C07	`08`	`X`	`SPA`	`@0 Pulmón patología @5 17`
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Le document en format XML

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<front><div type="abstract" xml:lang="en">We evaluated the efficacy of rhesus theta-defensin 1 (RTD-1), a novel cyclic antimicrobial peptide, as a prophylactic antiviral in a mouse model of severe acute respiratory syndrome (SARS) coronavirus (CoV) lung disease. BALB/c mice exposed to a mouse-adapted strain of SARS-CoV demonstrated 100% survival and modest reductions in lung pathology without reductions in virus titer when treated with two intranasal doses of RTD-1, while mortality in untreated mice was ˜75%. RTD-1-treated, SARS-CoV-infected mice displayed altered lung tissue cytokine responses 2 and 4 days postinfection compared to those of untreated animals, suggesting that one possible mechanism of action for RTD-1 is immunomodulatory.</div>
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   |texte=   Rhesus Theta-Defensin Prevents Death in a Mouse Model of Severe Acute Respiratory Syndrome Coronavirus Pulmonary Disease
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Rhesus Theta-Defensin Prevents Death in a Mouse Model of Severe Acute Respiratory Syndrome Coronavirus Pulmonary Disease

Rhesus Theta-Defensin Prevents Death in a Mouse Model of Severe Acute Respiratory Syndrome Coronavirus Pulmonary Disease

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