Detection of a novel and highly divergent coronavirus from asian leopard cats and chinese ferret badgers in southern china
Identifieur interne : 000650 ( PascalFrancis/Curation ); précédent : 000649; suivant : 000651Detection of a novel and highly divergent coronavirus from asian leopard cats and chinese ferret badgers in southern china
Auteurs : B. Q. Dong [République populaire de Chine] ; W. Liu [République populaire de Chine] ; X. H. Fan [République populaire de Chine] ; D. Vijaykrishna [Hong Kong] ; X. C. Tang [Hong Kong] ; F. Gao [République populaire de Chine] ; L. F. Li [Hong Kong] ; G. J. Li [République populaire de Chine] ; J. X. Zhang [Hong Kong] ; L. Q. Yang [République populaire de Chine] ; L. L. M. Poon [Hong Kong] ; S. Y. Zhang [République populaire de Chine] ; J. S. M. Peiris [Hong Kong] ; G. J. D. Smith [Hong Kong] ; H. Chen [Hong Kong] ; Y. Guan [Hong Kong]Source :
- Journal of virology [ 0022-538X ] ; 2007.
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Abstract
Since an outbreak of severe acute respiratory syndrome (SARS) was averted in 2004, many novel coronaviruses have been recognized from different species, including humans. Bats have provided the most diverse assemblages of coronaviruses, suggesting that they may be the natural reservoir. Continued virological surveillance has proven to be the best way to avert this infectious disease at the source. Here we provide the first description of a previously unidentified coronavirus lineage detected from wild Asian leopard cats (Prionailurus bengalensis) and Chinese ferret badgers (Melogale moschata) during virological surveillance in southern China. Partial genome analysis revealed a typical coronavirus genome but with a unique putative accessory gene organization. Phylogenetic analyses revealed that the envelope, membrane, and nucleoprotein structural proteins and the two conserved replicase domains, putative RNA-dependent RNA polymerase and RNA helicase, of these novel coronaviruses were most closely related to those of group 3 coronaviruses identified from birds, while the spike protein gene was most closely related to that of group 1 coronaviruses from mammals. However, these viruses always fell into an outgroup phylogenetic relationship with respect to other coronaviruses and had low amino acid similarity to all known coronavirus groups, indicating that they diverged early in the evolutionary history of coronaviruses. These results suggest that these viruses may represent a previously unrecognized evolutionary pathway, or possibly an unidentified coronavirus group. This study demonstrates the importance of systematic virological surveillance in market animals for understanding the evolution and emergence of viruses with infectious potential.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Detection of a novel and highly divergent coronavirus from asian leopard cats and chinese ferret badgers in southern china</title><author><name sortKey="Dong, B Q" sort="Dong, B Q" uniqKey="Dong B" first="B. Q." last="Dong">B. Q. Dong</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Guangxi Center for Disease Control and Prevention, Guangxi Medical University</s1><s2>Nanning 530021</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Liu, W" sort="Liu, W" uniqKey="Liu W" first="W." last="Liu">W. Liu</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Guangxi Center for Disease Control and Prevention, Guangxi Medical University</s1><s2>Nanning 530021</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Fan, X H" sort="Fan, X H" uniqKey="Fan X" first="X. H." last="Fan">X. H. Fan</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Microbiology and Immunology, Guangxi Medical University</s1><s2>Nanning 530021</s2><s3>CHN</s3><sZ>3 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Vijaykrishna, D" sort="Vijaykrishna, D" uniqKey="Vijaykrishna D" first="D." last="Vijaykrishna">D. Vijaykrishna</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country></affiliation></author><author><name sortKey="Tang, X C" sort="Tang, X C" uniqKey="Tang X" first="X. C." last="Tang">X. C. Tang</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country></affiliation></author><author><name sortKey="Gao, F" sort="Gao, F" uniqKey="Gao F" first="F." last="Gao">F. Gao</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Guangxi Center for Disease Control and Prevention, Guangxi Medical University</s1><s2>Nanning 530021</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Li, L F" sort="Li, L F" uniqKey="Li L" first="L. F." last="Li">L. F. Li</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country></affiliation></author><author><name sortKey="Li, G J" sort="Li, G J" uniqKey="Li G" first="G. J." last="Li">G. J. Li</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Microbiology and Immunology, Guangxi Medical University</s1><s2>Nanning 530021</s2><s3>CHN</s3><sZ>3 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Zhang, J X" sort="Zhang, J X" uniqKey="Zhang J" first="J. X." last="Zhang">J. X. Zhang</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country></affiliation></author><author><name sortKey="Yang, L Q" sort="Yang, L Q" uniqKey="Yang L" first="L. Q." last="Yang">L. Q. Yang</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Guangxi Center for Disease Control and Prevention, Guangxi Medical University</s1><s2>Nanning 530021</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Poon, L L M" sort="Poon, L L M" uniqKey="Poon L" first="L. L. M." last="Poon">L. L. M. Poon</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country></affiliation></author><author><name sortKey="Zhang, S Y" sort="Zhang, S Y" uniqKey="Zhang S" first="S. Y." last="Zhang">S. Y. Zhang</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>School of Life Sciences, East China Normal University</s1><s2>Shanghai 200062</s2><s3>CHN</s3><sZ>12 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Peiris, J S M" sort="Peiris, J S M" uniqKey="Peiris J" first="J. S. M." last="Peiris">J. S. M. Peiris</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country></affiliation></author><author><name sortKey="Smith, G J D" sort="Smith, G J D" uniqKey="Smith G" first="G. J. D." last="Smith">G. J. D. Smith</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country></affiliation></author><author><name sortKey="Chen, H" sort="Chen, H" uniqKey="Chen H" first="H." last="Chen">H. Chen</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country></affiliation></author><author><name sortKey="Guan, Y" sort="Guan, Y" uniqKey="Guan Y" first="Y." last="Guan">Y. Guan</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">07-0486092</idno><date when="2007">2007</date><idno type="stanalyst">PASCAL 07-0486092 INIST</idno><idno type="RBID">Pascal:07-0486092</idno><idno type="wicri:Area/PascalFrancis/Corpus">000339</idno><idno type="wicri:Area/PascalFrancis/Curation">000650</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Detection of a novel and highly divergent coronavirus from asian leopard cats and chinese ferret badgers in southern china</title><author><name sortKey="Dong, B Q" sort="Dong, B Q" uniqKey="Dong B" first="B. Q." last="Dong">B. Q. Dong</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Guangxi Center for Disease Control and Prevention, Guangxi Medical University</s1><s2>Nanning 530021</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Liu, W" sort="Liu, W" uniqKey="Liu W" first="W." last="Liu">W. Liu</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Guangxi Center for Disease Control and Prevention, Guangxi Medical University</s1><s2>Nanning 530021</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Fan, X H" sort="Fan, X H" uniqKey="Fan X" first="X. H." last="Fan">X. H. Fan</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Microbiology and Immunology, Guangxi Medical University</s1><s2>Nanning 530021</s2><s3>CHN</s3><sZ>3 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Vijaykrishna, D" sort="Vijaykrishna, D" uniqKey="Vijaykrishna D" first="D." last="Vijaykrishna">D. Vijaykrishna</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country></affiliation></author><author><name sortKey="Tang, X C" sort="Tang, X C" uniqKey="Tang X" first="X. C." last="Tang">X. C. Tang</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country></affiliation></author><author><name sortKey="Gao, F" sort="Gao, F" uniqKey="Gao F" first="F." last="Gao">F. Gao</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Guangxi Center for Disease Control and Prevention, Guangxi Medical University</s1><s2>Nanning 530021</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Li, L F" sort="Li, L F" uniqKey="Li L" first="L. F." last="Li">L. F. Li</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country></affiliation></author><author><name sortKey="Li, G J" sort="Li, G J" uniqKey="Li G" first="G. J." last="Li">G. J. Li</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Microbiology and Immunology, Guangxi Medical University</s1><s2>Nanning 530021</s2><s3>CHN</s3><sZ>3 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Zhang, J X" sort="Zhang, J X" uniqKey="Zhang J" first="J. X." last="Zhang">J. X. Zhang</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country></affiliation></author><author><name sortKey="Yang, L Q" sort="Yang, L Q" uniqKey="Yang L" first="L. Q." last="Yang">L. Q. Yang</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Guangxi Center for Disease Control and Prevention, Guangxi Medical University</s1><s2>Nanning 530021</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Poon, L L M" sort="Poon, L L M" uniqKey="Poon L" first="L. L. M." last="Poon">L. L. M. Poon</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country></affiliation></author><author><name sortKey="Zhang, S Y" sort="Zhang, S Y" uniqKey="Zhang S" first="S. Y." last="Zhang">S. Y. Zhang</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>School of Life Sciences, East China Normal University</s1><s2>Shanghai 200062</s2><s3>CHN</s3><sZ>12 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Peiris, J S M" sort="Peiris, J S M" uniqKey="Peiris J" first="J. S. M." last="Peiris">J. S. M. Peiris</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country></affiliation></author><author><name sortKey="Smith, G J D" sort="Smith, G J D" uniqKey="Smith G" first="G. J. D." last="Smith">G. J. D. Smith</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country></affiliation></author><author><name sortKey="Chen, H" sort="Chen, H" uniqKey="Chen H" first="H." last="Chen">H. Chen</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country></affiliation></author><author><name sortKey="Guan, Y" sort="Guan, Y" uniqKey="Guan Y" first="Y." last="Guan">Y. Guan</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country></affiliation></author></analytic><series><title level="j" type="main">Journal of virology</title><title level="j" type="abbreviated">J. virol.</title><idno type="ISSN">0022-538X</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of virology</title><title level="j" type="abbreviated">J. virol.</title><idno type="ISSN">0022-538X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term><term>China</term><term>Coronavirus</term><term>Detection</term><term>Ferret</term><term>Virology</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Coronavirus</term><term>Détection</term><term>Animal</term><term>Chine</term><term>Furet</term><term>Virologie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Since an outbreak of severe acute respiratory syndrome (SARS) was averted in 2004, many novel coronaviruses have been recognized from different species, including humans. Bats have provided the most diverse assemblages of coronaviruses, suggesting that they may be the natural reservoir. Continued virological surveillance has proven to be the best way to avert this infectious disease at the source. Here we provide the first description of a previously unidentified coronavirus lineage detected from wild Asian leopard cats (Prionailurus bengalensis) and Chinese ferret badgers (Melogale moschata) during virological surveillance in southern China. Partial genome analysis revealed a typical coronavirus genome but with a unique putative accessory gene organization. Phylogenetic analyses revealed that the envelope, membrane, and nucleoprotein structural proteins and the two conserved replicase domains, putative RNA-dependent RNA polymerase and RNA helicase, of these novel coronaviruses were most closely related to those of group 3 coronaviruses identified from birds, while the spike protein gene was most closely related to that of group 1 coronaviruses from mammals. However, these viruses always fell into an outgroup phylogenetic relationship with respect to other coronaviruses and had low amino acid similarity to all known coronavirus groups, indicating that they diverged early in the evolutionary history of coronaviruses. These results suggest that these viruses may represent a previously unrecognized evolutionary pathway, or possibly an unidentified coronavirus group. This study demonstrates the importance of systematic virological surveillance in market animals for understanding the evolution and emergence of viruses with infectious potential.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0022-538X</s0></fA01><fA03 i2="1"><s0>J. virol.</s0></fA03><fA05><s2>81</s2></fA05><fA06><s2>13</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Detection of a novel and highly divergent coronavirus from asian leopard cats and chinese ferret badgers in southern china</s1></fA08><fA11 i1="01" i2="1"><s1>DONG (B. Q.)</s1></fA11><fA11 i1="02" i2="1"><s1>LIU (W.)</s1></fA11><fA11 i1="03" i2="1"><s1>FAN (X. H.)</s1></fA11><fA11 i1="04" i2="1"><s1>VIJAYKRISHNA (D.)</s1></fA11><fA11 i1="05" i2="1"><s1>TANG (X. C.)</s1></fA11><fA11 i1="06" i2="1"><s1>GAO (F.)</s1></fA11><fA11 i1="07" i2="1"><s1>LI (L. F.)</s1></fA11><fA11 i1="08" i2="1"><s1>LI (G. J.)</s1></fA11><fA11 i1="09" i2="1"><s1>ZHANG (J. X.)</s1></fA11><fA11 i1="10" i2="1"><s1>YANG (L. Q.)</s1></fA11><fA11 i1="11" i2="1"><s1>POON (L. L. M.)</s1></fA11><fA11 i1="12" i2="1"><s1>ZHANG (S. Y.)</s1></fA11><fA11 i1="13" i2="1"><s1>PEIRIS (J. S. M.)</s1></fA11><fA11 i1="14" i2="1"><s1>SMITH (G. J. D.)</s1></fA11><fA11 i1="15" i2="1"><s1>CHEN (H.)</s1></fA11><fA11 i1="16" i2="1"><s1>GUAN (Y.)</s1></fA11><fA14 i1="01"><s1>Guangxi Center for Disease Control and Prevention, Guangxi Medical University</s1><s2>Nanning 530021</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>10 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Microbiology and Immunology, Guangxi Medical University</s1><s2>Nanning 530021</s2><s3>CHN</s3><sZ>3 aut.</sZ><sZ>8 aut.</sZ></fA14><fA14 i1="03"><s1>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></fA14><fA14 i1="04"><s1>School of Life Sciences, East China Normal University</s1><s2>Shanghai 200062</s2><s3>CHN</s3><sZ>12 aut.</sZ></fA14><fA20><s1>6920-6926</s1></fA20><fA21><s1>2007</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>13592</s2><s5>354000146560950150</s5></fA43><fA44><s0>0000</s0><s1>© 2007 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>29 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>07-0486092</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Journal of virology</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Since an outbreak of severe acute respiratory syndrome (SARS) was averted in 2004, many novel coronaviruses have been recognized from different species, including humans. Bats have provided the most diverse assemblages of coronaviruses, suggesting that they may be the natural reservoir. Continued virological surveillance has proven to be the best way to avert this infectious disease at the source. Here we provide the first description of a previously unidentified coronavirus lineage detected from wild Asian leopard cats (Prionailurus bengalensis) and Chinese ferret badgers (Melogale moschata) during virological surveillance in southern China. Partial genome analysis revealed a typical coronavirus genome but with a unique putative accessory gene organization. Phylogenetic analyses revealed that the envelope, membrane, and nucleoprotein structural proteins and the two conserved replicase domains, putative RNA-dependent RNA polymerase and RNA helicase, of these novel coronaviruses were most closely related to those of group 3 coronaviruses identified from birds, while the spike protein gene was most closely related to that of group 1 coronaviruses from mammals. However, these viruses always fell into an outgroup phylogenetic relationship with respect to other coronaviruses and had low amino acid similarity to all known coronavirus groups, indicating that they diverged early in the evolutionary history of coronaviruses. These results suggest that these viruses may represent a previously unrecognized evolutionary pathway, or possibly an unidentified coronavirus group. This study demonstrates the importance of systematic virological surveillance in market animals for understanding the evolution and emergence of viruses with infectious potential.</s0></fC01><fC02 i1="01" i2="X"><s0>002A05C10</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Coronavirus</s0><s2>NW</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Coronavirus</s0><s2>NW</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Coronavirus</s0><s2>NW</s2><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Détection</s0><s5>05</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Detection</s0><s5>05</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Detección</s0><s5>05</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Animal</s0><s5>06</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Animal</s0><s5>06</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Animal</s0><s5>06</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Chine</s0><s2>NG</s2><s5>07</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>China</s0><s2>NG</s2><s5>07</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>China</s0><s2>NG</s2><s5>07</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Furet</s0><s5>08</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Ferret</s0><s5>08</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Hurón</s0><s5>08</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Virologie</s0><s5>09</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Virology</s0><s5>09</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Virología</s0><s5>09</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Coronaviridae</s0><s2>NW</s2></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Coronaviridae</s0><s2>NW</s2></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Coronaviridae</s0><s2>NW</s2></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Nidovirales</s0><s2>NW</s2></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Nidovirales</s0><s2>NW</s2></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Nidovirales</s0><s2>NW</s2></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Asie</s0><s2>NG</s2></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Asia</s0><s2>NG</s2></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Asia</s0><s2>NG</s2></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Fissipedia</s0><s2>NS</s2></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Fissipedia</s0><s2>NS</s2></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Fissipedia</s0><s2>NS</s2></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Carnivora</s0><s2>NS</s2></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Carnivora</s0><s2>NS</s2></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Carnivora</s0><s2>NS</s2></fC07><fC07 i1="07" i2="X" l="FRE"><s0>Mammalia</s0><s2>NS</s2></fC07><fC07 i1="07" i2="X" l="ENG"><s0>Mammalia</s0><s2>NS</s2></fC07><fC07 i1="07" i2="X" l="SPA"><s0>Mammalia</s0><s2>NS</s2></fC07><fC07 i1="08" i2="X" l="FRE"><s0>Vertebrata</s0><s2>NS</s2></fC07><fC07 i1="08" i2="X" l="ENG"><s0>Vertebrata</s0><s2>NS</s2></fC07><fC07 i1="08" i2="X" l="SPA"><s0>Vertebrata</s0><s2>NS</s2></fC07><fN21><s1>316</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist></record>Pour manipuler ce document sous Unix (Dilib)
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