Inhibition of infection caused by severe acute respiratory syndrome-associated coronavirus by equine neutralizing antibody in aged mice
Identifieur interne : 000586 ( PascalFrancis/Curation ); précédent : 000585; suivant : 000587Inhibition of infection caused by severe acute respiratory syndrome-associated coronavirus by equine neutralizing antibody in aged mice
Auteurs : LILI ZHOU [République populaire de Chine] ; BING NI [République populaire de Chine] ; DEYAN LUO [République populaire de Chine] ; GUANGYU ZHAO [République populaire de Chine] ; ZHENGCAI JIA [République populaire de Chine] ; LIANGYAN ZHANG [République populaire de Chine] ; ZHIHUA LIN [République populaire de Chine] ; LI WANG [République populaire de Chine] ; SONGLE ZHANG [République populaire de Chine] ; LI XING [République populaire de Chine] ; JINTAO LI [République populaire de Chine] ; YUNFEI LIANG [République populaire de Chine] ; XINFU SHI [République populaire de Chine] ; TINGTING ZHAO [République populaire de Chine] ; LIYUN ZHOU [République populaire de Chine] ; YUZHANG WU [République populaire de Chine] ; XILIANG WANG [République populaire de Chine]Source :
- International immunopharmacology [ 1567-5769 ] ; 2007.
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Abstract
The high susceptibility of elderly to severe acute respiratory syndrome-associated coronavirus (SARS-CoV) indicates how crucial it is to protect the elderly by various strategies. Aged BALB/c mice displayed a high susceptibility to SARS-CoV and have been a valuable platform for evaluation of strategies against SARS-CoV infection. In this study, we confirmed the validity of this model using various methods, and verified that equine anti-SARS-CoV F(ab')2 can prevent aged animals from SARS-CoV infection. In a therapeutic setting, treatment with anti-SARS-CoV F(ab')2 decreased viral load more than several thousand folds in the lungs. Thus, this antibody should be a potential candidate for treatment of elderly patients suffering from SARS.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Inhibition of infection caused by severe acute respiratory syndrome-associated coronavirus by equine neutralizing antibody in aged mice</title><author><name sortKey="Lili Zhou" sort="Lili Zhou" uniqKey="Lili Zhou" last="Lili Zhou">LILI ZHOU</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Immunology, Institute of Microbiology Epidemiology, Academy of Military Medical Sciences</s1><s2>Beijing, 100071</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Bing Ni" sort="Bing Ni" uniqKey="Bing Ni" last="Bing Ni">BING NI</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Immunology, Third Military Medical University</s1><s2>Chongqing 400038</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Deyan Luo" sort="Deyan Luo" uniqKey="Deyan Luo" last="Deyan Luo">DEYAN LUO</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Immunology, Institute of Microbiology Epidemiology, Academy of Military Medical Sciences</s1><s2>Beijing, 100071</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Guangyu Zhao" sort="Guangyu Zhao" uniqKey="Guangyu Zhao" last="Guangyu Zhao">GUANGYU ZHAO</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Immunology, Institute of Microbiology Epidemiology, Academy of Military Medical Sciences</s1><s2>Beijing, 100071</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Zhengcai Jia" sort="Zhengcai Jia" uniqKey="Zhengcai Jia" last="Zhengcai Jia">ZHENGCAI JIA</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Immunology, Third Military Medical University</s1><s2>Chongqing 400038</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Liangyan Zhang" sort="Liangyan Zhang" uniqKey="Liangyan Zhang" last="Liangyan Zhang">LIANGYAN ZHANG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Immunology, Institute of Microbiology Epidemiology, Academy of Military Medical Sciences</s1><s2>Beijing, 100071</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Zhihua Lin" sort="Zhihua Lin" uniqKey="Zhihua Lin" last="Zhihua Lin">ZHIHUA LIN</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>College of Bioengineering. Chongqing Institute of Technology</s1><s2>Chongqing 400050</s2><s3>CHN</s3><sZ>7 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Li Wang" sort="Li Wang" uniqKey="Li Wang" last="Li Wang">LI WANG</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Immunology, Third Military Medical University</s1><s2>Chongqing 400038</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Songle Zhang" sort="Songle Zhang" uniqKey="Songle Zhang" last="Songle Zhang">SONGLE ZHANG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Immunology, Institute of Microbiology Epidemiology, Academy of Military Medical Sciences</s1><s2>Beijing, 100071</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Li Xing" sort="Li Xing" uniqKey="Li Xing" last="Li Xing">LI XING</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Immunology, Institute of Microbiology Epidemiology, Academy of Military Medical Sciences</s1><s2>Beijing, 100071</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Jintao Li" sort="Jintao Li" uniqKey="Jintao Li" last="Jintao Li">JINTAO LI</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Immunology, Third Military Medical University</s1><s2>Chongqing 400038</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Yunfei Liang" sort="Yunfei Liang" uniqKey="Yunfei Liang" last="Yunfei Liang">YUNFEI LIANG</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Immunology, Third Military Medical University</s1><s2>Chongqing 400038</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Xinfu Shi" sort="Xinfu Shi" uniqKey="Xinfu Shi" last="Xinfu Shi">XINFU SHI</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Immunology, Institute of Microbiology Epidemiology, Academy of Military Medical Sciences</s1><s2>Beijing, 100071</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Tingting Zhao" sort="Tingting Zhao" uniqKey="Tingting Zhao" last="Tingting Zhao">TINGTING ZHAO</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Immunology, Third Military Medical University</s1><s2>Chongqing 400038</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Liyun Zhou" sort="Liyun Zhou" uniqKey="Liyun Zhou" last="Liyun Zhou">LIYUN ZHOU</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Immunology, Third Military Medical University</s1><s2>Chongqing 400038</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Yuzhang Wu" sort="Yuzhang Wu" uniqKey="Yuzhang Wu" last="Yuzhang Wu">YUZHANG WU</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Immunology, Third Military Medical University</s1><s2>Chongqing 400038</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Xiliang Wang" sort="Xiliang Wang" uniqKey="Xiliang Wang" last="Xiliang Wang">XILIANG WANG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Immunology, Institute of Microbiology Epidemiology, Academy of Military Medical Sciences</s1><s2>Beijing, 100071</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">07-0132288</idno><date when="2007">2007</date><idno type="stanalyst">PASCAL 07-0132288 INIST</idno><idno type="RBID">Pascal:07-0132288</idno><idno type="wicri:Area/PascalFrancis/Corpus">000403</idno><idno type="wicri:Area/PascalFrancis/Curation">000586</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Inhibition of infection caused by severe acute respiratory syndrome-associated coronavirus by equine neutralizing antibody in aged mice</title><author><name sortKey="Lili Zhou" sort="Lili Zhou" uniqKey="Lili Zhou" last="Lili Zhou">LILI ZHOU</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Immunology, Institute of Microbiology Epidemiology, Academy of Military Medical Sciences</s1><s2>Beijing, 100071</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Bing Ni" sort="Bing Ni" uniqKey="Bing Ni" last="Bing Ni">BING NI</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Immunology, Third Military Medical University</s1><s2>Chongqing 400038</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Deyan Luo" sort="Deyan Luo" uniqKey="Deyan Luo" last="Deyan Luo">DEYAN LUO</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Immunology, Institute of Microbiology Epidemiology, Academy of Military Medical Sciences</s1><s2>Beijing, 100071</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Guangyu Zhao" sort="Guangyu Zhao" uniqKey="Guangyu Zhao" last="Guangyu Zhao">GUANGYU ZHAO</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Immunology, Institute of Microbiology Epidemiology, Academy of Military Medical Sciences</s1><s2>Beijing, 100071</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Zhengcai Jia" sort="Zhengcai Jia" uniqKey="Zhengcai Jia" last="Zhengcai Jia">ZHENGCAI JIA</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Immunology, Third Military Medical University</s1><s2>Chongqing 400038</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Liangyan Zhang" sort="Liangyan Zhang" uniqKey="Liangyan Zhang" last="Liangyan Zhang">LIANGYAN ZHANG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Immunology, Institute of Microbiology Epidemiology, Academy of Military Medical Sciences</s1><s2>Beijing, 100071</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Zhihua Lin" sort="Zhihua Lin" uniqKey="Zhihua Lin" last="Zhihua Lin">ZHIHUA LIN</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>College of Bioengineering. Chongqing Institute of Technology</s1><s2>Chongqing 400050</s2><s3>CHN</s3><sZ>7 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Li Wang" sort="Li Wang" uniqKey="Li Wang" last="Li Wang">LI WANG</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Immunology, Third Military Medical University</s1><s2>Chongqing 400038</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Songle Zhang" sort="Songle Zhang" uniqKey="Songle Zhang" last="Songle Zhang">SONGLE ZHANG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Immunology, Institute of Microbiology Epidemiology, Academy of Military Medical Sciences</s1><s2>Beijing, 100071</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Li Xing" sort="Li Xing" uniqKey="Li Xing" last="Li Xing">LI XING</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Immunology, Institute of Microbiology Epidemiology, Academy of Military Medical Sciences</s1><s2>Beijing, 100071</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Jintao Li" sort="Jintao Li" uniqKey="Jintao Li" last="Jintao Li">JINTAO LI</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Immunology, Third Military Medical University</s1><s2>Chongqing 400038</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Yunfei Liang" sort="Yunfei Liang" uniqKey="Yunfei Liang" last="Yunfei Liang">YUNFEI LIANG</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Immunology, Third Military Medical University</s1><s2>Chongqing 400038</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Xinfu Shi" sort="Xinfu Shi" uniqKey="Xinfu Shi" last="Xinfu Shi">XINFU SHI</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Immunology, Institute of Microbiology Epidemiology, Academy of Military Medical Sciences</s1><s2>Beijing, 100071</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Tingting Zhao" sort="Tingting Zhao" uniqKey="Tingting Zhao" last="Tingting Zhao">TINGTING ZHAO</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Immunology, Third Military Medical University</s1><s2>Chongqing 400038</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Liyun Zhou" sort="Liyun Zhou" uniqKey="Liyun Zhou" last="Liyun Zhou">LIYUN ZHOU</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Immunology, Third Military Medical University</s1><s2>Chongqing 400038</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Yuzhang Wu" sort="Yuzhang Wu" uniqKey="Yuzhang Wu" last="Yuzhang Wu">YUZHANG WU</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Immunology, Third Military Medical University</s1><s2>Chongqing 400038</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Xiliang Wang" sort="Xiliang Wang" uniqKey="Xiliang Wang" last="Xiliang Wang">XILIANG WANG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Immunology, Institute of Microbiology Epidemiology, Academy of Military Medical Sciences</s1><s2>Beijing, 100071</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author></analytic><series><title level="j" type="main">International immunopharmacology</title><title level="j" type="abbreviated">Int. immunopharmacol.</title><idno type="ISSN">1567-5769</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">International immunopharmacology</title><title level="j" type="abbreviated">Int. immunopharmacol.</title><idno type="ISSN">1567-5769</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term><term>Coronavirus</term><term>Infection</term><term>Inhibitor</term><term>Mouse</term><term>Neutralization</term><term>Severe acute respiratory syndrome</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Inhibiteur</term><term>Infection</term><term>Syndrome respiratoire aigu sévère</term><term>Coronavirus</term><term>Neutralisation</term><term>Animal</term><term>Souris</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The high susceptibility of elderly to severe acute respiratory syndrome-associated coronavirus (SARS-CoV) indicates how crucial it is to protect the elderly by various strategies. Aged BALB/c mice displayed a high susceptibility to SARS-CoV and have been a valuable platform for evaluation of strategies against SARS-CoV infection. In this study, we confirmed the validity of this model using various methods, and verified that equine anti-SARS-CoV F(ab')<sub>2</sub> can prevent aged animals from SARS-CoV infection. In a therapeutic setting, treatment with anti-SARS-CoV F(ab')<sub>2</sub> decreased viral load more than several thousand folds in the lungs. Thus, this antibody should be a potential candidate for treatment of elderly patients suffering from SARS.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>1567-5769</s0></fA01><fA03 i2="1"><s0>Int. immunopharmacol.</s0></fA03><fA05><s2>7</s2></fA05><fA06><s2>3</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Inhibition of infection caused by severe acute respiratory syndrome-associated coronavirus by equine neutralizing antibody in aged mice</s1></fA08><fA11 i1="01" i2="1"><s1>LILI ZHOU</s1></fA11><fA11 i1="02" i2="1"><s1>BING NI</s1></fA11><fA11 i1="03" i2="1"><s1>DEYAN LUO</s1></fA11><fA11 i1="04" i2="1"><s1>GUANGYU ZHAO</s1></fA11><fA11 i1="05" i2="1"><s1>ZHENGCAI JIA</s1></fA11><fA11 i1="06" i2="1"><s1>LIANGYAN ZHANG</s1></fA11><fA11 i1="07" i2="1"><s1>ZHIHUA LIN</s1></fA11><fA11 i1="08" i2="1"><s1>LI WANG</s1></fA11><fA11 i1="09" i2="1"><s1>SONGLE ZHANG</s1></fA11><fA11 i1="10" i2="1"><s1>LI XING</s1></fA11><fA11 i1="11" i2="1"><s1>JINTAO LI</s1></fA11><fA11 i1="12" i2="1"><s1>YUNFEI LIANG</s1></fA11><fA11 i1="13" i2="1"><s1>XINFU SHI</s1></fA11><fA11 i1="14" i2="1"><s1>TINGTING ZHAO</s1></fA11><fA11 i1="15" i2="1"><s1>LIYUN ZHOU</s1></fA11><fA11 i1="16" i2="1"><s1>YUZHANG WU</s1></fA11><fA11 i1="17" i2="1"><s1>XILIANG WANG</s1></fA11><fA14 i1="01"><s1>Department of Immunology, Institute of Microbiology Epidemiology, Academy of Military Medical Sciences</s1><s2>Beijing, 100071</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>17 aut.</sZ></fA14><fA14 i1="02"><s1>Institute of Immunology, Third Military Medical University</s1><s2>Chongqing 400038</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></fA14><fA14 i1="03"><s1>College of Bioengineering. Chongqing Institute of Technology</s1><s2>Chongqing 400050</s2><s3>CHN</s3><sZ>7 aut.</sZ></fA14><fA20><s1>392-400</s1></fA20><fA21><s1>2007</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>27109</s2><s5>354000145505530140</s5></fA43><fA44><s0>0000</s0><s1>© 2007 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>34 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>07-0132288</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>International immunopharmacology</s0></fA64><fA66 i1="01"><s0>NLD</s0></fA66><fC01 i1="01" l="ENG"><s0>The high susceptibility of elderly to severe acute respiratory syndrome-associated coronavirus (SARS-CoV) indicates how crucial it is to protect the elderly by various strategies. Aged BALB/c mice displayed a high susceptibility to SARS-CoV and have been a valuable platform for evaluation of strategies against SARS-CoV infection. In this study, we confirmed the validity of this model using various methods, and verified that equine anti-SARS-CoV F(ab')<sub>2</sub> can prevent aged animals from SARS-CoV infection. In a therapeutic setting, treatment with anti-SARS-CoV F(ab')<sub>2</sub> decreased viral load more than several thousand folds in the lungs. Thus, this antibody should be a potential candidate for treatment of elderly patients suffering from SARS.</s0></fC01><fC02 i1="01" i2="X"><s0>002B02</s0></fC02><fC02 i1="02" i2="X"><s0>002B05C02C</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Inhibiteur</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Inhibitor</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Inhibidor</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Infection</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Infection</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Infección</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Syndrome respiratoire aigu sévère</s0><s2>NM</s2><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Severe acute respiratory syndrome</s0><s2>NM</s2><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Síndrome respiratorio agudo severo</s0><s2>NM</s2><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Coronavirus</s0><s2>NW</s2><s5>04</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Coronavirus</s0><s2>NW</s2><s5>04</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Coronavirus</s0><s2>NW</s2><s5>04</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Neutralisation</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Neutralization</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Neutralización</s0><s5>05</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Animal</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Animal</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Animal</s0><s5>06</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Souris</s0><s5>07</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Mouse</s0><s5>07</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Ratón</s0><s5>07</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Virose</s0></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Viral disease</s0></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Virosis</s0></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Coronaviridae</s0><s2>NW</s2></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Coronaviridae</s0><s2>NW</s2></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Coronaviridae</s0><s2>NW</s2></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Nidovirales</s0><s2>NW</s2></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Nidovirales</s0><s2>NW</s2></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Nidovirales</s0><s2>NW</s2></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Rodentia</s0><s2>NS</s2></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Rodentia</s0><s2>NS</s2></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Rodentia</s0><s2>NS</s2></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Mammalia</s0><s2>NS</s2></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Mammalia</s0><s2>NS</s2></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Mammalia</s0><s2>NS</s2></fC07><fC07 i1="07" i2="X" l="FRE"><s0>Vertebrata</s0><s2>NS</s2></fC07><fC07 i1="07" i2="X" l="ENG"><s0>Vertebrata</s0><s2>NS</s2></fC07><fC07 i1="07" i2="X" l="SPA"><s0>Vertebrata</s0><s2>NS</s2></fC07><fC07 i1="08" i2="X" l="FRE"><s0>Appareil respiratoire pathologie</s0><s5>37</s5></fC07><fC07 i1="08" i2="X" l="ENG"><s0>Respiratory disease</s0><s5>37</s5></fC07><fC07 i1="08" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0><s5>37</s5></fC07><fC07 i1="09" i2="X" l="FRE"><s0>Poumon pathologie</s0><s5>38</s5></fC07><fC07 i1="09" i2="X" l="ENG"><s0>Lung disease</s0><s5>38</s5></fC07><fC07 i1="09" i2="X" l="SPA"><s0>Pulmón patología</s0><s5>38</s5></fC07><fN21><s1>085</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist></record>Pour manipuler ce document sous Unix (Dilib)
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