Understanding the accessory viral proteins unique to the severe acute respiratory syndrome (SARS) coronavirus
Identifieur interne : 000541 ( PascalFrancis/Curation ); précédent : 000540; suivant : 000542Understanding the accessory viral proteins unique to the severe acute respiratory syndrome (SARS) coronavirus
Auteurs : Yee-Joo Tan [Singapour] ; SENG GEE LIM [Singapour] ; WANJIN HONG [Singapour]Source :
- Antiviral research [ 0166-3542 ] ; 2006.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
A novel coronavirus, termed the severe acute respiratory syndrome coronavirus (SARS-CoV), infected humans in Guangdong, China, in November 2002 and the subsequent efficient human-to-human transmissions of this virus caused profound disturbances in over 30 countries worldwide in 2003. Eventually, this epidemic was controlled by isolation and there has been no human infection reported since January 2004. However, research on different aspects of the SARS-CoV is not waning, as it is not known if this virus will re-emerge, especially since its origins and potential reservoir(s) are unresolved. The SARS-CoV genome is nearly 30 kb in length and contains 14 potential open reading frames (ORFs). Some of these ORFs encode for genes that are homologous to proteins found in all known coronaviruses, namely the replicase genes (ORFs la and 1b) and the four structural proteins: nucleocapsid, spike, membrane and envelope, and these proteins are expected to be essential for the replication of the virus. The remaining eight ORFs encodes for accessory proteins, varying in length from 39 to 274 amino acids, which are unique to SARS-CoV. This review will summarize the expeditious research on these accessory viral proteins in three major areas: (i) the detection of antibodies against accessory proteins in the serum of infected patients, (ii) the expression, processing and cellular localization of the accessory proteins, and (iii) the effects of the accessory proteins on cellular functions. These in-depth molecular and biochemical characterizations of the SARS-CoV accessory proteins, which have no homologues in other coronaviruses, may offer clues as to why the SARS-CoV causes such a severe and rapid attack in humans, while other coronaviruses that infect humans seem to be more forgiving.
| pA |
|
|---|
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000449
Links to Exploration step
Pascal:06-0493742Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Understanding the accessory viral proteins unique to the severe acute respiratory syndrome (SARS) coronavirus</title><author><name sortKey="Tan, Yee Joo" sort="Tan, Yee Joo" uniqKey="Tan Y" first="Yee-Joo" last="Tan">Yee-Joo Tan</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos</s1><s2>Singapore 138673</s2><s3>SGP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Singapour</country></affiliation></author><author><name sortKey="Seng Gee Lim" sort="Seng Gee Lim" uniqKey="Seng Gee Lim" last="Seng Gee Lim">SENG GEE LIM</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos</s1><s2>Singapore 138673</s2><s3>SGP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Singapour</country></affiliation></author><author><name sortKey="Wanjin Hong" sort="Wanjin Hong" uniqKey="Wanjin Hong" last="Wanjin Hong">WANJIN HONG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos</s1><s2>Singapore 138673</s2><s3>SGP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Singapour</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">06-0493742</idno><date when="2006">2006</date><idno type="stanalyst">PASCAL 06-0493742 INIST</idno><idno type="RBID">Pascal:06-0493742</idno><idno type="wicri:Area/PascalFrancis/Corpus">000449</idno><idno type="wicri:Area/PascalFrancis/Curation">000541</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Understanding the accessory viral proteins unique to the severe acute respiratory syndrome (SARS) coronavirus</title><author><name sortKey="Tan, Yee Joo" sort="Tan, Yee Joo" uniqKey="Tan Y" first="Yee-Joo" last="Tan">Yee-Joo Tan</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos</s1><s2>Singapore 138673</s2><s3>SGP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Singapour</country></affiliation></author><author><name sortKey="Seng Gee Lim" sort="Seng Gee Lim" uniqKey="Seng Gee Lim" last="Seng Gee Lim">SENG GEE LIM</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos</s1><s2>Singapore 138673</s2><s3>SGP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Singapour</country></affiliation></author><author><name sortKey="Wanjin Hong" sort="Wanjin Hong" uniqKey="Wanjin Hong" last="Wanjin Hong">WANJIN HONG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos</s1><s2>Singapore 138673</s2><s3>SGP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Singapour</country></affiliation></author></analytic><series><title level="j" type="main">Antiviral research</title><title level="j" type="abbreviated">Antivir. res.</title><idno type="ISSN">0166-3542</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Antiviral research</title><title level="j" type="abbreviated">Antivir. res.</title><idno type="ISSN">0166-3542</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cell cell interaction</term><term>Gene expression</term><term>Interaction</term><term>Protein</term><term>Review</term><term>Severe acute respiratory syndrome</term><term>Severe acute respiratory syndrome virus</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Protéine</term><term>Syndrome respiratoire aigu sévère</term><term>Virus syndrome respiratoire aigu sévère</term><term>Interaction</term><term>Expression génique</term><term>Interaction cellulaire</term><term>Article synthèse</term><term>Interaction hôte virus</term><term>Protéine accessoire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A novel coronavirus, termed the severe acute respiratory syndrome coronavirus (SARS-CoV), infected humans in Guangdong, China, in November 2002 and the subsequent efficient human-to-human transmissions of this virus caused profound disturbances in over 30 countries worldwide in 2003. Eventually, this epidemic was controlled by isolation and there has been no human infection reported since January 2004. However, research on different aspects of the SARS-CoV is not waning, as it is not known if this virus will re-emerge, especially since its origins and potential reservoir(s) are unresolved. The SARS-CoV genome is nearly 30 kb in length and contains 14 potential open reading frames (ORFs). Some of these ORFs encode for genes that are homologous to proteins found in all known coronaviruses, namely the replicase genes (ORFs la and 1b) and the four structural proteins: nucleocapsid, spike, membrane and envelope, and these proteins are expected to be essential for the replication of the virus. The remaining eight ORFs encodes for accessory proteins, varying in length from 39 to 274 amino acids, which are unique to SARS-CoV. This review will summarize the expeditious research on these accessory viral proteins in three major areas: (i) the detection of antibodies against accessory proteins in the serum of infected patients, (ii) the expression, processing and cellular localization of the accessory proteins, and (iii) the effects of the accessory proteins on cellular functions. These in-depth molecular and biochemical characterizations of the SARS-CoV accessory proteins, which have no homologues in other coronaviruses, may offer clues as to why the SARS-CoV causes such a severe and rapid attack in humans, while other coronaviruses that infect humans seem to be more forgiving.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0166-3542</s0></fA01><fA02 i1="01"><s0>ARSRDR</s0></fA02><fA03 i2="1"><s0>Antivir. res.</s0></fA03><fA05><s2>72</s2></fA05><fA06><s2>2</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Understanding the accessory viral proteins unique to the severe acute respiratory syndrome (SARS) coronavirus</s1></fA08><fA11 i1="01" i2="1"><s1>TAN (Yee-Joo)</s1></fA11><fA11 i1="02" i2="1"><s1>SENG GEE LIM</s1></fA11><fA11 i1="03" i2="1"><s1>WANJIN HONG</s1></fA11><fA14 i1="01"><s1>Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos</s1><s2>Singapore 138673</s2><s3>SGP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></fA14><fA20><s1>78-88</s1></fA20><fA21><s1>2006</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>18839</s2><s5>354000157166580010</s5></fA43><fA44><s0>0000</s0><s1>© 2006 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>3 p.1/4</s0></fA45><fA47 i1="01" i2="1"><s0>06-0493742</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Antiviral research</s0></fA64><fA66 i1="01"><s0>NLD</s0></fA66><fC01 i1="01" l="ENG"><s0>A novel coronavirus, termed the severe acute respiratory syndrome coronavirus (SARS-CoV), infected humans in Guangdong, China, in November 2002 and the subsequent efficient human-to-human transmissions of this virus caused profound disturbances in over 30 countries worldwide in 2003. Eventually, this epidemic was controlled by isolation and there has been no human infection reported since January 2004. However, research on different aspects of the SARS-CoV is not waning, as it is not known if this virus will re-emerge, especially since its origins and potential reservoir(s) are unresolved. The SARS-CoV genome is nearly 30 kb in length and contains 14 potential open reading frames (ORFs). Some of these ORFs encode for genes that are homologous to proteins found in all known coronaviruses, namely the replicase genes (ORFs la and 1b) and the four structural proteins: nucleocapsid, spike, membrane and envelope, and these proteins are expected to be essential for the replication of the virus. The remaining eight ORFs encodes for accessory proteins, varying in length from 39 to 274 amino acids, which are unique to SARS-CoV. This review will summarize the expeditious research on these accessory viral proteins in three major areas: (i) the detection of antibodies against accessory proteins in the serum of infected patients, (ii) the expression, processing and cellular localization of the accessory proteins, and (iii) the effects of the accessory proteins on cellular functions. These in-depth molecular and biochemical characterizations of the SARS-CoV accessory proteins, which have no homologues in other coronaviruses, may offer clues as to why the SARS-CoV causes such a severe and rapid attack in humans, while other coronaviruses that infect humans seem to be more forgiving.</s0></fC01><fC02 i1="01" i2="X"><s0>002B02S05</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Protéine</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Protein</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Proteína</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Syndrome respiratoire aigu sévère</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Severe acute respiratory syndrome</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Síndrome respiratorio agudo severo</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Virus syndrome respiratoire aigu sévère</s0><s2>NW</s2><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Severe acute respiratory syndrome virus</s0><s2>NW</s2><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Severe acute respiratory syndrome virus</s0><s2>NW</s2><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Interaction</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Interaction</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Interacción</s0><s5>04</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Expression génique</s0><s5>06</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Gene expression</s0><s5>06</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Expresión genética</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Interaction cellulaire</s0><s5>07</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Cell cell interaction</s0><s5>07</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Interacción celular</s0><s5>07</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Article synthèse</s0><s5>08</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Review</s0><s5>08</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Artículo síntesis</s0><s5>08</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Interaction hôte virus</s0><s4>INC</s4><s5>86</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Protéine accessoire</s0><s4>INC</s4><s5>87</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Virose</s0></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Viral disease</s0></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Virosis</s0></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Infection</s0></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Infection</s0></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Infección</s0></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Coronavirus</s0><s2>NW</s2></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Coronavirus</s0><s2>NW</s2></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Coronavirus</s0><s2>NW</s2></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Coronaviridae</s0><s2>NW</s2></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Coronaviridae</s0><s2>NW</s2></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Coronaviridae</s0><s2>NW</s2></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Nidovirales</s0><s2>NW</s2></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Nidovirales</s0><s2>NW</s2></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Nidovirales</s0><s2>NW</s2></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="07" i2="X" l="FRE"><s0>Appareil respiratoire pathologie</s0><s5>37</s5></fC07><fC07 i1="07" i2="X" l="ENG"><s0>Respiratory disease</s0><s5>37</s5></fC07><fC07 i1="07" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0><s5>37</s5></fC07><fC07 i1="08" i2="X" l="FRE"><s0>Poumon pathologie</s0><s5>38</s5></fC07><fC07 i1="08" i2="X" l="ENG"><s0>Lung disease</s0><s5>38</s5></fC07><fC07 i1="08" i2="X" l="SPA"><s0>Pulmón patología</s0><s5>38</s5></fC07><fN21><s1>324</s1></fN21></pA></standard></inist></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/PascalFrancis/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000541 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Curation/biblio.hfd -nk 000541 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= PascalFrancis
|étape= Curation
|type= RBID
|clé= Pascal:06-0493742
|texte= Understanding the accessory viral proteins unique to the severe acute respiratory syndrome (SARS) coronavirus
}}
| This area was generated with Dilib version V0.6.33. |  |