SrasV1, PascalFrancis, Curation, bibRecord, 000539

Coronaviruses and their therapy

Identifieur interne : 000539 ( PascalFrancis/Curation ); précédent : 000538; suivant : 000540

Coronaviruses and their therapy

Auteurs : Bart L. Haagmans [Pays-Bas] ; Albert D. M. E. Osterhaus [Pays-Bas]

Source :

Antiviral research [ 0166-3542 ] ; 2006.

RBID : Pascal:06-0491674

Descripteurs français

Pascal (Inist)
- Traitement, Article synthèse, Syndrome respiratoire aigu sévère, Antiviral, Coronavirus, Inhibiteur d'entrée, inhibiteur de réplication, Inhibiteur de fusion.

English descriptors

KwdEn :
- Antiviral, Coronavirus, Fusion inhibitor, Review, Severe acute respiratory syndrome, Treatment.

Abstract

Coronaviruses may cause respiratory, enteric and central nervous system diseases in many species, including humans. Until recently, the relatively low burden of disease in humans caused by few of these viruses hampered development of coronavirus specific therapeutics. However, the emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) has prompted the discovery of such drugs. Subsequent studies in animal models demonstrated the efficacy of SARS-CoV specific monoclonal antibodies, pegylated-interferon-a and siRNAs against SARS-CoV. Furthermore, several antivirals shown to be effective against other viruses were tested in vitro. Because of availability and shown efficacy, the use of interferons may be considered should SARS-CoV or a related coronavirus (re)-emerge. The more recent design of wide-spectrum inhibitors targeting the coronavirus main proteases may lead to the discovery of new antivirals against multiple coronavirus induced diseases.

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A02	`01`			`@0 ARSRDR`
A03		`1`		`@0 Antivir. res.`
A05				`@2 71`
A06				`@2 2-3`
A08	`01`	`1`	`ENG`	`@1 Coronaviruses and their therapy`
A11	`01`	`1`		`@1 HAAGMANS (Bart L.)`
A11	`02`	`1`		`@1 OSTERHAUS (Albert D. M. E.)`
A14	`01`			`@1 Department of Virology, Erasmus Medical Center Rotterdam, Dr. Molewaterplein 50 @2 3015 GE Rotterdam @3 NLD @Z 1 aut. @Z 2 aut.`
A20				`@1 397-403`
A21				`@1 2006`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 18839 @5 354000142317820390`
A44				`@0 0000 @1 © 2006 INIST-CNRS. All rights reserved.`
A45				`@0 2 p.`
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A61				`@0 A`
A64	`01`	`1`		`@0 Antiviral research`
A66	`01`			`@0 NLD`
C01	`01`		`ENG`	@0 Coronaviruses may cause respiratory, enteric and central nervous system diseases in many species, including humans. Until recently, the relatively low burden of disease in humans caused by few of these viruses hampered development of coronavirus specific therapeutics. However, the emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) has prompted the discovery of such drugs. Subsequent studies in animal models demonstrated the efficacy of SARS-CoV specific monoclonal antibodies, pegylated-interferon-a and siRNAs against SARS-CoV. Furthermore, several antivirals shown to be effective against other viruses were tested in vitro. Because of availability and shown efficacy, the use of interferons may be considered should SARS-CoV or a related coronavirus (re)-emerge. The more recent design of wide-spectrum inhibitors targeting the coronavirus main proteases may lead to the discovery of new antivirals against multiple coronavirus induced diseases.
C02	`01`	`X`		`@0 002B02S05`
C03	`01`	`X`	`FRE`	`@0 Traitement @5 01`
C03	`01`	`X`	`ENG`	`@0 Treatment @5 01`
C03	`01`	`X`	`SPA`	`@0 Tratamiento @5 01`
C03	`02`	`X`	`FRE`	`@0 Article synthèse @5 02`
C03	`02`	`X`	`ENG`	`@0 Review @5 02`
C03	`02`	`X`	`SPA`	`@0 Artículo síntesis @5 02`
C03	`03`	`X`	`FRE`	`@0 Syndrome respiratoire aigu sévère @2 NM @5 03`
C03	`03`	`X`	`ENG`	`@0 Severe acute respiratory syndrome @2 NM @5 03`
C03	`03`	`X`	`SPA`	`@0 Síndrome respiratorio agudo severo @2 NM @5 03`
C03	`04`	`X`	`FRE`	`@0 Antiviral @5 04`
C03	`04`	`X`	`ENG`	`@0 Antiviral @5 04`
C03	`04`	`X`	`SPA`	`@0 Antiviral @5 04`
C03	`05`	`X`	`FRE`	`@0 Coronavirus @2 NW @5 05`
C03	`05`	`X`	`ENG`	`@0 Coronavirus @2 NW @5 05`
C03	`05`	`X`	`SPA`	`@0 Coronavirus @2 NW @5 05`
C03	`06`	`X`	`FRE`	`@0 Inhibiteur d'entrée @4 INC @5 86`
C03	`07`	`X`	`FRE`	`@0 inhibiteur de réplication @4 INC @5 87`
C03	`08`	`X`	`FRE`	`@0 Inhibiteur de fusion @4 CD @5 96`
C03	`08`	`X`	`ENG`	`@0 Fusion inhibitor @4 CD @5 96`
C03	`08`	`X`	`SPA`	`@0 Inhibidor fusión @4 CD @5 96`
C07	`01`	`X`	`FRE`	`@0 Virose`
C07	`01`	`X`	`ENG`	`@0 Viral disease`
C07	`01`	`X`	`SPA`	`@0 Virosis`
C07	`02`	`X`	`FRE`	`@0 Infection`
C07	`02`	`X`	`ENG`	`@0 Infection`
C07	`02`	`X`	`SPA`	`@0 Infección`
C07	`03`	`X`	`FRE`	`@0 Coronaviridae @2 NW`
C07	`03`	`X`	`ENG`	`@0 Coronaviridae @2 NW`
C07	`03`	`X`	`SPA`	`@0 Coronaviridae @2 NW`
C07	`04`	`X`	`FRE`	`@0 Nidovirales @2 NW`
C07	`04`	`X`	`ENG`	`@0 Nidovirales @2 NW`
C07	`04`	`X`	`SPA`	`@0 Nidovirales @2 NW`
C07	`05`	`X`	`FRE`	`@0 Virus @2 NW`
C07	`05`	`X`	`ENG`	`@0 Virus @2 NW`
C07	`05`	`X`	`SPA`	`@0 Virus @2 NW`
C07	`06`	`X`	`FRE`	`@0 Appareil respiratoire pathologie @5 37`
C07	`06`	`X`	`ENG`	`@0 Respiratory disease @5 37`
C07	`06`	`X`	`SPA`	`@0 Aparato respiratorio patología @5 37`
C07	`07`	`X`	`FRE`	`@0 Poumon pathologie @5 38`
C07	`07`	`X`	`ENG`	`@0 Lung disease @5 38`
C07	`07`	`X`	`SPA`	`@0 Pulmón patología @5 38`
N21				`@1 317`

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Le document en format XML

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<author><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L." last="Haagmans">Bart L. Haagmans</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Virology, Erasmus Medical Center Rotterdam, Dr. Molewaterplein 50</s1>
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<author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Coronaviruses and their therapy</title>
<author><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L." last="Haagmans">Bart L. Haagmans</name>
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<author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name>
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<series><title level="j" type="main">Antiviral research</title>
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<front><div type="abstract" xml:lang="en">Coronaviruses may cause respiratory, enteric and central nervous system diseases in many species, including humans. Until recently, the relatively low burden of disease in humans caused by few of these viruses hampered development of coronavirus specific therapeutics. However, the emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) has prompted the discovery of such drugs. Subsequent studies in animal models demonstrated the efficacy of SARS-CoV specific monoclonal antibodies, pegylated-interferon-a and siRNAs against SARS-CoV. Furthermore, several antivirals shown to be effective against other viruses were tested in vitro. Because of availability and shown efficacy, the use of interferons may be considered should SARS-CoV or a related coronavirus (re)-emerge. The more recent design of wide-spectrum inhibitors targeting the coronavirus main proteases may lead to the discovery of new antivirals against multiple coronavirus induced diseases.</div>
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<fC01 i1="01" l="ENG"><s0>Coronaviruses may cause respiratory, enteric and central nervous system diseases in many species, including humans. Until recently, the relatively low burden of disease in humans caused by few of these viruses hampered development of coronavirus specific therapeutics. However, the emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) has prompted the discovery of such drugs. Subsequent studies in animal models demonstrated the efficacy of SARS-CoV specific monoclonal antibodies, pegylated-interferon-a and siRNAs against SARS-CoV. Furthermore, several antivirals shown to be effective against other viruses were tested in vitro. Because of availability and shown efficacy, the use of interferons may be considered should SARS-CoV or a related coronavirus (re)-emerge. The more recent design of wide-spectrum inhibitors targeting the coronavirus main proteases may lead to the discovery of new antivirals against multiple coronavirus induced diseases.</s0>
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Coronaviruses and their therapy

Coronaviruses and their therapy

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Descripteurs français

English descriptors

Abstract

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