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Chemokine up-regulation in SARS-coronavirus -infected, monocyte-derived human dendritic cells

Identifieur interne : 000441 ( PascalFrancis/Curation ); précédent : 000440; suivant : 000442

Chemokine up-regulation in SARS-coronavirus -infected, monocyte-derived human dendritic cells

Auteurs : Helen K. W. Law [Hong Kong] ; CHUNG YAN CHEUNG ; HOI YEE NG ; SIN FUN SIA ; YUK ON CHAN ; Winsie Luk ; John M. Nicholls ; J. S. Malik Peiris ; YU LUNG LAU

Source :

RBID : Pascal:06-0102714

Descripteurs français

English descriptors

Abstract

Lymphopenia and increasing viral load in the first 10 days of severe acute respiratory syndrome (SARS) suggested immune evasion by SARS-coronavirus (CoV). In this study, we focused on dendritic cells (DCs) which play important roles in linking the innate and adaptive immunity. SARS-CoV was shown to infect both immature and mature human monocyte-derived DCs by electron microscopy and immunofluorescence. The detection of negative strands of SARS-CoV RNA in DCs suggested viral replication. However, no increase in viral RNA was observed. Using cytopathic assays, no increase in virus titer was detected in infected DCs and cell-culture supernatant, confirming that virus replication was incomplete. No induction of apoptosis or maturation was detected in SARS-CoV-infected DCs. The SARS-CoV-infected DCs showed low expression of antiviral cytokines (interferon a [IFN-a], IFN-β, IFN-γ, and interleukin 12p40 [IL-12p40]), moderate up-regulation of proinflammatory cytokines (tumor necrosis factor a [TNF-α] and IL-6) but significant up-regulation of inflammatory chemokines (macrophage inflammatory protein 1α [MIP-1α], regulated on activation normal T cell expressed and secreted [RANTES]), interferon-inducible protein of 10 kDa [IP-10], and monocyte chemo-attractant protein 1 [MCP-1]). The lack of antiviral cytokine response against a background of intense chemokine up-regulation could represent a mechanism of immune evasion by SARS-CoV.
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A11 02  1    @1 CHUNG YAN CHEUNG
A11 03  1    @1 HOI YEE NG
A11 04  1    @1 SIN FUN SIA
A11 05  1    @1 YUK ON CHAN
A11 06  1    @1 LUK (Winsie)
A11 07  1    @1 NICHOLLS (John M.)
A11 08  1    @1 PEIRIS (J. S. Malik)
A11 09  1    @1 YU LUNG LAU
A14 01      @1 Department of Paediatrics and Adolescent Medicine, the Department of Microbiology, and the Department of Pathology, Hong Kong Jockey Club Clinical Research Centre, Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital @2 Pokfulam @3 HKG
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C03 09  X  SPA  @0 evasión inmune @5 11
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C03 10  X  SPA  @0 Respuesta inmune @5 12
C07 01  X  FRE  @0 Coronaviridae @2 NW
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C07 02  X  FRE  @0 Nidovirales @2 NW
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C07 02  X  SPA  @0 Nidovirales @2 NW
C07 03  X  FRE  @0 Virus @2 NW
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C07 04  X  FRE  @0 Virose
C07 04  X  ENG  @0 Viral disease
C07 04  X  SPA  @0 Virosis
C07 05  X  FRE  @0 Infection
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C07 07  X  FRE  @0 Poumon pathologie @5 38
C07 07  X  ENG  @0 Lung disease @5 38
C07 07  X  SPA  @0 Pulmón patología @5 38
N21       @1 065

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Pascal:06-0102714

Le document en format XML

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<s5>12</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE">
<s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG">
<s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA">
<s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE">
<s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG">
<s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA">
<s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE">
<s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG">
<s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA">
<s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE">
<s0>Virose</s0>
</fC07>
<fC07 i1="04" i2="X" l="ENG">
<s0>Viral disease</s0>
</fC07>
<fC07 i1="04" i2="X" l="SPA">
<s0>Virosis</s0>
</fC07>
<fC07 i1="05" i2="X" l="FRE">
<s0>Infection</s0>
</fC07>
<fC07 i1="05" i2="X" l="ENG">
<s0>Infection</s0>
</fC07>
<fC07 i1="05" i2="X" l="SPA">
<s0>Infección</s0>
</fC07>
<fC07 i1="06" i2="X" l="FRE">
<s0>Appareil respiratoire pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG">
<s0>Respiratory disease</s0>
<s5>37</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA">
<s0>Aparato respiratorio patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE">
<s0>Poumon pathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG">
<s0>Lung disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA">
<s0>Pulmón patología</s0>
<s5>38</s5>
</fC07>
<fN21>
<s1>065</s1>
</fN21>
</pA>
</standard>
</inist>
</record>

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   |wiki=    Sante
   |area=    SrasV1
   |flux=    PascalFrancis
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   |texte=   Chemokine up-regulation in SARS-coronavirus -infected, monocyte-derived human dendritic cells
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