Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic α,β-unsaturated esters
Identifieur interne : 000413 ( PascalFrancis/Curation ); précédent : 000412; suivant : 000414Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic α,β-unsaturated esters
Auteurs : Jiun-Jie Shie [Taïwan] ; Jim-Min Fang [Taïwan] ; Tun-Hsun Kuo [Taïwan] ; Chih-Jung Kuo [Taïwan] ; Po-Huang Liang [Taïwan] ; Hung-Jyun Huang [Taïwan] ; Yin-Ta Wu [Taïwan] ; Jia-Tsrong Jan [Taïwan] ; Yih-Shyun E. Cheng [Taïwan] ; Chi-Huey Wong [Taïwan]Source :
- Bioorganic & medicinal chemistry [ 0968-0896 ] ; 2005.
Descripteurs français
- Pascal (Inist)
- Synthèse chimique, Syndrome respiratoire aigu sévère, Peptidases, Composé peptidomimétique, Ester, Virus syndrome respiratoire aigu sévère, Activité biologique, Inhibiteur protease, Complexe enzyme inhibiteur, Cinnamique acide dérivé, Antiviral, Modèle moléculaire, Composé vinylique, Inhibiteur enzyme, Modélisation, Phénylalaninamide(N-[1-benzyl-3-éthoxycarbonylallyl]-Nα-[4-(diméthylamino)cinnamoyl]), Phénylalanine dérivé.
English descriptors
- KwdEn :
- Antiviral, Biological activity, Chemical synthesis, Cinnamic acid derivatives, Enzyme inhibitor, Ester, Inhibitor enzyme complex, Modeling, Molecular model, Peptidases, Peptidomimetic compound, Protease inhibitor, Severe acute respiratory syndrome, Severe acute respiratory syndrome virus, Vinylic compound.
Abstract
The proteolytic processing of polyproteins by the 3CL protease of severe acute respiratory syndrome coronavirus is essential for the viral propagation. A series of tripeptide α,β-unsaturated esters and ketomethylene isosteres, including AG7088, are synthesized and assayed to target the 3CL protease. Though AG7088 is inactive (IC50 > 100 μM), the ketomethylene isosteres and tripeptide α,β-unsaturated esters containing both P1 and P2 phenylalanine residues show modest inhibitory activity (IC50 = 11-39 μM). The Phe-Phe dipeptide inhibitors 18a-e are designed on the basis of computer modeling of the enzyme-inhibitor complex. The most potent inhibitor 18c with an inhibition constant of 0.52 μM is obtained by condensation of the Phe-Phe dipeptide α,β-unsaturated ester with 4-(dimethylamino)cinnamic acid. The cell-based assays also indicate that 18c is a nontoxic anti-SARS agent with an EC50 value of 0.18 μM.
| pA |
|
|---|
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000577
Links to Exploration step
Pascal:05-0491084Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic α,β-unsaturated esters</title><author><name sortKey="Shie, Jiun Jie" sort="Shie, Jiun Jie" uniqKey="Shie J" first="Jiun-Jie" last="Shie">Jiun-Jie Shie</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Chemistry, National Taiwan University</s1><s2>Taipei 106</s2><s3>TWN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Taïwan</country></affiliation></author><author><name sortKey="Fang, Jim Min" sort="Fang, Jim Min" uniqKey="Fang J" first="Jim-Min" last="Fang">Jim-Min Fang</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Chemistry, National Taiwan University</s1><s2>Taipei 106</s2><s3>TWN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Taïwan</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>The Genomic. Research Center, Academw Sinica</s1><s2>Taipei 115</s2><s3>TWN</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Taïwan</country></affiliation></author><author><name sortKey="Kuo, Tun Hsun" sort="Kuo, Tun Hsun" uniqKey="Kuo T" first="Tun-Hsun" last="Kuo">Tun-Hsun Kuo</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Biological Chemistry, Academia Sinica</s1><s2>Tuipei 115</s2><s3>TWN</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Taïwan</country></affiliation></author><author><name sortKey="Kuo, Chih Jung" sort="Kuo, Chih Jung" uniqKey="Kuo C" first="Chih-Jung" last="Kuo">Chih-Jung Kuo</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Biological Chemistry, Academia Sinica</s1><s2>Tuipei 115</s2><s3>TWN</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Taïwan</country></affiliation></author><author><name sortKey="Liang, Po Huang" sort="Liang, Po Huang" uniqKey="Liang P" first="Po-Huang" last="Liang">Po-Huang Liang</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>The Genomic. Research Center, Academw Sinica</s1><s2>Taipei 115</s2><s3>TWN</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Taïwan</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Biological Chemistry, Academia Sinica</s1><s2>Tuipei 115</s2><s3>TWN</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Taïwan</country></affiliation></author><author><name sortKey="Huang, Hung Jyun" sort="Huang, Hung Jyun" uniqKey="Huang H" first="Hung-Jyun" last="Huang">Hung-Jyun Huang</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Chemistry, National Taiwan University</s1><s2>Taipei 106</s2><s3>TWN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Taïwan</country></affiliation></author><author><name sortKey="Wu, Yin Ta" sort="Wu, Yin Ta" uniqKey="Wu Y" first="Yin-Ta" last="Wu">Yin-Ta Wu</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>The Genomic. Research Center, Academw Sinica</s1><s2>Taipei 115</s2><s3>TWN</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Taïwan</country></affiliation></author><author><name sortKey="Jan, Jia Tsrong" sort="Jan, Jia Tsrong" uniqKey="Jan J" first="Jia-Tsrong" last="Jan">Jia-Tsrong Jan</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Institute of Preventive Medicine, National Defense University</s1><s2>Taipei</s2><s3>TWN</s3><sZ>8 aut.</sZ></inist:fA14><country>Taïwan</country></affiliation></author><author><name sortKey="Cheng, Yih Shyun E" sort="Cheng, Yih Shyun E" uniqKey="Cheng Y" first="Yih-Shyun E." last="Cheng">Yih-Shyun E. Cheng</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>The Genomic. Research Center, Academw Sinica</s1><s2>Taipei 115</s2><s3>TWN</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Taïwan</country></affiliation></author><author><name sortKey="Wong, Chi Huey" sort="Wong, Chi Huey" uniqKey="Wong C" first="Chi-Huey" last="Wong">Chi-Huey Wong</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>The Genomic. Research Center, Academw Sinica</s1><s2>Taipei 115</s2><s3>TWN</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Taïwan</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">05-0491084</idno><date when="2005">2005</date><idno type="stanalyst">PASCAL 05-0491084 INIST</idno><idno type="RBID">Pascal:05-0491084</idno><idno type="wicri:Area/PascalFrancis/Corpus">000577</idno><idno type="wicri:Area/PascalFrancis/Curation">000413</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic α,β-unsaturated esters</title><author><name sortKey="Shie, Jiun Jie" sort="Shie, Jiun Jie" uniqKey="Shie J" first="Jiun-Jie" last="Shie">Jiun-Jie Shie</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Chemistry, National Taiwan University</s1><s2>Taipei 106</s2><s3>TWN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Taïwan</country></affiliation></author><author><name sortKey="Fang, Jim Min" sort="Fang, Jim Min" uniqKey="Fang J" first="Jim-Min" last="Fang">Jim-Min Fang</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Chemistry, National Taiwan University</s1><s2>Taipei 106</s2><s3>TWN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Taïwan</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>The Genomic. Research Center, Academw Sinica</s1><s2>Taipei 115</s2><s3>TWN</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Taïwan</country></affiliation></author><author><name sortKey="Kuo, Tun Hsun" sort="Kuo, Tun Hsun" uniqKey="Kuo T" first="Tun-Hsun" last="Kuo">Tun-Hsun Kuo</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Biological Chemistry, Academia Sinica</s1><s2>Tuipei 115</s2><s3>TWN</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Taïwan</country></affiliation></author><author><name sortKey="Kuo, Chih Jung" sort="Kuo, Chih Jung" uniqKey="Kuo C" first="Chih-Jung" last="Kuo">Chih-Jung Kuo</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Biological Chemistry, Academia Sinica</s1><s2>Tuipei 115</s2><s3>TWN</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Taïwan</country></affiliation></author><author><name sortKey="Liang, Po Huang" sort="Liang, Po Huang" uniqKey="Liang P" first="Po-Huang" last="Liang">Po-Huang Liang</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>The Genomic. Research Center, Academw Sinica</s1><s2>Taipei 115</s2><s3>TWN</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Taïwan</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Biological Chemistry, Academia Sinica</s1><s2>Tuipei 115</s2><s3>TWN</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Taïwan</country></affiliation></author><author><name sortKey="Huang, Hung Jyun" sort="Huang, Hung Jyun" uniqKey="Huang H" first="Hung-Jyun" last="Huang">Hung-Jyun Huang</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Chemistry, National Taiwan University</s1><s2>Taipei 106</s2><s3>TWN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Taïwan</country></affiliation></author><author><name sortKey="Wu, Yin Ta" sort="Wu, Yin Ta" uniqKey="Wu Y" first="Yin-Ta" last="Wu">Yin-Ta Wu</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>The Genomic. Research Center, Academw Sinica</s1><s2>Taipei 115</s2><s3>TWN</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Taïwan</country></affiliation></author><author><name sortKey="Jan, Jia Tsrong" sort="Jan, Jia Tsrong" uniqKey="Jan J" first="Jia-Tsrong" last="Jan">Jia-Tsrong Jan</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Institute of Preventive Medicine, National Defense University</s1><s2>Taipei</s2><s3>TWN</s3><sZ>8 aut.</sZ></inist:fA14><country>Taïwan</country></affiliation></author><author><name sortKey="Cheng, Yih Shyun E" sort="Cheng, Yih Shyun E" uniqKey="Cheng Y" first="Yih-Shyun E." last="Cheng">Yih-Shyun E. Cheng</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>The Genomic. Research Center, Academw Sinica</s1><s2>Taipei 115</s2><s3>TWN</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Taïwan</country></affiliation></author><author><name sortKey="Wong, Chi Huey" sort="Wong, Chi Huey" uniqKey="Wong C" first="Chi-Huey" last="Wong">Chi-Huey Wong</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>The Genomic. Research Center, Academw Sinica</s1><s2>Taipei 115</s2><s3>TWN</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Taïwan</country></affiliation></author></analytic><series><title level="j" type="main">Bioorganic & medicinal chemistry</title><title level="j" type="abbreviated">Bioorg. med. chem.</title><idno type="ISSN">0968-0896</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Bioorganic & medicinal chemistry</title><title level="j" type="abbreviated">Bioorg. med. chem.</title><idno type="ISSN">0968-0896</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral</term><term>Biological activity</term><term>Chemical synthesis</term><term>Cinnamic acid derivatives</term><term>Enzyme inhibitor</term><term>Ester</term><term>Inhibitor enzyme complex</term><term>Modeling</term><term>Molecular model</term><term>Peptidases</term><term>Peptidomimetic compound</term><term>Protease inhibitor</term><term>Severe acute respiratory syndrome</term><term>Severe acute respiratory syndrome virus</term><term>Vinylic compound</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Synthèse chimique</term><term>Syndrome respiratoire aigu sévère</term><term>Peptidases</term><term>Composé peptidomimétique</term><term>Ester</term><term>Virus syndrome respiratoire aigu sévère</term><term>Activité biologique</term><term>Inhibiteur protease</term><term>Complexe enzyme inhibiteur</term><term>Cinnamique acide dérivé</term><term>Antiviral</term><term>Modèle moléculaire</term><term>Composé vinylique</term><term>Inhibiteur enzyme</term><term>Modélisation</term><term>Phénylalaninamide(N-[1-benzyl-3-éthoxycarbonylallyl]-Nα-[4-(diméthylamino)cinnamoyl])</term><term>Phénylalanine dérivé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The proteolytic processing of polyproteins by the 3CL protease of severe acute respiratory syndrome coronavirus is essential for the viral propagation. A series of tripeptide α,β-unsaturated esters and ketomethylene isosteres, including AG7088, are synthesized and assayed to target the 3CL protease. Though AG7088 is inactive (IC<sub>50</sub> > 100 μM), the ketomethylene isosteres and tripeptide α,β-unsaturated esters containing both P1 and P<sup>2</sup> phenylalanine residues show modest inhibitory activity (IC<sub>50</sub> = 11-39 μM). The Phe-Phe dipeptide inhibitors 18a-e are designed on the basis of computer modeling of the enzyme-inhibitor complex. The most potent inhibitor 18c with an inhibition constant of 0.52 μM is obtained by condensation of the Phe-Phe dipeptide α,β-unsaturated ester with 4-(dimethylamino)cinnamic acid. The cell-based assays also indicate that 18c is a nontoxic anti-SARS agent with an EC<sub>50</sub> value of 0.18 μM.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0968-0896</s0></fA01><fA03 i2="1"><s0>Bioorg. med. chem.</s0></fA03><fA05><s2>13</s2></fA05><fA06><s2>17</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic α,β-unsaturated esters</s1></fA08><fA09 i1="01" i2="1" l="ENG"><s1>Chemistry & Biology of Natural Products, Tetrahedron Prize for Creativity in Organic Chemistry 2004 K. Nakanishi</s1></fA09><fA11 i1="01" i2="1"><s1>SHIE (Jiun-Jie)</s1></fA11><fA11 i1="02" i2="1"><s1>FANG (Jim-Min)</s1></fA11><fA11 i1="03" i2="1"><s1>KUO (Tun-Hsun)</s1></fA11><fA11 i1="04" i2="1"><s1>KUO (Chih-Jung)</s1></fA11><fA11 i1="05" i2="1"><s1>LIANG (Po-Huang)</s1></fA11><fA11 i1="06" i2="1"><s1>HUANG (Hung-Jyun)</s1></fA11><fA11 i1="07" i2="1"><s1>WU (Yin-Ta)</s1></fA11><fA11 i1="08" i2="1"><s1>JAN (Jia-Tsrong)</s1></fA11><fA11 i1="09" i2="1"><s1>CHENG (Yih-Shyun E.)</s1></fA11><fA11 i1="10" i2="1"><s1>WONG (Chi-Huey)</s1></fA11><fA12 i1="01" i2="1"><s1>WONG (Chi-Huey)</s1><s9>ed.</s9></fA12><fA14 i1="01"><s1>Department of Chemistry, National Taiwan University</s1><s2>Taipei 106</s2><s3>TWN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ></fA14><fA14 i1="02"><s1>The Genomic. Research Center, Academw Sinica</s1><s2>Taipei 115</s2><s3>TWN</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></fA14><fA14 i1="03"><s1>Institute of Biological Chemistry, Academia Sinica</s1><s2>Tuipei 115</s2><s3>TWN</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></fA14><fA14 i1="04"><s1>Institute of Preventive Medicine, National Defense University</s1><s2>Taipei</s2><s3>TWN</s3><sZ>8 aut.</sZ></fA14><fA15 i1="01"><s1>Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road</s1><s2>La Jolla, CA 92037</s2><s3>USA</s3><sZ>1 aut.</sZ></fA15><fA20><s1>5240-5252</s1></fA20><fA21><s1>2005</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>26564</s2><s5>354000131485400270</s5></fA43><fA44><s0>0000</s0><s1>© 2005 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>28 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>05-0491084</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Bioorganic & medicinal chemistry</s0></fA64><fA66 i1="01"><s0>GBR</s0></fA66><fC01 i1="01" l="ENG"><s0>The proteolytic processing of polyproteins by the 3CL protease of severe acute respiratory syndrome coronavirus is essential for the viral propagation. A series of tripeptide α,β-unsaturated esters and ketomethylene isosteres, including AG7088, are synthesized and assayed to target the 3CL protease. Though AG7088 is inactive (IC<sub>50</sub> > 100 μM), the ketomethylene isosteres and tripeptide α,β-unsaturated esters containing both P1 and P<sup>2</sup> phenylalanine residues show modest inhibitory activity (IC<sub>50</sub> = 11-39 μM). The Phe-Phe dipeptide inhibitors 18a-e are designed on the basis of computer modeling of the enzyme-inhibitor complex. The most potent inhibitor 18c with an inhibition constant of 0.52 μM is obtained by condensation of the Phe-Phe dipeptide α,β-unsaturated ester with 4-(dimethylamino)cinnamic acid. The cell-based assays also indicate that 18c is a nontoxic anti-SARS agent with an EC<sub>50</sub> value of 0.18 μM.</s0></fC01><fC02 i1="01" i2="X"><s0>002B02S05</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Synthèse chimique</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Chemical synthesis</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Síntesis química</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Syndrome respiratoire aigu sévère</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Severe acute respiratory syndrome</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Síndrome respiratorio agudo severo</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Peptidases</s0><s2>FE</s2><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Peptidases</s0><s2>FE</s2><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Peptidases</s0><s2>FE</s2><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Composé peptidomimétique</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Peptidomimetic compound</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Compuesto peptidomimético</s0><s5>04</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Ester</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Ester</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Ester</s0><s5>05</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Virus syndrome respiratoire aigu sévère</s0><s2>NW</s2><s5>06</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Severe acute respiratory syndrome virus</s0><s2>NW</s2><s5>06</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Severe acute respiratory syndrome virus</s0><s2>NW</s2><s5>06</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Activité biologique</s0><s5>09</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Biological activity</s0><s5>09</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Actividad biológica</s0><s5>09</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Inhibiteur protease</s0><s2>FR</s2><s5>11</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Protease inhibitor</s0><s2>FR</s2><s5>11</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Inhibidor proteasa</s0><s2>FR</s2><s5>11</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Complexe enzyme inhibiteur</s0><s5>13</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Inhibitor enzyme complex</s0><s5>13</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Complejo enzima inhibidor</s0><s5>13</s5></fC03><fC03 i1="10" i2="X" l="FRE"><s0>Cinnamique acide dérivé</s0><s2>NK</s2><s5>14</s5></fC03><fC03 i1="10" i2="X" l="ENG"><s0>Cinnamic acid derivatives</s0><s2>NK</s2><s5>14</s5></fC03><fC03 i1="10" i2="X" l="SPA"><s0>Cinámico ácido derivado</s0><s2>NK</s2><s5>14</s5></fC03><fC03 i1="11" i2="X" l="FRE"><s0>Antiviral</s0><s5>16</s5></fC03><fC03 i1="11" i2="X" l="ENG"><s0>Antiviral</s0><s5>16</s5></fC03><fC03 i1="11" i2="X" l="SPA"><s0>Antiviral</s0><s5>16</s5></fC03><fC03 i1="12" i2="X" l="FRE"><s0>Modèle moléculaire</s0><s5>17</s5></fC03><fC03 i1="12" i2="X" l="ENG"><s0>Molecular model</s0><s5>17</s5></fC03><fC03 i1="12" i2="X" l="SPA"><s0>Modelo molecular</s0><s5>17</s5></fC03><fC03 i1="13" i2="X" l="FRE"><s0>Composé vinylique</s0><s5>18</s5></fC03><fC03 i1="13" i2="X" l="ENG"><s0>Vinylic compound</s0><s5>18</s5></fC03><fC03 i1="13" i2="X" l="SPA"><s0>Compuesto vinílico</s0><s5>18</s5></fC03><fC03 i1="14" i2="X" l="FRE"><s0>Inhibiteur enzyme</s0><s5>32</s5></fC03><fC03 i1="14" i2="X" l="ENG"><s0>Enzyme inhibitor</s0><s5>32</s5></fC03><fC03 i1="14" i2="X" l="SPA"><s0>Inhibidor enzima</s0><s5>32</s5></fC03><fC03 i1="15" i2="X" l="FRE"><s0>Modélisation</s0><s5>33</s5></fC03><fC03 i1="15" i2="X" l="ENG"><s0>Modeling</s0><s5>33</s5></fC03><fC03 i1="15" i2="X" l="SPA"><s0>Modelización</s0><s5>33</s5></fC03><fC03 i1="16" i2="X" l="FRE"><s0>Phénylalaninamide(N-[1-benzyl-3-éthoxycarbonylallyl]-Nα-[4-(diméthylamino)cinnamoyl])</s0><s2>NK</s2><s4>INC</s4><s5>76</s5></fC03><fC03 i1="17" i2="X" l="FRE"><s0>Phénylalanine dérivé</s0><s2>NK</s2><s4>INC</s4><s5>77</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Virose</s0></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Viral disease</s0></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Virosis</s0></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Infection</s0></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Infection</s0></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Infección</s0></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Hydrolases</s0><s2>FE</s2></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Hydrolases</s0><s2>FE</s2></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Hydrolases</s0><s2>FE</s2></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Enzyme</s0><s2>FE</s2></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Enzyme</s0><s2>FE</s2></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Enzima</s0><s2>FE</s2></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Coronavirus</s0><s2>NW</s2></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Coronavirus</s0><s2>NW</s2></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Coronavirus</s0><s2>NW</s2></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Coronaviridae</s0><s2>NW</s2></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Coronaviridae</s0><s2>NW</s2></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Coronaviridae</s0><s2>NW</s2></fC07><fC07 i1="07" i2="X" l="FRE"><s0>Nidovirales</s0><s2>NW</s2></fC07><fC07 i1="07" i2="X" l="ENG"><s0>Nidovirales</s0><s2>NW</s2></fC07><fC07 i1="07" i2="X" l="SPA"><s0>Nidovirales</s0><s2>NW</s2></fC07><fC07 i1="08" i2="X" l="FRE"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="08" i2="X" l="ENG"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="08" i2="X" l="SPA"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="09" i2="X" l="FRE"><s0>Appareil respiratoire pathologie</s0><s5>53</s5></fC07><fC07 i1="09" i2="X" l="ENG"><s0>Respiratory disease</s0><s5>53</s5></fC07><fC07 i1="09" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0><s5>53</s5></fC07><fN21><s1>346</s1></fN21></pA></standard></inist></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/PascalFrancis/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000413 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Curation/biblio.hfd -nk 000413 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= PascalFrancis
|étape= Curation
|type= RBID
|clé= Pascal:05-0491084
|texte= Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic α,β-unsaturated esters
}}
| This area was generated with Dilib version V0.6.33. |  |