SrasV1, PascalFrancis, Curation, bibRecord, 000341

Identification of an alternative 5'-untranslated exon and new polymorphisms of angiotensin-converting enzyme 2 gene : Lack of association with SARS in the vietnamese population

Identifieur interne : 000341 ( PascalFrancis/Curation ); précédent : 000340; suivant : 000342

Identification of an alternative 5'-untranslated exon and new polymorphisms of angiotensin-converting enzyme 2 gene : Lack of association with SARS in the vietnamese population

Auteurs : Satoru Itoyama [Japon] ; Naoto Keicho [Japon] ; Minako Hijikata [Japon] ; Tran Quy [Viêt Nam] ; NGUYEN CHI PHI [Viêt Nam] ; HOANG THUY LONG [Viêt Nam] ; LE DANG HA [Viêt Nam] ; VO VAN BAN [Viêt Nam] ; Ikumi Matsushita [Japon] ; Hideki Yanai [Japon] ; Fumiko Kirikae [Japon] ; Teruo Kirikae [Japon] ; Tadatoshi Kuratsuji [Japon] ; Takehiko Sasazuki [Japon]

Source :

American journal of medical genetics [ 0148-7299 ] ; 2005.

RBID : Pascal:05-0314695

Descripteurs français

Pascal (Inist)
- Identification, Exon, Polymorphisme, Peptidyl-dipeptidase A, Gène, Association, Syndrome respiratoire aigu sévère, Vietnam, Population, Coronavirus, Récepteur biologique, Génétique, Homme.
Wicri :
- topic : Association, Génétique, Homme.

English descriptors

KwdEn :
- Association, Biological receptor, Coronavirus, Exon, Gene, Genetics, Human, Identification, Peptidyl-dipeptidase A, Polymorphism, Population, Severe acute respiratory syndrome, Vietnam.

Abstract

We analyzed genetic variations of angiotensin-converting enzyme 2 (ACE2), considering that it might influence patients' susceptibility to severe acute respiratory syndrome-associated coronavirus (SARS-CoV) or development of SARS as a functional receptor. By cloning of the full-length cDNA of the ACE2 gene in the lung, where replication occurs on SARS-CoV, it was shown that there are different splicing sites. All exons including the new alternative exon, exon-intron boundaries, and the corresponding 5'-flanking region of the gene were investigated and 19 single nucleotide polymorphisms (SNPs) were found. Out of these, 13 SNPs including one non-synonymous substitution and three 3'-UTR polymorphisms were newly identified. A case control study involving 44 SARS cases, 16 anti-SARS-CoV antibody-positive contacts, 87 antibody-negative contacts, and 50 non-contacts in Vietnam, failed to obtain any evidence that the ACE2 gene polymorphisms are involved in the disease process in the population. Nevertheless, identification of new 5'-untranslated exon and new SNPs is considered helpful in investigating regulation of ACE2 gene expression in the future.

A01	`01`	`1`		`@0 0148-7299`
A02	`01`			`@0 AJMGDA`
A03		`1`		`@0 Am. j. med. genet.`
A05				`@2 136A`
A06				`@2 1`
A08	`01`	`1`	`ENG`	`@1 Identification of an alternative 5'-untranslated exon and new polymorphisms of angiotensin-converting enzyme 2 gene : Lack of association with SARS in the vietnamese population`
A11	`01`	`1`		`@1 ITOYAMA (Satoru)`
A11	`02`	`1`		`@1 KEICHO (Naoto)`
A11	`03`	`1`		`@1 HIJIKATA (Minako)`
A11	`04`	`1`		`@1 QUY (Tran)`
A11	`05`	`1`		`@1 NGUYEN CHI PHI`
A11	`06`	`1`		`@1 HOANG THUY LONG`
A11	`07`	`1`		`@1 LE DANG HA`
A11	`08`	`1`		`@1 VO VAN BAN`
A11	`09`	`1`		`@1 MATSUSHITA (Ikumi)`
A11	`10`	`1`		`@1 YANAI (Hideki)`
A11	`11`	`1`		`@1 KIRIKAE (Fumiko)`
A11	`12`	`1`		`@1 KIRIKAE (Teruo)`
A11	`13`	`1`		`@1 KURATSUJI (Tadatoshi)`
A11	`14`	`1`		`@1 SASAZUKI (Takehiko)`
A14	`01`			`@1 Department of Respiratory Diseases, Research Institute, International Medical Center of Japan @2 Tokyo @3 JPN @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 9 aut.`
A14	`02`			`@1 Bach Mai Hospital @2 Hanoi @3 VNM @Z 4 aut. @Z 5 aut.`
A14	`03`			`@1 National Institute of Hygiene and Epidemiology @2 Hanoi @3 VNM @Z 6 aut.`
A14	`04`			`@1 Institute for Clinical Research in Tropical Medicine @3 VNM @Z 7 aut.`
A14	`05`			`@1 Hanoi-French Hospital @3 VNM @Z 8 aut.`
A14	`06`			`@1 The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association @3 JPN @Z 10 aut.`
A14	`07`			`@1 Department of Infectious Diseases, Research Institute, International Medical Center of Japan @3 JPN @Z 11 aut. @Z 12 aut.`
A14	`08`			`@1 Research Institute, International Medical Center of Japan @3 JPN @Z 13 aut.`
A14	`09`			`@1 International Medical Center of Japan @3 JPN @Z 14 aut.`
A20				`@1 52-57`
A21				`@1 2005`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 17405 @5 354000132241680100`
A44				`@0 0000 @1 © 2005 INIST-CNRS. All rights reserved.`
A45				`@0 25 ref.`
A47	`01`	`1`		`@0 05-0314695`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 American journal of medical genetics`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 We analyzed genetic variations of angiotensin-converting enzyme 2 (ACE2), considering that it might influence patients' susceptibility to severe acute respiratory syndrome-associated coronavirus (SARS-CoV) or development of SARS as a functional receptor. By cloning of the full-length cDNA of the ACE2 gene in the lung, where replication occurs on SARS-CoV, it was shown that there are different splicing sites. All exons including the new alternative exon, exon-intron boundaries, and the corresponding 5'-flanking region of the gene were investigated and 19 single nucleotide polymorphisms (SNPs) were found. Out of these, 13 SNPs including one non-synonymous substitution and three 3'-UTR polymorphisms were newly identified. A case control study involving 44 SARS cases, 16 anti-SARS-CoV antibody-positive contacts, 87 antibody-negative contacts, and 50 non-contacts in Vietnam, failed to obtain any evidence that the ACE2 gene polymorphisms are involved in the disease process in the population. Nevertheless, identification of new 5'-untranslated exon and new SNPs is considered helpful in investigating regulation of ACE2 gene expression in the future.
C02	`01`	`X`		`@0 002B23A`
C02	`02`	`X`		`@0 002B05C02C`
C03	`01`	`X`	`FRE`	`@0 Identification @5 09`
C03	`01`	`X`	`ENG`	`@0 Identification @5 09`
C03	`01`	`X`	`SPA`	`@0 Identificación @5 09`
C03	`02`	`X`	`FRE`	`@0 Exon @5 10`
C03	`02`	`X`	`ENG`	`@0 Exon @5 10`
C03	`02`	`X`	`SPA`	`@0 Exón @5 10`
C03	`03`	`X`	`FRE`	`@0 Polymorphisme @5 11`
C03	`03`	`X`	`ENG`	`@0 Polymorphism @5 11`
C03	`03`	`X`	`SPA`	`@0 Polimorfismo @5 11`
C03	`04`	`X`	`FRE`	`@0 Peptidyl-dipeptidase A @2 FE @5 12`
C03	`04`	`X`	`ENG`	`@0 Peptidyl-dipeptidase A @2 FE @5 12`
C03	`04`	`X`	`SPA`	`@0 Peptidyl-dipeptidase A @2 FE @5 12`
C03	`05`	`X`	`FRE`	`@0 Gène @5 13`
C03	`05`	`X`	`ENG`	`@0 Gene @5 13`
C03	`05`	`X`	`SPA`	`@0 Gen @5 13`
C03	`06`	`X`	`FRE`	`@0 Association @5 14`
C03	`06`	`X`	`ENG`	`@0 Association @5 14`
C03	`06`	`X`	`SPA`	`@0 Asociación @5 14`
C03	`07`	`X`	`FRE`	`@0 Syndrome respiratoire aigu sévère @2 NM @5 15`
C03	`07`	`X`	`ENG`	`@0 Severe acute respiratory syndrome @2 NM @5 15`
C03	`07`	`X`	`SPA`	`@0 Síndrome respiratorio agudo severo @2 NM @5 15`
C03	`08`	`X`	`FRE`	`@0 Vietnam @2 NG @5 17`
C03	`08`	`X`	`ENG`	`@0 Vietnam @2 NG @5 17`
C03	`08`	`X`	`SPA`	`@0 Vietnam @2 NG @5 17`
C03	`09`	`X`	`FRE`	`@0 Population @5 18`
C03	`09`	`X`	`ENG`	`@0 Population @5 18`
C03	`09`	`X`	`SPA`	`@0 Población @5 18`
C03	`10`	`X`	`FRE`	`@0 Coronavirus @2 NW @5 19`
C03	`10`	`X`	`ENG`	`@0 Coronavirus @2 NW @5 19`
C03	`10`	`X`	`SPA`	`@0 Coronavirus @2 NW @5 19`
C03	`11`	`X`	`FRE`	`@0 Récepteur biologique @5 21`
C03	`11`	`X`	`ENG`	`@0 Biological receptor @5 21`
C03	`11`	`X`	`SPA`	`@0 Receptor biológico @5 21`
C03	`12`	`X`	`FRE`	`@0 Génétique @5 22`
C03	`12`	`X`	`ENG`	`@0 Genetics @5 22`
C03	`12`	`X`	`SPA`	`@0 Genética @5 22`
C03	`13`	`X`	`FRE`	`@0 Homme @5 23`
C03	`13`	`X`	`ENG`	`@0 Human @5 23`
C03	`13`	`X`	`SPA`	`@0 Hombre @5 23`
C07	`01`	`X`	`FRE`	`@0 Peptidyl-dipeptidases @2 FE`
C07	`01`	`X`	`ENG`	`@0 Peptidyl-dipeptidases @2 FE`
C07	`01`	`X`	`SPA`	`@0 Peptidyl-dipeptidases @2 FE`
C07	`02`	`X`	`FRE`	`@0 Peptidases @2 FE`
C07	`02`	`X`	`ENG`	`@0 Peptidases @2 FE`
C07	`02`	`X`	`SPA`	`@0 Peptidases @2 FE`
C07	`03`	`X`	`FRE`	`@0 Hydrolases @2 FE`
C07	`03`	`X`	`ENG`	`@0 Hydrolases @2 FE`
C07	`03`	`X`	`SPA`	`@0 Hydrolases @2 FE`
C07	`04`	`X`	`FRE`	`@0 Enzyme @2 FE`
C07	`04`	`X`	`ENG`	`@0 Enzyme @2 FE`
C07	`04`	`X`	`SPA`	`@0 Enzima @2 FE`
C07	`05`	`X`	`FRE`	`@0 Virose`
C07	`05`	`X`	`ENG`	`@0 Viral disease`
C07	`05`	`X`	`SPA`	`@0 Virosis`
C07	`06`	`X`	`FRE`	`@0 Infection`
C07	`06`	`X`	`ENG`	`@0 Infection`
C07	`06`	`X`	`SPA`	`@0 Infección`
C07	`07`	`X`	`FRE`	`@0 Asie @2 NG`
C07	`07`	`X`	`ENG`	`@0 Asia @2 NG`
C07	`07`	`X`	`SPA`	`@0 Asia @2 NG`
C07	`08`	`X`	`FRE`	`@0 Coronaviridae @2 NW`
C07	`08`	`X`	`ENG`	`@0 Coronaviridae @2 NW`
C07	`08`	`X`	`SPA`	`@0 Coronaviridae @2 NW`
C07	`09`	`X`	`FRE`	`@0 Nidovirales @2 NW`
C07	`09`	`X`	`ENG`	`@0 Nidovirales @2 NW`
C07	`09`	`X`	`SPA`	`@0 Nidovirales @2 NW`
C07	`10`	`X`	`FRE`	`@0 Virus @2 NW`
C07	`10`	`X`	`ENG`	`@0 Virus @2 NW`
C07	`10`	`X`	`SPA`	`@0 Virus @2 NW`
C07	`11`	`X`	`FRE`	`@0 Appareil respiratoire pathologie @5 37`
C07	`11`	`X`	`ENG`	`@0 Respiratory disease @5 37`
C07	`11`	`X`	`SPA`	`@0 Aparato respiratorio patología @5 37`
C07	`12`	`X`	`FRE`	`@0 Poumon pathologie @5 38`
C07	`12`	`X`	`ENG`	`@0 Lung disease @5 38`
C07	`12`	`X`	`SPA`	`@0 Pulmón patología @5 38`
N21				`@1 220`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000649

Links to Exploration step

Pascal:05-0314695

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Identification of an alternative 5'-untranslated exon and new polymorphisms of angiotensin-converting enzyme 2 gene : Lack of association with SARS in the vietnamese population</title>
<author><name sortKey="Itoyama, Satoru" sort="Itoyama, Satoru" uniqKey="Itoyama S" first="Satoru" last="Itoyama">Satoru Itoyama</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Respiratory Diseases, Research Institute, International Medical Center of Japan</s1>
<s2>Tokyo</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Keicho, Naoto" sort="Keicho, Naoto" uniqKey="Keicho N" first="Naoto" last="Keicho">Naoto Keicho</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Respiratory Diseases, Research Institute, International Medical Center of Japan</s1>
<s2>Tokyo</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Hijikata, Minako" sort="Hijikata, Minako" uniqKey="Hijikata M" first="Minako" last="Hijikata">Minako Hijikata</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Respiratory Diseases, Research Institute, International Medical Center of Japan</s1>
<s2>Tokyo</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Quy, Tran" sort="Quy, Tran" uniqKey="Quy T" first="Tran" last="Quy">Tran Quy</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Bach Mai Hospital</s1>
<s2>Hanoi</s2>
<s3>VNM</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Viêt Nam</country>
</affiliation>
</author>
<author><name sortKey="Nguyen Chi Phi" sort="Nguyen Chi Phi" uniqKey="Nguyen Chi Phi" last="Nguyen Chi Phi">NGUYEN CHI PHI</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Bach Mai Hospital</s1>
<s2>Hanoi</s2>
<s3>VNM</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Viêt Nam</country>
</affiliation>
</author>
<author><name sortKey="Hoang Thuy Long" sort="Hoang Thuy Long" uniqKey="Hoang Thuy Long" last="Hoang Thuy Long">HOANG THUY LONG</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Institute of Hygiene and Epidemiology</s1>
<s2>Hanoi</s2>
<s3>VNM</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Viêt Nam</country>
</affiliation>
</author>
<author><name sortKey="Le Dang Ha" sort="Le Dang Ha" uniqKey="Le Dang Ha" last="Le Dang Ha">LE DANG HA</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Institute for Clinical Research in Tropical Medicine</s1>
<s3>VNM</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Viêt Nam</country>
</affiliation>
</author>
<author><name sortKey="Vo Van Ban" sort="Vo Van Ban" uniqKey="Vo Van Ban" last="Vo Van Ban">VO VAN BAN</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Hanoi-French Hospital</s1>
<s3>VNM</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Viêt Nam</country>
</affiliation>
</author>
<author><name sortKey="Matsushita, Ikumi" sort="Matsushita, Ikumi" uniqKey="Matsushita I" first="Ikumi" last="Matsushita">Ikumi Matsushita</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Respiratory Diseases, Research Institute, International Medical Center of Japan</s1>
<s2>Tokyo</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Yanai, Hideki" sort="Yanai, Hideki" uniqKey="Yanai H" first="Hideki" last="Yanai">Hideki Yanai</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association</s1>
<s3>JPN</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Kirikae, Fumiko" sort="Kirikae, Fumiko" uniqKey="Kirikae F" first="Fumiko" last="Kirikae">Fumiko Kirikae</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Infectious Diseases, Research Institute, International Medical Center of Japan</s1>
<s3>JPN</s3>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Kirikae, Teruo" sort="Kirikae, Teruo" uniqKey="Kirikae T" first="Teruo" last="Kirikae">Teruo Kirikae</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Infectious Diseases, Research Institute, International Medical Center of Japan</s1>
<s3>JPN</s3>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Kuratsuji, Tadatoshi" sort="Kuratsuji, Tadatoshi" uniqKey="Kuratsuji T" first="Tadatoshi" last="Kuratsuji">Tadatoshi Kuratsuji</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Research Institute, International Medical Center of Japan</s1>
<s3>JPN</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Sasazuki, Takehiko" sort="Sasazuki, Takehiko" uniqKey="Sasazuki T" first="Takehiko" last="Sasazuki">Takehiko Sasazuki</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>International Medical Center of Japan</s1>
<s3>JPN</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">05-0314695</idno>
<date when="2005">2005</date>
<idno type="stanalyst">PASCAL 05-0314695 INIST</idno>
<idno type="RBID">Pascal:05-0314695</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000649</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000341</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Identification of an alternative 5'-untranslated exon and new polymorphisms of angiotensin-converting enzyme 2 gene : Lack of association with SARS in the vietnamese population</title>
<author><name sortKey="Itoyama, Satoru" sort="Itoyama, Satoru" uniqKey="Itoyama S" first="Satoru" last="Itoyama">Satoru Itoyama</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Respiratory Diseases, Research Institute, International Medical Center of Japan</s1>
<s2>Tokyo</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Keicho, Naoto" sort="Keicho, Naoto" uniqKey="Keicho N" first="Naoto" last="Keicho">Naoto Keicho</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Respiratory Diseases, Research Institute, International Medical Center of Japan</s1>
<s2>Tokyo</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Hijikata, Minako" sort="Hijikata, Minako" uniqKey="Hijikata M" first="Minako" last="Hijikata">Minako Hijikata</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Respiratory Diseases, Research Institute, International Medical Center of Japan</s1>
<s2>Tokyo</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Quy, Tran" sort="Quy, Tran" uniqKey="Quy T" first="Tran" last="Quy">Tran Quy</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Bach Mai Hospital</s1>
<s2>Hanoi</s2>
<s3>VNM</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Viêt Nam</country>
</affiliation>
</author>
<author><name sortKey="Nguyen Chi Phi" sort="Nguyen Chi Phi" uniqKey="Nguyen Chi Phi" last="Nguyen Chi Phi">NGUYEN CHI PHI</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Bach Mai Hospital</s1>
<s2>Hanoi</s2>
<s3>VNM</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Viêt Nam</country>
</affiliation>
</author>
<author><name sortKey="Hoang Thuy Long" sort="Hoang Thuy Long" uniqKey="Hoang Thuy Long" last="Hoang Thuy Long">HOANG THUY LONG</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Institute of Hygiene and Epidemiology</s1>
<s2>Hanoi</s2>
<s3>VNM</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Viêt Nam</country>
</affiliation>
</author>
<author><name sortKey="Le Dang Ha" sort="Le Dang Ha" uniqKey="Le Dang Ha" last="Le Dang Ha">LE DANG HA</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Institute for Clinical Research in Tropical Medicine</s1>
<s3>VNM</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Viêt Nam</country>
</affiliation>
</author>
<author><name sortKey="Vo Van Ban" sort="Vo Van Ban" uniqKey="Vo Van Ban" last="Vo Van Ban">VO VAN BAN</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Hanoi-French Hospital</s1>
<s3>VNM</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Viêt Nam</country>
</affiliation>
</author>
<author><name sortKey="Matsushita, Ikumi" sort="Matsushita, Ikumi" uniqKey="Matsushita I" first="Ikumi" last="Matsushita">Ikumi Matsushita</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Respiratory Diseases, Research Institute, International Medical Center of Japan</s1>
<s2>Tokyo</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Yanai, Hideki" sort="Yanai, Hideki" uniqKey="Yanai H" first="Hideki" last="Yanai">Hideki Yanai</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association</s1>
<s3>JPN</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Kirikae, Fumiko" sort="Kirikae, Fumiko" uniqKey="Kirikae F" first="Fumiko" last="Kirikae">Fumiko Kirikae</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Infectious Diseases, Research Institute, International Medical Center of Japan</s1>
<s3>JPN</s3>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Kirikae, Teruo" sort="Kirikae, Teruo" uniqKey="Kirikae T" first="Teruo" last="Kirikae">Teruo Kirikae</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Infectious Diseases, Research Institute, International Medical Center of Japan</s1>
<s3>JPN</s3>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Kuratsuji, Tadatoshi" sort="Kuratsuji, Tadatoshi" uniqKey="Kuratsuji T" first="Tadatoshi" last="Kuratsuji">Tadatoshi Kuratsuji</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Research Institute, International Medical Center of Japan</s1>
<s3>JPN</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Sasazuki, Takehiko" sort="Sasazuki, Takehiko" uniqKey="Sasazuki T" first="Takehiko" last="Sasazuki">Takehiko Sasazuki</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>International Medical Center of Japan</s1>
<s3>JPN</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">American journal of medical genetics</title>
<title level="j" type="abbreviated">Am. j. med. genet.</title>
<idno type="ISSN">0148-7299</idno>
<imprint><date when="2005">2005</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">American journal of medical genetics</title>
<title level="j" type="abbreviated">Am. j. med. genet.</title>
<idno type="ISSN">0148-7299</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Association</term>
<term>Biological receptor</term>
<term>Coronavirus</term>
<term>Exon</term>
<term>Gene</term>
<term>Genetics</term>
<term>Human</term>
<term>Identification</term>
<term>Peptidyl-dipeptidase A</term>
<term>Polymorphism</term>
<term>Population</term>
<term>Severe acute respiratory syndrome</term>
<term>Vietnam</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Identification</term>
<term>Exon</term>
<term>Polymorphisme</term>
<term>Peptidyl-dipeptidase A</term>
<term>Gène</term>
<term>Association</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Vietnam</term>
<term>Population</term>
<term>Coronavirus</term>
<term>Récepteur biologique</term>
<term>Génétique</term>
<term>Homme</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Association</term>
<term>Génétique</term>
<term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We analyzed genetic variations of angiotensin-converting enzyme 2 (ACE2), considering that it might influence patients' susceptibility to severe acute respiratory syndrome-associated coronavirus (SARS-CoV) or development of SARS as a functional receptor. By cloning of the full-length cDNA of the ACE2 gene in the lung, where replication occurs on SARS-CoV, it was shown that there are different splicing sites. All exons including the new alternative exon, exon-intron boundaries, and the corresponding 5'-flanking region of the gene were investigated and 19 single nucleotide polymorphisms (SNPs) were found. Out of these, 13 SNPs including one non-synonymous substitution and three 3'-UTR polymorphisms were newly identified. A case control study involving 44 SARS cases, 16 anti-SARS-CoV antibody-positive contacts, 87 antibody-negative contacts, and 50 non-contacts in Vietnam, failed to obtain any evidence that the ACE2 gene polymorphisms are involved in the disease process in the population. Nevertheless, identification of new 5'-untranslated exon and new SNPs is considered helpful in investigating regulation of ACE2 gene expression in the future.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0148-7299</s0>
</fA01>
<fA02 i1="01"><s0>AJMGDA</s0>
</fA02>
<fA03 i2="1"><s0>Am. j. med. genet.</s0>
</fA03>
<fA05><s2>136A</s2>
</fA05>
<fA06><s2>1</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Identification of an alternative 5'-untranslated exon and new polymorphisms of angiotensin-converting enzyme 2 gene : Lack of association with SARS in the vietnamese population</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>ITOYAMA (Satoru)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>KEICHO (Naoto)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>HIJIKATA (Minako)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>QUY (Tran)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>NGUYEN CHI PHI</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>HOANG THUY LONG</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>LE DANG HA</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>VO VAN BAN</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>MATSUSHITA (Ikumi)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>YANAI (Hideki)</s1>
</fA11>
<fA11 i1="11" i2="1"><s1>KIRIKAE (Fumiko)</s1>
</fA11>
<fA11 i1="12" i2="1"><s1>KIRIKAE (Teruo)</s1>
</fA11>
<fA11 i1="13" i2="1"><s1>KURATSUJI (Tadatoshi)</s1>
</fA11>
<fA11 i1="14" i2="1"><s1>SASAZUKI (Takehiko)</s1>
</fA11>
<fA14 i1="01"><s1>Department of Respiratory Diseases, Research Institute, International Medical Center of Japan</s1>
<s2>Tokyo</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Bach Mai Hospital</s1>
<s2>Hanoi</s2>
<s3>VNM</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>National Institute of Hygiene and Epidemiology</s1>
<s2>Hanoi</s2>
<s3>VNM</s3>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Institute for Clinical Research in Tropical Medicine</s1>
<s3>VNM</s3>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Hanoi-French Hospital</s1>
<s3>VNM</s3>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association</s1>
<s3>JPN</s3>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="07"><s1>Department of Infectious Diseases, Research Institute, International Medical Center of Japan</s1>
<s3>JPN</s3>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</fA14>
<fA14 i1="08"><s1>Research Institute, International Medical Center of Japan</s1>
<s3>JPN</s3>
<sZ>13 aut.</sZ>
</fA14>
<fA14 i1="09"><s1>International Medical Center of Japan</s1>
<s3>JPN</s3>
<sZ>14 aut.</sZ>
</fA14>
<fA20><s1>52-57</s1>
</fA20>
<fA21><s1>2005</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>17405</s2>
<s5>354000132241680100</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2005 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>25 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>05-0314695</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>American journal of medical genetics</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>We analyzed genetic variations of angiotensin-converting enzyme 2 (ACE2), considering that it might influence patients' susceptibility to severe acute respiratory syndrome-associated coronavirus (SARS-CoV) or development of SARS as a functional receptor. By cloning of the full-length cDNA of the ACE2 gene in the lung, where replication occurs on SARS-CoV, it was shown that there are different splicing sites. All exons including the new alternative exon, exon-intron boundaries, and the corresponding 5'-flanking region of the gene were investigated and 19 single nucleotide polymorphisms (SNPs) were found. Out of these, 13 SNPs including one non-synonymous substitution and three 3'-UTR polymorphisms were newly identified. A case control study involving 44 SARS cases, 16 anti-SARS-CoV antibody-positive contacts, 87 antibody-negative contacts, and 50 non-contacts in Vietnam, failed to obtain any evidence that the ACE2 gene polymorphisms are involved in the disease process in the population. Nevertheless, identification of new 5'-untranslated exon and new SNPs is considered helpful in investigating regulation of ACE2 gene expression in the future.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B23A</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B05C02C</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Identification</s0>
<s5>09</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Identification</s0>
<s5>09</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Identificación</s0>
<s5>09</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Exon</s0>
<s5>10</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Exon</s0>
<s5>10</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Exón</s0>
<s5>10</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Polymorphisme</s0>
<s5>11</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Polymorphism</s0>
<s5>11</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Polimorfismo</s0>
<s5>11</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Peptidyl-dipeptidase A</s0>
<s2>FE</s2>
<s5>12</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Peptidyl-dipeptidase A</s0>
<s2>FE</s2>
<s5>12</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Peptidyl-dipeptidase A</s0>
<s2>FE</s2>
<s5>12</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Gène</s0>
<s5>13</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Gene</s0>
<s5>13</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Gen</s0>
<s5>13</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Association</s0>
<s5>14</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Association</s0>
<s5>14</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Asociación</s0>
<s5>14</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Syndrome respiratoire aigu sévère</s0>
<s2>NM</s2>
<s5>15</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Severe acute respiratory syndrome</s0>
<s2>NM</s2>
<s5>15</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Síndrome respiratorio agudo severo</s0>
<s2>NM</s2>
<s5>15</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Vietnam</s0>
<s2>NG</s2>
<s5>17</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Vietnam</s0>
<s2>NG</s2>
<s5>17</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Vietnam</s0>
<s2>NG</s2>
<s5>17</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Population</s0>
<s5>18</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Population</s0>
<s5>18</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Población</s0>
<s5>18</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>19</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>19</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>19</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Récepteur biologique</s0>
<s5>21</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Biological receptor</s0>
<s5>21</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Receptor biológico</s0>
<s5>21</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Génétique</s0>
<s5>22</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Genetics</s0>
<s5>22</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Genética</s0>
<s5>22</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Homme</s0>
<s5>23</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Human</s0>
<s5>23</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>Hombre</s0>
<s5>23</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Peptidyl-dipeptidases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Peptidyl-dipeptidases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Peptidyl-dipeptidases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Peptidases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Peptidases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Peptidases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Hydrolases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Hydrolases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Hydrolases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Enzyme</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Enzyme</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Enzima</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Virose</s0>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Viral disease</s0>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Virosis</s0>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Infection</s0>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Infection</s0>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Infección</s0>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Asie</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Asia</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Asia</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="10" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="10" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="10" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="11" i2="X" l="FRE"><s0>Appareil respiratoire pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="11" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>37</s5>
</fC07>
<fC07 i1="11" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="12" i2="X" l="FRE"><s0>Poumon pathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="12" i2="X" l="ENG"><s0>Lung disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="12" i2="X" l="SPA"><s0>Pulmón patología</s0>
<s5>38</s5>
</fC07>
<fN21><s1>220</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/PascalFrancis/Curation

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000341 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Curation/biblio.hfd -nk 000341 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    SrasV1
   |flux=    PascalFrancis
   |étape=   Curation
   |type=    RBID
   |clé=     Pascal:05-0314695
   |texte=   Identification of an alternative 5'-untranslated exon and new polymorphisms of angiotensin-converting enzyme 2 gene : Lack of association with SARS in the vietnamese population
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 28 14:49:16 2020. Site generation: Sat Mar 27 22:06:49 2021

	Serveur d'exploration SRAS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration SRAS

Identification of an alternative 5'-untranslated exon and new polymorphisms of angiotensin-converting enzyme 2 gene : Lack of association with SARS in the vietnamese population

Identification of an alternative 5'-untranslated exon and new polymorphisms of angiotensin-converting enzyme 2 gene : Lack of association with SARS in the vietnamese population

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri