An animal model of SARS produced by infection of Nacaca mulatto with SARS coronavirus
Identifieur interne : 000336 ( PascalFrancis/Curation ); précédent : 000335; suivant : 000337An animal model of SARS produced by infection of Nacaca mulatto with SARS coronavirus
Auteurs : CHUAN QIN [République populaire de Chine] ; JIANWEI WANG [République populaire de Chine] ; QIANG WEI [République populaire de Chine] ; MINGPENG SHE [République populaire de Chine] ; Wayne A. Marasco [États-Unis] ; HONG JIANG [République populaire de Chine] ; XINMING TU [République populaire de Chine] ; HUA ZHU [République populaire de Chine] ; LILI REN [République populaire de Chine] ; HONG GAO [République populaire de Chine] ; LI GUO [République populaire de Chine] ; LAN HUANG [République populaire de Chine] ; RENQUAN YANG [République populaire de Chine] ; ZHE GONG [République populaire de Chine] ; LAN GUO [République populaire de Chine] ; YANBIN WANG [République populaire de Chine] ; YALI LIU [République populaire de Chine] ; YILI SUN [République populaire de Chine] ; SHUMIN DUAN [République populaire de Chine] ; JIANGUO QU [République populaire de Chine] ; LIANGBIAO CHEN [République populaire de Chine] ; WEI TONG [République populaire de Chine] ; LI RUAN [République populaire de Chine] ; PEIMAO LIU [République populaire de Chine] ; HUA ZHANG [République populaire de Chine] ; JIANMIN ZHANG [République populaire de Chine] ; HUIYUAN ZHANG [République populaire de Chine] ; DEPEI LIU [République populaire de Chine] ; QIAN LIU [République populaire de Chine] ; TAO HONG [République populaire de Chine] ; WEI HE [République populaire de Chine]Source :
- Journal of pathology [ 0022-3417 ] ; 2005.
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- Pascal (Inist)
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Abstract
A new SARS animal model was established by inoculating SARS coronavirus (SARS-CoV) into rhesus macaques (Macaca mulatta) through the nasal cavity. Pathological pulmonary changes were successively detected on days 5-60 after virus inoculation. All eight animals showed a transient fever 2-3 days after inoculation. Immunological, molecular biological, and pathological studies support the establishment of this SARS animal model. Firstly, SARS-CoV-specific IgGs were detected in the sera of macaques from 11 to 60 days after inoculation. Secondly, SARS-CoV RNA could be detected in pharyngeal swab samples using nested RT-PCR in all infected animals from 5 days after virus inoculation. Finally, histopathological changes of interstitial pneumonia were found in the lungs during the 60 days after viral inoculation: these changes were less marked at later time points, indicating that an active healing process together with resolution of an acute inflammatory response was taking place in these animals. This animal model should provide insight into the mechanisms of SARS-CoV-related pulmonary disease and greatly facilitate the development of vaccines and therapeutics against SARS.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">An animal model of SARS produced by infection of Nacaca mulatto with SARS coronavirus</title><author><name sortKey="Chuan Qin" sort="Chuan Qin" uniqKey="Chuan Qin" last="Chuan Qin">CHUAN QIN</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</s1><s2>Beijing, 100021</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ><sZ>22 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Jianwei Wang" sort="Jianwei Wang" uniqKey="Jianwei Wang" last="Jianwei Wang">JIANWEI WANG</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC)</s1><s2>Beijing, 100052</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>23 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Qiang Wei" sort="Qiang Wei" uniqKey="Qiang Wei" last="Qiang Wei">QIANG WEI</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</s1><s2>Beijing, 100021</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ><sZ>22 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Mingpeng She" sort="Mingpeng She" uniqKey="Mingpeng She" last="Mingpeng She">MINGPENG SHE</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</s1><s2>Beijing, 100005</s2><s3>CHN</s3><sZ>4 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>30 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Marasco, Wayne A" sort="Marasco, Wayne A" uniqKey="Marasco W" first="Wayne A." last="Marasco">Wayne A. Marasco</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School</s1><s2>Boston, MA 02115</s2><s3>USA</s3><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Hong Jiang" sort="Hong Jiang" uniqKey="Hong Jiang" last="Hong Jiang">HONG JIANG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</s1><s2>Beijing, 100021</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ><sZ>22 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Xinming Tu" sort="Xinming Tu" uniqKey="Xinming Tu" last="Xinming Tu">XINMING TU</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</s1><s2>Beijing, 100021</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ><sZ>22 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Hua Zhu" sort="Hua Zhu" uniqKey="Hua Zhu" last="Hua Zhu">HUA ZHU</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</s1><s2>Beijing, 100021</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ><sZ>22 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Lili Ren" sort="Lili Ren" uniqKey="Lili Ren" last="Lili Ren">LILI REN</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC)</s1><s2>Beijing, 100052</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>23 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Hong Gao" sort="Hong Gao" uniqKey="Hong Gao" last="Hong Gao">HONG GAO</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</s1><s2>Beijing, 100021</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>12 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100021</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ><sZ>22 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Renquan Yang" sort="Renquan Yang" uniqKey="Renquan Yang" last="Renquan Yang">RENQUAN YANG</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC)</s1><s2>Beijing, 100052</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>23 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Zhe Gong" sort="Zhe Gong" uniqKey="Zhe Gong" last="Zhe Gong">ZHE GONG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</s1><s2>Beijing, 100021</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ><sZ>22 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Lan Guo" sort="Lan Guo" uniqKey="Lan Guo" last="Lan Guo">LAN GUO</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC)</s1><s2>Beijing, 100052</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>23 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Yanbin Wang" sort="Yanbin Wang" uniqKey="Yanbin Wang" last="Yanbin Wang">YANBIN WANG</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC)</s1><s2>Beijing, 100052</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>23 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Yali Liu" sort="Yali Liu" uniqKey="Yali Liu" last="Yali Liu">YALI LIU</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</s1><s2>Beijing, 100021</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ><sZ>22 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Yili Sun" sort="Yili Sun" uniqKey="Yili Sun" last="Yili Sun">YILI SUN</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC)</s1><s2>Beijing, 100052</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>23 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Shumin Duan" sort="Shumin Duan" uniqKey="Shumin Duan" last="Shumin Duan">SHUMIN DUAN</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC)</s1><s2>Beijing, 100052</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>23 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Jianguo Qu" sort="Jianguo Qu" uniqKey="Jianguo Qu" last="Jianguo Qu">JIANGUO QU</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC)</s1><s2>Beijing, 100052</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>23 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Liangbiao Chen" sort="Liangbiao Chen" uniqKey="Liangbiao Chen" last="Liangbiao Chen">LIANGBIAO CHEN</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC)</s1><s2>Beijing, 100052</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>23 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Wei Tong" sort="Wei Tong" uniqKey="Wei Tong" last="Wei Tong">WEI TONG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</s1><s2>Beijing, 100021</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ><sZ>22 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Li Ruan" sort="Li Ruan" uniqKey="Li Ruan" last="Li Ruan">LI RUAN</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC)</s1><s2>Beijing, 100052</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>23 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Peimao Liu" sort="Peimao Liu" uniqKey="Peimao Liu" last="Peimao Liu">PEIMAO LIU</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</s1><s2>Beijing, 100005</s2><s3>CHN</s3><sZ>4 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>30 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Hua Zhang" sort="Hua Zhang" uniqKey="Hua Zhang" last="Hua Zhang">HUA ZHANG</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</s1><s2>Beijing, 100005</s2><s3>CHN</s3><sZ>4 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>30 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Jianmin Zhang" sort="Jianmin Zhang" uniqKey="Jianmin Zhang" last="Jianmin Zhang">JIANMIN ZHANG</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</s1><s2>Beijing, 100005</s2><s3>CHN</s3><sZ>4 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>30 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Huiyuan Zhang" sort="Huiyuan Zhang" uniqKey="Huiyuan Zhang" last="Huiyuan Zhang">HUIYUAN ZHANG</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</s1><s2>Beijing, 100005</s2><s3>CHN</s3><sZ>4 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>30 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Depei Liu" sort="Depei Liu" uniqKey="Depei Liu" last="Depei Liu">DEPEI LIU</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</s1><s2>Beijing, 100005</s2><s3>CHN</s3><sZ>4 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>30 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Qian Liu" sort="Qian Liu" uniqKey="Qian Liu" last="Qian Liu">QIAN LIU</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</s1><s2>Beijing, 100005</s2><s3>CHN</s3><sZ>4 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>30 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Tao Hong" sort="Tao Hong" uniqKey="Tao Hong" last="Tao Hong">TAO HONG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</s1><s2>Beijing, 100021</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ><sZ>22 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC)</s1><s2>Beijing, 100052</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>23 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</s1><s2>Beijing, 100005</s2><s3>CHN</s3><sZ>4 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>30 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Wei He" sort="Wei He" uniqKey="Wei He" last="Wei He">WEI HE</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</s1><s2>Beijing, 100005</s2><s3>CHN</s3><sZ>4 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>30 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">05-0289692</idno><date when="2005">2005</date><idno type="stanalyst">PASCAL 05-0289692 INIST</idno><idno type="RBID">Pascal:05-0289692</idno><idno type="wicri:Area/PascalFrancis/Corpus">000654</idno><idno type="wicri:Area/PascalFrancis/Curation">000336</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">An animal model of SARS produced by infection of Nacaca mulatto with SARS coronavirus</title><author><name sortKey="Chuan Qin" sort="Chuan Qin" uniqKey="Chuan Qin" last="Chuan Qin">CHUAN QIN</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</s1><s2>Beijing, 100021</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ><sZ>22 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Jianwei Wang" sort="Jianwei Wang" uniqKey="Jianwei Wang" last="Jianwei Wang">JIANWEI WANG</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC)</s1><s2>Beijing, 100052</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>23 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Qiang Wei" sort="Qiang Wei" uniqKey="Qiang Wei" last="Qiang Wei">QIANG WEI</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</s1><s2>Beijing, 100021</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ><sZ>22 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Mingpeng She" sort="Mingpeng She" uniqKey="Mingpeng She" last="Mingpeng She">MINGPENG SHE</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</s1><s2>Beijing, 100005</s2><s3>CHN</s3><sZ>4 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>30 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Marasco, Wayne A" sort="Marasco, Wayne A" uniqKey="Marasco W" first="Wayne A." last="Marasco">Wayne A. Marasco</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School</s1><s2>Boston, MA 02115</s2><s3>USA</s3><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Hong Jiang" sort="Hong Jiang" uniqKey="Hong Jiang" last="Hong Jiang">HONG JIANG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</s1><s2>Beijing, 100021</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ><sZ>22 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Xinming Tu" sort="Xinming Tu" uniqKey="Xinming Tu" last="Xinming Tu">XINMING TU</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</s1><s2>Beijing, 100021</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ><sZ>22 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Hua Zhu" sort="Hua Zhu" uniqKey="Hua Zhu" last="Hua Zhu">HUA ZHU</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</s1><s2>Beijing, 100021</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ><sZ>22 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Lili Ren" sort="Lili Ren" uniqKey="Lili Ren" last="Lili Ren">LILI REN</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC)</s1><s2>Beijing, 100052</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>23 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Hong Gao" sort="Hong Gao" uniqKey="Hong Gao" last="Hong Gao">HONG GAO</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</s1><s2>Beijing, 100021</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ><sZ>22 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Li Guo" sort="Li Guo" uniqKey="Li Guo" last="Li Guo">LI GUO</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC)</s1><s2>Beijing, 100052</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>23 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Lan Huang" sort="Lan Huang" uniqKey="Lan Huang" last="Lan Huang">LAN HUANG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</s1><s2>Beijing, 100021</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ><sZ>22 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Renquan Yang" sort="Renquan Yang" uniqKey="Renquan Yang" last="Renquan Yang">RENQUAN YANG</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC)</s1><s2>Beijing, 100052</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>23 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Zhe Gong" sort="Zhe Gong" uniqKey="Zhe Gong" last="Zhe Gong">ZHE GONG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</s1><s2>Beijing, 100021</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ><sZ>22 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Lan Guo" sort="Lan Guo" uniqKey="Lan Guo" last="Lan Guo">LAN GUO</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC)</s1><s2>Beijing, 100052</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>23 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Yanbin Wang" sort="Yanbin Wang" uniqKey="Yanbin Wang" last="Yanbin Wang">YANBIN WANG</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC)</s1><s2>Beijing, 100052</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>23 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Yali Liu" sort="Yali Liu" uniqKey="Yali Liu" last="Yali Liu">YALI LIU</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</s1><s2>Beijing, 100021</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ><sZ>22 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Yili Sun" sort="Yili Sun" uniqKey="Yili Sun" last="Yili Sun">YILI SUN</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC)</s1><s2>Beijing, 100052</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>23 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Shumin Duan" sort="Shumin Duan" uniqKey="Shumin Duan" last="Shumin Duan">SHUMIN DUAN</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC)</s1><s2>Beijing, 100052</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>23 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Jianguo Qu" sort="Jianguo Qu" uniqKey="Jianguo Qu" last="Jianguo Qu">JIANGUO QU</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC)</s1><s2>Beijing, 100052</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>23 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Liangbiao Chen" sort="Liangbiao Chen" uniqKey="Liangbiao Chen" last="Liangbiao Chen">LIANGBIAO CHEN</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC)</s1><s2>Beijing, 100052</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>23 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Wei Tong" sort="Wei Tong" uniqKey="Wei Tong" last="Wei Tong">WEI TONG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</s1><s2>Beijing, 100021</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ><sZ>22 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Li Ruan" sort="Li Ruan" uniqKey="Li Ruan" last="Li Ruan">LI RUAN</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC)</s1><s2>Beijing, 100052</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>23 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Peimao Liu" sort="Peimao Liu" uniqKey="Peimao Liu" last="Peimao Liu">PEIMAO LIU</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</s1><s2>Beijing, 100005</s2><s3>CHN</s3><sZ>4 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>30 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Hua Zhang" sort="Hua Zhang" uniqKey="Hua Zhang" last="Hua Zhang">HUA ZHANG</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</s1><s2>Beijing, 100005</s2><s3>CHN</s3><sZ>4 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>30 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Jianmin Zhang" sort="Jianmin Zhang" uniqKey="Jianmin Zhang" last="Jianmin Zhang">JIANMIN ZHANG</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</s1><s2>Beijing, 100005</s2><s3>CHN</s3><sZ>4 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>30 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Huiyuan Zhang" sort="Huiyuan Zhang" uniqKey="Huiyuan Zhang" last="Huiyuan Zhang">HUIYUAN ZHANG</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</s1><s2>Beijing, 100005</s2><s3>CHN</s3><sZ>4 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>30 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Depei Liu" sort="Depei Liu" uniqKey="Depei Liu" last="Depei Liu">DEPEI LIU</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</s1><s2>Beijing, 100005</s2><s3>CHN</s3><sZ>4 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>30 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Qian Liu" sort="Qian Liu" uniqKey="Qian Liu" last="Qian Liu">QIAN LIU</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</s1><s2>Beijing, 100005</s2><s3>CHN</s3><sZ>4 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>30 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Tao Hong" sort="Tao Hong" uniqKey="Tao Hong" last="Tao Hong">TAO HONG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</s1><s2>Beijing, 100021</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ><sZ>22 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC)</s1><s2>Beijing, 100052</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>23 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</s1><s2>Beijing, 100005</s2><s3>CHN</s3><sZ>4 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>30 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Wei He" sort="Wei He" uniqKey="Wei He" last="Wei He">WEI HE</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</s1><s2>Beijing, 100005</s2><s3>CHN</s3><sZ>4 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>30 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author></analytic><series><title level="j" type="main">Journal of pathology</title><title level="j" type="abbreviated">J. pathol.</title><idno type="ISSN">0022-3417</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of pathology</title><title level="j" type="abbreviated">J. pathol.</title><idno type="ISSN">0022-3417</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anatomic pathology</term><term>Animal model</term><term>Coronavirus</term><term>Infection</term><term>Macaca mulatta</term><term>Severe acute respiratory syndrome</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Infection</term><term>Modèle animal</term><term>Syndrome respiratoire aigu sévère</term><term>Coronavirus</term><term>Anatomopathologie</term><term>Macaca mulatta</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A new SARS animal model was established by inoculating SARS coronavirus (SARS-CoV) into rhesus macaques (Macaca mulatta) through the nasal cavity. Pathological pulmonary changes were successively detected on days 5-60 after virus inoculation. All eight animals showed a transient fever 2-3 days after inoculation. Immunological, molecular biological, and pathological studies support the establishment of this SARS animal model. Firstly, SARS-CoV-specific IgGs were detected in the sera of macaques from 11 to 60 days after inoculation. Secondly, SARS-CoV RNA could be detected in pharyngeal swab samples using nested RT-PCR in all infected animals from 5 days after virus inoculation. Finally, histopathological changes of interstitial pneumonia were found in the lungs during the 60 days after viral inoculation: these changes were less marked at later time points, indicating that an active healing process together with resolution of an acute inflammatory response was taking place in these animals. This animal model should provide insight into the mechanisms of SARS-CoV-related pulmonary disease and greatly facilitate the development of vaccines and therapeutics against SARS.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0022-3417</s0></fA01><fA02 i1="01"><s0>JPTLAS</s0></fA02><fA03 i2="1"><s0>J. pathol.</s0></fA03><fA05><s2>206</s2></fA05><fA06><s2>3</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>An animal model of SARS produced by infection of Nacaca mulatto with SARS coronavirus</s1></fA08><fA11 i1="01" i2="1"><s1>CHUAN QIN</s1></fA11><fA11 i1="02" i2="1"><s1>JIANWEI WANG</s1></fA11><fA11 i1="03" i2="1"><s1>QIANG WEI</s1></fA11><fA11 i1="04" i2="1"><s1>MINGPENG SHE</s1></fA11><fA11 i1="05" i2="1"><s1>MARASCO (Wayne A.)</s1></fA11><fA11 i1="06" i2="1"><s1>HONG JIANG</s1></fA11><fA11 i1="07" i2="1"><s1>XINMING TU</s1></fA11><fA11 i1="08" i2="1"><s1>HUA ZHU</s1></fA11><fA11 i1="09" i2="1"><s1>LILI REN</s1></fA11><fA11 i1="10" i2="1"><s1>HONG GAO</s1></fA11><fA11 i1="11" i2="1"><s1>LI GUO</s1></fA11><fA11 i1="12" i2="1"><s1>LAN HUANG</s1></fA11><fA11 i1="13" i2="1"><s1>RENQUAN YANG</s1></fA11><fA11 i1="14" i2="1"><s1>ZHE GONG</s1></fA11><fA11 i1="15" i2="1"><s1>LAN GUO</s1></fA11><fA11 i1="16" i2="1"><s1>YANBIN WANG</s1></fA11><fA11 i1="17" i2="1"><s1>YALI LIU</s1></fA11><fA11 i1="18" i2="1"><s1>YILI SUN</s1></fA11><fA11 i1="19" i2="1"><s1>SHUMIN DUAN</s1></fA11><fA11 i1="20" i2="1"><s1>JIANGUO QU</s1></fA11><fA11 i1="21" i2="1"><s1>LIANGBIAO CHEN</s1></fA11><fA11 i1="22" i2="1"><s1>WEI TONG</s1></fA11><fA11 i1="23" i2="1"><s1>LI RUAN</s1></fA11><fA11 i1="24" i2="1"><s1>PEIMAO LIU</s1></fA11><fA11 i1="25" i2="1"><s1>HUA ZHANG</s1></fA11><fA11 i1="26" i2="1"><s1>JIANMIN ZHANG</s1></fA11><fA11 i1="27" i2="1"><s1>HUIYUAN ZHANG</s1></fA11><fA11 i1="28" i2="1"><s1>DEPEI LIU</s1></fA11><fA11 i1="29" i2="1"><s1>QIAN LIU</s1></fA11><fA11 i1="30" i2="1"><s1>TAO HONG</s1></fA11><fA11 i1="31" i2="1"><s1>WEI HE</s1></fA11><fA14 i1="01"><s1>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</s1><s2>Beijing, 100021</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ><sZ>22 aut.</sZ><sZ>30 aut.</sZ></fA14><fA14 i1="02"><s1>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC)</s1><s2>Beijing, 100052</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>23 aut.</sZ><sZ>30 aut.</sZ></fA14><fA14 i1="03"><s1>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</s1><s2>Beijing, 100005</s2><s3>CHN</s3><sZ>4 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>30 aut.</sZ><sZ>31 aut.</sZ></fA14><fA14 i1="04"><s1>Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School</s1><s2>Boston, MA 02115</s2><s3>USA</s3><sZ>5 aut.</sZ></fA14><fA20><s1>251-259</s1></fA20><fA21><s1>2005</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>988A</s2><s5>354000138234230010</s5></fA43><fA44><s0>0000</s0><s1>© 2005 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>24 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>05-0289692</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Journal of pathology</s0></fA64><fA66 i1="01"><s0>GBR</s0></fA66><fC01 i1="01" l="ENG"><s0>A new SARS animal model was established by inoculating SARS coronavirus (SARS-CoV) into rhesus macaques (Macaca mulatta) through the nasal cavity. Pathological pulmonary changes were successively detected on days 5-60 after virus inoculation. All eight animals showed a transient fever 2-3 days after inoculation. Immunological, molecular biological, and pathological studies support the establishment of this SARS animal model. Firstly, SARS-CoV-specific IgGs were detected in the sera of macaques from 11 to 60 days after inoculation. Secondly, SARS-CoV RNA could be detected in pharyngeal swab samples using nested RT-PCR in all infected animals from 5 days after virus inoculation. Finally, histopathological changes of interstitial pneumonia were found in the lungs during the 60 days after viral inoculation: these changes were less marked at later time points, indicating that an active healing process together with resolution of an acute inflammatory response was taking place in these animals. This animal model should provide insight into the mechanisms of SARS-CoV-related pulmonary disease and greatly facilitate the development of vaccines and therapeutics against SARS.</s0></fC01><fC02 i1="01" i2="X"><s0>002B24O</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Infection</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Infection</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Infección</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Modèle animal</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Animal model</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Modelo animal</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Syndrome respiratoire aigu sévère</s0><s2>NM</s2><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Severe acute respiratory syndrome</s0><s2>NM</s2><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Síndrome respiratorio agudo severo</s0><s2>NM</s2><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Coronavirus</s0><s2>NW</s2><s5>05</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Coronavirus</s0><s2>NW</s2><s5>05</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Coronavirus</s0><s2>NW</s2><s5>05</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Anatomopathologie</s0><s5>06</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Anatomic pathology</s0><s5>06</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Anatomía patológica</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Macaca mulatta</s0><s2>NS</s2><s5>08</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Macaca mulatta</s0><s2>NS</s2><s5>08</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Macaca mulatta</s0><s2>NS</s2><s5>08</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Virose</s0></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Viral disease</s0></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Virosis</s0></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Coronaviridae</s0><s2>NW</s2></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Coronaviridae</s0><s2>NW</s2></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Coronaviridae</s0><s2>NW</s2></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Nidovirales</s0><s2>NW</s2></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Nidovirales</s0><s2>NW</s2></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Nidovirales</s0><s2>NW</s2></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Simioidea</s0><s2>NS</s2></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Simioidea</s0><s2>NS</s2></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Simioidea</s0><s2>NS</s2></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Primates</s0><s2>NS</s2></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Primates</s0><s2>NS</s2></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Primates</s0><s2>NS</s2></fC07><fC07 i1="07" i2="X" l="FRE"><s0>Mammalia</s0><s2>NS</s2></fC07><fC07 i1="07" i2="X" l="ENG"><s0>Mammalia</s0><s2>NS</s2></fC07><fC07 i1="07" i2="X" l="SPA"><s0>Mammalia</s0><s2>NS</s2></fC07><fC07 i1="08" i2="X" l="FRE"><s0>Vertebrata</s0><s2>NS</s2></fC07><fC07 i1="08" i2="X" l="ENG"><s0>Vertebrata</s0><s2>NS</s2></fC07><fC07 i1="08" i2="X" l="SPA"><s0>Vertebrata</s0><s2>NS</s2></fC07><fC07 i1="09" i2="X" l="FRE"><s0>Appareil respiratoire pathologie</s0><s5>37</s5></fC07><fC07 i1="09" i2="X" l="ENG"><s0>Respiratory disease</s0><s5>37</s5></fC07><fC07 i1="09" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0><s5>37</s5></fC07><fC07 i1="10" i2="X" l="FRE"><s0>Poumon pathologie</s0><s5>38</s5></fC07><fC07 i1="10" i2="X" l="ENG"><s0>Lung disease</s0><s5>38</s5></fC07><fC07 i1="10" i2="X" l="SPA"><s0>Pulmón patología</s0><s5>38</s5></fC07><fN21><s1>199</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist></record>Pour manipuler ce document sous Unix (Dilib)
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