SrasV1, PascalFrancis, Curation, bibRecord, 000256

Temporal relationship of viral load, ribavirin, interleukin (IL)-6, IL-8, and clinical progression in patients with severe acute respiratory syndrome

Identifieur interne : 000256 ( PascalFrancis/Curation ); précédent : 000255; suivant : 000257

Temporal relationship of viral load, ribavirin, interleukin (IL)-6, IL-8, and clinical progression in patients with severe acute respiratory syndrome

Auteurs : Wei-Kung Wang [Taïwan] ; Shey-Ying Chen [Taïwan] ; I.-Jung Liu [Taïwan] ; Chuan-Liang Kao [Taïwan] ; Hui-Ling Chen [Taïwan] ; Bor-Liang Chiang [Taïwan] ; Jann-Tay Wang [Taïwan] ; Wang-Hwei Sheng [Taïwan] ; Po-Ren Hsueh [Taïwan] ; Chao-Fu Yang [Taïwan] ; Pan-Chyr Yang [Taïwan] ; Shan-Chwen Chang [Taïwan]

Source :

Clinical infectious diseases [ 1058-4838 ] ; 2004.

RBID : Pascal:05-0094726

Descripteurs français

Pascal (Inist)
- Syndrome respiratoire aigu sévère, Lymphopénie, Ribavirine, Charge virale, Interleukine 6, Interleukine 8, Coronavirus, Pronostic, Evolution, Homme, Réplication, Réponse immune, Cytokine, Lymphocyte, L-Lactate dehydrogenase, Information thérapeutique, Antiviral.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Antiviral, Coronavirus, Cytokine, Evolution, Human, Immune response, Interleukin 6, Interleukin 8, L-Lactate dehydrogenase, Lymphocyte, Lymphocytopenia, Prognosis, Replication, Ribavirin, Severe acute respiratory syndrome, Therapeutic information, Viral load.

Abstract

Although viral replication and overwhelming immune responses are believed to contribute to the progression of severe acute respiratory syndrome (SARS), little is known about the temporal relationship between viral load, ribavirin, proinflammatory cytokines, and clinical progression. We report that ribavirin was not effective in reducing the SARS coronavirus load in 3 of 8 probable cases studied and that elevated levels of interleukin (IL)-6 and IL-8 subsequent to the peak viral load were found in 8 and 6 cases, respectively. The nadir lymphocyte count during lymphopenia, the peak level of lactate dehydrogenase, and the peak density of pulmonary infiltrates lag further behind the peak viral load by a median of 4, 5, and 3.5 days, respectively. These findings provide important information for therapeutic strategies to treat SARS.

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A08	`01`	`1`	`ENG`	`@1 Temporal relationship of viral load, ribavirin, interleukin (IL)-6, IL-8, and clinical progression in patients with severe acute respiratory syndrome`
A11	`01`	`1`		`@1 WANG (Wei-Kung)`
A11	`02`	`1`		`@1 CHEN (Shey-Ying)`
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A11	`09`	`1`		`@1 HSUEH (Po-Ren)`
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A14	`05`			`@1 Department of Pediatrics, National Taiwan University Hospital @2 Taipei @3 TWN @Z 6 aut.`
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C01	`01`		`ENG`	@0 Although viral replication and overwhelming immune responses are believed to contribute to the progression of severe acute respiratory syndrome (SARS), little is known about the temporal relationship between viral load, ribavirin, proinflammatory cytokines, and clinical progression. We report that ribavirin was not effective in reducing the SARS coronavirus load in 3 of 8 probable cases studied and that elevated levels of interleukin (IL)-6 and IL-8 subsequent to the peak viral load were found in 8 and 6 cases, respectively. The nadir lymphocyte count during lymphopenia, the peak level of lactate dehydrogenase, and the peak density of pulmonary infiltrates lag further behind the peak viral load by a median of 4, 5, and 3.5 days, respectively. These findings provide important information for therapeutic strategies to treat SARS.
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Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Temporal relationship of viral load, ribavirin, interleukin (IL)-6, IL-8, and clinical progression in patients with severe acute respiratory syndrome</title>
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<author><name sortKey="Kao, Chuan Liang" sort="Kao, Chuan Liang" uniqKey="Kao C" first="Chuan-Liang" last="Kao">Chuan-Liang Kao</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Medical Technology, College of Medicine, National Taiwan University</s1>
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<s3>TWN</s3>
<sZ>4 aut.</sZ>
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<author><name sortKey="Chen, Hui Ling" sort="Chen, Hui Ling" uniqKey="Chen H" first="Hui-Ling" last="Chen">Hui-Ling Chen</name>
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<s3>TWN</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
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<author><name sortKey="Sheng, Wang Hwei" sort="Sheng, Wang Hwei" uniqKey="Sheng W" first="Wang-Hwei" last="Sheng">Wang-Hwei Sheng</name>
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<s2>Taipei</s2>
<s3>TWN</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
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<author><name sortKey="Hsueh, Po Ren" sort="Hsueh, Po Ren" uniqKey="Hsueh P" first="Po-Ren" last="Hsueh">Po-Ren Hsueh</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Internal Medicine, National Taiwan University Hospital</s1>
<s2>Taipei</s2>
<s3>TWN</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
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<sZ>12 aut.</sZ>
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<author><name sortKey="Yang, Chao Fu" sort="Yang, Chao Fu" uniqKey="Yang C" first="Chao-Fu" last="Yang">Chao-Fu Yang</name>
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<s2>Taipei</s2>
<s3>TWN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>10 aut.</sZ>
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<country>Taïwan</country>
</affiliation>
</author>
<author><name sortKey="Yang, Pan Chyr" sort="Yang, Pan Chyr" uniqKey="Yang P" first="Pan-Chyr" last="Yang">Pan-Chyr Yang</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Internal Medicine, National Taiwan University Hospital</s1>
<s2>Taipei</s2>
<s3>TWN</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
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<sZ>12 aut.</sZ>
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<author><name sortKey="Chang, Shan Chwen" sort="Chang, Shan Chwen" uniqKey="Chang S" first="Shan-Chwen" last="Chang">Shan-Chwen Chang</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Internal Medicine, National Taiwan University Hospital</s1>
<s2>Taipei</s2>
<s3>TWN</s3>
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<sZ>8 aut.</sZ>
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<series><title level="j" type="main">Clinical infectious diseases</title>
<title level="j" type="abbreviated">Clin. infect. dis.</title>
<idno type="ISSN">1058-4838</idno>
<imprint><date when="2004">2004</date>
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<seriesStmt><title level="j" type="main">Clinical infectious diseases</title>
<title level="j" type="abbreviated">Clin. infect. dis.</title>
<idno type="ISSN">1058-4838</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral</term>
<term>Coronavirus</term>
<term>Cytokine</term>
<term>Evolution</term>
<term>Human</term>
<term>Immune response</term>
<term>Interleukin 6</term>
<term>Interleukin 8</term>
<term>L-Lactate dehydrogenase</term>
<term>Lymphocyte</term>
<term>Lymphocytopenia</term>
<term>Prognosis</term>
<term>Replication</term>
<term>Ribavirin</term>
<term>Severe acute respiratory syndrome</term>
<term>Therapeutic information</term>
<term>Viral load</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term>
<term>Lymphopénie</term>
<term>Ribavirine</term>
<term>Charge virale</term>
<term>Interleukine 6</term>
<term>Interleukine 8</term>
<term>Coronavirus</term>
<term>Pronostic</term>
<term>Evolution</term>
<term>Homme</term>
<term>Réplication</term>
<term>Réponse immune</term>
<term>Cytokine</term>
<term>Lymphocyte</term>
<term>L-Lactate dehydrogenase</term>
<term>Information thérapeutique</term>
<term>Antiviral</term>
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<front><div type="abstract" xml:lang="en">Although viral replication and overwhelming immune responses are believed to contribute to the progression of severe acute respiratory syndrome (SARS), little is known about the temporal relationship between viral load, ribavirin, proinflammatory cytokines, and clinical progression. We report that ribavirin was not effective in reducing the SARS coronavirus load in 3 of 8 probable cases studied and that elevated levels of interleukin (IL)-6 and IL-8 subsequent to the peak viral load were found in 8 and 6 cases, respectively. The nadir lymphocyte count during lymphopenia, the peak level of lactate dehydrogenase, and the peak density of pulmonary infiltrates lag further behind the peak viral load by a median of 4, 5, and 3.5 days, respectively. These findings provide important information for therapeutic strategies to treat SARS.</div>
</front>
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<fA08 i1="01" i2="1" l="ENG"><s1>Temporal relationship of viral load, ribavirin, interleukin (IL)-6, IL-8, and clinical progression in patients with severe acute respiratory syndrome</s1>
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<fA11 i1="01" i2="1"><s1>WANG (Wei-Kung)</s1>
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<fA11 i1="02" i2="1"><s1>CHEN (Shey-Ying)</s1>
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<fA11 i1="09" i2="1"><s1>HSUEH (Po-Ren)</s1>
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<fA11 i1="10" i2="1"><s1>YANG (Chao-Fu)</s1>
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<fA11 i1="11" i2="1"><s1>YANG (Pan-Chyr)</s1>
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<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Department of Internal Medicine, National Taiwan University Hospital</s1>
<s2>Taipei</s2>
<s3>TWN</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Department of Emergency Medicine, National Taiwan University Hospital</s1>
<s2>Taipei</s2>
<s3>TWN</s3>
<sZ>2 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Medical Technology, College of Medicine, National Taiwan University</s1>
<s2>Taipei</s2>
<s3>TWN</s3>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Department of Pediatrics, National Taiwan University Hospital</s1>
<s2>Taipei</s2>
<s3>TWN</s3>
<sZ>6 aut.</sZ>
</fA14>
<fA17 i1="01" i2="1"><s1>National Taiwan University (NTU) College of Medicine/NTU Hospital. Severe Acute Respiratory Syndrome Research Group</s1>
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<fA20><s1>1071-1075</s1>
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<s1>© 2005 INIST-CNRS. All rights reserved.</s1>
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<fC01 i1="01" l="ENG"><s0>Although viral replication and overwhelming immune responses are believed to contribute to the progression of severe acute respiratory syndrome (SARS), little is known about the temporal relationship between viral load, ribavirin, proinflammatory cytokines, and clinical progression. We report that ribavirin was not effective in reducing the SARS coronavirus load in 3 of 8 probable cases studied and that elevated levels of interleukin (IL)-6 and IL-8 subsequent to the peak viral load were found in 8 and 6 cases, respectively. The nadir lymphocyte count during lymphopenia, the peak level of lactate dehydrogenase, and the peak density of pulmonary infiltrates lag further behind the peak viral load by a median of 4, 5, and 3.5 days, respectively. These findings provide important information for therapeutic strategies to treat SARS.</s0>
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<fC02 i1="01" i2="X"><s0>002B05C02C</s0>
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<fC03 i1="01" i2="X" l="FRE"><s0>Syndrome respiratoire aigu sévère</s0>
<s2>NM</s2>
<s5>01</s5>
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<fC03 i1="01" i2="X" l="ENG"><s0>Severe acute respiratory syndrome</s0>
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<fC03 i1="03" i2="X" l="SPA"><s0>Ribavirina</s0>
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<s2>FR</s2>
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<fC03 i1="04" i2="X" l="FRE"><s0>Charge virale</s0>
<s5>07</s5>
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<s5>09</s5>
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<fC03 i1="07" i2="X" l="SPA"><s0>Coronavirus</s0>
<s2>NW</s2>
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<s2>FE</s2>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Enzima</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Exploration microbiologique</s0>
<s5>37</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Microbiological investigation</s0>
<s5>37</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Análisis microbiológico</s0>
<s5>37</s5>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Analogue nucléoside</s0>
<s5>38</s5>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Nucleoside analog</s0>
<s5>38</s5>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Análogo nucleósido</s0>
<s5>38</s5>
</fC07>
<fC07 i1="10" i2="X" l="FRE"><s0>Appareil respiratoire pathologie</s0>
<s5>39</s5>
</fC07>
<fC07 i1="10" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="10" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0>
<s5>39</s5>
</fC07>
<fC07 i1="11" i2="X" l="FRE"><s0>Poumon pathologie</s0>
<s5>40</s5>
</fC07>
<fC07 i1="11" i2="X" l="ENG"><s0>Lung disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="11" i2="X" l="SPA"><s0>Pulmón patología</s0>
<s5>40</s5>
</fC07>
<fC07 i1="12" i2="X" l="FRE"><s0>Hémopathie</s0>
<s5>42</s5>
</fC07>
<fC07 i1="12" i2="X" l="ENG"><s0>Hemopathy</s0>
<s5>42</s5>
</fC07>
<fC07 i1="12" i2="X" l="SPA"><s0>Hemopatía</s0>
<s5>42</s5>
</fC07>
<fC07 i1="13" i2="X" l="FRE"><s0>Leucopénie</s0>
<s5>43</s5>
</fC07>
<fC07 i1="13" i2="X" l="ENG"><s0>Leukopenia</s0>
<s5>43</s5>
</fC07>
<fC07 i1="13" i2="X" l="SPA"><s0>Leucopenia</s0>
<s5>43</s5>
</fC07>
<fN21><s1>059</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

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{{Explor lien
   |wiki=    Sante
   |area=    SrasV1
   |flux=    PascalFrancis
   |étape=   Curation
   |type=    RBID
   |clé=     Pascal:05-0094726
   |texte=   Temporal relationship of viral load, ribavirin, interleukin (IL)-6, IL-8, and clinical progression in patients with severe acute respiratory syndrome
}}

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Temporal relationship of viral load, ribavirin, interleukin (IL)-6, IL-8, and clinical progression in patients with severe acute respiratory syndrome

Temporal relationship of viral load, ribavirin, interleukin (IL)-6, IL-8, and clinical progression in patients with severe acute respiratory syndrome

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