SrasV1, PascalFrancis, Curation, bibRecord, 000235

Mapping of antigenic sites on the nucleocapsid protein of the severe acute respiratory syndrome coronavirus

Identifieur interne : 000235 ( PascalFrancis/Curation ); précédent : 000234; suivant : 000236

Mapping of antigenic sites on the nucleocapsid protein of the severe acute respiratory syndrome coronavirus

Auteurs : YUXIAN HE [États-Unis] ; YUSEN ZHOU [République populaire de Chine] ; HAO WU [République populaire de Chine] ; ZHIHUA KOU [République populaire de Chine] ; SHUWEN LIU [États-Unis] ; SHIBO JIANG [États-Unis]

Source :

Journal of clinical microbiology : (Print) [ 0095-1137 ] ; 2004.

RBID : Pascal:05-0019887

Descripteurs français

Pascal (Inist)
- Coronavirus, Nucléocapside, Protéine, Microbiologie, Syndrome respiratoire aigu sévère.

English descriptors

KwdEn :
- Coronavirus, Microbiology, Nucleocapsid, Protein, Severe acute respiratory syndrome.

Abstract

Antigenic sites on the nucleocapsid (N) protein of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) were mapped by Pepscan analysis with overlapping peptides that span the N protein sequence. Two major immunodominant epitopes located in the C-terminal region (amino acids [aal 362 to 412) and middle region (aa 153 to 178) reacted with more than 75% of sera from SARS patients. Several minor immunodominant epitopes were reactive with about 50% of the SARS sera. Antisera from mice immunized with inactivated SARS-CoV recognized the two major immunodominant epitopes and one antigenic site located adjacent to the N-terminal region (aa 76 to 101), which did not react with the sera from SARS patients. Several monoclonal antibodies against SARS-CoV bound to the N- or C-terminal antigenic sites. These results suggest that the above antigenic sites on the N protein are important in eliciting humoral immune response against SARS-CoV in humans and animals and can be used as antigens for developing diagnostic tests.

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A02	`01`			`@0 JCMIDW`
A03		`1`		`@0 J. clin. microbiol. : (Print)`
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A08	`01`	`1`	`ENG`	`@1 Mapping of antigenic sites on the nucleocapsid protein of the severe acute respiratory syndrome coronavirus`
A11	`01`	`1`		`@1 YUXIAN HE`
A11	`02`	`1`		`@1 YUSEN ZHOU`
A11	`03`	`1`		`@1 HAO WU`
A11	`04`	`1`		`@1 ZHIHUA KOU`
A11	`05`	`1`		`@1 SHUWEN LIU`
A11	`06`	`1`		`@1 SHIBO JIANG`
A14	`01`			`@1 Lindsley F. Kimball Research Institute, New York Blood Center @2 New York, New York @3 USA @Z 1 aut. @Z 5 aut. @Z 6 aut.`
A14	`02`			`@1 Beijing Institute of Microbiology and Epidemiology, Capital University of Medical Sciences @2 Beijing @3 CHN @Z 2 aut. @Z 4 aut.`
A14	`03`			`@1 YouAn Hospital, Capital University of Medical Sciences @2 Beijing @3 CHN @Z 3 aut.`
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A21				`@1 2004`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 17088 @5 354000122608250570`
A44				`@0 0000 @1 © 2005 INIST-CNRS. All rights reserved.`
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A64	`01`	`1`		`@0 Journal of clinical microbiology : (Print)`
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C01	`01`		`ENG`	@0 Antigenic sites on the nucleocapsid (N) protein of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) were mapped by Pepscan analysis with overlapping peptides that span the N protein sequence. Two major immunodominant epitopes located in the C-terminal region (amino acids [aal 362 to 412) and middle region (aa 153 to 178) reacted with more than 75% of sera from SARS patients. Several minor immunodominant epitopes were reactive with about 50% of the SARS sera. Antisera from mice immunized with inactivated SARS-CoV recognized the two major immunodominant epitopes and one antigenic site located adjacent to the N-terminal region (aa 76 to 101), which did not react with the sera from SARS patients. Several monoclonal antibodies against SARS-CoV bound to the N- or C-terminal antigenic sites. These results suggest that the above antigenic sites on the N protein are important in eliciting humoral immune response against SARS-CoV in humans and animals and can be used as antigens for developing diagnostic tests.
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C02	`02`	`X`		`@0 002B05`
C03	`01`	`X`	`FRE`	`@0 Coronavirus @2 NW @5 01`
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C03	`01`	`X`	`SPA`	`@0 Coronavirus @2 NW @5 01`
C03	`02`	`X`	`FRE`	`@0 Nucléocapside @5 05`
C03	`02`	`X`	`ENG`	`@0 Nucleocapsid @5 05`
C03	`02`	`X`	`SPA`	`@0 Nucleocápside @5 05`
C03	`03`	`X`	`FRE`	`@0 Protéine @5 06`
C03	`03`	`X`	`ENG`	`@0 Protein @5 06`
C03	`03`	`X`	`SPA`	`@0 Proteína @5 06`
C03	`04`	`X`	`FRE`	`@0 Microbiologie @5 07`
C03	`04`	`X`	`ENG`	`@0 Microbiology @5 07`
C03	`04`	`X`	`SPA`	`@0 Microbiología @5 07`
C03	`05`	`X`	`FRE`	`@0 Syndrome respiratoire aigu sévère @2 NM @5 14`
C03	`05`	`X`	`ENG`	`@0 Severe acute respiratory syndrome @2 NM @5 14`
C03	`05`	`X`	`SPA`	`@0 Síndrome respiratorio agudo severo @2 NM @5 14`
C07	`01`	`X`	`FRE`	`@0 Coronaviridae @2 NW`
C07	`01`	`X`	`ENG`	`@0 Coronaviridae @2 NW`
C07	`01`	`X`	`SPA`	`@0 Coronaviridae @2 NW`
C07	`02`	`X`	`FRE`	`@0 Nidovirales @2 NW`
C07	`02`	`X`	`ENG`	`@0 Nidovirales @2 NW`
C07	`02`	`X`	`SPA`	`@0 Nidovirales @2 NW`
C07	`03`	`X`	`FRE`	`@0 Virus @2 NW`
C07	`03`	`X`	`ENG`	`@0 Virus @2 NW`
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C07	`04`	`X`	`FRE`	`@0 Virose @2 NM`
C07	`04`	`X`	`ENG`	`@0 Viral disease @2 NM`
C07	`04`	`X`	`SPA`	`@0 Virosis @2 NM`
C07	`05`	`X`	`FRE`	`@0 Infection @2 NM`
C07	`05`	`X`	`ENG`	`@0 Infection @2 NM`
C07	`05`	`X`	`SPA`	`@0 Infección @2 NM`
C07	`06`	`X`	`FRE`	`@0 Appareil respiratoire pathologie @5 19`
C07	`06`	`X`	`ENG`	`@0 Respiratory disease @5 19`
C07	`06`	`X`	`SPA`	`@0 Aparato respiratorio patología @5 19`
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C07	`07`	`X`	`SPA`	`@0 Pulmón patología @5 20`
N21				`@1 010`
N44	`01`			`@1 OTO`
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Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Mapping of antigenic sites on the nucleocapsid protein of the severe acute respiratory syndrome coronavirus</title>
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<author><name sortKey="Yusen Zhou" sort="Yusen Zhou" uniqKey="Yusen Zhou" last="Yusen Zhou">YUSEN ZHOU</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Beijing Institute of Microbiology and Epidemiology, Capital University of Medical Sciences</s1>
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<author><name sortKey="Hao Wu" sort="Hao Wu" uniqKey="Hao Wu" last="Hao Wu">HAO WU</name>
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<author><name sortKey="Zhihua Kou" sort="Zhihua Kou" uniqKey="Zhihua Kou" last="Zhihua Kou">ZHIHUA KOU</name>
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<series><title level="j" type="main">Journal of clinical microbiology : (Print)</title>
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</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Coronavirus</term>
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<front><div type="abstract" xml:lang="en">Antigenic sites on the nucleocapsid (N) protein of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) were mapped by Pepscan analysis with overlapping peptides that span the N protein sequence. Two major immunodominant epitopes located in the C-terminal region (amino acids [aal 362 to 412) and middle region (aa 153 to 178) reacted with more than 75% of sera from SARS patients. Several minor immunodominant epitopes were reactive with about 50% of the SARS sera. Antisera from mice immunized with inactivated SARS-CoV recognized the two major immunodominant epitopes and one antigenic site located adjacent to the N-terminal region (aa 76 to 101), which did not react with the sera from SARS patients. Several monoclonal antibodies against SARS-CoV bound to the N- or C-terminal antigenic sites. These results suggest that the above antigenic sites on the N protein are important in eliciting humoral immune response against SARS-CoV in humans and animals and can be used as antigens for developing diagnostic tests.</div>
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<fC01 i1="01" l="ENG"><s0>Antigenic sites on the nucleocapsid (N) protein of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) were mapped by Pepscan analysis with overlapping peptides that span the N protein sequence. Two major immunodominant epitopes located in the C-terminal region (amino acids [aal 362 to 412) and middle region (aa 153 to 178) reacted with more than 75% of sera from SARS patients. Several minor immunodominant epitopes were reactive with about 50% of the SARS sera. Antisera from mice immunized with inactivated SARS-CoV recognized the two major immunodominant epitopes and one antigenic site located adjacent to the N-terminal region (aa 76 to 101), which did not react with the sera from SARS patients. Several monoclonal antibodies against SARS-CoV bound to the N- or C-terminal antigenic sites. These results suggest that the above antigenic sites on the N protein are important in eliciting humoral immune response against SARS-CoV in humans and animals and can be used as antigens for developing diagnostic tests.</s0>
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<fC07 i1="03" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Virose</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Viral disease</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Virosis</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Infection</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Infection</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Infección</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Appareil respiratoire pathologie</s0>
<s5>19</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>19</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0>
<s5>19</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Poumon pathologie</s0>
<s5>20</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Lung disease</s0>
<s5>20</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Pulmón patología</s0>
<s5>20</s5>
</fC07>
<fN21><s1>010</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

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{{Explor lien
   |wiki=    Sante
   |area=    SrasV1
   |flux=    PascalFrancis
   |étape=   Curation
   |type=    RBID
   |clé=     Pascal:05-0019887
   |texte=   Mapping of antigenic sites on the nucleocapsid protein of the severe acute respiratory syndrome coronavirus
}}

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Data generation: Tue Apr 28 14:49:16 2020. Site generation: Sat Mar 27 22:06:49 2021

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Mapping of antigenic sites on the nucleocapsid protein of the severe acute respiratory syndrome coronavirus

Mapping of antigenic sites on the nucleocapsid protein of the severe acute respiratory syndrome coronavirus

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Descripteurs français

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Abstract

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