SrasV1, PascalFrancis, Curation, bibRecord, 000163

Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferrets. Commentary

Identifieur interne : 000163 ( PascalFrancis/Curation ); précédent : 000162; suivant : 000164

Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferrets. Commentary

Auteurs : Jan Ter Meulen [Pays-Bas] ; Alexander B. H. Bakker [Pays-Bas] ; Edward N. Van Den Brink [Pays-Bas] ; Gerrit J. Weverling [Pays-Bas] ; Byron E. E. Martina [Pays-Bas] ; Bart L. Haagmans [Pays-Bas] ; Thijs Kuiken [Pays-Bas] ; John De Kruif [Pays-Bas] ; Wolfgang Preiser [Allemagne] ; Willy Spaan [Pays-Bas] ; Hans R. Gelderblom [Allemagne] ; Jaap Goudsmit [Pays-Bas] ; Albert D. M. E. Osterhaus [Pays-Bas] ; A. R. Foxwell [Australie] ; A. W. Cripps [Australie]

Source :

Lancet : (British edition) [ 0140-6736 ] ; 2004.

RBID : Pascal:04-0452196

Descripteurs français

Pascal (Inist)
- Homme, Anticorps monoclonal, Chimioprophylaxie, Coronavirus, Furet, Etude critique, Médecine, Animal, Vaccination, Recherche scientifique, Essai préclinique, Syndrome respiratoire aigu sévère.
Wicri :
- topic : Homme, Médecine, Vaccination, Recherche scientifique.

English descriptors

KwdEn :
- Animal, Chemoprophylaxis, Coronavirus, Critical study, Ferret, Human, Medicine, Monoclonal antibody, Preclinical trial, Scientific research, Severe acute respiratory syndrome, Vaccination.

Abstract

SARS coronavirus continues to cause sporadic cases of severe acute respiratory syndrome (SARS) In China. No active or passive Immunoprophylaxis for disease Induced by SARS coronavirus Is available. We investigated prophylaxis of SARS coronavirus infection with a neutralising human monoclonal antibody In ferrets, which can be readily infected with the virus. Prophylactic administration of the monoclonal antibody at 10 mg/kg reduced replication of SARS coronavirus in the lungs of Infected ferrets by 3.3 logs (95% Cl 2.6-4.0 logs; p<0.001), completely prevented the development of SARS coronavirus-induced macroscopic lung pathology (p=0.013), and abolished shedding of virus In pharyngeal secretions. The data generated In this animal model show that administration of a human monoclonal antibody might offer a feasible and effective prophylaxis for the control of human SARS coronavirus infection.

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A11	`01`	`1`		`@1 TER MEULEN (Jan)`
A11	`02`	`1`		`@1 BAKKER (Alexander B. H.)`
A11	`03`	`1`		`@1 VAN DEN BRINK (Edward N.)`
A11	`04`	`1`		`@1 WEVERLING (Gerrit J.)`
A11	`05`	`1`		`@1 MARTINA (Byron E. E.)`
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A11	`13`	`1`		`@1 OSTERHAUS (Albert D. M. E.)`
A11	`14`	`1`		`@1 FOXWELL (A. R.) @9 comment.`
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A14	`03`			`@1 Institute of Medical Virology, Johann Wolfgang Goethe University @2 Frankfurt am Main @3 DEU @Z 9 aut.`
A14	`04`			`@1 Department of Medical Microbiology, Leiden University Medical Centre @2 Leiden @3 NLD @Z 10 aut.`
A14	`05`			`@1 Robert Koch-institut @2 Berlin @3 DEU @Z 11 aut.`
A14	`06`			`@1 Gadi Research Centre for Medical and Health Sciences, University of Canberra @2 Canberra, ACT 2601 @3 AUS @Z 14 aut.`
A14	`07`			`@1 School of Medicine, Griffith University, Gold Coast Campus @2 Gold Coast, Queensland @3 AUS @Z 15 aut.`
A20				`@2 2102-2103,2139-2141 [5 p.]`
A21				`@1 2004`
A23	`01`			`@0 ENG`
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C01	`01`		`ENG`	@0 SARS coronavirus continues to cause sporadic cases of severe acute respiratory syndrome (SARS) In China. No active or passive Immunoprophylaxis for disease Induced by SARS coronavirus Is available. We investigated prophylaxis of SARS coronavirus infection with a neutralising human monoclonal antibody In ferrets, which can be readily infected with the virus. Prophylactic administration of the monoclonal antibody at 10 mg/kg reduced replication of SARS coronavirus in the lungs of Infected ferrets by 3.3 logs (95% Cl 2.6-4.0 logs; p<0.001), completely prevented the development of SARS coronavirus-induced macroscopic lung pathology (p=0.013), and abolished shedding of virus In pharyngeal secretions. The data generated In this animal model show that administration of a human monoclonal antibody might offer a feasible and effective prophylaxis for the control of human SARS coronavirus infection.
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C03	`01`	`X`	`SPA`	`@0 Hombre @5 02`
C03	`02`	`X`	`FRE`	`@0 Anticorps monoclonal @5 03`
C03	`02`	`X`	`ENG`	`@0 Monoclonal antibody @5 03`
C03	`02`	`X`	`SPA`	`@0 Anticuerpo monoclonal @5 03`
C03	`03`	`X`	`FRE`	`@0 Chimioprophylaxie @5 05`
C03	`03`	`X`	`ENG`	`@0 Chemoprophylaxis @5 05`
C03	`03`	`X`	`SPA`	`@0 Quimioprofilaxis @5 05`
C03	`04`	`X`	`FRE`	`@0 Coronavirus @2 NW @5 06`
C03	`04`	`X`	`ENG`	`@0 Coronavirus @2 NW @5 06`
C03	`04`	`X`	`SPA`	`@0 Coronavirus @2 NW @5 06`
C03	`05`	`X`	`FRE`	`@0 Furet @5 08`
C03	`05`	`X`	`ENG`	`@0 Ferret @5 08`
C03	`05`	`X`	`SPA`	`@0 Hurón @5 08`
C03	`06`	`X`	`FRE`	`@0 Etude critique @5 09`
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C03	`08`	`X`	`SPA`	`@0 Animal @5 13`
C03	`09`	`X`	`FRE`	`@0 Vaccination @5 18`
C03	`09`	`X`	`ENG`	`@0 Vaccination @5 18`
C03	`09`	`X`	`SPA`	`@0 Vacunación @5 18`
C03	`10`	`X`	`FRE`	`@0 Recherche scientifique @5 19`
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C03	`10`	`X`	`SPA`	`@0 Investigación científica @5 19`
C03	`11`	`X`	`FRE`	`@0 Essai préclinique @5 20`
C03	`11`	`X`	`ENG`	`@0 Preclinical trial @5 20`
C03	`11`	`X`	`SPA`	`@0 Ensayo preclínico @5 20`
C03	`12`	`X`	`FRE`	`@0 Syndrome respiratoire aigu sévère @4 CD @5 96`
C03	`12`	`X`	`ENG`	`@0 Severe acute respiratory syndrome @4 CD @5 96`
C03	`12`	`X`	`SPA`	`@0 Síndrome respiratorio agudo severo @4 CD @5 96`
C07	`01`	`X`	`FRE`	`@0 Coronaviridae @2 NW`
C07	`01`	`X`	`ENG`	`@0 Coronaviridae @2 NW`
C07	`01`	`X`	`SPA`	`@0 Coronaviridae @2 NW`
C07	`02`	`X`	`FRE`	`@0 Nidovirales @2 NW`
C07	`02`	`X`	`ENG`	`@0 Nidovirales @2 NW`
C07	`02`	`X`	`SPA`	`@0 Nidovirales @2 NW`
C07	`03`	`X`	`FRE`	`@0 Virus @2 NW`
C07	`03`	`X`	`ENG`	`@0 Virus @2 NW`
C07	`03`	`X`	`SPA`	`@0 Virus @2 NW`
C07	`04`	`X`	`FRE`	`@0 Fissipedia @2 NS`
C07	`04`	`X`	`ENG`	`@0 Fissipedia @2 NS`
C07	`04`	`X`	`SPA`	`@0 Fissipedia @2 NS`
C07	`05`	`X`	`FRE`	`@0 Carnivora @2 NS`
C07	`05`	`X`	`ENG`	`@0 Carnivora @2 NS`
C07	`05`	`X`	`SPA`	`@0 Carnivora @2 NS`
C07	`06`	`X`	`FRE`	`@0 Mammalia @2 NS`
C07	`06`	`X`	`ENG`	`@0 Mammalia @2 NS`
C07	`06`	`X`	`SPA`	`@0 Mammalia @2 NS`
C07	`07`	`X`	`FRE`	`@0 Vertebrata @2 NS`
C07	`07`	`X`	`ENG`	`@0 Vertebrata @2 NS`
C07	`07`	`X`	`SPA`	`@0 Vertebrata @2 NS`
C07	`08`	`X`	`FRE`	`@0 Appareil respiratoire pathologie @5 37`
C07	`08`	`X`	`ENG`	`@0 Respiratory disease @5 37`
C07	`08`	`X`	`SPA`	`@0 Aparato respiratorio patología @5 37`
C07	`09`	`X`	`FRE`	`@0 Poumon pathologie @5 38`
C07	`09`	`X`	`ENG`	`@0 Lung disease @5 38`
C07	`09`	`X`	`SPA`	`@0 Pulmón patología @5 38`
C07	`10`	`X`	`FRE`	`@0 Virose @2 NM @5 39`
C07	`10`	`X`	`ENG`	`@0 Viral disease @2 NM @5 39`
C07	`10`	`X`	`SPA`	`@0 Virosis @2 NM @5 39`
C07	`11`	`X`	`FRE`	`@0 Infection @2 NM`
C07	`11`	`X`	`ENG`	`@0 Infection @2 NM`
C07	`11`	`X`	`SPA`	`@0 Infección @2 NM`
N21				`@1 257`
N44	`01`			`@1 PSI`
N82				`@1 PSI`

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Pascal:04-0452196

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferrets. Commentary</title>
<author><name sortKey="Ter Meulen, Jan" sort="Ter Meulen, Jan" uniqKey="Ter Meulen J" first="Jan" last="Ter Meulen">Jan Ter Meulen</name>
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<author><name sortKey="Bakker, Alexander B H" sort="Bakker, Alexander B H" uniqKey="Bakker A" first="Alexander B. H." last="Bakker">Alexander B. H. Bakker</name>
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<author><name sortKey="Van Den Brink, Edward N" sort="Van Den Brink, Edward N" uniqKey="Van Den Brink E" first="Edward N." last="Van Den Brink">Edward N. Van Den Brink</name>
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<author><name sortKey="Weverling, Gerrit J" sort="Weverling, Gerrit J" uniqKey="Weverling G" first="Gerrit J." last="Weverling">Gerrit J. Weverling</name>
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<author><name sortKey="Martina, Byron E E" sort="Martina, Byron E E" uniqKey="Martina B" first="Byron E. E." last="Martina">Byron E. E. Martina</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Virology, Erasmus Medical Center</s1>
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<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>13 aut.</sZ>
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<author><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L." last="Haagmans">Bart L. Haagmans</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Virology, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>13 aut.</sZ>
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<country>Pays-Bas</country>
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<author><name sortKey="Kuiken, Thijs" sort="Kuiken, Thijs" uniqKey="Kuiken T" first="Thijs" last="Kuiken">Thijs Kuiken</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Virology, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>13 aut.</sZ>
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<author><name sortKey="De Kruif, John" sort="De Kruif, John" uniqKey="De Kruif J" first="John" last="De Kruif">John De Kruif</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Crucell Holland BV</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>12 aut.</sZ>
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<country>Pays-Bas</country>
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</author>
<author><name sortKey="Preiser, Wolfgang" sort="Preiser, Wolfgang" uniqKey="Preiser W" first="Wolfgang" last="Preiser">Wolfgang Preiser</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Medical Virology, Johann Wolfgang Goethe University</s1>
<s2>Frankfurt am Main</s2>
<s3>DEU</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
</affiliation>
</author>
<author><name sortKey="Spaan, Willy" sort="Spaan, Willy" uniqKey="Spaan W" first="Willy" last="Spaan">Willy Spaan</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Medical Microbiology, Leiden University Medical Centre</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
</affiliation>
</author>
<author><name sortKey="Gelderblom, Hans R" sort="Gelderblom, Hans R" uniqKey="Gelderblom H" first="Hans R." last="Gelderblom">Hans R. Gelderblom</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Robert Koch-institut</s1>
<s2>Berlin</s2>
<s3>DEU</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
</affiliation>
</author>
<author><name sortKey="Goudsmit, Jaap" sort="Goudsmit, Jaap" uniqKey="Goudsmit J" first="Jaap" last="Goudsmit">Jaap Goudsmit</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Crucell Holland BV</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
</affiliation>
</author>
<author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Virology, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
</affiliation>
</author>
<author><name sortKey="Foxwell, A R" sort="Foxwell, A R" uniqKey="Foxwell A" first="A. R." last="Foxwell">A. R. Foxwell</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Gadi Research Centre for Medical and Health Sciences, University of Canberra</s1>
<s2>Canberra, ACT 2601</s2>
<s3>AUS</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Australie</country>
</affiliation>
</author>
<author><name sortKey="Cripps, A W" sort="Cripps, A W" uniqKey="Cripps A" first="A. W." last="Cripps">A. W. Cripps</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>School of Medicine, Griffith University, Gold Coast Campus</s1>
<s2>Gold Coast, Queensland</s2>
<s3>AUS</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Australie</country>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Lancet : (British edition)</title>
<title level="j" type="abbreviated">Lancet : (Br. ed.)</title>
<idno type="ISSN">0140-6736</idno>
<imprint><date when="2004">2004</date>
</imprint>
</series>
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<seriesStmt><title level="j" type="main">Lancet : (British edition)</title>
<title level="j" type="abbreviated">Lancet : (Br. ed.)</title>
<idno type="ISSN">0140-6736</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term>
<term>Chemoprophylaxis</term>
<term>Coronavirus</term>
<term>Critical study</term>
<term>Ferret</term>
<term>Human</term>
<term>Medicine</term>
<term>Monoclonal antibody</term>
<term>Preclinical trial</term>
<term>Scientific research</term>
<term>Severe acute respiratory syndrome</term>
<term>Vaccination</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Homme</term>
<term>Anticorps monoclonal</term>
<term>Chimioprophylaxie</term>
<term>Coronavirus</term>
<term>Furet</term>
<term>Etude critique</term>
<term>Médecine</term>
<term>Animal</term>
<term>Vaccination</term>
<term>Recherche scientifique</term>
<term>Essai préclinique</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
<term>Médecine</term>
<term>Vaccination</term>
<term>Recherche scientifique</term>
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<front><div type="abstract" xml:lang="en">SARS coronavirus continues to cause sporadic cases of severe acute respiratory syndrome (SARS) In China. No active or passive Immunoprophylaxis for disease Induced by SARS coronavirus Is available. We investigated prophylaxis of SARS coronavirus infection with a neutralising human monoclonal antibody In ferrets, which can be readily infected with the virus. Prophylactic administration of the monoclonal antibody at 10 mg/kg reduced replication of SARS coronavirus in the lungs of Infected ferrets by 3.3 logs (95% Cl 2.6-4.0 logs; p<0.001), completely prevented the development of SARS coronavirus-induced macroscopic lung pathology (p=0.013), and abolished shedding of virus In pharyngeal secretions. The data generated In this animal model show that administration of a human monoclonal antibody might offer a feasible and effective prophylaxis for the control of human SARS coronavirus infection.</div>
</front>
</TEI>
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<fA05><s2>363</s2>
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<fA06><s2>9427</s2>
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<fA08 i1="01" i2="1" l="ENG"><s1>Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferrets. Commentary</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>TER MEULEN (Jan)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>BAKKER (Alexander B. H.)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>VAN DEN BRINK (Edward N.)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>WEVERLING (Gerrit J.)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>MARTINA (Byron E. E.)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>HAAGMANS (Bart L.)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>KUIKEN (Thijs)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>DE KRUIF (John)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>PREISER (Wolfgang)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>SPAAN (Willy)</s1>
</fA11>
<fA11 i1="11" i2="1"><s1>GELDERBLOM (Hans R.)</s1>
</fA11>
<fA11 i1="12" i2="1"><s1>GOUDSMIT (Jaap)</s1>
</fA11>
<fA11 i1="13" i2="1"><s1>OSTERHAUS (Albert D. M. E.)</s1>
</fA11>
<fA11 i1="14" i2="1"><s1>FOXWELL (A. R.)</s1>
<s9>comment.</s9>
</fA11>
<fA11 i1="15" i2="1"><s1>CRIPPS (A. W.)</s1>
<s9>comment.</s9>
</fA11>
<fA14 i1="01"><s1>Crucell Holland BV</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>12 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Department of Virology, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>13 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Institute of Medical Virology, Johann Wolfgang Goethe University</s1>
<s2>Frankfurt am Main</s2>
<s3>DEU</s3>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Department of Medical Microbiology, Leiden University Medical Centre</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Robert Koch-institut</s1>
<s2>Berlin</s2>
<s3>DEU</s3>
<sZ>11 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>Gadi Research Centre for Medical and Health Sciences, University of Canberra</s1>
<s2>Canberra, ACT 2601</s2>
<s3>AUS</s3>
<sZ>14 aut.</sZ>
</fA14>
<fA14 i1="07"><s1>School of Medicine, Griffith University, Gold Coast Campus</s1>
<s2>Gold Coast, Queensland</s2>
<s3>AUS</s3>
<sZ>15 aut.</sZ>
</fA14>
<fA20><s2>2102-2103,2139-2141 [5 p.]</s2>
</fA20>
<fA21><s1>2004</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>5004</s2>
<s5>354000110516130070</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2004 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>17 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>04-0452196</s0>
</fA47>
<fA60><s1>P</s1>
<s3>CR</s3>
<s3>CT</s3>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Lancet : (British edition)</s0>
</fA64>
<fA66 i1="01"><s0>GBR</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>SARS coronavirus continues to cause sporadic cases of severe acute respiratory syndrome (SARS) In China. No active or passive Immunoprophylaxis for disease Induced by SARS coronavirus Is available. We investigated prophylaxis of SARS coronavirus infection with a neutralising human monoclonal antibody In ferrets, which can be readily infected with the virus. Prophylactic administration of the monoclonal antibody at 10 mg/kg reduced replication of SARS coronavirus in the lungs of Infected ferrets by 3.3 logs (95% Cl 2.6-4.0 logs; p<0.001), completely prevented the development of SARS coronavirus-induced macroscopic lung pathology (p=0.013), and abolished shedding of virus In pharyngeal secretions. The data generated In this animal model show that administration of a human monoclonal antibody might offer a feasible and effective prophylaxis for the control of human SARS coronavirus infection.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B01</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Homme</s0>
<s5>02</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Human</s0>
<s5>02</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Hombre</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Anticorps monoclonal</s0>
<s5>03</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Monoclonal antibody</s0>
<s5>03</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Anticuerpo monoclonal</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Chimioprophylaxie</s0>
<s5>05</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Chemoprophylaxis</s0>
<s5>05</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Quimioprofilaxis</s0>
<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>06</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>06</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>06</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Furet</s0>
<s5>08</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Ferret</s0>
<s5>08</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Hurón</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Etude critique</s0>
<s5>09</s5>
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<fC03 i1="06" i2="X" l="ENG"><s0>Critical study</s0>
<s5>09</s5>
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<fC03 i1="06" i2="X" l="SPA"><s0>Estudio crítico</s0>
<s5>09</s5>
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<fC03 i1="07" i2="X" l="FRE"><s0>Médecine</s0>
<s5>11</s5>
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<s5>11</s5>
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<s5>11</s5>
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<fC03 i1="08" i2="X" l="FRE"><s0>Animal</s0>
<s5>13</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Animal</s0>
<s5>13</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Animal</s0>
<s5>13</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Vaccination</s0>
<s5>18</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Vaccination</s0>
<s5>18</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Vacunación</s0>
<s5>18</s5>
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<s5>19</s5>
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<s5>19</s5>
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<s5>19</s5>
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<s5>20</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Preclinical trial</s0>
<s5>20</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Ensayo preclínico</s0>
<s5>20</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Syndrome respiratoire aigu sévère</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Severe acute respiratory syndrome</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Síndrome respiratorio agudo severo</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Coronaviridae</s0>
<s2>NW</s2>
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<fC07 i1="01" i2="X" l="SPA"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Nidovirales</s0>
<s2>NW</s2>
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<fC07 i1="02" i2="X" l="ENG"><s0>Nidovirales</s0>
<s2>NW</s2>
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<fC07 i1="02" i2="X" l="SPA"><s0>Nidovirales</s0>
<s2>NW</s2>
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<fC07 i1="03" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
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<s2>NW</s2>
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<fC07 i1="03" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
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<fC07 i1="04" i2="X" l="FRE"><s0>Fissipedia</s0>
<s2>NS</s2>
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<fC07 i1="04" i2="X" l="ENG"><s0>Fissipedia</s0>
<s2>NS</s2>
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<fC07 i1="04" i2="X" l="SPA"><s0>Fissipedia</s0>
<s2>NS</s2>
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<s2>NS</s2>
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<s2>NS</s2>
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<s2>NS</s2>
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<fC07 i1="06" i2="X" l="FRE"><s0>Mammalia</s0>
<s2>NS</s2>
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<fC07 i1="06" i2="X" l="ENG"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Vertebrata</s0>
<s2>NS</s2>
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<fC07 i1="08" i2="X" l="FRE"><s0>Appareil respiratoire pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>37</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0>
<s5>37</s5>
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<fC07 i1="09" i2="X" l="FRE"><s0>Poumon pathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Lung disease</s0>
<s5>38</s5>
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<s5>38</s5>
</fC07>
<fC07 i1="10" i2="X" l="FRE"><s0>Virose</s0>
<s2>NM</s2>
<s5>39</s5>
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   |wiki=    Sante
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   |flux=    PascalFrancis
   |étape=   Curation
   |type=    RBID
   |clé=     Pascal:04-0452196
   |texte=   Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferrets. Commentary
}}

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Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferrets. Commentary

Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferrets. Commentary

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English descriptors

Abstract

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