SrasV1, PascalFrancis, Curation, bibRecord, 000117

Mutational patterns correlate with genome organization in SARS and other coronaviruses

Identifieur interne : 000117 ( PascalFrancis/Curation ); précédent : 000116; suivant : 000118

Mutational patterns correlate with genome organization in SARS and other coronaviruses

Auteurs : Andrei Grigoriev [Allemagne]

Source :

Trends in genetics : (Regular ed.) [ 0168-9525 ] ; 2004.

RBID : Pascal:04-0322792

Descripteurs français

Pascal (Inist)
- Mutation, Organisation génome, Génétique, Coronavirus, Syndrome respiratoire aigu sévère.
Wicri :
- topic : Génétique.

English descriptors

KwdEn :
- Coronavirus, Genetics, Genome organization, Mutation, Severe acute respiratory syndrome.

Abstract

Focused efforts by several international laboratories have resulted in the sequencing of the genome of the causative agent of severe acute respiratory syndrome (SARS), novel coronavirus SARS-CoV, in record time. Using cumulative skew diagrams, I found that mutational patterns in the SARS-CoV genome were strikingly different from other coronaviruses in terms of mutation rates, although they were in general agreement with the model of the coronavirus lifecycle. These findings might be relevant for the development of sequence-based diagnostics and the design of agents to treat SARS.

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A08	`01`	`1`	`ENG`	`@1 Mutational patterns correlate with genome organization in SARS and other coronaviruses`
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C01	`01`		`ENG`	@0 Focused efforts by several international laboratories have resulted in the sequencing of the genome of the causative agent of severe acute respiratory syndrome (SARS), novel coronavirus SARS-CoV, in record time. Using cumulative skew diagrams, I found that mutational patterns in the SARS-CoV genome were strikingly different from other coronaviruses in terms of mutation rates, although they were in general agreement with the model of the coronavirus lifecycle. These findings might be relevant for the development of sequence-based diagnostics and the design of agents to treat SARS.
C02	`01`	`X`		`@0 002A07`
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C03	`01`	`X`	`SPA`	`@0 Mutación @5 01`
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C03	`02`	`X`	`ENG`	`@0 Genome organization @5 02`
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C07	`05`	`X`	`SPA`	`@0 Pulmón patología @5 20`
C07	`06`	`X`	`FRE`	`@0 Virose @2 NM @5 21`
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N21				`@1 194`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Focused efforts by several international laboratories have resulted in the sequencing of the genome of the causative agent of severe acute respiratory syndrome (SARS), novel coronavirus SARS-CoV, in record time. Using cumulative skew diagrams, I found that mutational patterns in the SARS-CoV genome were strikingly different from other coronaviruses in terms of mutation rates, although they were in general agreement with the model of the coronavirus lifecycle. These findings might be relevant for the development of sequence-based diagnostics and the design of agents to treat SARS.</div>
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Mutational patterns correlate with genome organization in SARS and other coronaviruses

Mutational patterns correlate with genome organization in SARS and other coronaviruses

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri