SrasV1, PascalFrancis, Curation, bibRecord, 000033

Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome

Identifieur interne : 000033 ( PascalFrancis/Curation ); précédent : 000032; suivant : 000034

Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome

Auteurs : This Kuiken [Pays-Bas] ; Ron A. M. Fouchier [Pays-Bas] ; Martin Schutten [Pays-Bas] ; Guus F. Rimmelzwaan [Pays-Bas] ; Geert Van Amerongen [Pays-Bas] ; Debby Van Riel [Pays-Bas] ; Jon D. Laman [Pays-Bas] ; Ton De Jong [Pays-Bas] ; Gerard Van Doornum [Pays-Bas] ; Wilina Lim [République populaire de Chine] ; AI EE LING [Singapour] ; Paul K. S. Chan [Hong Kong] ; John S. Tam [Hong Kong] ; Maria C. Zambon [Royaume-Uni] ; Robin Gopal [Royaume-Uni] ; Christian Drosten [Allemagne] ; Sylvie Van Der Werf [France] ; Nicolas Escriou [France] ; Jean-Claude Manuguerra [France] ; Klaus Stöhr [Suisse] ; J. S. Malik Peiris [Hong Kong] ; Albert D. M. E. Osterhaus [Pays-Bas]

Source :

Lancet : (British edition) [ 0140-6736 ] ; 2003.

RBID : Pascal:03-0484722

Descripteurs français

Pascal (Inist)
- Coronavirus, Homme, Syndrome respiratoire aigu sévère.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Coronavirus, Human, Severe acute respiratory syndrome.

Abstract

Background The worldwide outbreak of severe acute respiratory syndrome (SARS) is associated with a newly discovered coronavirus, SARS-associated coronavirus (SARS-CoV). We did clinical and experimental studies to assess the role of this virus in the cause of SARS. Methods We tested clinical and postmortem samples from 436 SARS patients in six countries for infection with SARS-CoV, human metapneumovirus, and other respiratory pathogens. We infected four cynomolgus macaques (Macaca fascicularis) with SARS-CoV in an attempt to replicate SARS and did necropsies on day 6 after infection. Findings SARS-CoV infection was diagnosed in 329 (75%) of 436 patients fitting the case definition of SARS; human metapneumovirus was diagnosed in 41 (12%) of 335, and other respiratory pathogens were diagnosed only sporadically. SARS-CoV was, therefore, the most likely causal agent of SARS. The four SARS-CoV-infected macaques excreted SARS-CoV from nose, mouth, and pharynx from 2 days after infection. Three of four macaques developed diffuse alveolar damage, similar to that in SARS patients, and characterised by epithelial necrosis, serosanguineous exudate, formation of hyaline membranes, type 2 pneumocyte hyperplasia, and the presence of syncytia. SARS-CoV was detected in pneumonic areas by virus isolation and RT-PCR, and was localised to alveolar epithelial cells and syncytia by immunohistochemistry and transmission electron microscopy. Interpretation Replication in SARS-CoV-infected macaques of pneumonia similar to that in human beings with SARS, combined with the high prevalence of SARS-CoV infection in SARS patients, fulfill the criteria required to prove that SARS-CoV is the primary cause of SARS.

A01	`01`	`1`		`@0 0140-6736`
A02	`01`			`@0 LANCAO`
A03		`1`		`@0 Lancet : (Br. ed.)`
A05				`@2 362`
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A08	`01`	`1`	`ENG`	`@1 Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome`
A11	`01`	`1`		`@1 KUIKEN (This)`
A11	`02`	`1`		`@1 FOUCHIER (Ron A. M.)`
A11	`03`	`1`		`@1 SCHUTTEN (Martin)`
A11	`04`	`1`		`@1 RIMMELZWAAN (Guus F.)`
A11	`05`	`1`		`@1 VAN AMERONGEN (Geert)`
A11	`06`	`1`		`@1 VAN RIEL (Debby)`
A11	`07`	`1`		`@1 LAMAN (Jon D.)`
A11	`08`	`1`		`@1 DE JONG (Ton)`
A11	`09`	`1`		`@1 VAN DOORNUM (Gerard)`
A11	`10`	`1`		`@1 LIM (Wilina)`
A11	`11`	`1`		`@1 AI EE LING`
A11	`12`	`1`		`@1 CHAN (Paul K. S.)`
A11	`13`	`1`		`@1 TAM (John S.)`
A11	`14`	`1`		`@1 ZAMBON (Maria C.)`
A11	`15`	`1`		`@1 GOPAL (Robin)`
A11	`16`	`1`		`@1 DROSTEN (Christian)`
A11	`17`	`1`		`@1 VAN DER WERF (Sylvie)`
A11	`18`	`1`		`@1 ESCRIOU (Nicolas)`
A11	`19`	`1`		`@1 MANUGUERRA (Jean-Claude)`
A11	`20`	`1`		`@1 STÖHR (Klaus)`
A11	`21`	`1`		`@1 PEIRIS (J. S. Malik)`
A11	`22`	`1`		`@1 OSTERHAUS (Albert D. M. E.)`
A14	`01`			`@1 Department of Virology, Erasmus Medical Centre, PO Box 1738 @2 3000 DR Rotterdam @3 NLD @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 9 aut. @Z 22 aut.`
A14	`02`			`@1 Department of Immunology, Erasmus Medical Centre, PO Box 1738 @2 3000 DR Rotterdam @3 NLD @Z 6 aut. @Z 7 aut.`
A14	`03`			`@1 Department of Pathology, Erasmus Medical Centre, PO Box 1738 @2 3000 DR Rotterdam @3 NLD @Z 8 aut.`
A14	`04`			`@1 Government Virus Unit, Public Health Laboratory Centre, Shek Kip Mei, Kowloon, Hong Kong Special Administrative Region @2 Kowloon @3 CHN @Z 10 aut.`
A14	`05`			`@1 Department of Pathology, Singapore General Hospital @3 SGP @Z 11 aut.`
A14	`06`			`@1 Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital @3 HKG @Z 12 aut. @Z 13 aut.`
A14	`07`			`@1 Enteric Respiratory and Neurological Virus Laboratory, Health Protection Agency @2 London @3 GBR @Z 14 aut. @Z 15 aut.`
A14	`08`			`@1 Department of Virology, Bernhard-Nocht Institute for Tropical Medicine @2 Hamburg @3 DEU @Z 16 aut.`
A14	`09`			`@1 Unité de Génétique Moléculaire des Virus Respiratoires, Institut Pasteur @2 Paris @3 FRA @Z 17 aut. @Z 18 aut. @Z 19 aut.`
A14	`10`			`@1 SARS Aetiology Study Group, WHO @2 Geneva @3 CHE @Z 20 aut.`
A14	`11`			`@1 Department of Microbiology and Medicine, Queen Mary Hospital, University of Hong Kong @3 HKG @Z 21 aut.`
A20				`@1 263-270`
A21				`@1 2003`
A23	`01`			`@0 ENG`
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A44				`@0 0000 @1 © 2003 INIST-CNRS. All rights reserved.`
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A64	`01`	`1`		`@0 Lancet : (British edition)`
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C01	`01`		`ENG`	@0 Background The worldwide outbreak of severe acute respiratory syndrome (SARS) is associated with a newly discovered coronavirus, SARS-associated coronavirus (SARS-CoV). We did clinical and experimental studies to assess the role of this virus in the cause of SARS. Methods We tested clinical and postmortem samples from 436 SARS patients in six countries for infection with SARS-CoV, human metapneumovirus, and other respiratory pathogens. We infected four cynomolgus macaques (Macaca fascicularis) with SARS-CoV in an attempt to replicate SARS and did necropsies on day 6 after infection. Findings SARS-CoV infection was diagnosed in 329 (75%) of 436 patients fitting the case definition of SARS; human metapneumovirus was diagnosed in 41 (12%) of 335, and other respiratory pathogens were diagnosed only sporadically. SARS-CoV was, therefore, the most likely causal agent of SARS. The four SARS-CoV-infected macaques excreted SARS-CoV from nose, mouth, and pharynx from 2 days after infection. Three of four macaques developed diffuse alveolar damage, similar to that in SARS patients, and characterised by epithelial necrosis, serosanguineous exudate, formation of hyaline membranes, type 2 pneumocyte hyperplasia, and the presence of syncytia. SARS-CoV was detected in pneumonic areas by virus isolation and RT-PCR, and was localised to alveolar epithelial cells and syncytia by immunohistochemistry and transmission electron microscopy. Interpretation Replication in SARS-CoV-infected macaques of pneumonia similar to that in human beings with SARS, combined with the high prevalence of SARS-CoV infection in SARS patients, fulfill the criteria required to prove that SARS-CoV is the primary cause of SARS.
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C03	`01`	`X`	`SPA`	`@0 Coronavirus @2 NW @5 02`
C03	`02`	`X`	`FRE`	`@0 Homme @5 03`
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C07	`01`	`X`	`FRE`	`@0 Coronaviridae @2 NW`
C07	`01`	`X`	`ENG`	`@0 Coronaviridae @2 NW`
C07	`01`	`X`	`SPA`	`@0 Coronaviridae @2 NW`
C07	`02`	`X`	`FRE`	`@0 Nidovirales @2 NW`
C07	`02`	`X`	`ENG`	`@0 Nidovirales @2 NW`
C07	`02`	`X`	`SPA`	`@0 Nidovirales @2 NW`
C07	`03`	`X`	`FRE`	`@0 Virus @2 NW`
C07	`03`	`X`	`ENG`	`@0 Virus @2 NW`
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C07	`04`	`X`	`FRE`	`@0 Appareil respiratoire pathologie @5 37`
C07	`04`	`X`	`ENG`	`@0 Respiratory disease @5 37`
C07	`04`	`X`	`SPA`	`@0 Aparato respiratorio patología @5 37`
C07	`05`	`X`	`FRE`	`@0 Poumon pathologie @5 38`
C07	`05`	`X`	`ENG`	`@0 Lung disease @5 38`
C07	`05`	`X`	`SPA`	`@0 Pulmón patología @5 38`
C07	`06`	`X`	`FRE`	`@0 Virose @5 39`
C07	`06`	`X`	`ENG`	`@0 Viral disease @5 39`
C07	`06`	`X`	`SPA`	`@0 Virosis @5 39`
C07	`07`	`X`	`FRE`	`@0 Infection`
C07	`07`	`X`	`ENG`	`@0 Infection`
C07	`07`	`X`	`SPA`	`@0 Infección`
N21				`@1 328`
N82				`@1 PSI`

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Le document en format XML

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<author><name sortKey="Kuiken, This" sort="Kuiken, This" uniqKey="Kuiken T" first="This" last="Kuiken">This Kuiken</name>
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<author><name sortKey="Rimmelzwaan, Guus F" sort="Rimmelzwaan, Guus F" uniqKey="Rimmelzwaan G" first="Guus F." last="Rimmelzwaan">Guus F. Rimmelzwaan</name>
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<author><name sortKey="Van Riel, Debby" sort="Van Riel, Debby" uniqKey="Van Riel D" first="Debby" last="Van Riel">Debby Van Riel</name>
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<author><name sortKey="Laman, Jon D" sort="Laman, Jon D" uniqKey="Laman J" first="Jon D." last="Laman">Jon D. Laman</name>
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<author><name sortKey="De Jong, Ton" sort="De Jong, Ton" uniqKey="De Jong T" first="Ton" last="De Jong">Ton De Jong</name>
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<author><name sortKey="Van Doornum, Gerard" sort="Van Doornum, Gerard" uniqKey="Van Doornum G" first="Gerard" last="Van Doornum">Gerard Van Doornum</name>
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<author><name sortKey="Lim, Wilina" sort="Lim, Wilina" uniqKey="Lim W" first="Wilina" last="Lim">Wilina Lim</name>
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<author><name sortKey="Chan, Paul K S" sort="Chan, Paul K S" uniqKey="Chan P" first="Paul K. S." last="Chan">Paul K. S. Chan</name>
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<author><name sortKey="Tam, John S" sort="Tam, John S" uniqKey="Tam J" first="John S." last="Tam">John S. Tam</name>
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<author><name sortKey="Gopal, Robin" sort="Gopal, Robin" uniqKey="Gopal R" first="Robin" last="Gopal">Robin Gopal</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Enteric Respiratory and Neurological Virus Laboratory, Health Protection Agency</s1>
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<author><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Virology, Bernhard-Nocht Institute for Tropical Medicine</s1>
<s2>Hamburg</s2>
<s3>DEU</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
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</author>
<author><name sortKey="Van Der Werf, Sylvie" sort="Van Der Werf, Sylvie" uniqKey="Van Der Werf S" first="Sylvie" last="Van Der Werf">Sylvie Van Der Werf</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Unité de Génétique Moléculaire des Virus Respiratoires, Institut Pasteur</s1>
<s2>Paris</s2>
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<country>France</country>
</affiliation>
</author>
<author><name sortKey="Escriou, Nicolas" sort="Escriou, Nicolas" uniqKey="Escriou N" first="Nicolas" last="Escriou">Nicolas Escriou</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Unité de Génétique Moléculaire des Virus Respiratoires, Institut Pasteur</s1>
<s2>Paris</s2>
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<country>France</country>
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<author><name sortKey="Manuguerra, Jean Claude" sort="Manuguerra, Jean Claude" uniqKey="Manuguerra J" first="Jean-Claude" last="Manuguerra">Jean-Claude Manuguerra</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Unité de Génétique Moléculaire des Virus Respiratoires, Institut Pasteur</s1>
<s2>Paris</s2>
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<country>France</country>
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<author><name sortKey="Stohr, Klaus" sort="Stohr, Klaus" uniqKey="Stohr K" first="Klaus" last="Stöhr">Klaus Stöhr</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>SARS Aetiology Study Group, WHO</s1>
<s2>Geneva</s2>
<s3>CHE</s3>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Suisse</country>
</affiliation>
</author>
<author><name sortKey="Peiris, J S Malik" sort="Peiris, J S Malik" uniqKey="Peiris J" first="J. S. Malik" last="Peiris">J. S. Malik Peiris</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Microbiology and Medicine, Queen Mary Hospital, University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
</affiliation>
</author>
<author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Virology, Erasmus Medical Centre, PO Box 1738</s1>
<s2>3000 DR Rotterdam</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
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<country>Pays-Bas</country>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome</title>
<author><name sortKey="Kuiken, This" sort="Kuiken, This" uniqKey="Kuiken T" first="This" last="Kuiken">This Kuiken</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Virology, Erasmus Medical Centre, PO Box 1738</s1>
<s2>3000 DR Rotterdam</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>22 aut.</sZ>
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<author><name sortKey="Fouchier, Ron A M" sort="Fouchier, Ron A M" uniqKey="Fouchier R" first="Ron A. M." last="Fouchier">Ron A. M. Fouchier</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Virology, Erasmus Medical Centre, PO Box 1738</s1>
<s2>3000 DR Rotterdam</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
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<sZ>22 aut.</sZ>
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<country>Pays-Bas</country>
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<author><name sortKey="Schutten, Martin" sort="Schutten, Martin" uniqKey="Schutten M" first="Martin" last="Schutten">Martin Schutten</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Virology, Erasmus Medical Centre, PO Box 1738</s1>
<s2>3000 DR Rotterdam</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
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<country>Pays-Bas</country>
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<author><name sortKey="Rimmelzwaan, Guus F" sort="Rimmelzwaan, Guus F" uniqKey="Rimmelzwaan G" first="Guus F." last="Rimmelzwaan">Guus F. Rimmelzwaan</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Virology, Erasmus Medical Centre, PO Box 1738</s1>
<s2>3000 DR Rotterdam</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
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<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>22 aut.</sZ>
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<country>Pays-Bas</country>
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</author>
<author><name sortKey="Van Amerongen, Geert" sort="Van Amerongen, Geert" uniqKey="Van Amerongen G" first="Geert" last="Van Amerongen">Geert Van Amerongen</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Virology, Erasmus Medical Centre, PO Box 1738</s1>
<s2>3000 DR Rotterdam</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>22 aut.</sZ>
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<country>Pays-Bas</country>
</affiliation>
</author>
<author><name sortKey="Van Riel, Debby" sort="Van Riel, Debby" uniqKey="Van Riel D" first="Debby" last="Van Riel">Debby Van Riel</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Immunology, Erasmus Medical Centre, PO Box 1738</s1>
<s2>3000 DR Rotterdam</s2>
<s3>NLD</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
</affiliation>
</author>
<author><name sortKey="Laman, Jon D" sort="Laman, Jon D" uniqKey="Laman J" first="Jon D." last="Laman">Jon D. Laman</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Immunology, Erasmus Medical Centre, PO Box 1738</s1>
<s2>3000 DR Rotterdam</s2>
<s3>NLD</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
</affiliation>
</author>
<author><name sortKey="De Jong, Ton" sort="De Jong, Ton" uniqKey="De Jong T" first="Ton" last="De Jong">Ton De Jong</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Pathology, Erasmus Medical Centre, PO Box 1738</s1>
<s2>3000 DR Rotterdam</s2>
<s3>NLD</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
</affiliation>
</author>
<author><name sortKey="Van Doornum, Gerard" sort="Van Doornum, Gerard" uniqKey="Van Doornum G" first="Gerard" last="Van Doornum">Gerard Van Doornum</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Virology, Erasmus Medical Centre, PO Box 1738</s1>
<s2>3000 DR Rotterdam</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>22 aut.</sZ>
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<country>Pays-Bas</country>
</affiliation>
</author>
<author><name sortKey="Lim, Wilina" sort="Lim, Wilina" uniqKey="Lim W" first="Wilina" last="Lim">Wilina Lim</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Government Virus Unit, Public Health Laboratory Centre, Shek Kip Mei, Kowloon, Hong Kong Special Administrative Region</s1>
<s2>Kowloon</s2>
<s3>CHN</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Ai Ee Ling" sort="Ai Ee Ling" uniqKey="Ai Ee Ling" last="Ai Ee Ling">AI EE LING</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Pathology, Singapore General Hospital</s1>
<s3>SGP</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Singapour</country>
</affiliation>
</author>
<author><name sortKey="Chan, Paul K S" sort="Chan, Paul K S" uniqKey="Chan P" first="Paul K. S." last="Chan">Paul K. S. Chan</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital</s1>
<s3>HKG</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
</affiliation>
</author>
<author><name sortKey="Tam, John S" sort="Tam, John S" uniqKey="Tam J" first="John S." last="Tam">John S. Tam</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital</s1>
<s3>HKG</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
</affiliation>
</author>
<author><name sortKey="Zambon, Maria C" sort="Zambon, Maria C" uniqKey="Zambon M" first="Maria C." last="Zambon">Maria C. Zambon</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Enteric Respiratory and Neurological Virus Laboratory, Health Protection Agency</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
</affiliation>
</author>
<author><name sortKey="Gopal, Robin" sort="Gopal, Robin" uniqKey="Gopal R" first="Robin" last="Gopal">Robin Gopal</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Enteric Respiratory and Neurological Virus Laboratory, Health Protection Agency</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
</affiliation>
</author>
<author><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Virology, Bernhard-Nocht Institute for Tropical Medicine</s1>
<s2>Hamburg</s2>
<s3>DEU</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
</affiliation>
</author>
<author><name sortKey="Van Der Werf, Sylvie" sort="Van Der Werf, Sylvie" uniqKey="Van Der Werf S" first="Sylvie" last="Van Der Werf">Sylvie Van Der Werf</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Unité de Génétique Moléculaire des Virus Respiratoires, Institut Pasteur</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Escriou, Nicolas" sort="Escriou, Nicolas" uniqKey="Escriou N" first="Nicolas" last="Escriou">Nicolas Escriou</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Unité de Génétique Moléculaire des Virus Respiratoires, Institut Pasteur</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Manuguerra, Jean Claude" sort="Manuguerra, Jean Claude" uniqKey="Manuguerra J" first="Jean-Claude" last="Manuguerra">Jean-Claude Manuguerra</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Unité de Génétique Moléculaire des Virus Respiratoires, Institut Pasteur</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Stohr, Klaus" sort="Stohr, Klaus" uniqKey="Stohr K" first="Klaus" last="Stöhr">Klaus Stöhr</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>SARS Aetiology Study Group, WHO</s1>
<s2>Geneva</s2>
<s3>CHE</s3>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Suisse</country>
</affiliation>
</author>
<author><name sortKey="Peiris, J S Malik" sort="Peiris, J S Malik" uniqKey="Peiris J" first="J. S. Malik" last="Peiris">J. S. Malik Peiris</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Microbiology and Medicine, Queen Mary Hospital, University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
</affiliation>
</author>
<author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Virology, Erasmus Medical Centre, PO Box 1738</s1>
<s2>3000 DR Rotterdam</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
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</author>
</analytic>
<series><title level="j" type="main">Lancet : (British edition)</title>
<title level="j" type="abbreviated">Lancet : (Br. ed.)</title>
<idno type="ISSN">0140-6736</idno>
<imprint><date when="2003">2003</date>
</imprint>
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<seriesStmt><title level="j" type="main">Lancet : (British edition)</title>
<title level="j" type="abbreviated">Lancet : (Br. ed.)</title>
<idno type="ISSN">0140-6736</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Coronavirus</term>
<term>Human</term>
<term>Severe acute respiratory syndrome</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Coronavirus</term>
<term>Homme</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
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<front><div type="abstract" xml:lang="en">Background The worldwide outbreak of severe acute respiratory syndrome (SARS) is associated with a newly discovered coronavirus, SARS-associated coronavirus (SARS-CoV). We did clinical and experimental studies to assess the role of this virus in the cause of SARS. Methods We tested clinical and postmortem samples from 436 SARS patients in six countries for infection with SARS-CoV, human metapneumovirus, and other respiratory pathogens. We infected four cynomolgus macaques (Macaca fascicularis) with SARS-CoV in an attempt to replicate SARS and did necropsies on day 6 after infection. Findings SARS-CoV infection was diagnosed in 329 (75%) of 436 patients fitting the case definition of SARS; human metapneumovirus was diagnosed in 41 (12%) of 335, and other respiratory pathogens were diagnosed only sporadically. SARS-CoV was, therefore, the most likely causal agent of SARS. The four SARS-CoV-infected macaques excreted SARS-CoV from nose, mouth, and pharynx from 2 days after infection. Three of four macaques developed diffuse alveolar damage, similar to that in SARS patients, and characterised by epithelial necrosis, serosanguineous exudate, formation of hyaline membranes, type 2 pneumocyte hyperplasia, and the presence of syncytia. SARS-CoV was detected in pneumonic areas by virus isolation and RT-PCR, and was localised to alveolar epithelial cells and syncytia by immunohistochemistry and transmission electron microscopy. Interpretation Replication in SARS-CoV-infected macaques of pneumonia similar to that in human beings with SARS, combined with the high prevalence of SARS-CoV infection in SARS patients, fulfill the criteria required to prove that SARS-CoV is the primary cause of SARS.</div>
</front>
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<fA08 i1="01" i2="1" l="ENG"><s1>Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>KUIKEN (This)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>FOUCHIER (Ron A. M.)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>SCHUTTEN (Martin)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>RIMMELZWAAN (Guus F.)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>VAN AMERONGEN (Geert)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>VAN RIEL (Debby)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>LAMAN (Jon D.)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>DE JONG (Ton)</s1>
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<fA11 i1="09" i2="1"><s1>VAN DOORNUM (Gerard)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>LIM (Wilina)</s1>
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<fA11 i1="11" i2="1"><s1>AI EE LING</s1>
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<fA11 i1="12" i2="1"><s1>CHAN (Paul K. S.)</s1>
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<fA11 i1="13" i2="1"><s1>TAM (John S.)</s1>
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<fA11 i1="14" i2="1"><s1>ZAMBON (Maria C.)</s1>
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<fA11 i1="15" i2="1"><s1>GOPAL (Robin)</s1>
</fA11>
<fA11 i1="16" i2="1"><s1>DROSTEN (Christian)</s1>
</fA11>
<fA11 i1="17" i2="1"><s1>VAN DER WERF (Sylvie)</s1>
</fA11>
<fA11 i1="18" i2="1"><s1>ESCRIOU (Nicolas)</s1>
</fA11>
<fA11 i1="19" i2="1"><s1>MANUGUERRA (Jean-Claude)</s1>
</fA11>
<fA11 i1="20" i2="1"><s1>STÖHR (Klaus)</s1>
</fA11>
<fA11 i1="21" i2="1"><s1>PEIRIS (J. S. Malik)</s1>
</fA11>
<fA11 i1="22" i2="1"><s1>OSTERHAUS (Albert D. M. E.)</s1>
</fA11>
<fA14 i1="01"><s1>Department of Virology, Erasmus Medical Centre, PO Box 1738</s1>
<s2>3000 DR Rotterdam</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>22 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Department of Immunology, Erasmus Medical Centre, PO Box 1738</s1>
<s2>3000 DR Rotterdam</s2>
<s3>NLD</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Department of Pathology, Erasmus Medical Centre, PO Box 1738</s1>
<s2>3000 DR Rotterdam</s2>
<s3>NLD</s3>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Government Virus Unit, Public Health Laboratory Centre, Shek Kip Mei, Kowloon, Hong Kong Special Administrative Region</s1>
<s2>Kowloon</s2>
<s3>CHN</s3>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Department of Pathology, Singapore General Hospital</s1>
<s3>SGP</s3>
<sZ>11 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital</s1>
<s3>HKG</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</fA14>
<fA14 i1="07"><s1>Enteric Respiratory and Neurological Virus Laboratory, Health Protection Agency</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
</fA14>
<fA14 i1="08"><s1>Department of Virology, Bernhard-Nocht Institute for Tropical Medicine</s1>
<s2>Hamburg</s2>
<s3>DEU</s3>
<sZ>16 aut.</sZ>
</fA14>
<fA14 i1="09"><s1>Unité de Génétique Moléculaire des Virus Respiratoires, Institut Pasteur</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</fA14>
<fA14 i1="10"><s1>SARS Aetiology Study Group, WHO</s1>
<s2>Geneva</s2>
<s3>CHE</s3>
<sZ>20 aut.</sZ>
</fA14>
<fA14 i1="11"><s1>Department of Microbiology and Medicine, Queen Mary Hospital, University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>21 aut.</sZ>
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<fC01 i1="01" l="ENG"><s0>Background The worldwide outbreak of severe acute respiratory syndrome (SARS) is associated with a newly discovered coronavirus, SARS-associated coronavirus (SARS-CoV). We did clinical and experimental studies to assess the role of this virus in the cause of SARS. Methods We tested clinical and postmortem samples from 436 SARS patients in six countries for infection with SARS-CoV, human metapneumovirus, and other respiratory pathogens. We infected four cynomolgus macaques (Macaca fascicularis) with SARS-CoV in an attempt to replicate SARS and did necropsies on day 6 after infection. Findings SARS-CoV infection was diagnosed in 329 (75%) of 436 patients fitting the case definition of SARS; human metapneumovirus was diagnosed in 41 (12%) of 335, and other respiratory pathogens were diagnosed only sporadically. SARS-CoV was, therefore, the most likely causal agent of SARS. The four SARS-CoV-infected macaques excreted SARS-CoV from nose, mouth, and pharynx from 2 days after infection. Three of four macaques developed diffuse alveolar damage, similar to that in SARS patients, and characterised by epithelial necrosis, serosanguineous exudate, formation of hyaline membranes, type 2 pneumocyte hyperplasia, and the presence of syncytia. SARS-CoV was detected in pneumonic areas by virus isolation and RT-PCR, and was localised to alveolar epithelial cells and syncytia by immunohistochemistry and transmission electron microscopy. Interpretation Replication in SARS-CoV-infected macaques of pneumonia similar to that in human beings with SARS, combined with the high prevalence of SARS-CoV infection in SARS patients, fulfill the criteria required to prove that SARS-CoV is the primary cause of SARS.</s0>
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<s5>03</s5>
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<fC03 i1="03" i2="X" l="FRE"><s0>Syndrome respiratoire aigu sévère</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Severe acute respiratory syndrome</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Appareil respiratoire pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>37</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Poumon pathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Lung disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Pulmón patología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Virose</s0>
<s5>39</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Viral disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Virosis</s0>
<s5>39</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Infection</s0>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Infection</s0>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Infección</s0>
</fC07>
<fN21><s1>328</s1>
</fN21>
<fN82><s1>PSI</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

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   |wiki=    Sante
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   |type=    RBID
   |clé=     Pascal:03-0484722
   |texte=   Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome
}}

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Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome

Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome

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Descripteurs français

English descriptors

Abstract

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