Characterization of a novel coronavirus associated with severe acute respiratory syndrome
Identifieur interne : 000014 ( PascalFrancis/Curation ); précédent : 000013; suivant : 000015Characterization of a novel coronavirus associated with severe acute respiratory syndrome
Auteurs : Paul A. Rota [États-Unis] ; M. Steven Oberste [États-Unis] ; Stephan S. Monroe [États-Unis] ; W. Allan Nix [États-Unis] ; Ray Campagnoli [États-Unis] ; Joseph P. Icenogle [États-Unis] ; Silvia Penaranda [États-Unis] ; Bettina Bankamp [États-Unis] ; Kaija Maher [États-Unis] ; Min-Hsin Chen [États-Unis] ; SUXIONG TONG [États-Unis] ; Azaibi Tamin [États-Unis] ; Luis Lowe [États-Unis] ; Michael Frace [États-Unis] ; Joseph L. Derisi [États-Unis] ; QI CHEN [États-Unis] ; David Wang [États-Unis] ; Dean D. Erdman [États-Unis] ; Teresa C. T. Peret [États-Unis] ; Cara Burns [États-Unis] ; Thomas G. Ksiazek [États-Unis] ; Pierre E. Rollin [États-Unis] ; Anthony Sanchez [États-Unis] ; Stephanie Liffick [États-Unis] ; Brian Holloway [États-Unis] ; Josef Limor [États-Unis] ; Karen Mccaustland [États-Unis] ; Melissa Olsen-Rasmussen [États-Unis] ; Ron Fouchier [Pays-Bas] ; Stephan Günther [Allemagne] ; Albert D. M. E. Osterhaus [Pays-Bas] ; Christian Drosten [Allemagne] ; Mark A. Pallansch [États-Unis] ; Larry J. Anderson [États-Unis] ; William J. Bellini [États-Unis]Source :
- Science : (Washington, D.C.) [ 0036-8075 ] ; 2003.
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Abstract
In March 2003, a novel coronavirus (SARS-CoV) was discovered in association with cases of severe acute respiratory syndrome (SARS). The sequence of the complete genome of SARS-CoV was determined, and the initial characterization of the viral genome is presented in this report. The genome of SARS-CoV is 29,727 nucleotides in length and has 11 open reading frames, and its genome organization is similar to that of other coronaviruses. Phylogenetic analyses and sequence comparisons showed that SARS-CoV is not closely related to any of the previously characterized coronaviruses.
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Rollin</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Sanchez, Anthony" sort="Sanchez, Anthony" uniqKey="Sanchez A" first="Anthony" last="Sanchez">Anthony Sanchez</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>23 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Liffick, Stephanie" sort="Liffick, Stephanie" uniqKey="Liffick S" first="Stephanie" last="Liffick">Stephanie Liffick</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>23 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Holloway, Brian" sort="Holloway, Brian" uniqKey="Holloway B" first="Brian" last="Holloway">Brian Holloway</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>23 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Limor, Josef" sort="Limor, Josef" uniqKey="Limor J" first="Josef" last="Limor">Josef Limor</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>23 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Mccaustland, Karen" sort="Mccaustland, Karen" uniqKey="Mccaustland K" first="Karen" last="Mccaustland">Karen Mccaustland</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>23 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Olsen Rasmussen, Melissa" sort="Olsen Rasmussen, Melissa" uniqKey="Olsen Rasmussen M" first="Melissa" last="Olsen-Rasmussen">Melissa Olsen-Rasmussen</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>23 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Fouchier, Ron" sort="Fouchier, Ron" uniqKey="Fouchier R" first="Ron" last="Fouchier">Ron Fouchier</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Virology, Erasmus University</s1><s2>Rotterdam, 3000 DR</s2><s3>NLD</s3><sZ>29 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>Pays-Bas</country></affiliation></author><author><name sortKey="Gunther, Stephan" sort="Gunther, Stephan" uniqKey="Gunther S" first="Stephan" last="Günther">Stephan Günther</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Virology, Bernhard Nocht Institute for Tropical Medicine</s1><s2>20359 Hamburg</s2><s3>DEU</s3><sZ>30 aut.</sZ><sZ>32 aut.</sZ></inist:fA14><country>Allemagne</country></affiliation></author><author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Virology, Erasmus University</s1><s2>Rotterdam, 3000 DR</s2><s3>NLD</s3><sZ>29 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>Pays-Bas</country></affiliation></author><author><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Virology, Bernhard Nocht Institute for Tropical Medicine</s1><s2>20359 Hamburg</s2><s3>DEU</s3><sZ>30 aut.</sZ><sZ>32 aut.</sZ></inist:fA14><country>Allemagne</country></affiliation></author><author><name sortKey="Pallansch, Mark A" sort="Pallansch, Mark A" uniqKey="Pallansch M" first="Mark A." last="Pallansch">Mark A. Pallansch</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>23 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Anderson, Larry J" sort="Anderson, Larry J" uniqKey="Anderson L" first="Larry J." last="Anderson">Larry J. Anderson</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>23 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Bellini, William J" sort="Bellini, William J" uniqKey="Bellini W" first="William J." last="Bellini">William J. Bellini</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>23 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">03-0339876</idno><date when="2003">2003</date><idno type="stanalyst">PASCAL 03-0339876 INIST</idno><idno type="RBID">Pascal:03-0339876</idno><idno type="wicri:Area/PascalFrancis/Corpus">000977</idno><idno type="wicri:Area/PascalFrancis/Curation">000014</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Characterization of a novel coronavirus associated with severe acute respiratory syndrome</title><author><name sortKey="Rota, Paul A" sort="Rota, Paul A" uniqKey="Rota P" first="Paul A." last="Rota">Paul A. Rota</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Oberste, M Steven" sort="Oberste, M Steven" uniqKey="Oberste M" first="M. Steven" last="Oberste">M. Steven Oberste</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Monroe, Stephan S" sort="Monroe, Stephan S" uniqKey="Monroe S" first="Stephan S." last="Monroe">Stephan S. Monroe</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Nix, W Allan" sort="Nix, W Allan" uniqKey="Nix W" first="W. Allan" last="Nix">W. Allan Nix</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Campagnoli, Ray" sort="Campagnoli, Ray" uniqKey="Campagnoli R" first="Ray" last="Campagnoli">Ray Campagnoli</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Icenogle, Joseph P" sort="Icenogle, Joseph P" uniqKey="Icenogle J" first="Joseph P." last="Icenogle">Joseph P. Icenogle</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Penaranda, Silvia" sort="Penaranda, Silvia" uniqKey="Penaranda S" first="Silvia" last="Penaranda">Silvia Penaranda</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Bankamp, Bettina" sort="Bankamp, Bettina" uniqKey="Bankamp B" first="Bettina" last="Bankamp">Bettina Bankamp</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Maher, Kaija" sort="Maher, Kaija" uniqKey="Maher K" first="Kaija" last="Maher">Kaija Maher</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Chen, Min Hsin" sort="Chen, Min Hsin" uniqKey="Chen M" first="Min-Hsin" last="Chen">Min-Hsin Chen</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Suxiong Tong" sort="Suxiong Tong" uniqKey="Suxiong Tong" last="Suxiong Tong">SUXIONG TONG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Tamin, Azaibi" sort="Tamin, Azaibi" uniqKey="Tamin A" first="Azaibi" last="Tamin">Azaibi Tamin</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Lowe, Luis" sort="Lowe, Luis" uniqKey="Lowe L" first="Luis" last="Lowe">Luis Lowe</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Frace, Michael" sort="Frace, Michael" uniqKey="Frace M" first="Michael" last="Frace">Michael Frace</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Derisi, Joseph L" sort="Derisi, Joseph L" uniqKey="Derisi J" first="Joseph L." last="Derisi">Joseph L. 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Erdman</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Peret, Teresa C T" sort="Peret, Teresa C T" uniqKey="Peret T" first="Teresa C. T." last="Peret">Teresa C. T. Peret</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Burns, Cara" sort="Burns, Cara" uniqKey="Burns C" first="Cara" last="Burns">Cara Burns</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Ksiazek, Thomas G" sort="Ksiazek, Thomas G" uniqKey="Ksiazek T" first="Thomas G." last="Ksiazek">Thomas G. Ksiazek</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Rollin, Pierre E" sort="Rollin, Pierre E" uniqKey="Rollin P" first="Pierre E." last="Rollin">Pierre E. Rollin</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Sanchez, Anthony" sort="Sanchez, Anthony" uniqKey="Sanchez A" first="Anthony" last="Sanchez">Anthony Sanchez</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>23 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Liffick, Stephanie" sort="Liffick, Stephanie" uniqKey="Liffick S" first="Stephanie" last="Liffick">Stephanie Liffick</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>23 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Holloway, Brian" sort="Holloway, Brian" uniqKey="Holloway B" first="Brian" last="Holloway">Brian Holloway</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>23 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Limor, Josef" sort="Limor, Josef" uniqKey="Limor J" first="Josef" last="Limor">Josef Limor</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>23 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Mccaustland, Karen" sort="Mccaustland, Karen" uniqKey="Mccaustland K" first="Karen" last="Mccaustland">Karen Mccaustland</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>23 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Olsen Rasmussen, Melissa" sort="Olsen Rasmussen, Melissa" uniqKey="Olsen Rasmussen M" first="Melissa" last="Olsen-Rasmussen">Melissa Olsen-Rasmussen</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>23 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Fouchier, Ron" sort="Fouchier, Ron" uniqKey="Fouchier R" first="Ron" last="Fouchier">Ron Fouchier</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Virology, Erasmus University</s1><s2>Rotterdam, 3000 DR</s2><s3>NLD</s3><sZ>29 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>Pays-Bas</country></affiliation></author><author><name sortKey="Gunther, Stephan" sort="Gunther, Stephan" uniqKey="Gunther S" first="Stephan" last="Günther">Stephan Günther</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Virology, Bernhard Nocht Institute for Tropical Medicine</s1><s2>20359 Hamburg</s2><s3>DEU</s3><sZ>30 aut.</sZ><sZ>32 aut.</sZ></inist:fA14><country>Allemagne</country></affiliation></author><author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Virology, Erasmus University</s1><s2>Rotterdam, 3000 DR</s2><s3>NLD</s3><sZ>29 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>Pays-Bas</country></affiliation></author><author><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Virology, Bernhard Nocht Institute for Tropical Medicine</s1><s2>20359 Hamburg</s2><s3>DEU</s3><sZ>30 aut.</sZ><sZ>32 aut.</sZ></inist:fA14><country>Allemagne</country></affiliation></author><author><name sortKey="Pallansch, Mark A" sort="Pallansch, Mark A" uniqKey="Pallansch M" first="Mark A." last="Pallansch">Mark A. Pallansch</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>23 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Anderson, Larry J" sort="Anderson, Larry J" uniqKey="Anderson L" first="Larry J." last="Anderson">Larry J. Anderson</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>23 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Bellini, William J" sort="Bellini, William J" uniqKey="Bellini W" first="William J." last="Bellini">William J. Bellini</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>23 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author></analytic><series><title level="j" type="main">Science : (Washington, D.C.)</title><title level="j" type="abbreviated">Science : (Wash. D.C.)</title><idno type="ISSN">0036-8075</idno><imprint><date when="2003">2003</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Science : (Washington, D.C.)</title><title level="j" type="abbreviated">Science : (Wash. D.C.)</title><idno type="ISSN">0036-8075</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Coronavirus</term><term>Genetic distance</term><term>Genome</term><term>Genome organization</term><term>Nucleotide sequence</term><term>Phylogeny</term><term>Severe acute respiratory syndrome</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Coronavirus</term><term>Génome</term><term>Séquence nucléotide</term><term>Organisation génome</term><term>Phylogenèse</term><term>Distance génétique</term><term>Syndrome respiratoire aigu sévère</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In March 2003, a novel coronavirus (SARS-CoV) was discovered in association with cases of severe acute respiratory syndrome (SARS). The sequence of the complete genome of SARS-CoV was determined, and the initial characterization of the viral genome is presented in this report. The genome of SARS-CoV is 29,727 nucleotides in length and has 11 open reading frames, and its genome organization is similar to that of other coronaviruses. Phylogenetic analyses and sequence comparisons showed that SARS-CoV is not closely related to any of the previously characterized coronaviruses.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0036-8075</s0></fA01><fA02 i1="01"><s0>SCIEAS</s0></fA02><fA03 i2="1"><s0>Science : (Wash. D.C.)</s0></fA03><fA05><s2>300</s2></fA05><fA06><s2>5624</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Characterization of a novel coronavirus associated with severe acute respiratory syndrome</s1></fA08><fA11 i1="01" i2="1"><s1>ROTA (Paul A.)</s1></fA11><fA11 i1="02" i2="1"><s1>OBERSTE (M. Steven)</s1></fA11><fA11 i1="03" i2="1"><s1>MONROE (Stephan S.)</s1></fA11><fA11 i1="04" i2="1"><s1>NIX (W. Allan)</s1></fA11><fA11 i1="05" i2="1"><s1>CAMPAGNOLI (Ray)</s1></fA11><fA11 i1="06" i2="1"><s1>ICENOGLE (Joseph P.)</s1></fA11><fA11 i1="07" i2="1"><s1>PENARANDA (Silvia)</s1></fA11><fA11 i1="08" i2="1"><s1>BANKAMP (Bettina)</s1></fA11><fA11 i1="09" i2="1"><s1>MAHER (Kaija)</s1></fA11><fA11 i1="10" i2="1"><s1>CHEN (Min-Hsin)</s1></fA11><fA11 i1="11" i2="1"><s1>SUXIONG TONG</s1></fA11><fA11 i1="12" i2="1"><s1>TAMIN (Azaibi)</s1></fA11><fA11 i1="13" i2="1"><s1>LOWE (Luis)</s1></fA11><fA11 i1="14" i2="1"><s1>FRACE (Michael)</s1></fA11><fA11 i1="15" i2="1"><s1>DERISI (Joseph L.)</s1></fA11><fA11 i1="16" i2="1"><s1>QI CHEN</s1></fA11><fA11 i1="17" i2="1"><s1>WANG (David)</s1></fA11><fA11 i1="18" i2="1"><s1>ERDMAN (Dean D.)</s1></fA11><fA11 i1="19" i2="1"><s1>PERET (Teresa C. T.)</s1></fA11><fA11 i1="20" i2="1"><s1>BURNS (Cara)</s1></fA11><fA11 i1="21" i2="1"><s1>KSIAZEK (Thomas G.)</s1></fA11><fA11 i1="22" i2="1"><s1>ROLLIN (Pierre E.)</s1></fA11><fA11 i1="23" i2="1"><s1>SANCHEZ (Anthony)</s1></fA11><fA11 i1="24" i2="1"><s1>LIFFICK (Stephanie)</s1></fA11><fA11 i1="25" i2="1"><s1>HOLLOWAY (Brian)</s1></fA11><fA11 i1="26" i2="1"><s1>LIMOR (Josef)</s1></fA11><fA11 i1="27" i2="1"><s1>MCCAUSTLAND (Karen)</s1></fA11><fA11 i1="28" i2="1"><s1>OLSEN-RASMUSSEN (Melissa)</s1></fA11><fA11 i1="29" i2="1"><s1>FOUCHIER (Ron)</s1></fA11><fA11 i1="30" i2="1"><s1>GÜNTHER (Stephan)</s1></fA11><fA11 i1="31" i2="1"><s1>OSTERHAUS (Albert D. M. E.)</s1></fA11><fA11 i1="32" i2="1"><s1>DROSTEN (Christian)</s1></fA11><fA11 i1="33" i2="1"><s1>PALLANSCH (Mark A.)</s1></fA11><fA11 i1="34" i2="1"><s1>ANDERSON (Larry J.)</s1></fA11><fA11 i1="35" i2="1"><s1>BELLINI (William J.)</s1></fA11><fA14 i1="01"><s1>National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></fA14><fA14 i1="02"><s1>Departments of Biochemistry and Biophysics, University of California-San Francisco</s1><s2>San Francisco, CA 94143</s2><s3>USA</s3><sZ>15 aut.</sZ><sZ>17 aut.</sZ></fA14><fA14 i1="03"><s1>National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>23 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>28 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></fA14><fA14 i1="04"><s1>Department of Virology, Erasmus University</s1><s2>Rotterdam, 3000 DR</s2><s3>NLD</s3><sZ>29 aut.</sZ><sZ>31 aut.</sZ></fA14><fA14 i1="05"><s1>Department of Virology, Bernhard Nocht Institute for Tropical Medicine</s1><s2>20359 Hamburg</s2><s3>DEU</s3><sZ>30 aut.</sZ><sZ>32 aut.</sZ></fA14><fA20><s1>1394-1399</s1></fA20><fA21><s1>2003</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>6040</s2><s5>354000118350720150</s5></fA43><fA44><s0>0000</s0><s1>© 2003 INIST-CNRS. All rights reserved.</s1></fA44><fA47 i1="01" i2="1"><s0>03-0339876</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Science : (Washington, D.C.)</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fA99><s0>1/2 p. ref. et notes</s0></fA99><fC01 i1="01" l="ENG"><s0>In March 2003, a novel coronavirus (SARS-CoV) was discovered in association with cases of severe acute respiratory syndrome (SARS). The sequence of the complete genome of SARS-CoV was determined, and the initial characterization of the viral genome is presented in this report. The genome of SARS-CoV is 29,727 nucleotides in length and has 11 open reading frames, and its genome organization is similar to that of other coronaviruses. Phylogenetic analyses and sequence comparisons showed that SARS-CoV is not closely related to any of the previously characterized coronaviruses.</s0></fC01><fC02 i1="01" i2="X"><s0>002A05C05</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Coronavirus</s0><s2>NW</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Coronavirus</s0><s2>NW</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Coronavirus</s0><s2>NW</s2><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Génome</s0><s5>05</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Genome</s0><s5>05</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Genoma</s0><s5>05</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Séquence nucléotide</s0><s5>06</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Nucleotide sequence</s0><s5>06</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Secuencia nucleótido</s0><s5>06</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Organisation génome</s0><s5>07</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Genome organization</s0><s5>07</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Organización genoma</s0><s5>07</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Phylogenèse</s0><s5>08</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Phylogeny</s0><s5>08</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Filogénesis</s0><s5>08</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Distance génétique</s0><s5>09</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Genetic distance</s0><s5>09</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Distancia genética</s0><s5>09</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Syndrome respiratoire aigu sévère</s0><s4>CD</s4><s5>97</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Severe acute respiratory syndrome</s0><s4>CD</s4><s5>97</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Coronaviridae</s0><s2>NW</s2></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Coronaviridae</s0><s2>NW</s2></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Coronaviridae</s0><s2>NW</s2></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Nidovirales</s0><s2>NW</s2></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Nidovirales</s0><s2>NW</s2></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Nidovirales</s0><s2>NW</s2></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Virus</s0><s2>NW</s2></fC07><fN21><s1>237</s1></fN21><fN82><s1>PSI</s1></fN82></pA></standard></inist></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Characterization of a novel coronavirus associated with severe acute respiratory syndrome
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