SrasV1, PascalFrancis, Corpus, bibRecord, 000720

Identification of two neutralizing regions on the severe acute respiratory syndrome coronavirus Spike glycoprotein produced from the mammalian expression system

Identifieur interne : 000720 ( PascalFrancis/Corpus ); précédent : 000719; suivant : 000721

Identification of two neutralizing regions on the severe acute respiratory syndrome coronavirus Spike glycoprotein produced from the mammalian expression system

Auteurs : SHIXIA WANG ; Te-Hui W. Chou ; Pavlo V. Sakhatskyy ; SONG HUANG ; John M. Lawrence ; HONG CAO ; XIAOYUN HUANG ; SHAN LU

Source :

Journal of virology [ 0022-538X ] ; 2005.

RBID : Pascal:05-0133038

Descripteurs français

Pascal (Inist)
- Coronavirus, Mammalia, Identification, Glycoprotéine, Microbiologie, Virologie, Syndrome respiratoire aigu sévère.

English descriptors

KwdEn :
- Coronavirus, Glycoprotein, Identification, Mammalia, Microbiology, Severe acute respiratory syndrome, Virology.

Abstract

The Spike (S) protein of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) plays important roles in viral pathogenesis and potentially in the development of an effective vaccine against this virulent infectious disease. In this study, the codon-optimized S gene of SARS-CoV was synthesized to construct DNA vaccine plasmids expressing either the full-length or segments of the S protein. High titer S-specific immunoglobulin G antibody responses were elicited in rabbits immunized with DNA against various segments of the S protein. Two neutralizing domains were identified on the S protein, one at the N terminus (Ser12-Thr535) and the other near the C terminus (Arg797-Ile1192).

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A03		`1`		`@0 J. virol.`
A05				`@2 79`
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A08	`01`	`1`	`ENG`	`@1 Identification of two neutralizing regions on the severe acute respiratory syndrome coronavirus Spike glycoprotein produced from the mammalian expression system`
A11	`01`	`1`		`@1 SHIXIA WANG`
A11	`02`	`1`		`@1 CHOU (Te-Hui W.)`
A11	`03`	`1`		`@1 SAKHATSKYY (Pavlo V.)`
A11	`04`	`1`		`@1 SONG HUANG`
A11	`05`	`1`		`@1 LAWRENCE (John M.)`
A11	`06`	`1`		`@1 HONG CAO`
A11	`07`	`1`		`@1 XIAOYUN HUANG`
A11	`08`	`1`		`@1 SHAN LU`
A14	`01`			`@1 Laboratory of Nucleic Acid Vaccines, Department of Medicine, University of Massachusetts Medical School @2 Worcester, Massachusetts @3 USA @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut. @Z 7 aut. @Z 8 aut.`
A20				`@1 1906-1910`
A21				`@1 2005`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 13592 @5 354000127060900550`
A44				`@0 0000 @1 © 2005 INIST-CNRS. All rights reserved.`
A45				`@0 29 ref.`
A47	`01`	`1`		`@0 05-0133038`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Journal of virology`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 The Spike (S) protein of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) plays important roles in viral pathogenesis and potentially in the development of an effective vaccine against this virulent infectious disease. In this study, the codon-optimized S gene of SARS-CoV was synthesized to construct DNA vaccine plasmids expressing either the full-length or segments of the S protein. High titer S-specific immunoglobulin G antibody responses were elicited in rabbits immunized with DNA against various segments of the S protein. Two neutralizing domains were identified on the S protein, one at the N terminus (Ser12-Thr535) and the other near the C terminus (Arg797-Ile1192).
C02	`01`	`X`		`@0 002A05C10`
C03	`01`	`X`	`FRE`	`@0 Coronavirus @2 NW @5 01`
C03	`01`	`X`	`ENG`	`@0 Coronavirus @2 NW @5 01`
C03	`01`	`X`	`SPA`	`@0 Coronavirus @2 NW @5 01`
C03	`02`	`X`	`FRE`	`@0 Mammalia @2 NS @5 02`
C03	`02`	`X`	`ENG`	`@0 Mammalia @2 NS @5 02`
C03	`02`	`X`	`SPA`	`@0 Mammalia @2 NS @5 02`
C03	`03`	`X`	`FRE`	`@0 Identification @5 05`
C03	`03`	`X`	`ENG`	`@0 Identification @5 05`
C03	`03`	`X`	`SPA`	`@0 Identificación @5 05`
C03	`04`	`X`	`FRE`	`@0 Glycoprotéine @5 06`
C03	`04`	`X`	`ENG`	`@0 Glycoprotein @5 06`
C03	`04`	`X`	`SPA`	`@0 Glicoproteína @5 06`
C03	`05`	`X`	`FRE`	`@0 Microbiologie @5 07`
C03	`05`	`X`	`ENG`	`@0 Microbiology @5 07`
C03	`05`	`X`	`SPA`	`@0 Microbiología @5 07`
C03	`06`	`X`	`FRE`	`@0 Virologie @5 08`
C03	`06`	`X`	`ENG`	`@0 Virology @5 08`
C03	`06`	`X`	`SPA`	`@0 Virología @5 08`
C03	`07`	`X`	`FRE`	`@0 Syndrome respiratoire aigu sévère @2 NM @5 14`
C03	`07`	`X`	`ENG`	`@0 Severe acute respiratory syndrome @2 NM @5 14`
C03	`07`	`X`	`SPA`	`@0 Síndrome respiratorio agudo severo @2 NM @5 14`
C07	`01`	`X`	`FRE`	`@0 Coronaviridae @2 NW`
C07	`01`	`X`	`ENG`	`@0 Coronaviridae @2 NW`
C07	`01`	`X`	`SPA`	`@0 Coronaviridae @2 NW`
C07	`02`	`X`	`FRE`	`@0 Nidovirales @2 NW`
C07	`02`	`X`	`ENG`	`@0 Nidovirales @2 NW`
C07	`02`	`X`	`SPA`	`@0 Nidovirales @2 NW`
C07	`03`	`X`	`FRE`	`@0 Virus @2 NW`
C07	`03`	`X`	`ENG`	`@0 Virus @2 NW`
C07	`03`	`X`	`SPA`	`@0 Virus @2 NW`
C07	`04`	`X`	`FRE`	`@0 Vertebrata @2 NS`
C07	`04`	`X`	`ENG`	`@0 Vertebrata @2 NS`
C07	`04`	`X`	`SPA`	`@0 Vertebrata @2 NS`
C07	`05`	`X`	`FRE`	`@0 Appareil respiratoire pathologie @5 13`
C07	`05`	`X`	`ENG`	`@0 Respiratory disease @5 13`
C07	`05`	`X`	`SPA`	`@0 Aparato respiratorio patología @5 13`
C07	`06`	`X`	`FRE`	`@0 Virose`
C07	`06`	`X`	`ENG`	`@0 Viral disease`
C07	`06`	`X`	`SPA`	`@0 Virosis`
C07	`07`	`X`	`FRE`	`@0 Infection`
C07	`07`	`X`	`ENG`	`@0 Infection`
C07	`07`	`X`	`SPA`	`@0 Infección`
C07	`08`	`X`	`FRE`	`@0 Poumon pathologie @5 16`
C07	`08`	`X`	`ENG`	`@0 Lung disease @5 16`
C07	`08`	`X`	`SPA`	`@0 Pulmón patología @5 16`
N21				`@1 087`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 05-0133038 INIST
ET :	Identification of two neutralizing regions on the severe acute respiratory syndrome coronavirus Spike glycoprotein produced from the mammalian expression system
AU :	SHIXIA WANG; CHOU (Te-Hui W.); SAKHATSKYY (Pavlo V.); SONG HUANG; LAWRENCE (John M.); HONG CAO; XIAOYUN HUANG; SHAN LU
AF :	Laboratory of Nucleic Acid Vaccines, Department of Medicine, University of Massachusetts Medical School/Worcester, Massachusetts/Etats-Unis (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut., 8 aut.)
DT :	Publication en série; Niveau analytique
SO :	Journal of virology; ISSN 0022-538X; Etats-Unis; Da. 2005; Vol. 79; No. 3; Pp. 1906-1910; Bibl. 29 ref.
LA :	Anglais
EA :	The Spike (S) protein of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) plays important roles in viral pathogenesis and potentially in the development of an effective vaccine against this virulent infectious disease. In this study, the codon-optimized S gene of SARS-CoV was synthesized to construct DNA vaccine plasmids expressing either the full-length or segments of the S protein. High titer S-specific immunoglobulin G antibody responses were elicited in rabbits immunized with DNA against various segments of the S protein. Two neutralizing domains were identified on the S protein, one at the N terminus (Ser12-Thr535) and the other near the C terminus (Arg797-Ile1192).
CC :	002A05C10
FD :	Coronavirus; Mammalia; Identification; Glycoprotéine; Microbiologie; Virologie; Syndrome respiratoire aigu sévère
FG :	Coronaviridae; Nidovirales; Virus; Vertebrata; Appareil respiratoire pathologie; Virose; Infection; Poumon pathologie
ED :	Coronavirus; Mammalia; Identification; Glycoprotein; Microbiology; Virology; Severe acute respiratory syndrome
EG :	Coronaviridae; Nidovirales; Virus; Vertebrata; Respiratory disease; Viral disease; Infection; Lung disease
SD :	Coronavirus; Mammalia; Identificación; Glicoproteína; Microbiología; Virología; Síndrome respiratorio agudo severo
LO :	INIST-13592.354000127060900550
ID :	05-0133038

Links to Exploration step

Pascal:05-0133038

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Identification of two neutralizing regions on the severe acute respiratory syndrome coronavirus Spike glycoprotein produced from the mammalian expression system</title>
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<series><title level="j" type="main">Journal of virology</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Coronavirus</term>
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<front><div type="abstract" xml:lang="en">The Spike (S) protein of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) plays important roles in viral pathogenesis and potentially in the development of an effective vaccine against this virulent infectious disease. In this study, the codon-optimized S gene of SARS-CoV was synthesized to construct DNA vaccine plasmids expressing either the full-length or segments of the S protein. High titer S-specific immunoglobulin G antibody responses were elicited in rabbits immunized with DNA against various segments of the S protein. Two neutralizing domains were identified on the S protein, one at the N terminus (Ser12-Thr535) and the other near the C terminus (Arg797-Ile1192).</div>
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<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0022-538X</s0>
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<fA08 i1="01" i2="1" l="ENG"><s1>Identification of two neutralizing regions on the severe acute respiratory syndrome coronavirus Spike glycoprotein produced from the mammalian expression system</s1>
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<fA11 i1="01" i2="1"><s1>SHIXIA WANG</s1>
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<fA11 i1="02" i2="1"><s1>CHOU (Te-Hui W.)</s1>
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<fA11 i1="03" i2="1"><s1>SAKHATSKYY (Pavlo V.)</s1>
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<fA11 i1="04" i2="1"><s1>SONG HUANG</s1>
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<fA11 i1="06" i2="1"><s1>HONG CAO</s1>
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<fA11 i1="07" i2="1"><s1>XIAOYUN HUANG</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>SHAN LU</s1>
</fA11>
<fA14 i1="01"><s1>Laboratory of Nucleic Acid Vaccines, Department of Medicine, University of Massachusetts Medical School</s1>
<s2>Worcester, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</fA14>
<fA20><s1>1906-1910</s1>
</fA20>
<fA21><s1>2005</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>13592</s2>
<s5>354000127060900550</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2005 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>29 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>05-0133038</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Journal of virology</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>The Spike (S) protein of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) plays important roles in viral pathogenesis and potentially in the development of an effective vaccine against this virulent infectious disease. In this study, the codon-optimized S gene of SARS-CoV was synthesized to construct DNA vaccine plasmids expressing either the full-length or segments of the S protein. High titer S-specific immunoglobulin G antibody responses were elicited in rabbits immunized with DNA against various segments of the S protein. Two neutralizing domains were identified on the S protein, one at the N terminus (Ser12-Thr535) and the other near the C terminus (Arg797-Ile1192).</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002A05C10</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Mammalia</s0>
<s2>NS</s2>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Mammalia</s0>
<s2>NS</s2>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Mammalia</s0>
<s2>NS</s2>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Identification</s0>
<s5>05</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Identification</s0>
<s5>05</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Identificación</s0>
<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Glycoprotéine</s0>
<s5>06</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Glycoprotein</s0>
<s5>06</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Glicoproteína</s0>
<s5>06</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Microbiologie</s0>
<s5>07</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Microbiology</s0>
<s5>07</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Microbiología</s0>
<s5>07</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Virologie</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Virology</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Virología</s0>
<s5>08</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Syndrome respiratoire aigu sévère</s0>
<s2>NM</s2>
<s5>14</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Severe acute respiratory syndrome</s0>
<s2>NM</s2>
<s5>14</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Síndrome respiratorio agudo severo</s0>
<s2>NM</s2>
<s5>14</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Appareil respiratoire pathologie</s0>
<s5>13</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>13</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0>
<s5>13</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Virose</s0>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Viral disease</s0>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Virosis</s0>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Infection</s0>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Infection</s0>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Infección</s0>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Poumon pathologie</s0>
<s5>16</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Lung disease</s0>
<s5>16</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Pulmón patología</s0>
<s5>16</s5>
</fC07>
<fN21><s1>087</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 05-0133038 INIST</NO>
<ET>Identification of two neutralizing regions on the severe acute respiratory syndrome coronavirus Spike glycoprotein produced from the mammalian expression system</ET>
<AU>SHIXIA WANG; CHOU (Te-Hui W.); SAKHATSKYY (Pavlo V.); SONG HUANG; LAWRENCE (John M.); HONG CAO; XIAOYUN HUANG; SHAN LU</AU>
<AF>Laboratory of Nucleic Acid Vaccines, Department of Medicine, University of Massachusetts Medical School/Worcester, Massachusetts/Etats-Unis (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut., 8 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Journal of virology; ISSN 0022-538X; Etats-Unis; Da. 2005; Vol. 79; No. 3; Pp. 1906-1910; Bibl. 29 ref.</SO>
<LA>Anglais</LA>
<EA>The Spike (S) protein of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) plays important roles in viral pathogenesis and potentially in the development of an effective vaccine against this virulent infectious disease. In this study, the codon-optimized S gene of SARS-CoV was synthesized to construct DNA vaccine plasmids expressing either the full-length or segments of the S protein. High titer S-specific immunoglobulin G antibody responses were elicited in rabbits immunized with DNA against various segments of the S protein. Two neutralizing domains were identified on the S protein, one at the N terminus (Ser12-Thr535) and the other near the C terminus (Arg797-Ile1192).</EA>
<CC>002A05C10</CC>
<FD>Coronavirus; Mammalia; Identification; Glycoprotéine; Microbiologie; Virologie; Syndrome respiratoire aigu sévère</FD>
<FG>Coronaviridae; Nidovirales; Virus; Vertebrata; Appareil respiratoire pathologie; Virose; Infection; Poumon pathologie</FG>
<ED>Coronavirus; Mammalia; Identification; Glycoprotein; Microbiology; Virology; Severe acute respiratory syndrome</ED>
<EG>Coronaviridae; Nidovirales; Virus; Vertebrata; Respiratory disease; Viral disease; Infection; Lung disease</EG>
<SD>Coronavirus; Mammalia; Identificación; Glicoproteína; Microbiología; Virología; Síndrome respiratorio agudo severo</SD>
<LO>INIST-13592.354000127060900550</LO>
<ID>05-0133038</ID>
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Identification of two neutralizing regions on the severe acute respiratory syndrome coronavirus Spike glycoprotein produced from the mammalian expression system

Identification of two neutralizing regions on the severe acute respiratory syndrome coronavirus Spike glycoprotein produced from the mammalian expression system

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