SrasV1, PascalFrancis, Corpus, bibRecord, 000695

Function of HAbl8G/CD147 in invasion of host cells by severe acute respiratory syndrome coronavirus

Identifieur interne : 000695 ( PascalFrancis/Corpus ); précédent : 000694; suivant : 000696

Function of HAbl8G/CD147 in invasion of host cells by severe acute respiratory syndrome coronavirus

Auteurs : ZHINAN CHEN ; LI MI ; JING XU ; JIYUN YU ; XIANHUI WANG ; JIANLI JIANG ; JINLIANG XING ; PENG SHANG ; AIRONG QIAN ; YU LI ; Peter X. Shaw ; JIANWEI WANG ; SHUMIN DUAN ; JIN DING ; CHUNMEI FAN ; YANG ZHANG ; YONG YANG ; XIAOLING YU ; QIANG FENG ; BIEHU LI ; XIYING YAO ; ZHENG ZHANG ; LING LI ; XIAOPING XUE ; PING ZHU

Source :

The Journal of infectious diseases [ 0022-1899 ] ; 2005.

RBID : Pascal:05-0213138

Descripteurs français

Pascal (Inist)
- Coronavirus, Microbiologie, Infection, Syndrome respiratoire aigu sévère.

English descriptors

KwdEn :
- Coronavirus, Infection, Microbiology, Severe acute respiratory syndrome.

Abstract

To identify the function of HAb18G/CD147 in invasion of host cells by severe acute respiratory syndrome (SARS) coronavirus (CoV), we analyzed the protein-protein interaction among HAbl8G/CD147, cyclophilin A (CyPA), and SARS-CoV structural proteins by coimmunoprecipitation and surface plasmon resonance analysis. Although none of the SARS-CoV proteins was found to be directly bound to HAbl8G/CD147, the nu-cleocapsid (N) protein of SARS-CoV was bound to CyPA, which interacted with HAb18G/CD147. Further research showed that HAbl8G/CD147, a transmembrane molecule, was highly expressed on 293 cells and that CyPA was integrated with SARS-CoV. HAb18G/CD147-antagonistic peptide (AP)-9, an AP of HAb18G/CD147, had a high rate of binding to 293 cells and an inhibitory effect on SARS-CoV. These results show that HAb18G/ CD147, mediated by CyPA bound to SARS-CoV N protein, plays a functional role in facilitating invasion of host cells by SARS-CoV. Our findings provide some evidence for the cytologic mechanism of invasion by SARS-CoV and provide a molecular basis for screening anti-SARS drugs.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A08	`01`	`1`	`ENG`	`@1 Function of HAbl8G/CD147 in invasion of host cells by severe acute respiratory syndrome coronavirus`
A11	`01`	`1`		`@1 ZHINAN CHEN`
A11	`02`	`1`		`@1 LI MI`
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A11	`07`	`1`		`@1 JINLIANG XING`
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A11	`13`	`1`		`@1 SHUMIN DUAN`
A11	`14`	`1`		`@1 JIN DING`
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A11	`16`	`1`		`@1 YANG ZHANG`
A11	`17`	`1`		`@1 YONG YANG`
A11	`18`	`1`		`@1 XIAOLING YU`
A11	`19`	`1`		`@1 QIANG FENG`
A11	`20`	`1`		`@1 BIEHU LI`
A11	`21`	`1`		`@1 XIYING YAO`
A11	`22`	`1`		`@1 ZHENG ZHANG`
A11	`23`	`1`		`@1 LING LI`
A11	`24`	`1`		`@1 XIAOPING XUE`
A11	`25`	`1`		`@1 PING ZHU`
A14	`01`			`@1 Department of Cell Biology, the Fourth Military Medical University @3 CAN @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 5 aut. @Z 6 aut. @Z 7 aut. @Z 8 aut. @Z 9 aut. @Z 10 aut. @Z 16 aut. @Z 17 aut. @Z 18 aut. @Z 19 aut. @Z 20 aut. @Z 21 aut. @Z 22 aut. @Z 23 aut. @Z 24 aut.`
A14	`02`			`@1 Institute of Basic Medical Sciences, Academy of Military Medical Sciences @3 CHN @Z 4 aut.`
A14	`03`			`@1 Department of Molecular Medicine, University of California, San Diego @2 San Diego @3 USA @Z 11 aut.`
A14	`04`			`@1 Institute of Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention @2 Beijing @3 CHN @Z 12 aut. @Z 13 aut.`
A14	`05`			`@1 Department of Clinical Immunology, Xijing Hospital, the Fourth Military Medical University @2 Xi'an @3 CHN @Z 14 aut. @Z 15 aut. @Z 25 aut.`
A20				`@1 755-760`
A21				`@1 2005`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 2052 @5 354000125691260150`
A44				`@0 0000 @1 © 2005 INIST-CNRS. All rights reserved.`
A45				`@0 36 ref.`
A47	`01`	`1`		`@0 05-0213138`
A60				`@1 P`
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A64	`01`	`1`		`@0 The Journal of infectious diseases`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 To identify the function of HAb18G/CD147 in invasion of host cells by severe acute respiratory syndrome (SARS) coronavirus (CoV), we analyzed the protein-protein interaction among HAbl8G/CD147, cyclophilin A (CyPA), and SARS-CoV structural proteins by coimmunoprecipitation and surface plasmon resonance analysis. Although none of the SARS-CoV proteins was found to be directly bound to HAbl8G/CD147, the nu-cleocapsid (N) protein of SARS-CoV was bound to CyPA, which interacted with HAb18G/CD147. Further research showed that HAbl8G/CD147, a transmembrane molecule, was highly expressed on 293 cells and that CyPA was integrated with SARS-CoV. HAb18G/CD147-antagonistic peptide (AP)-9, an AP of HAb18G/CD147, had a high rate of binding to 293 cells and an inhibitory effect on SARS-CoV. These results show that HAb18G/ CD147, mediated by CyPA bound to SARS-CoV N protein, plays a functional role in facilitating invasion of host cells by SARS-CoV. Our findings provide some evidence for the cytologic mechanism of invasion by SARS-CoV and provide a molecular basis for screening anti-SARS drugs.
C02	`01`	`X`		`@0 002A05C10`
C02	`02`	`X`		`@0 002B05`
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C03	`01`	`X`	`ENG`	`@0 Coronavirus @2 NW @5 01`
C03	`01`	`X`	`SPA`	`@0 Coronavirus @2 NW @5 01`
C03	`02`	`X`	`FRE`	`@0 Microbiologie @5 05`
C03	`02`	`X`	`ENG`	`@0 Microbiology @5 05`
C03	`02`	`X`	`SPA`	`@0 Microbiología @5 05`
C03	`03`	`X`	`FRE`	`@0 Infection @5 06`
C03	`03`	`X`	`ENG`	`@0 Infection @5 06`
C03	`03`	`X`	`SPA`	`@0 Infección @5 06`
C03	`04`	`X`	`FRE`	`@0 Syndrome respiratoire aigu sévère @2 NM @5 14`
C03	`04`	`X`	`ENG`	`@0 Severe acute respiratory syndrome @2 NM @5 14`
C03	`04`	`X`	`SPA`	`@0 Síndrome respiratorio agudo severo @2 NM @5 14`
C07	`01`	`X`	`FRE`	`@0 Coronaviridae @2 NW`
C07	`01`	`X`	`ENG`	`@0 Coronaviridae @2 NW`
C07	`01`	`X`	`SPA`	`@0 Coronaviridae @2 NW`
C07	`02`	`X`	`FRE`	`@0 Nidovirales @2 NW`
C07	`02`	`X`	`ENG`	`@0 Nidovirales @2 NW`
C07	`02`	`X`	`SPA`	`@0 Nidovirales @2 NW`
C07	`03`	`X`	`FRE`	`@0 Virus @2 NW`
C07	`03`	`X`	`ENG`	`@0 Virus @2 NW`
C07	`03`	`X`	`SPA`	`@0 Virus @2 NW`
C07	`04`	`X`	`FRE`	`@0 Appareil respiratoire pathologie @5 13`
C07	`04`	`X`	`ENG`	`@0 Respiratory disease @5 13`
C07	`04`	`X`	`SPA`	`@0 Aparato respiratorio patología @5 13`
C07	`05`	`X`	`FRE`	`@0 Virose`
C07	`05`	`X`	`ENG`	`@0 Viral disease`
C07	`05`	`X`	`SPA`	`@0 Virosis`
C07	`06`	`X`	`FRE`	`@0 Poumon pathologie @5 16`
C07	`06`	`X`	`ENG`	`@0 Lung disease @5 16`
C07	`06`	`X`	`SPA`	`@0 Pulmón patología @5 16`
N21				`@1 150`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 05-0213138 INIST
ET :	Function of HAbl8G/CD147 in invasion of host cells by severe acute respiratory syndrome coronavirus
AU :	ZHINAN CHEN; LI MI; JING XU; JIYUN YU; XIANHUI WANG; JIANLI JIANG; JINLIANG XING; PENG SHANG; AIRONG QIAN; YU LI; SHAW (Peter X.); JIANWEI WANG; SHUMIN DUAN; JIN DING; CHUNMEI FAN; YANG ZHANG; YONG YANG; XIAOLING YU; QIANG FENG; BIEHU LI; XIYING YAO; ZHENG ZHANG; LING LI; XIAOPING XUE; PING ZHU
AF :	Department of Cell Biology, the Fourth Military Medical University/Canada (1 aut., 2 aut., 3 aut., 5 aut., 6 aut., 7 aut., 8 aut., 9 aut., 10 aut., 16 aut., 17 aut., 18 aut., 19 aut., 20 aut., 21 aut., 22 aut., 23 aut., 24 aut.); Institute of Basic Medical Sciences, Academy of Military Medical Sciences/Chine (4 aut.); Department of Molecular Medicine, University of California, San Diego/San Diego/Etats-Unis (11 aut.); Institute of Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention/Beijing/Chine (12 aut., 13 aut.); Department of Clinical Immunology, Xijing Hospital, the Fourth Military Medical University/Xi'an/Chine (14 aut., 15 aut., 25 aut.)
DT :	Publication en série; Niveau analytique
SO :	The Journal of infectious diseases; ISSN 0022-1899; Coden JIDIAQ; Etats-Unis; Da. 2005; Vol. 191; No. 5; Pp. 755-760; Bibl. 36 ref.
LA :	Anglais
EA :	To identify the function of HAb18G/CD147 in invasion of host cells by severe acute respiratory syndrome (SARS) coronavirus (CoV), we analyzed the protein-protein interaction among HAbl8G/CD147, cyclophilin A (CyPA), and SARS-CoV structural proteins by coimmunoprecipitation and surface plasmon resonance analysis. Although none of the SARS-CoV proteins was found to be directly bound to HAbl8G/CD147, the nu-cleocapsid (N) protein of SARS-CoV was bound to CyPA, which interacted with HAb18G/CD147. Further research showed that HAbl8G/CD147, a transmembrane molecule, was highly expressed on 293 cells and that CyPA was integrated with SARS-CoV. HAb18G/CD147-antagonistic peptide (AP)-9, an AP of HAb18G/CD147, had a high rate of binding to 293 cells and an inhibitory effect on SARS-CoV. These results show that HAb18G/ CD147, mediated by CyPA bound to SARS-CoV N protein, plays a functional role in facilitating invasion of host cells by SARS-CoV. Our findings provide some evidence for the cytologic mechanism of invasion by SARS-CoV and provide a molecular basis for screening anti-SARS drugs.
CC :	002A05C10; 002B05
FD :	Coronavirus; Microbiologie; Infection; Syndrome respiratoire aigu sévère
FG :	Coronaviridae; Nidovirales; Virus; Appareil respiratoire pathologie; Virose; Poumon pathologie
ED :	Coronavirus; Microbiology; Infection; Severe acute respiratory syndrome
EG :	Coronaviridae; Nidovirales; Virus; Respiratory disease; Viral disease; Lung disease
SD :	Coronavirus; Microbiología; Infección; Síndrome respiratorio agudo severo
LO :	INIST-2052.354000125691260150
ID :	05-0213138

Links to Exploration step

Pascal:05-0213138

Le document en format XML

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<author><name sortKey="Shumin Duan" sort="Shumin Duan" uniqKey="Shumin Duan" last="Shumin Duan">SHUMIN DUAN</name>
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<author><name sortKey="Jin Ding" sort="Jin Ding" uniqKey="Jin Ding" last="Jin Ding">JIN DING</name>
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<author><name sortKey="Yang Zhang" sort="Yang Zhang" uniqKey="Yang Zhang" last="Yang Zhang">YANG ZHANG</name>
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</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Yong Yang" sort="Yong Yang" uniqKey="Yong Yang" last="Yong Yang">YONG YANG</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Cell Biology, the Fourth Military Medical University</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
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<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
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</affiliation>
</author>
<author><name sortKey="Xiaoling Yu" sort="Xiaoling Yu" uniqKey="Xiaoling Yu" last="Xiaoling Yu">XIAOLING YU</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Cell Biology, the Fourth Military Medical University</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
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<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
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</affiliation>
</author>
<author><name sortKey="Qiang Feng" sort="Qiang Feng" uniqKey="Qiang Feng" last="Qiang Feng">QIANG FENG</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Cell Biology, the Fourth Military Medical University</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
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<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Biehu Li" sort="Biehu Li" uniqKey="Biehu Li" last="Biehu Li">BIEHU LI</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Cell Biology, the Fourth Military Medical University</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
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<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
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</author>
<author><name sortKey="Xiying Yao" sort="Xiying Yao" uniqKey="Xiying Yao" last="Xiying Yao">XIYING YAO</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Cell Biology, the Fourth Military Medical University</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
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<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
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</affiliation>
</author>
<author><name sortKey="Zheng Zhang" sort="Zheng Zhang" uniqKey="Zheng Zhang" last="Zheng Zhang">ZHENG ZHANG</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Cell Biology, the Fourth Military Medical University</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
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<sZ>10 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Ling Li" sort="Ling Li" uniqKey="Ling Li" last="Ling Li">LING LI</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Cell Biology, the Fourth Military Medical University</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
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<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
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</affiliation>
</author>
<author><name sortKey="Xiaoping Xue" sort="Xiaoping Xue" uniqKey="Xiaoping Xue" last="Xiaoping Xue">XIAOPING XUE</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Cell Biology, the Fourth Military Medical University</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Ping Zhu" sort="Ping Zhu" uniqKey="Ping Zhu" last="Ping Zhu">PING ZHU</name>
<affiliation><inist:fA14 i1="05"><s1>Department of Clinical Immunology, Xijing Hospital, the Fourth Military Medical University</s1>
<s2>Xi'an</s2>
<s3>CHN</s3>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">05-0213138</idno>
<date when="2005">2005</date>
<idno type="stanalyst">PASCAL 05-0213138 INIST</idno>
<idno type="RBID">Pascal:05-0213138</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000695</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Function of HAbl8G/CD147 in invasion of host cells by severe acute respiratory syndrome coronavirus</title>
<author><name sortKey="Zhinan Chen" sort="Zhinan Chen" uniqKey="Zhinan Chen" last="Zhinan Chen">ZHINAN CHEN</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Cell Biology, the Fourth Military Medical University</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
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<sZ>10 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Li Mi" sort="Li Mi" uniqKey="Li Mi" last="Li Mi">LI MI</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Cell Biology, the Fourth Military Medical University</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
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<sZ>17 aut.</sZ>
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<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Jing Xu" sort="Jing Xu" uniqKey="Jing Xu" last="Jing Xu">JING XU</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Cell Biology, the Fourth Military Medical University</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
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<sZ>10 aut.</sZ>
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<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
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<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Jiyun Yu" sort="Jiyun Yu" uniqKey="Jiyun Yu" last="Jiyun Yu">JIYUN YU</name>
<affiliation><inist:fA14 i1="02"><s1>Institute of Basic Medical Sciences, Academy of Military Medical Sciences</s1>
<s3>CHN</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Xianhui Wang" sort="Xianhui Wang" uniqKey="Xianhui Wang" last="Xianhui Wang">XIANHUI WANG</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Cell Biology, the Fourth Military Medical University</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
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<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Jianli Jiang" sort="Jianli Jiang" uniqKey="Jianli Jiang" last="Jianli Jiang">JIANLI JIANG</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Cell Biology, the Fourth Military Medical University</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
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<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
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</affiliation>
</author>
<author><name sortKey="Jinliang Xing" sort="Jinliang Xing" uniqKey="Jinliang Xing" last="Jinliang Xing">JINLIANG XING</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Cell Biology, the Fourth Military Medical University</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
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<sZ>10 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Peng Shang" sort="Peng Shang" uniqKey="Peng Shang" last="Peng Shang">PENG SHANG</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Cell Biology, the Fourth Military Medical University</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Airong Qian" sort="Airong Qian" uniqKey="Airong Qian" last="Airong Qian">AIRONG QIAN</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Cell Biology, the Fourth Military Medical University</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Yu Li" sort="Yu Li" uniqKey="Yu Li" last="Yu Li">YU LI</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Cell Biology, the Fourth Military Medical University</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Shaw, Peter X" sort="Shaw, Peter X" uniqKey="Shaw P" first="Peter X." last="Shaw">Peter X. Shaw</name>
<affiliation><inist:fA14 i1="03"><s1>Department of Molecular Medicine, University of California, San Diego</s1>
<s2>San Diego</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Jianwei Wang" sort="Jianwei Wang" uniqKey="Jianwei Wang" last="Jianwei Wang">JIANWEI WANG</name>
<affiliation><inist:fA14 i1="04"><s1>Institute of Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Shumin Duan" sort="Shumin Duan" uniqKey="Shumin Duan" last="Shumin Duan">SHUMIN DUAN</name>
<affiliation><inist:fA14 i1="04"><s1>Institute of Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Jin Ding" sort="Jin Ding" uniqKey="Jin Ding" last="Jin Ding">JIN DING</name>
<affiliation><inist:fA14 i1="05"><s1>Department of Clinical Immunology, Xijing Hospital, the Fourth Military Medical University</s1>
<s2>Xi'an</s2>
<s3>CHN</s3>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Chunmei Fan" sort="Chunmei Fan" uniqKey="Chunmei Fan" last="Chunmei Fan">CHUNMEI FAN</name>
<affiliation><inist:fA14 i1="05"><s1>Department of Clinical Immunology, Xijing Hospital, the Fourth Military Medical University</s1>
<s2>Xi'an</s2>
<s3>CHN</s3>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Yang Zhang" sort="Yang Zhang" uniqKey="Yang Zhang" last="Yang Zhang">YANG ZHANG</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Cell Biology, the Fourth Military Medical University</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Yong Yang" sort="Yong Yang" uniqKey="Yong Yang" last="Yong Yang">YONG YANG</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Cell Biology, the Fourth Military Medical University</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Xiaoling Yu" sort="Xiaoling Yu" uniqKey="Xiaoling Yu" last="Xiaoling Yu">XIAOLING YU</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Cell Biology, the Fourth Military Medical University</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Qiang Feng" sort="Qiang Feng" uniqKey="Qiang Feng" last="Qiang Feng">QIANG FENG</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Cell Biology, the Fourth Military Medical University</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
</affiliation>
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<author><name sortKey="Biehu Li" sort="Biehu Li" uniqKey="Biehu Li" last="Biehu Li">BIEHU LI</name>
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<series><title level="j" type="main">The Journal of infectious diseases</title>
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<front><div type="abstract" xml:lang="en">To identify the function of HAb18G/CD147 in invasion of host cells by severe acute respiratory syndrome (SARS) coronavirus (CoV), we analyzed the protein-protein interaction among HAbl8G/CD147, cyclophilin A (CyPA), and SARS-CoV structural proteins by coimmunoprecipitation and surface plasmon resonance analysis. Although none of the SARS-CoV proteins was found to be directly bound to HAbl8G/CD147, the nu-cleocapsid (N) protein of SARS-CoV was bound to CyPA, which interacted with HAb18G/CD147. Further research showed that HAbl8G/CD147, a transmembrane molecule, was highly expressed on 293 cells and that CyPA was integrated with SARS-CoV. HAb18G/CD147-antagonistic peptide (AP)-9, an AP of HAb18G/CD147, had a high rate of binding to 293 cells and an inhibitory effect on SARS-CoV. These results show that HAb18G/ CD147, mediated by CyPA bound to SARS-CoV N protein, plays a functional role in facilitating invasion of host cells by SARS-CoV. Our findings provide some evidence for the cytologic mechanism of invasion by SARS-CoV and provide a molecular basis for screening anti-SARS drugs.</div>
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<ET>Function of HAbl8G/CD147 in invasion of host cells by severe acute respiratory syndrome coronavirus</ET>
<AU>ZHINAN CHEN; LI MI; JING XU; JIYUN YU; XIANHUI WANG; JIANLI JIANG; JINLIANG XING; PENG SHANG; AIRONG QIAN; YU LI; SHAW (Peter X.); JIANWEI WANG; SHUMIN DUAN; JIN DING; CHUNMEI FAN; YANG ZHANG; YONG YANG; XIAOLING YU; QIANG FENG; BIEHU LI; XIYING YAO; ZHENG ZHANG; LING LI; XIAOPING XUE; PING ZHU</AU>
<AF>Department of Cell Biology, the Fourth Military Medical University/Canada (1 aut., 2 aut., 3 aut., 5 aut., 6 aut., 7 aut., 8 aut., 9 aut., 10 aut., 16 aut., 17 aut., 18 aut., 19 aut., 20 aut., 21 aut., 22 aut., 23 aut., 24 aut.); Institute of Basic Medical Sciences, Academy of Military Medical Sciences/Chine (4 aut.); Department of Molecular Medicine, University of California, San Diego/San Diego/Etats-Unis (11 aut.); Institute of Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention/Beijing/Chine (12 aut., 13 aut.); Department of Clinical Immunology, Xijing Hospital, the Fourth Military Medical University/Xi'an/Chine (14 aut., 15 aut., 25 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>The Journal of infectious diseases; ISSN 0022-1899; Coden JIDIAQ; Etats-Unis; Da. 2005; Vol. 191; No. 5; Pp. 755-760; Bibl. 36 ref.</SO>
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<EA>To identify the function of HAb18G/CD147 in invasion of host cells by severe acute respiratory syndrome (SARS) coronavirus (CoV), we analyzed the protein-protein interaction among HAbl8G/CD147, cyclophilin A (CyPA), and SARS-CoV structural proteins by coimmunoprecipitation and surface plasmon resonance analysis. Although none of the SARS-CoV proteins was found to be directly bound to HAbl8G/CD147, the nu-cleocapsid (N) protein of SARS-CoV was bound to CyPA, which interacted with HAb18G/CD147. Further research showed that HAbl8G/CD147, a transmembrane molecule, was highly expressed on 293 cells and that CyPA was integrated with SARS-CoV. HAb18G/CD147-antagonistic peptide (AP)-9, an AP of HAb18G/CD147, had a high rate of binding to 293 cells and an inhibitory effect on SARS-CoV. These results show that HAb18G/ CD147, mediated by CyPA bound to SARS-CoV N protein, plays a functional role in facilitating invasion of host cells by SARS-CoV. Our findings provide some evidence for the cytologic mechanism of invasion by SARS-CoV and provide a molecular basis for screening anti-SARS drugs.</EA>
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Function of HAbl8G/CD147 in invasion of host cells by severe acute respiratory syndrome coronavirus

Function of HAbl8G/CD147 in invasion of host cells by severe acute respiratory syndrome coronavirus

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