SrasV1, PascalFrancis, Corpus, bibRecord, 000631

Pneumonitis and multi-organ system disease in common marmosets (Callithrix jacchus) infected with the severe acute respiratory syndrome-associated coronavirus

Identifieur interne : 000631 ( PascalFrancis/Corpus ); précédent : 000630; suivant : 000632

Pneumonitis and multi-organ system disease in common marmosets (Callithrix jacchus) infected with the severe acute respiratory syndrome-associated coronavirus

Auteurs : Thomas C. Greenough ; Angela Carville ; James Coderre ; Mohan Somasundaran ; John L. Sullivan ; Katherine Luzuriaga ; Keith Mansfield

Source :

The American journal of pathology [ 0002-9440 ] ; 2005.

RBID : Pascal:05-0352007

Descripteurs français

Pascal (Inist)
- Pneumonie, Organe, Callithrix jacchus, Infection, Syndrome respiratoire aigu sévère, Coronavirus, Anatomopathologie.

English descriptors

KwdEn :
- Anatomic pathology, Callithrix jacchus, Coronavirus, Infection, Organ, Pneumonia, Severe acute respiratory syndrome.

Abstract

Severe acute respiratory syndrome (SARS) is a significant emerging infectious disease. Humans infected with the etiological agent, SARS-associated coronavirus (SARS-CoV), primarily present with pneumonitis but may also develop hepatic, gastrointestinal, and renal pathology. We inoculated common marmosets (Callithrix jaccbus) with the objective of developing a small nonhuman primate model of SARS. Two groups of C. jacchus were inoculated intratracheally with cell culture supernatant containing SARS-CoV. In a time course pathogenesis study, animals were evaluated at 2, 4, and 7 days after infection for morphological changes and evidence of viral replication. All animals developed a multifocal mononuclear cell interstitial pneumonitis, accompanied by multinucleated syncytial cells, edema, and bronchiolitis in most animals. Viral antigen localized primarily to infected alveolar macrophages and type-1 pneumocytes by immunohistochemistry. Viral RNA was detected in all animals from pulmonary tissue extracts obtained at necropsy. Viral RNA was also detected in tracheobronchial lymph node and myocardium, together with inflammatory changes, in some animals. Hepatic inflammation was observed in most animals, predominantly as a multifocal lymphocytic hepatitis accompanied by necrosis of individual hepatocytes. These findings identify the common marmoset as a promising nonhuman primate to study SARS-CoV pathogenesis.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

A01	`01`	`1`		`@0 0002-9440`
A02	`01`			`@0 AJPAA4`
A03		`1`		`@0 Am. j. pathol.`
A05				`@2 167`
A06				`@2 2`
A08	`01`	`1`	`ENG`	`@1 Pneumonitis and multi-organ system disease in common marmosets (Callithrix jacchus) infected with the severe acute respiratory syndrome-associated coronavirus`
A11	`01`	`1`		`@1 GREENOUGH (Thomas C.)`
A11	`02`	`1`		`@1 CARVILLE (Angela)`
A11	`03`	`1`		`@1 CODERRE (James)`
A11	`04`	`1`		`@1 SOMASUNDARAN (Mohan)`
A11	`05`	`1`		`@1 SULLIVAN (John L.)`
A11	`06`	`1`		`@1 LUZURIAGA (Katherine)`
A11	`07`	`1`		`@1 MANSFIELD (Keith)`
A14	`01`			`@1 Department of Pediatrics, University of Massachusetts Medical School @2 Worcester @3 USA @Z 1 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut.`
A14	`02`			`@1 Department of Pathology, New England Primate Research Center, Harvard Medical School @2 Southborough, Massachusetts @3 USA @Z 2 aut. @Z 7 aut.`
A20				`@1 455-463`
A21				`@1 2005`
A23	`01`			`@0 ENG`
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A44				`@0 0000 @1 © 2005 INIST-CNRS. All rights reserved.`
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A61				`@0 A`
A64	`01`	`1`		`@0 The American journal of pathology`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 Severe acute respiratory syndrome (SARS) is a significant emerging infectious disease. Humans infected with the etiological agent, SARS-associated coronavirus (SARS-CoV), primarily present with pneumonitis but may also develop hepatic, gastrointestinal, and renal pathology. We inoculated common marmosets (Callithrix jaccbus) with the objective of developing a small nonhuman primate model of SARS. Two groups of C. jacchus were inoculated intratracheally with cell culture supernatant containing SARS-CoV. In a time course pathogenesis study, animals were evaluated at 2, 4, and 7 days after infection for morphological changes and evidence of viral replication. All animals developed a multifocal mononuclear cell interstitial pneumonitis, accompanied by multinucleated syncytial cells, edema, and bronchiolitis in most animals. Viral antigen localized primarily to infected alveolar macrophages and type-1 pneumocytes by immunohistochemistry. Viral RNA was detected in all animals from pulmonary tissue extracts obtained at necropsy. Viral RNA was also detected in tracheobronchial lymph node and myocardium, together with inflammatory changes, in some animals. Hepatic inflammation was observed in most animals, predominantly as a multifocal lymphocytic hepatitis accompanied by necrosis of individual hepatocytes. These findings identify the common marmoset as a promising nonhuman primate to study SARS-CoV pathogenesis.
C02	`01`	`X`		`@0 002B24O`
C03	`01`	`X`	`FRE`	`@0 Pneumonie @5 01`
C03	`01`	`X`	`ENG`	`@0 Pneumonia @5 01`
C03	`01`	`X`	`SPA`	`@0 Neumonía @5 01`
C03	`02`	`X`	`FRE`	`@0 Organe @5 02`
C03	`02`	`X`	`ENG`	`@0 Organ @5 02`
C03	`02`	`X`	`SPA`	`@0 Organo @5 02`
C03	`03`	`X`	`FRE`	`@0 Callithrix jacchus @2 NS @5 03`
C03	`03`	`X`	`ENG`	`@0 Callithrix jacchus @2 NS @5 03`
C03	`03`	`X`	`SPA`	`@0 Callithrix jacchus @2 NS @5 03`
C03	`04`	`X`	`FRE`	`@0 Infection @5 04`
C03	`04`	`X`	`ENG`	`@0 Infection @5 04`
C03	`04`	`X`	`SPA`	`@0 Infección @5 04`
C03	`05`	`X`	`FRE`	`@0 Syndrome respiratoire aigu sévère @2 NM @5 05`
C03	`05`	`X`	`ENG`	`@0 Severe acute respiratory syndrome @2 NM @5 05`
C03	`05`	`X`	`SPA`	`@0 Síndrome respiratorio agudo severo @2 NM @5 05`
C03	`06`	`X`	`FRE`	`@0 Coronavirus @2 NW @5 06`
C03	`06`	`X`	`ENG`	`@0 Coronavirus @2 NW @5 06`
C03	`06`	`X`	`SPA`	`@0 Coronavirus @2 NW @5 06`
C03	`07`	`X`	`FRE`	`@0 Anatomopathologie @5 08`
C03	`07`	`X`	`ENG`	`@0 Anatomic pathology @5 08`
C03	`07`	`X`	`SPA`	`@0 Anatomía patológica @5 08`
C07	`01`	`X`	`FRE`	`@0 Simioidea @2 NS`
C07	`01`	`X`	`ENG`	`@0 Simioidea @2 NS`
C07	`01`	`X`	`SPA`	`@0 Simioidea @2 NS`
C07	`02`	`X`	`FRE`	`@0 Primates @2 NS`
C07	`02`	`X`	`ENG`	`@0 Primates @2 NS`
C07	`02`	`X`	`SPA`	`@0 Primates @2 NS`
C07	`03`	`X`	`FRE`	`@0 Mammalia @2 NS`
C07	`03`	`X`	`ENG`	`@0 Mammalia @2 NS`
C07	`03`	`X`	`SPA`	`@0 Mammalia @2 NS`
C07	`04`	`X`	`FRE`	`@0 Vertebrata @2 NS`
C07	`04`	`X`	`ENG`	`@0 Vertebrata @2 NS`
C07	`04`	`X`	`SPA`	`@0 Vertebrata @2 NS`
C07	`05`	`X`	`FRE`	`@0 Virose`
C07	`05`	`X`	`ENG`	`@0 Viral disease`
C07	`05`	`X`	`SPA`	`@0 Virosis`
C07	`06`	`X`	`FRE`	`@0 Coronaviridae @2 NW`
C07	`06`	`X`	`ENG`	`@0 Coronaviridae @2 NW`
C07	`06`	`X`	`SPA`	`@0 Coronaviridae @2 NW`
C07	`07`	`X`	`FRE`	`@0 Nidovirales @2 NW`
C07	`07`	`X`	`ENG`	`@0 Nidovirales @2 NW`
C07	`07`	`X`	`SPA`	`@0 Nidovirales @2 NW`
C07	`08`	`X`	`FRE`	`@0 Virus @2 NW`
C07	`08`	`X`	`ENG`	`@0 Virus @2 NW`
C07	`08`	`X`	`SPA`	`@0 Virus @2 NW`
C07	`09`	`X`	`FRE`	`@0 Appareil respiratoire pathologie @5 37`
C07	`09`	`X`	`ENG`	`@0 Respiratory disease @5 37`
C07	`09`	`X`	`SPA`	`@0 Aparato respiratorio patología @5 37`
C07	`10`	`X`	`FRE`	`@0 Poumon pathologie @5 38`
C07	`10`	`X`	`ENG`	`@0 Lung disease @5 38`
C07	`10`	`X`	`SPA`	`@0 Pulmón patología @5 38`
N21				`@1 248`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 05-0352007 INIST
ET :	Pneumonitis and multi-organ system disease in common marmosets (Callithrix jacchus) infected with the severe acute respiratory syndrome-associated coronavirus
AU :	GREENOUGH (Thomas C.); CARVILLE (Angela); CODERRE (James); SOMASUNDARAN (Mohan); SULLIVAN (John L.); LUZURIAGA (Katherine); MANSFIELD (Keith)
AF :	Department of Pediatrics, University of Massachusetts Medical School/Worcester/Etats-Unis (1 aut., 3 aut., 4 aut., 5 aut., 6 aut.); Department of Pathology, New England Primate Research Center, Harvard Medical School/Southborough, Massachusetts/Etats-Unis (2 aut., 7 aut.)
DT :	Publication en série; Niveau analytique
SO :	The American journal of pathology; ISSN 0002-9440; Coden AJPAA4; Etats-Unis; Da. 2005; Vol. 167; No. 2; Pp. 455-463; Bibl. 40 ref.
LA :	Anglais
EA :	Severe acute respiratory syndrome (SARS) is a significant emerging infectious disease. Humans infected with the etiological agent, SARS-associated coronavirus (SARS-CoV), primarily present with pneumonitis but may also develop hepatic, gastrointestinal, and renal pathology. We inoculated common marmosets (Callithrix jaccbus) with the objective of developing a small nonhuman primate model of SARS. Two groups of C. jacchus were inoculated intratracheally with cell culture supernatant containing SARS-CoV. In a time course pathogenesis study, animals were evaluated at 2, 4, and 7 days after infection for morphological changes and evidence of viral replication. All animals developed a multifocal mononuclear cell interstitial pneumonitis, accompanied by multinucleated syncytial cells, edema, and bronchiolitis in most animals. Viral antigen localized primarily to infected alveolar macrophages and type-1 pneumocytes by immunohistochemistry. Viral RNA was detected in all animals from pulmonary tissue extracts obtained at necropsy. Viral RNA was also detected in tracheobronchial lymph node and myocardium, together with inflammatory changes, in some animals. Hepatic inflammation was observed in most animals, predominantly as a multifocal lymphocytic hepatitis accompanied by necrosis of individual hepatocytes. These findings identify the common marmoset as a promising nonhuman primate to study SARS-CoV pathogenesis.
CC :	002B24O
FD :	Pneumonie; Organe; Callithrix jacchus; Infection; Syndrome respiratoire aigu sévère; Coronavirus; Anatomopathologie
FG :	Simioidea; Primates; Mammalia; Vertebrata; Virose; Coronaviridae; Nidovirales; Virus; Appareil respiratoire pathologie; Poumon pathologie
ED :	Pneumonia; Organ; Callithrix jacchus; Infection; Severe acute respiratory syndrome; Coronavirus; Anatomic pathology
EG :	Simioidea; Primates; Mammalia; Vertebrata; Viral disease; Coronaviridae; Nidovirales; Virus; Respiratory disease; Lung disease
SD :	Neumonía; Organo; Callithrix jacchus; Infección; Síndrome respiratorio agudo severo; Coronavirus; Anatomía patológica
LO :	INIST-2047.354000131462540150
ID :	05-0352007

Links to Exploration step

Pascal:05-0352007

Le document en format XML

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<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is a significant emerging infectious disease. Humans infected with the etiological agent, SARS-associated coronavirus (SARS-CoV), primarily present with pneumonitis but may also develop hepatic, gastrointestinal, and renal pathology. We inoculated common marmosets (Callithrix jaccbus) with the objective of developing a small nonhuman primate model of SARS. Two groups of C. jacchus were inoculated intratracheally with cell culture supernatant containing SARS-CoV. In a time course pathogenesis study, animals were evaluated at 2, 4, and 7 days after infection for morphological changes and evidence of viral replication. All animals developed a multifocal mononuclear cell interstitial pneumonitis, accompanied by multinucleated syncytial cells, edema, and bronchiolitis in most animals. Viral antigen localized primarily to infected alveolar macrophages and type-1 pneumocytes by immunohistochemistry. Viral RNA was detected in all animals from pulmonary tissue extracts obtained at necropsy. Viral RNA was also detected in tracheobronchial lymph node and myocardium, together with inflammatory changes, in some animals. Hepatic inflammation was observed in most animals, predominantly as a multifocal lymphocytic hepatitis accompanied by necrosis of individual hepatocytes. These findings identify the common marmoset as a promising nonhuman primate to study SARS-CoV pathogenesis.</div>
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<server><NO>PASCAL 05-0352007 INIST</NO>
<ET>Pneumonitis and multi-organ system disease in common marmosets (Callithrix jacchus) infected with the severe acute respiratory syndrome-associated coronavirus</ET>
<AU>GREENOUGH (Thomas C.); CARVILLE (Angela); CODERRE (James); SOMASUNDARAN (Mohan); SULLIVAN (John L.); LUZURIAGA (Katherine); MANSFIELD (Keith)</AU>
<AF>Department of Pediatrics, University of Massachusetts Medical School/Worcester/Etats-Unis (1 aut., 3 aut., 4 aut., 5 aut., 6 aut.); Department of Pathology, New England Primate Research Center, Harvard Medical School/Southborough, Massachusetts/Etats-Unis (2 aut., 7 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>The American journal of pathology; ISSN 0002-9440; Coden AJPAA4; Etats-Unis; Da. 2005; Vol. 167; No. 2; Pp. 455-463; Bibl. 40 ref.</SO>
<LA>Anglais</LA>
<EA>Severe acute respiratory syndrome (SARS) is a significant emerging infectious disease. Humans infected with the etiological agent, SARS-associated coronavirus (SARS-CoV), primarily present with pneumonitis but may also develop hepatic, gastrointestinal, and renal pathology. We inoculated common marmosets (Callithrix jaccbus) with the objective of developing a small nonhuman primate model of SARS. Two groups of C. jacchus were inoculated intratracheally with cell culture supernatant containing SARS-CoV. In a time course pathogenesis study, animals were evaluated at 2, 4, and 7 days after infection for morphological changes and evidence of viral replication. All animals developed a multifocal mononuclear cell interstitial pneumonitis, accompanied by multinucleated syncytial cells, edema, and bronchiolitis in most animals. Viral antigen localized primarily to infected alveolar macrophages and type-1 pneumocytes by immunohistochemistry. Viral RNA was detected in all animals from pulmonary tissue extracts obtained at necropsy. Viral RNA was also detected in tracheobronchial lymph node and myocardium, together with inflammatory changes, in some animals. Hepatic inflammation was observed in most animals, predominantly as a multifocal lymphocytic hepatitis accompanied by necrosis of individual hepatocytes. These findings identify the common marmoset as a promising nonhuman primate to study SARS-CoV pathogenesis.</EA>
<CC>002B24O</CC>
<FD>Pneumonie; Organe; Callithrix jacchus; Infection; Syndrome respiratoire aigu sévère; Coronavirus; Anatomopathologie</FD>
<FG>Simioidea; Primates; Mammalia; Vertebrata; Virose; Coronaviridae; Nidovirales; Virus; Appareil respiratoire pathologie; Poumon pathologie</FG>
<ED>Pneumonia; Organ; Callithrix jacchus; Infection; Severe acute respiratory syndrome; Coronavirus; Anatomic pathology</ED>
<EG>Simioidea; Primates; Mammalia; Vertebrata; Viral disease; Coronaviridae; Nidovirales; Virus; Respiratory disease; Lung disease</EG>
<SD>Neumonía; Organo; Callithrix jacchus; Infección; Síndrome respiratorio agudo severo; Coronavirus; Anatomía patológica</SD>
<LO>INIST-2047.354000131462540150</LO>
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Pneumonitis and multi-organ system disease in common marmosets (Callithrix jacchus) infected with the severe acute respiratory syndrome-associated coronavirus

Pneumonitis and multi-organ system disease in common marmosets (Callithrix jacchus) infected with the severe acute respiratory syndrome-associated coronavirus

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