Pneumonitis and multi-organ system disease in common marmosets (Callithrix jacchus) infected with the severe acute respiratory syndrome-associated coronavirus
Identifieur interne : 000631 ( PascalFrancis/Corpus ); précédent : 000630; suivant : 000632Pneumonitis and multi-organ system disease in common marmosets (Callithrix jacchus) infected with the severe acute respiratory syndrome-associated coronavirus
Auteurs : Thomas C. Greenough ; Angela Carville ; James Coderre ; Mohan Somasundaran ; John L. Sullivan ; Katherine Luzuriaga ; Keith MansfieldSource :
- The American journal of pathology [ 0002-9440 ] ; 2005.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Severe acute respiratory syndrome (SARS) is a significant emerging infectious disease. Humans infected with the etiological agent, SARS-associated coronavirus (SARS-CoV), primarily present with pneumonitis but may also develop hepatic, gastrointestinal, and renal pathology. We inoculated common marmosets (Callithrix jaccbus) with the objective of developing a small nonhuman primate model of SARS. Two groups of C. jacchus were inoculated intratracheally with cell culture supernatant containing SARS-CoV. In a time course pathogenesis study, animals were evaluated at 2, 4, and 7 days after infection for morphological changes and evidence of viral replication. All animals developed a multifocal mononuclear cell interstitial pneumonitis, accompanied by multinucleated syncytial cells, edema, and bronchiolitis in most animals. Viral antigen localized primarily to infected alveolar macrophages and type-1 pneumocytes by immunohistochemistry. Viral RNA was detected in all animals from pulmonary tissue extracts obtained at necropsy. Viral RNA was also detected in tracheobronchial lymph node and myocardium, together with inflammatory changes, in some animals. Hepatic inflammation was observed in most animals, predominantly as a multifocal lymphocytic hepatitis accompanied by necrosis of individual hepatocytes. These findings identify the common marmoset as a promising nonhuman primate to study SARS-CoV pathogenesis.
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Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
NO : | PASCAL 05-0352007 INIST |
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ET : | Pneumonitis and multi-organ system disease in common marmosets (Callithrix jacchus) infected with the severe acute respiratory syndrome-associated coronavirus |
AU : | GREENOUGH (Thomas C.); CARVILLE (Angela); CODERRE (James); SOMASUNDARAN (Mohan); SULLIVAN (John L.); LUZURIAGA (Katherine); MANSFIELD (Keith) |
AF : | Department of Pediatrics, University of Massachusetts Medical School/Worcester/Etats-Unis (1 aut., 3 aut., 4 aut., 5 aut., 6 aut.); Department of Pathology, New England Primate Research Center, Harvard Medical School/Southborough, Massachusetts/Etats-Unis (2 aut., 7 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | The American journal of pathology; ISSN 0002-9440; Coden AJPAA4; Etats-Unis; Da. 2005; Vol. 167; No. 2; Pp. 455-463; Bibl. 40 ref. |
LA : | Anglais |
EA : | Severe acute respiratory syndrome (SARS) is a significant emerging infectious disease. Humans infected with the etiological agent, SARS-associated coronavirus (SARS-CoV), primarily present with pneumonitis but may also develop hepatic, gastrointestinal, and renal pathology. We inoculated common marmosets (Callithrix jaccbus) with the objective of developing a small nonhuman primate model of SARS. Two groups of C. jacchus were inoculated intratracheally with cell culture supernatant containing SARS-CoV. In a time course pathogenesis study, animals were evaluated at 2, 4, and 7 days after infection for morphological changes and evidence of viral replication. All animals developed a multifocal mononuclear cell interstitial pneumonitis, accompanied by multinucleated syncytial cells, edema, and bronchiolitis in most animals. Viral antigen localized primarily to infected alveolar macrophages and type-1 pneumocytes by immunohistochemistry. Viral RNA was detected in all animals from pulmonary tissue extracts obtained at necropsy. Viral RNA was also detected in tracheobronchial lymph node and myocardium, together with inflammatory changes, in some animals. Hepatic inflammation was observed in most animals, predominantly as a multifocal lymphocytic hepatitis accompanied by necrosis of individual hepatocytes. These findings identify the common marmoset as a promising nonhuman primate to study SARS-CoV pathogenesis. |
CC : | 002B24O |
FD : | Pneumonie; Organe; Callithrix jacchus; Infection; Syndrome respiratoire aigu sévère; Coronavirus; Anatomopathologie |
FG : | Simioidea; Primates; Mammalia; Vertebrata; Virose; Coronaviridae; Nidovirales; Virus; Appareil respiratoire pathologie; Poumon pathologie |
ED : | Pneumonia; Organ; Callithrix jacchus; Infection; Severe acute respiratory syndrome; Coronavirus; Anatomic pathology |
EG : | Simioidea; Primates; Mammalia; Vertebrata; Viral disease; Coronaviridae; Nidovirales; Virus; Respiratory disease; Lung disease |
SD : | Neumonía; Organo; Callithrix jacchus; Infección; Síndrome respiratorio agudo severo; Coronavirus; Anatomía patológica |
LO : | INIST-2047.354000131462540150 |
ID : | 05-0352007 |
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Pascal:05-0352007Le document en format XML
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</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
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<s2>NW</s2>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
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<s2>NW</s2>
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<fC07 i1="08" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Appareil respiratoire pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>37</s5>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="10" i2="X" l="FRE"><s0>Poumon pathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="10" i2="X" l="ENG"><s0>Lung disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="10" i2="X" l="SPA"><s0>Pulmón patología</s0>
<s5>38</s5>
</fC07>
<fN21><s1>248</s1>
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<server><NO>PASCAL 05-0352007 INIST</NO>
<ET>Pneumonitis and multi-organ system disease in common marmosets (Callithrix jacchus) infected with the severe acute respiratory syndrome-associated coronavirus</ET>
<AU>GREENOUGH (Thomas C.); CARVILLE (Angela); CODERRE (James); SOMASUNDARAN (Mohan); SULLIVAN (John L.); LUZURIAGA (Katherine); MANSFIELD (Keith)</AU>
<AF>Department of Pediatrics, University of Massachusetts Medical School/Worcester/Etats-Unis (1 aut., 3 aut., 4 aut., 5 aut., 6 aut.); Department of Pathology, New England Primate Research Center, Harvard Medical School/Southborough, Massachusetts/Etats-Unis (2 aut., 7 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>The American journal of pathology; ISSN 0002-9440; Coden AJPAA4; Etats-Unis; Da. 2005; Vol. 167; No. 2; Pp. 455-463; Bibl. 40 ref.</SO>
<LA>Anglais</LA>
<EA>Severe acute respiratory syndrome (SARS) is a significant emerging infectious disease. Humans infected with the etiological agent, SARS-associated coronavirus (SARS-CoV), primarily present with pneumonitis but may also develop hepatic, gastrointestinal, and renal pathology. We inoculated common marmosets (Callithrix jaccbus) with the objective of developing a small nonhuman primate model of SARS. Two groups of C. jacchus were inoculated intratracheally with cell culture supernatant containing SARS-CoV. In a time course pathogenesis study, animals were evaluated at 2, 4, and 7 days after infection for morphological changes and evidence of viral replication. All animals developed a multifocal mononuclear cell interstitial pneumonitis, accompanied by multinucleated syncytial cells, edema, and bronchiolitis in most animals. Viral antigen localized primarily to infected alveolar macrophages and type-1 pneumocytes by immunohistochemistry. Viral RNA was detected in all animals from pulmonary tissue extracts obtained at necropsy. Viral RNA was also detected in tracheobronchial lymph node and myocardium, together with inflammatory changes, in some animals. Hepatic inflammation was observed in most animals, predominantly as a multifocal lymphocytic hepatitis accompanied by necrosis of individual hepatocytes. These findings identify the common marmoset as a promising nonhuman primate to study SARS-CoV pathogenesis.</EA>
<CC>002B24O</CC>
<FD>Pneumonie; Organe; Callithrix jacchus; Infection; Syndrome respiratoire aigu sévère; Coronavirus; Anatomopathologie</FD>
<FG>Simioidea; Primates; Mammalia; Vertebrata; Virose; Coronaviridae; Nidovirales; Virus; Appareil respiratoire pathologie; Poumon pathologie</FG>
<ED>Pneumonia; Organ; Callithrix jacchus; Infection; Severe acute respiratory syndrome; Coronavirus; Anatomic pathology</ED>
<EG>Simioidea; Primates; Mammalia; Vertebrata; Viral disease; Coronaviridae; Nidovirales; Virus; Respiratory disease; Lung disease</EG>
<SD>Neumonía; Organo; Callithrix jacchus; Infección; Síndrome respiratorio agudo severo; Coronavirus; Anatomía patológica</SD>
<LO>INIST-2047.354000131462540150</LO>
<ID>05-0352007</ID>
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