SrasV1, PascalFrancis, Corpus, bibRecord, 000611

Longitudinal alteration of circulating dendritic cell subsets and its correlation with steroid treatment in patients with severe acute respiratory syndrome

Identifieur interne : 000611 ( PascalFrancis/Corpus ); précédent : 000610; suivant : 000612

Longitudinal alteration of circulating dendritic cell subsets and its correlation with steroid treatment in patients with severe acute respiratory syndrome

Auteurs : ZHENG ZHANG ; DONGPING XU ; YONGGANG LI ; LEI JIN ; MING SHI ; MIN WANG ; XIANZHI ZHOU ; HAO WU ; George F. Gao ; Fu-Sheng Wang

Source :

Clinical immunology : (Orlando, Fla. Print) [ 1521-6616 ] ; 2005.

RBID : Pascal:05-0404718

Descripteurs français

Pascal (Inist)
- Syndrome respiratoire aigu sévère, Cellule dendritique, Cellule APC, Stéroïde, Traitement, Homme, Coronavirus, Cellule dendritique myéloïde, Cellule dendritique plasmocytoïde.

English descriptors

KwdEn :
- Antigen presenting cell, Coronavirus, Dendritic cell, Human, Myeloid dendritic cell, Plasmacytoid dendritic cell, Severe acute respiratory syndrome, Steroid, Treatment.

Abstract

In this study, we found that 74 patients with severe acute respiratory syndrome (SARS) exhibited a rapid, dramatic decrease in numbers of circulating myeloid and plasmacytoid dendritic cells (mDCs and pDCs) during the first 2 weeks of illness (5.3- and 28.4-fold reductions for mDCs and pDCs compared with 25 healthy individuals, respectively), with slow return to normal cell numbers during convalescence (weeks 5-7 of illness on average). In addition, numbers of circulating CD4 and CD8 T cells exhibited milder reductions (2.1- and 1.8-fold at week 1) and earlier return to normal at a mean of weeks 3 and 4, respectively. A significant inverse correlation was found between numbers of DC and T-cell subsets and high-dose steroid treatment. Our novel findings thus suggest that the acute SARS-coronavirus infection probably contributes to the initial reduction of DC and T-cell subsets in blood, and that high-dose steroid administration may subsequently exacerbate and prolong low expression of the cell subsets. These findings will aid the framing of further studies of the immunopathogenesis of SARS.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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Format Inist (serveur)

NO :	PASCAL 05-0404718 INIST
ET :	Longitudinal alteration of circulating dendritic cell subsets and its correlation with steroid treatment in patients with severe acute respiratory syndrome
AU :	ZHENG ZHANG; DONGPING XU; YONGGANG LI; LEI JIN; MING SHI; MIN WANG; XIANZHI ZHOU; HAO WU; GAO (George F.); WANG (Fu-Sheng)
AF :	Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road/Beijing 100039/Chine (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut., 10 aut.); Beijing You'an Hospital, Capital Medical University/Beijing 100054/Chine (8 aut.); Institute of Microbiology, Chinese Academy of Sciences/Beijing 100080/Chine (9 aut.)
DT :	Publication en série; Niveau analytique
SO :	Clinical immunology : (Orlando, Fla. Print); ISSN 1521-6616; Coden CLIIFY; Etats-Unis; Da. 2005; Vol. 116; No. 3; Pp. 225-235; Bibl. 48 ref.
LA :	Anglais
EA :	In this study, we found that 74 patients with severe acute respiratory syndrome (SARS) exhibited a rapid, dramatic decrease in numbers of circulating myeloid and plasmacytoid dendritic cells (mDCs and pDCs) during the first 2 weeks of illness (5.3- and 28.4-fold reductions for mDCs and pDCs compared with 25 healthy individuals, respectively), with slow return to normal cell numbers during convalescence (weeks 5-7 of illness on average). In addition, numbers of circulating CD4 and CD8 T cells exhibited milder reductions (2.1- and 1.8-fold at week 1) and earlier return to normal at a mean of weeks 3 and 4, respectively. A significant inverse correlation was found between numbers of DC and T-cell subsets and high-dose steroid treatment. Our novel findings thus suggest that the acute SARS-coronavirus infection probably contributes to the initial reduction of DC and T-cell subsets in blood, and that high-dose steroid administration may subsequently exacerbate and prolong low expression of the cell subsets. These findings will aid the framing of further studies of the immunopathogenesis of SARS.
CC :	002B06; 002A06
FD :	Syndrome respiratoire aigu sévère; Cellule dendritique; Cellule APC; Stéroïde; Traitement; Homme; Coronavirus; Cellule dendritique myéloïde; Cellule dendritique plasmocytoïde
FG :	Virose; Infection; Coronaviridae; Nidovirales; Virus; Immunologie; Immunopathologie; Appareil respiratoire pathologie; Poumon pathologie
ED :	Severe acute respiratory syndrome; Dendritic cell; Antigen presenting cell; Steroid; Treatment; Human; Coronavirus; Myeloid dendritic cell; Plasmacytoid dendritic cell
EG :	Viral disease; Infection; Coronaviridae; Nidovirales; Virus; Immunology; Immunopathology; Respiratory disease; Lung disease
SD :	Síndrome respiratorio agudo severo; Célula dendrítica; Célula presentadora de antígeno; Esteroide; Tratamiento; Hombre; Coronavirus
LO :	INIST-15461.354000131594300050
ID :	05-0404718

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Pascal:05-0404718

Le document en format XML

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<author><name sortKey="Gao, George F" sort="Gao, George F" uniqKey="Gao G" first="George F." last="Gao">George F. Gao</name>
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<author><name sortKey="Wang, Fu Sheng" sort="Wang, Fu Sheng" uniqKey="Wang F" first="Fu-Sheng" last="Wang">Fu-Sheng Wang</name>
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<series><title level="j" type="main">Clinical immunology : (Orlando, Fla. Print)</title>
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<front><div type="abstract" xml:lang="en">In this study, we found that 74 patients with severe acute respiratory syndrome (SARS) exhibited a rapid, dramatic decrease in numbers of circulating myeloid and plasmacytoid dendritic cells (mDCs and pDCs) during the first 2 weeks of illness (5.3- and 28.4-fold reductions for mDCs and pDCs compared with 25 healthy individuals, respectively), with slow return to normal cell numbers during convalescence (weeks 5-7 of illness on average). In addition, numbers of circulating CD4 and CD8 T cells exhibited milder reductions (2.1- and 1.8-fold at week 1) and earlier return to normal at a mean of weeks 3 and 4, respectively. A significant inverse correlation was found between numbers of DC and T-cell subsets and high-dose steroid treatment. Our novel findings thus suggest that the acute SARS-coronavirus infection probably contributes to the initial reduction of DC and T-cell subsets in blood, and that high-dose steroid administration may subsequently exacerbate and prolong low expression of the cell subsets. These findings will aid the framing of further studies of the immunopathogenesis of SARS.</div>
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<ET>Longitudinal alteration of circulating dendritic cell subsets and its correlation with steroid treatment in patients with severe acute respiratory syndrome</ET>
<AU>ZHENG ZHANG; DONGPING XU; YONGGANG LI; LEI JIN; MING SHI; MIN WANG; XIANZHI ZHOU; HAO WU; GAO (George F.); WANG (Fu-Sheng)</AU>
<AF>Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road/Beijing 100039/Chine (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut., 10 aut.); Beijing You'an Hospital, Capital Medical University/Beijing 100054/Chine (8 aut.); Institute of Microbiology, Chinese Academy of Sciences/Beijing 100080/Chine (9 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Clinical immunology : (Orlando, Fla. Print); ISSN 1521-6616; Coden CLIIFY; Etats-Unis; Da. 2005; Vol. 116; No. 3; Pp. 225-235; Bibl. 48 ref.</SO>
<LA>Anglais</LA>
<EA>In this study, we found that 74 patients with severe acute respiratory syndrome (SARS) exhibited a rapid, dramatic decrease in numbers of circulating myeloid and plasmacytoid dendritic cells (mDCs and pDCs) during the first 2 weeks of illness (5.3- and 28.4-fold reductions for mDCs and pDCs compared with 25 healthy individuals, respectively), with slow return to normal cell numbers during convalescence (weeks 5-7 of illness on average). In addition, numbers of circulating CD4 and CD8 T cells exhibited milder reductions (2.1- and 1.8-fold at week 1) and earlier return to normal at a mean of weeks 3 and 4, respectively. A significant inverse correlation was found between numbers of DC and T-cell subsets and high-dose steroid treatment. Our novel findings thus suggest that the acute SARS-coronavirus infection probably contributes to the initial reduction of DC and T-cell subsets in blood, and that high-dose steroid administration may subsequently exacerbate and prolong low expression of the cell subsets. These findings will aid the framing of further studies of the immunopathogenesis of SARS.</EA>
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<FD>Syndrome respiratoire aigu sévère; Cellule dendritique; Cellule APC; Stéroïde; Traitement; Homme; Coronavirus; Cellule dendritique myéloïde; Cellule dendritique plasmocytoïde</FD>
<FG>Virose; Infection; Coronaviridae; Nidovirales; Virus; Immunologie; Immunopathologie; Appareil respiratoire pathologie; Poumon pathologie</FG>
<ED>Severe acute respiratory syndrome; Dendritic cell; Antigen presenting cell; Steroid; Treatment; Human; Coronavirus; Myeloid dendritic cell; Plasmacytoid dendritic cell</ED>
<EG>Viral disease; Infection; Coronaviridae; Nidovirales; Virus; Immunology; Immunopathology; Respiratory disease; Lung disease</EG>
<SD>Síndrome respiratorio agudo severo; Célula dendrítica; Célula presentadora de antígeno; Esteroide; Tratamiento; Hombre; Coronavirus</SD>
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Longitudinal alteration of circulating dendritic cell subsets and its correlation with steroid treatment in patients with severe acute respiratory syndrome

Longitudinal alteration of circulating dendritic cell subsets and its correlation with steroid treatment in patients with severe acute respiratory syndrome

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