Anti-SARS-CoV immunity induced by a novel CpG oligodeoxynucleotide
Identifieur interne : 000533 ( PascalFrancis/Corpus ); précédent : 000532; suivant : 000534Anti-SARS-CoV immunity induced by a novel CpG oligodeoxynucleotide
Auteurs : MUSHENG BAO ; YI ZHANG ; MIN WAN ; LI DAI ; XIAOPING HU ; XIULI WU ; LI WANG ; PING DENG ; JUNZHI WANG ; JIANZHU CHEN ; YONGJUN LIU ; YONGLI YU ; LIYING WANGSource :
- Clinical immunology : (Orlando, Fla. Print) [ 1521-6616 ] ; 2006.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
To develop CpG oligodeoxynucleotides (CpG ODNs) based therapy for prevention and treatment of severe acute respiratory syndrome (SARS), we selected a novel CpG ODN (BW001), which displays B-type CpG ODN structure feature at the 5' and A-type CpG ODN structure feature at the 3', and tested for its anti-SARS-CoV activity. We found that the supematants of human PBMCs stimulated by BW001 significantly protected Vero cells from SARS-CoV infection. BW001 could stimulate human PBMCs and pDCs to secrete high level of IFN-α and promote human PBMCs and B cells to proliferate. Furthermore, we demonstrated that BW001 could activate CD19+ B cells and CD56+ NK cells in human PBMCs. In addition, BW001 could enhance NK cytotoxicity and IFN-γ secretion in human PBMCs. Together, BW001 represents a novel type of CpG ODN and may have potential for the development of treatment and prevention for SARS as well as other viral associated diseases.
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Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
NO : | PASCAL 06-0171874 INIST |
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ET : | Anti-SARS-CoV immunity induced by a novel CpG oligodeoxynucleotide |
AU : | MUSHENG BAO; YI ZHANG; MIN WAN; LI DAI; XIAOPING HU; XIULI WU; LI WANG; PING DENG; JUNZHI WANG; JIANZHU CHEN; YONGJUN LIU; YONGLI YU; LIYING WANG |
AF : | Department of Molecular Biology, College of Basic Medicine, Jilin University/Changchun 130021/Chine (1 aut., 3 aut., 4 aut., 5 aut., 6 aut., 13 aut.); National Institute for the Control of Pharmaceutical and Biological Products/Beijing 100050/Chine (2 aut., 9 aut.); Department of Immunology, College of Basic Medicine, Jilin University/Changchun 130021/Chine (7 aut., 12 aut.); The Blood Center of Jilin Province/Changchun 130033/Chine (8 aut.); Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology/Cambridge, MA 02139/Etats-Unis (10 aut.); Department of Immunology and Center for Cancer Immunology Research, University of Texas, M.D. Anderson Cancer Center/Houston, TX 77030/Etats-Unis (11 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Clinical immunology : (Orlando, Fla. Print); ISSN 1521-6616; Coden CLIIFY; Etats-Unis; Da. 2006; Vol. 118; No. 2-3; Pp. 180-187; Bibl. 29 ref. |
LA : | Anglais |
EA : | To develop CpG oligodeoxynucleotides (CpG ODNs) based therapy for prevention and treatment of severe acute respiratory syndrome (SARS), we selected a novel CpG ODN (BW001), which displays B-type CpG ODN structure feature at the 5' and A-type CpG ODN structure feature at the 3', and tested for its anti-SARS-CoV activity. We found that the supematants of human PBMCs stimulated by BW001 significantly protected Vero cells from SARS-CoV infection. BW001 could stimulate human PBMCs and pDCs to secrete high level of IFN-α and promote human PBMCs and B cells to proliferate. Furthermore, we demonstrated that BW001 could activate CD19+ B cells and CD56+ NK cells in human PBMCs. In addition, BW001 could enhance NK cytotoxicity and IFN-γ secretion in human PBMCs. Together, BW001 represents a novel type of CpG ODN and may have potential for the development of treatment and prevention for SARS as well as other viral associated diseases. |
CC : | 002B06; 002A06 |
FD : | Syndrome respiratoire aigu sévère; Coronavirus; Immunité; Interféron gamma; Séquence riche GC; Séquence nucléotide; Oligodésoxyribonucléotide; Mononucléaire; Lymphocyte B; Cellule NK |
FG : | Virose; Infection; Coronaviridae; Nidovirales; Virus; Immunologie; Immunopathologie; Appareil respiratoire pathologie; Poumon pathologie |
ED : | Severe acute respiratory syndrome; Coronavirus; Immunity; Gamma interferon; GC rich sequence; Nucleotide sequence; Oligodeoxyribonucleotide; Mononuclear cell; B-Lymphocyte; Natural killer cell |
EG : | Viral disease; Infection; Coronaviridae; Nidovirales; Virus; Immunology; Immunopathology; Respiratory disease; Lung disease |
SD : | Síndrome respiratorio agudo severo; Coronavirus; Inmunidad; Interferón gamma; Secuencia rica GC; Secuencia nucleótido; Oligodesoxirribonucleótido; Mononuclear; Linfocito B; Célula NK |
LO : | INIST-15461.354000153419030080 |
ID : | 06-0171874 |
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Pascal:06-0171874Le document en format XML
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<front><div type="abstract" xml:lang="en">To develop CpG oligodeoxynucleotides (CpG ODNs) based therapy for prevention and treatment of severe acute respiratory syndrome (SARS), we selected a novel CpG ODN (BW001), which displays B-type CpG ODN structure feature at the 5' and A-type CpG ODN structure feature at the 3', and tested for its anti-SARS-CoV activity. We found that the supematants of human PBMCs stimulated by BW001 significantly protected Vero cells from SARS-CoV infection. BW001 could stimulate human PBMCs and pDCs to secrete high level of IFN-α and promote human PBMCs and B cells to proliferate. Furthermore, we demonstrated that BW001 could activate CD19<sup>+</sup>
B cells and CD56<sup>+</sup>
NK cells in human PBMCs. In addition, BW001 could enhance NK cytotoxicity and IFN-γ secretion in human PBMCs. Together, BW001 represents a novel type of CpG ODN and may have potential for the development of treatment and prevention for SARS as well as other viral associated diseases.</div>
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<fA14 i1="06"><s1>Department of Immunology and Center for Cancer Immunology Research, University of Texas, M.D. Anderson Cancer Center</s1>
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<fA21><s1>2006</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>15461</s2>
<s5>354000153419030080</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2006 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>29 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>06-0171874</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Clinical immunology : (Orlando, Fla. Print)</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>To develop CpG oligodeoxynucleotides (CpG ODNs) based therapy for prevention and treatment of severe acute respiratory syndrome (SARS), we selected a novel CpG ODN (BW001), which displays B-type CpG ODN structure feature at the 5' and A-type CpG ODN structure feature at the 3', and tested for its anti-SARS-CoV activity. We found that the supematants of human PBMCs stimulated by BW001 significantly protected Vero cells from SARS-CoV infection. BW001 could stimulate human PBMCs and pDCs to secrete high level of IFN-α and promote human PBMCs and B cells to proliferate. Furthermore, we demonstrated that BW001 could activate CD19<sup>+</sup>
B cells and CD56<sup>+</sup>
NK cells in human PBMCs. In addition, BW001 could enhance NK cytotoxicity and IFN-γ secretion in human PBMCs. Together, BW001 represents a novel type of CpG ODN and may have potential for the development of treatment and prevention for SARS as well as other viral associated diseases.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B06</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002A06</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Syndrome respiratoire aigu sévère</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Severe acute respiratory syndrome</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Síndrome respiratorio agudo severo</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Immunité</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Immunity</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Inmunidad</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Interféron gamma</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Gamma interferon</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Interferón gamma</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Séquence riche GC</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>GC rich sequence</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Secuencia rica GC</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Séquence nucléotide</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Nucleotide sequence</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Secuencia nucleótido</s0>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Oligodésoxyribonucléotide</s0>
<s5>08</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Oligodeoxyribonucleotide</s0>
<s5>08</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Oligodesoxirribonucleótido</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Mononucléaire</s0>
<s5>11</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Mononuclear cell</s0>
<s5>11</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Mononuclear</s0>
<s5>11</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Lymphocyte B</s0>
<s5>12</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>B-Lymphocyte</s0>
<s5>12</s5>
<s6>«B»-Lymphocyte</s6>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Linfocito B</s0>
<s5>12</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Cellule NK</s0>
<s5>17</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Natural killer cell</s0>
<s5>17</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Célula NK</s0>
<s5>17</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Virose</s0>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Viral disease</s0>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Virosis</s0>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Infection</s0>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Infection</s0>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Infección</s0>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Immunologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Immunology</s0>
<s5>37</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Inmunología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Immunopathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Immunopathology</s0>
<s5>38</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Inmunopatología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Appareil respiratoire pathologie</s0>
<s5>39</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0>
<s5>39</s5>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Poumon pathologie</s0>
<s5>40</s5>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Lung disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Pulmón patología</s0>
<s5>40</s5>
</fC07>
<fN21><s1>107</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 06-0171874 INIST</NO>
<ET>Anti-SARS-CoV immunity induced by a novel CpG oligodeoxynucleotide</ET>
<AU>MUSHENG BAO; YI ZHANG; MIN WAN; LI DAI; XIAOPING HU; XIULI WU; LI WANG; PING DENG; JUNZHI WANG; JIANZHU CHEN; YONGJUN LIU; YONGLI YU; LIYING WANG</AU>
<AF>Department of Molecular Biology, College of Basic Medicine, Jilin University/Changchun 130021/Chine (1 aut., 3 aut., 4 aut., 5 aut., 6 aut., 13 aut.); National Institute for the Control of Pharmaceutical and Biological Products/Beijing 100050/Chine (2 aut., 9 aut.); Department of Immunology, College of Basic Medicine, Jilin University/Changchun 130021/Chine (7 aut., 12 aut.); The Blood Center of Jilin Province/Changchun 130033/Chine (8 aut.); Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology/Cambridge, MA 02139/Etats-Unis (10 aut.); Department of Immunology and Center for Cancer Immunology Research, University of Texas, M.D. Anderson Cancer Center/Houston, TX 77030/Etats-Unis (11 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Clinical immunology : (Orlando, Fla. Print); ISSN 1521-6616; Coden CLIIFY; Etats-Unis; Da. 2006; Vol. 118; No. 2-3; Pp. 180-187; Bibl. 29 ref.</SO>
<LA>Anglais</LA>
<EA>To develop CpG oligodeoxynucleotides (CpG ODNs) based therapy for prevention and treatment of severe acute respiratory syndrome (SARS), we selected a novel CpG ODN (BW001), which displays B-type CpG ODN structure feature at the 5' and A-type CpG ODN structure feature at the 3', and tested for its anti-SARS-CoV activity. We found that the supematants of human PBMCs stimulated by BW001 significantly protected Vero cells from SARS-CoV infection. BW001 could stimulate human PBMCs and pDCs to secrete high level of IFN-α and promote human PBMCs and B cells to proliferate. Furthermore, we demonstrated that BW001 could activate CD19<sup>+</sup>
B cells and CD56<sup>+</sup>
NK cells in human PBMCs. In addition, BW001 could enhance NK cytotoxicity and IFN-γ secretion in human PBMCs. Together, BW001 represents a novel type of CpG ODN and may have potential for the development of treatment and prevention for SARS as well as other viral associated diseases.</EA>
<CC>002B06; 002A06</CC>
<FD>Syndrome respiratoire aigu sévère; Coronavirus; Immunité; Interféron gamma; Séquence riche GC; Séquence nucléotide; Oligodésoxyribonucléotide; Mononucléaire; Lymphocyte B; Cellule NK</FD>
<FG>Virose; Infection; Coronaviridae; Nidovirales; Virus; Immunologie; Immunopathologie; Appareil respiratoire pathologie; Poumon pathologie</FG>
<ED>Severe acute respiratory syndrome; Coronavirus; Immunity; Gamma interferon; GC rich sequence; Nucleotide sequence; Oligodeoxyribonucleotide; Mononuclear cell; B-Lymphocyte; Natural killer cell</ED>
<EG>Viral disease; Infection; Coronaviridae; Nidovirales; Virus; Immunology; Immunopathology; Respiratory disease; Lung disease</EG>
<SD>Síndrome respiratorio agudo severo; Coronavirus; Inmunidad; Interferón gamma; Secuencia rica GC; Secuencia nucleótido; Oligodesoxirribonucleótido; Mononuclear; Linfocito B; Célula NK</SD>
<LO>INIST-15461.354000153419030080</LO>
<ID>06-0171874</ID>
</server>
</inist>
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