SrasV1, PascalFrancis, Corpus, bibRecord, 000480

Interaction of severe acute respiratory syndrome- associated coronavirus with dendritic cells

Identifieur interne : 000480 ( PascalFrancis/Corpus ); précédent : 000479; suivant : 000481

Interaction of severe acute respiratory syndrome- associated coronavirus with dendritic cells

Auteurs : Martin Spiegel ; Kerstin Schneider ; Friedemann Weber ; Manfred Weidmann ; Frank T. Hufert

Source :

Journal of general virology [ 0022-1317 ] ; 2006.

RBID : Pascal:06-0345668

Descripteurs français

Pascal (Inist)
- Coronavirus, Cellule dendritique, Microbiologie, Virologie, Syndrome respiratoire aigu sévère.

English descriptors

KwdEn :
- Coronavirus, Dendritic cell, Microbiology, Severe acute respiratory syndrome, Virology.

Abstract

Severe acute respiratory syndrome (SARS) of humans is caused by a novel coronavirus of zoonotic origin termed SARS-associated coronavirus (SARS-CoV). The virus induces severe injury of lung tissue, as well as lymphopenia and destruction of the architecture of lymphatic tissue by as-yet-unknown mechanisms. In this study, the interaction of SARS-CoV with dendritic cells (DCs), the key regulators of immune responses, was analysed. Monocyte-derived DCs were infected with SARS-CoV and analysed for viability, surface-marker expression and alpha interferon (IFN-α) induction. SARS-CoV infection was monitored by quantitative RT-PCR, immunofluorescence analysis and recovery experiments. SARS-CoV infected both immature and mature DCs, although replication efficiency was low. Immature DCs were activated by SARS-CoV infection and by UV-inactivated SARS-CoV. Infected DCs were still viable on day 6 post-infection, but major histocompatibility complex class I upregulation was missing, indicating that DC function was impaired. Additionally, SARS-CoV infection induced a delayed activation of IFN-a expression. Therefore, it is concluded that SARS-CoV has the ability to circumvent both the innate and the adaptive immune systems.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A14	`01`			`@1 Institute for Virology, University of Goettingen, Kreuzbergring 57 @2 37075 Goettingen @3 DEU @Z 1 aut. @Z 4 aut. @Z 5 aut.`
A14	`02`			`@1 Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Hermann-Herder-Strasse 11 @2 79104 Freiburg @3 DEU @Z 2 aut. @Z 3 aut.`
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C01	`01`		`ENG`	@0 Severe acute respiratory syndrome (SARS) of humans is caused by a novel coronavirus of zoonotic origin termed SARS-associated coronavirus (SARS-CoV). The virus induces severe injury of lung tissue, as well as lymphopenia and destruction of the architecture of lymphatic tissue by as-yet-unknown mechanisms. In this study, the interaction of SARS-CoV with dendritic cells (DCs), the key regulators of immune responses, was analysed. Monocyte-derived DCs were infected with SARS-CoV and analysed for viability, surface-marker expression and alpha interferon (IFN-α) induction. SARS-CoV infection was monitored by quantitative RT-PCR, immunofluorescence analysis and recovery experiments. SARS-CoV infected both immature and mature DCs, although replication efficiency was low. Immature DCs were activated by SARS-CoV infection and by UV-inactivated SARS-CoV. Infected DCs were still viable on day 6 post-infection, but major histocompatibility complex class I upregulation was missing, indicating that DC function was impaired. Additionally, SARS-CoV infection induced a delayed activation of IFN-a expression. Therefore, it is concluded that SARS-CoV has the ability to circumvent both the innate and the adaptive immune systems.
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Format Inist (serveur)

NO :	PASCAL 06-0345668 INIST
ET :	Interaction of severe acute respiratory syndrome- associated coronavirus with dendritic cells
AU :	SPIEGEL (Martin); SCHNEIDER (Kerstin); WEBER (Friedemann); WEIDMANN (Manfred); HUFERT (Frank T.)
AF :	Institute for Virology, University of Goettingen, Kreuzbergring 57/37075 Goettingen/Allemagne (1 aut., 4 aut., 5 aut.); Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Hermann-Herder-Strasse 11/79104 Freiburg/Allemagne (2 aut., 3 aut.)
DT :	Publication en série; Niveau analytique
SO :	Journal of general virology; ISSN 0022-1317; Coden JGVIAY; Royaume-Uni; Da. 2006; Vol. 87; No. p.7; Pp. 1953-1960; Bibl. 1 p.1/4
LA :	Anglais
EA :	Severe acute respiratory syndrome (SARS) of humans is caused by a novel coronavirus of zoonotic origin termed SARS-associated coronavirus (SARS-CoV). The virus induces severe injury of lung tissue, as well as lymphopenia and destruction of the architecture of lymphatic tissue by as-yet-unknown mechanisms. In this study, the interaction of SARS-CoV with dendritic cells (DCs), the key regulators of immune responses, was analysed. Monocyte-derived DCs were infected with SARS-CoV and analysed for viability, surface-marker expression and alpha interferon (IFN-α) induction. SARS-CoV infection was monitored by quantitative RT-PCR, immunofluorescence analysis and recovery experiments. SARS-CoV infected both immature and mature DCs, although replication efficiency was low. Immature DCs were activated by SARS-CoV infection and by UV-inactivated SARS-CoV. Infected DCs were still viable on day 6 post-infection, but major histocompatibility complex class I upregulation was missing, indicating that DC function was impaired. Additionally, SARS-CoV infection induced a delayed activation of IFN-a expression. Therefore, it is concluded that SARS-CoV has the ability to circumvent both the innate and the adaptive immune systems.
CC :	002A05C10
FD :	Coronavirus; Cellule dendritique; Microbiologie; Virologie; Syndrome respiratoire aigu sévère
FG :	Coronaviridae; Nidovirales; Virus; Appareil respiratoire pathologie; Virose; Infection; Poumon pathologie
ED :	Coronavirus; Dendritic cell; Microbiology; Virology; Severe acute respiratory syndrome
EG :	Coronaviridae; Nidovirales; Virus; Respiratory disease; Viral disease; Infection; Lung disease
SD :	Coronavirus; Célula dendrítica; Microbiología; Virología; Síndrome respiratorio agudo severo
LO :	INIST-13533.354000142400560170
ID :	06-0345668

Links to Exploration step

Pascal:06-0345668

Le document en format XML

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<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) of humans is caused by a novel coronavirus of zoonotic origin termed SARS-associated coronavirus (SARS-CoV). The virus induces severe injury of lung tissue, as well as lymphopenia and destruction of the architecture of lymphatic tissue by as-yet-unknown mechanisms. In this study, the interaction of SARS-CoV with dendritic cells (DCs), the key regulators of immune responses, was analysed. Monocyte-derived DCs were infected with SARS-CoV and analysed for viability, surface-marker expression and alpha interferon (IFN-α) induction. SARS-CoV infection was monitored by quantitative RT-PCR, immunofluorescence analysis and recovery experiments. SARS-CoV infected both immature and mature DCs, although replication efficiency was low. Immature DCs were activated by SARS-CoV infection and by UV-inactivated SARS-CoV. Infected DCs were still viable on day 6 post-infection, but major histocompatibility complex class I upregulation was missing, indicating that DC function was impaired. Additionally, SARS-CoV infection induced a delayed activation of IFN-a expression. Therefore, it is concluded that SARS-CoV has the ability to circumvent both the innate and the adaptive immune systems.</div>
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<server><NO>PASCAL 06-0345668 INIST</NO>
<ET>Interaction of severe acute respiratory syndrome- associated coronavirus with dendritic cells</ET>
<AU>SPIEGEL (Martin); SCHNEIDER (Kerstin); WEBER (Friedemann); WEIDMANN (Manfred); HUFERT (Frank T.)</AU>
<AF>Institute for Virology, University of Goettingen, Kreuzbergring 57/37075 Goettingen/Allemagne (1 aut., 4 aut., 5 aut.); Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Hermann-Herder-Strasse 11/79104 Freiburg/Allemagne (2 aut., 3 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Journal of general virology; ISSN 0022-1317; Coden JGVIAY; Royaume-Uni; Da. 2006; Vol. 87; No. p.7; Pp. 1953-1960; Bibl. 1 p.1/4</SO>
<LA>Anglais</LA>
<EA>Severe acute respiratory syndrome (SARS) of humans is caused by a novel coronavirus of zoonotic origin termed SARS-associated coronavirus (SARS-CoV). The virus induces severe injury of lung tissue, as well as lymphopenia and destruction of the architecture of lymphatic tissue by as-yet-unknown mechanisms. In this study, the interaction of SARS-CoV with dendritic cells (DCs), the key regulators of immune responses, was analysed. Monocyte-derived DCs were infected with SARS-CoV and analysed for viability, surface-marker expression and alpha interferon (IFN-α) induction. SARS-CoV infection was monitored by quantitative RT-PCR, immunofluorescence analysis and recovery experiments. SARS-CoV infected both immature and mature DCs, although replication efficiency was low. Immature DCs were activated by SARS-CoV infection and by UV-inactivated SARS-CoV. Infected DCs were still viable on day 6 post-infection, but major histocompatibility complex class I upregulation was missing, indicating that DC function was impaired. Additionally, SARS-CoV infection induced a delayed activation of IFN-a expression. Therefore, it is concluded that SARS-CoV has the ability to circumvent both the innate and the adaptive immune systems.</EA>
<CC>002A05C10</CC>
<FD>Coronavirus; Cellule dendritique; Microbiologie; Virologie; Syndrome respiratoire aigu sévère</FD>
<FG>Coronaviridae; Nidovirales; Virus; Appareil respiratoire pathologie; Virose; Infection; Poumon pathologie</FG>
<ED>Coronavirus; Dendritic cell; Microbiology; Virology; Severe acute respiratory syndrome</ED>
<EG>Coronaviridae; Nidovirales; Virus; Respiratory disease; Viral disease; Infection; Lung disease</EG>
<SD>Coronavirus; Célula dendrítica; Microbiología; Virología; Síndrome respiratorio agudo severo</SD>
<LO>INIST-13533.354000142400560170</LO>
<ID>06-0345668</ID>
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Interaction of severe acute respiratory syndrome- associated coronavirus with dendritic cells

Interaction of severe acute respiratory syndrome- associated coronavirus with dendritic cells

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