Molecular pathology in the lungs of severe acute respiratory syndrome patients
Identifieur interne : 000410 ( PascalFrancis/Corpus ); précédent : 000409; suivant : 000411Molecular pathology in the lungs of severe acute respiratory syndrome patients
Auteurs : JUXIANG YE ; BO ZHANG ; JIAN XU ; QING CHANG ; Michael A. Mcnutt ; Christine Korteweg ; Encong Gong ; JIANG GUSource :
- The American journal of pathology [ 0002-9440 ] ; 2007.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Severe acute respiratory syndrome (SARS) is a novel infectious disease with disastrous clinical consequences, in which the lungs are the major target organs. Previous studies have described the general pathology in the lungs of SARS patients and have identified some of the cell types infected by SARS coronavirus (SARS-CoV). However, at the time of this writing, there were no comprehensive reports of the cellular distribution of the virus in lung tissue. In this study, we have performed double labeling combining in situ hybridization with immunohistochemistry and alternating each of these techniques separately in consecutive sections to evaluate the viral distribution on various cell types in the lungs of seven patients affected with SARS. We found that SARS-CoV was present in bronchial epithelium, type I and II pneumocytes, T lymphocytes, and macrophages/monocytes. For pneumocytes, T lymphocytes, and macrophages, the infection rates were calculated. In addition, our present study is the first to demonstrate infection of endothelial cells and fibroblasts in SARS.
Notice en format standard (ISO 2709)
Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
NO : | PASCAL 07-0102218 INIST |
---|---|
ET : | Molecular pathology in the lungs of severe acute respiratory syndrome patients |
AU : | JUXIANG YE; BO ZHANG; JIAN XU; QING CHANG; MCNUTT (Michael A.); KORTEWEG (Christine); GONG (Encong); JIANG GU |
AF : | Department of Pathology, School of Basic Medical Science, Peking University Health Science Center/Beijing/Chine (1 aut., 2 aut., 4 aut., 5 aut., 6 aut., 7 aut., 8 aut.); Department of Histology and Embryology, Peking University Health Science Center/Beijing/Chine (3 aut.); Department of Pathology, State University of New York-Health Science Center at Brooklyn/Brooklyn, New York/Etats-Unis (8 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | The American journal of pathology; ISSN 0002-9440; Coden AJPAA4; Etats-Unis; Da. 2007; Vol. 170; No. 2; Pp. 538-545; Bibl. 30 ref. |
LA : | Anglais |
EA : | Severe acute respiratory syndrome (SARS) is a novel infectious disease with disastrous clinical consequences, in which the lungs are the major target organs. Previous studies have described the general pathology in the lungs of SARS patients and have identified some of the cell types infected by SARS coronavirus (SARS-CoV). However, at the time of this writing, there were no comprehensive reports of the cellular distribution of the virus in lung tissue. In this study, we have performed double labeling combining in situ hybridization with immunohistochemistry and alternating each of these techniques separately in consecutive sections to evaluate the viral distribution on various cell types in the lungs of seven patients affected with SARS. We found that SARS-CoV was present in bronchial epithelium, type I and II pneumocytes, T lymphocytes, and macrophages/monocytes. For pneumocytes, T lymphocytes, and macrophages, the infection rates were calculated. In addition, our present study is the first to demonstrate infection of endothelial cells and fibroblasts in SARS. |
CC : | 002B24O; 002B05C02C |
FD : | Génétique; Poumon pathologie; Syndrome respiratoire aigu sévère; Homme; Anatomopathologie |
FG : | Virose; Infection; Appareil respiratoire pathologie |
ED : | Genetics; Lung disease; Severe acute respiratory syndrome; Human; Anatomic pathology |
EG : | Viral disease; Infection; Respiratory disease |
SD : | Genética; Pulmón patología; Síndrome respiratorio agudo severo; Hombre; Anatomía patológica |
LO : | INIST-2047.354000159754450120 |
ID : | 07-0102218 |
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<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is a novel infectious disease with disastrous clinical consequences, in which the lungs are the major target organs. Previous studies have described the general pathology in the lungs of SARS patients and have identified some of the cell types infected by SARS coronavirus (SARS-CoV). However, at the time of this writing, there were no comprehensive reports of the cellular distribution of the virus in lung tissue. In this study, we have performed double labeling combining in situ hybridization with immunohistochemistry and alternating each of these techniques separately in consecutive sections to evaluate the viral distribution on various cell types in the lungs of seven patients affected with SARS. We found that SARS-CoV was present in bronchial epithelium, type I and II pneumocytes, T lymphocytes, and macrophages/monocytes. For pneumocytes, T lymphocytes, and macrophages, the infection rates were calculated. In addition, our present study is the first to demonstrate infection of endothelial cells and fibroblasts in SARS.</div>
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<server><NO>PASCAL 07-0102218 INIST</NO>
<ET>Molecular pathology in the lungs of severe acute respiratory syndrome patients</ET>
<AU>JUXIANG YE; BO ZHANG; JIAN XU; QING CHANG; MCNUTT (Michael A.); KORTEWEG (Christine); GONG (Encong); JIANG GU</AU>
<AF>Department of Pathology, School of Basic Medical Science, Peking University Health Science Center/Beijing/Chine (1 aut., 2 aut., 4 aut., 5 aut., 6 aut., 7 aut., 8 aut.); Department of Histology and Embryology, Peking University Health Science Center/Beijing/Chine (3 aut.); Department of Pathology, State University of New York-Health Science Center at Brooklyn/Brooklyn, New York/Etats-Unis (8 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>The American journal of pathology; ISSN 0002-9440; Coden AJPAA4; Etats-Unis; Da. 2007; Vol. 170; No. 2; Pp. 538-545; Bibl. 30 ref.</SO>
<LA>Anglais</LA>
<EA>Severe acute respiratory syndrome (SARS) is a novel infectious disease with disastrous clinical consequences, in which the lungs are the major target organs. Previous studies have described the general pathology in the lungs of SARS patients and have identified some of the cell types infected by SARS coronavirus (SARS-CoV). However, at the time of this writing, there were no comprehensive reports of the cellular distribution of the virus in lung tissue. In this study, we have performed double labeling combining in situ hybridization with immunohistochemistry and alternating each of these techniques separately in consecutive sections to evaluate the viral distribution on various cell types in the lungs of seven patients affected with SARS. We found that SARS-CoV was present in bronchial epithelium, type I and II pneumocytes, T lymphocytes, and macrophages/monocytes. For pneumocytes, T lymphocytes, and macrophages, the infection rates were calculated. In addition, our present study is the first to demonstrate infection of endothelial cells and fibroblasts in SARS.</EA>
<CC>002B24O; 002B05C02C</CC>
<FD>Génétique; Poumon pathologie; Syndrome respiratoire aigu sévère; Homme; Anatomopathologie</FD>
<FG>Virose; Infection; Appareil respiratoire pathologie</FG>
<ED>Genetics; Lung disease; Severe acute respiratory syndrome; Human; Anatomic pathology</ED>
<EG>Viral disease; Infection; Respiratory disease</EG>
<SD>Genética; Pulmón patología; Síndrome respiratorio agudo severo; Hombre; Anatomía patológica</SD>
<LO>INIST-2047.354000159754450120</LO>
<ID>07-0102218</ID>
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