SrasV1, PascalFrancis, Corpus, bibRecord, 000410

Molecular pathology in the lungs of severe acute respiratory syndrome patients

Identifieur interne : 000410 ( PascalFrancis/Corpus ); précédent : 000409; suivant : 000411

Molecular pathology in the lungs of severe acute respiratory syndrome patients

Auteurs : JUXIANG YE ; BO ZHANG ; JIAN XU ; QING CHANG ; Michael A. Mcnutt ; Christine Korteweg ; Encong Gong ; JIANG GU

Source :

The American journal of pathology [ 0002-9440 ] ; 2007.

RBID : Pascal:07-0102218

Descripteurs français

Pascal (Inist)
- Génétique, Poumon pathologie, Syndrome respiratoire aigu sévère, Homme, Anatomopathologie.

English descriptors

KwdEn :
- Anatomic pathology, Genetics, Human, Lung disease, Severe acute respiratory syndrome.

Abstract

Severe acute respiratory syndrome (SARS) is a novel infectious disease with disastrous clinical consequences, in which the lungs are the major target organs. Previous studies have described the general pathology in the lungs of SARS patients and have identified some of the cell types infected by SARS coronavirus (SARS-CoV). However, at the time of this writing, there were no comprehensive reports of the cellular distribution of the virus in lung tissue. In this study, we have performed double labeling combining in situ hybridization with immunohistochemistry and alternating each of these techniques separately in consecutive sections to evaluate the viral distribution on various cell types in the lungs of seven patients affected with SARS. We found that SARS-CoV was present in bronchial epithelium, type I and II pneumocytes, T lymphocytes, and macrophages/monocytes. For pneumocytes, T lymphocytes, and macrophages, the infection rates were calculated. In addition, our present study is the first to demonstrate infection of endothelial cells and fibroblasts in SARS.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A02	`01`			`@0 AJPAA4`
A03		`1`		`@0 Am. j. pathol.`
A05				`@2 170`
A06				`@2 2`
A08	`01`	`1`	`ENG`	`@1 Molecular pathology in the lungs of severe acute respiratory syndrome patients`
A11	`01`	`1`		`@1 JUXIANG YE`
A11	`02`	`1`		`@1 BO ZHANG`
A11	`03`	`1`		`@1 JIAN XU`
A11	`04`	`1`		`@1 QING CHANG`
A11	`05`	`1`		`@1 MCNUTT (Michael A.)`
A11	`06`	`1`		`@1 KORTEWEG (Christine)`
A11	`07`	`1`		`@1 GONG (Encong)`
A11	`08`	`1`		`@1 JIANG GU`
A14	`01`			`@1 Department of Pathology, School of Basic Medical Science, Peking University Health Science Center @2 Beijing @3 CHN @Z 1 aut. @Z 2 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut. @Z 7 aut. @Z 8 aut.`
A14	`02`			`@1 Department of Histology and Embryology, Peking University Health Science Center @2 Beijing @3 CHN @Z 3 aut.`
A14	`03`			`@1 Department of Pathology, State University of New York-Health Science Center at Brooklyn @2 Brooklyn, New York @3 USA @Z 8 aut.`
A20				`@1 538-545`
A21				`@1 2007`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 2047 @5 354000159754450120`
A44				`@0 0000 @1 © 2007 INIST-CNRS. All rights reserved.`
A45				`@0 30 ref.`
A47	`01`	`1`		`@0 07-0102218`
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A61				`@0 A`
A64	`01`	`1`		`@0 The American journal of pathology`
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C01	`01`		`ENG`	@0 Severe acute respiratory syndrome (SARS) is a novel infectious disease with disastrous clinical consequences, in which the lungs are the major target organs. Previous studies have described the general pathology in the lungs of SARS patients and have identified some of the cell types infected by SARS coronavirus (SARS-CoV). However, at the time of this writing, there were no comprehensive reports of the cellular distribution of the virus in lung tissue. In this study, we have performed double labeling combining in situ hybridization with immunohistochemistry and alternating each of these techniques separately in consecutive sections to evaluate the viral distribution on various cell types in the lungs of seven patients affected with SARS. We found that SARS-CoV was present in bronchial epithelium, type I and II pneumocytes, T lymphocytes, and macrophages/monocytes. For pneumocytes, T lymphocytes, and macrophages, the infection rates were calculated. In addition, our present study is the first to demonstrate infection of endothelial cells and fibroblasts in SARS.
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C03	`01`	`X`	`SPA`	`@0 Genética @5 02`
C03	`02`	`X`	`FRE`	`@0 Poumon pathologie @5 03`
C03	`02`	`X`	`ENG`	`@0 Lung disease @5 03`
C03	`02`	`X`	`SPA`	`@0 Pulmón patología @5 03`
C03	`03`	`X`	`FRE`	`@0 Syndrome respiratoire aigu sévère @2 NM @5 05`
C03	`03`	`X`	`ENG`	`@0 Severe acute respiratory syndrome @2 NM @5 05`
C03	`03`	`X`	`SPA`	`@0 Síndrome respiratorio agudo severo @2 NM @5 05`
C03	`04`	`X`	`FRE`	`@0 Homme @5 06`
C03	`04`	`X`	`ENG`	`@0 Human @5 06`
C03	`04`	`X`	`SPA`	`@0 Hombre @5 06`
C03	`05`	`X`	`FRE`	`@0 Anatomopathologie @5 08`
C03	`05`	`X`	`ENG`	`@0 Anatomic pathology @5 08`
C03	`05`	`X`	`SPA`	`@0 Anatomía patológica @5 08`
C07	`01`	`X`	`FRE`	`@0 Virose`
C07	`01`	`X`	`ENG`	`@0 Viral disease`
C07	`01`	`X`	`SPA`	`@0 Virosis`
C07	`02`	`X`	`FRE`	`@0 Infection`
C07	`02`	`X`	`ENG`	`@0 Infection`
C07	`02`	`X`	`SPA`	`@0 Infección`
C07	`03`	`X`	`FRE`	`@0 Appareil respiratoire pathologie @5 37`
C07	`03`	`X`	`ENG`	`@0 Respiratory disease @5 37`
C07	`03`	`X`	`SPA`	`@0 Aparato respiratorio patología @5 37`
N21				`@1 064`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 07-0102218 INIST
ET :	Molecular pathology in the lungs of severe acute respiratory syndrome patients
AU :	JUXIANG YE; BO ZHANG; JIAN XU; QING CHANG; MCNUTT (Michael A.); KORTEWEG (Christine); GONG (Encong); JIANG GU
AF :	Department of Pathology, School of Basic Medical Science, Peking University Health Science Center/Beijing/Chine (1 aut., 2 aut., 4 aut., 5 aut., 6 aut., 7 aut., 8 aut.); Department of Histology and Embryology, Peking University Health Science Center/Beijing/Chine (3 aut.); Department of Pathology, State University of New York-Health Science Center at Brooklyn/Brooklyn, New York/Etats-Unis (8 aut.)
DT :	Publication en série; Niveau analytique
SO :	The American journal of pathology; ISSN 0002-9440; Coden AJPAA4; Etats-Unis; Da. 2007; Vol. 170; No. 2; Pp. 538-545; Bibl. 30 ref.
LA :	Anglais
EA :	Severe acute respiratory syndrome (SARS) is a novel infectious disease with disastrous clinical consequences, in which the lungs are the major target organs. Previous studies have described the general pathology in the lungs of SARS patients and have identified some of the cell types infected by SARS coronavirus (SARS-CoV). However, at the time of this writing, there were no comprehensive reports of the cellular distribution of the virus in lung tissue. In this study, we have performed double labeling combining in situ hybridization with immunohistochemistry and alternating each of these techniques separately in consecutive sections to evaluate the viral distribution on various cell types in the lungs of seven patients affected with SARS. We found that SARS-CoV was present in bronchial epithelium, type I and II pneumocytes, T lymphocytes, and macrophages/monocytes. For pneumocytes, T lymphocytes, and macrophages, the infection rates were calculated. In addition, our present study is the first to demonstrate infection of endothelial cells and fibroblasts in SARS.
CC :	002B24O; 002B05C02C
FD :	Génétique; Poumon pathologie; Syndrome respiratoire aigu sévère; Homme; Anatomopathologie
FG :	Virose; Infection; Appareil respiratoire pathologie
ED :	Genetics; Lung disease; Severe acute respiratory syndrome; Human; Anatomic pathology
EG :	Viral disease; Infection; Respiratory disease
SD :	Genética; Pulmón patología; Síndrome respiratorio agudo severo; Hombre; Anatomía patológica
LO :	INIST-2047.354000159754450120
ID :	07-0102218

Links to Exploration step

Pascal:07-0102218

Le document en format XML

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<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is a novel infectious disease with disastrous clinical consequences, in which the lungs are the major target organs. Previous studies have described the general pathology in the lungs of SARS patients and have identified some of the cell types infected by SARS coronavirus (SARS-CoV). However, at the time of this writing, there were no comprehensive reports of the cellular distribution of the virus in lung tissue. In this study, we have performed double labeling combining in situ hybridization with immunohistochemistry and alternating each of these techniques separately in consecutive sections to evaluate the viral distribution on various cell types in the lungs of seven patients affected with SARS. We found that SARS-CoV was present in bronchial epithelium, type I and II pneumocytes, T lymphocytes, and macrophages/monocytes. For pneumocytes, T lymphocytes, and macrophages, the infection rates were calculated. In addition, our present study is the first to demonstrate infection of endothelial cells and fibroblasts in SARS.</div>
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<server><NO>PASCAL 07-0102218 INIST</NO>
<ET>Molecular pathology in the lungs of severe acute respiratory syndrome patients</ET>
<AU>JUXIANG YE; BO ZHANG; JIAN XU; QING CHANG; MCNUTT (Michael A.); KORTEWEG (Christine); GONG (Encong); JIANG GU</AU>
<AF>Department of Pathology, School of Basic Medical Science, Peking University Health Science Center/Beijing/Chine (1 aut., 2 aut., 4 aut., 5 aut., 6 aut., 7 aut., 8 aut.); Department of Histology and Embryology, Peking University Health Science Center/Beijing/Chine (3 aut.); Department of Pathology, State University of New York-Health Science Center at Brooklyn/Brooklyn, New York/Etats-Unis (8 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>The American journal of pathology; ISSN 0002-9440; Coden AJPAA4; Etats-Unis; Da. 2007; Vol. 170; No. 2; Pp. 538-545; Bibl. 30 ref.</SO>
<LA>Anglais</LA>
<EA>Severe acute respiratory syndrome (SARS) is a novel infectious disease with disastrous clinical consequences, in which the lungs are the major target organs. Previous studies have described the general pathology in the lungs of SARS patients and have identified some of the cell types infected by SARS coronavirus (SARS-CoV). However, at the time of this writing, there were no comprehensive reports of the cellular distribution of the virus in lung tissue. In this study, we have performed double labeling combining in situ hybridization with immunohistochemistry and alternating each of these techniques separately in consecutive sections to evaluate the viral distribution on various cell types in the lungs of seven patients affected with SARS. We found that SARS-CoV was present in bronchial epithelium, type I and II pneumocytes, T lymphocytes, and macrophages/monocytes. For pneumocytes, T lymphocytes, and macrophages, the infection rates were calculated. In addition, our present study is the first to demonstrate infection of endothelial cells and fibroblasts in SARS.</EA>
<CC>002B24O; 002B05C02C</CC>
<FD>Génétique; Poumon pathologie; Syndrome respiratoire aigu sévère; Homme; Anatomopathologie</FD>
<FG>Virose; Infection; Appareil respiratoire pathologie</FG>
<ED>Genetics; Lung disease; Severe acute respiratory syndrome; Human; Anatomic pathology</ED>
<EG>Viral disease; Infection; Respiratory disease</EG>
<SD>Genética; Pulmón patología; Síndrome respiratorio agudo severo; Hombre; Anatomía patológica</SD>
<LO>INIST-2047.354000159754450120</LO>
<ID>07-0102218</ID>
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Molecular pathology in the lungs of severe acute respiratory syndrome patients

Molecular pathology in the lungs of severe acute respiratory syndrome patients

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