SrasV1, PascalFrancis, Corpus, bibRecord, 000304

Avian coronavirus infectious bronchitis attenuated live vaccines undergo selection of subpopulations and mutations following vaccination

Identifieur interne : 000304 ( PascalFrancis/Corpus ); précédent : 000303; suivant : 000305

Avian coronavirus infectious bronchitis attenuated live vaccines undergo selection of subpopulations and mutations following vaccination

Auteurs : Enid T. Mckinley ; Deborah A. Hilt ; Mark W. Jackwood

Source :

Vaccine [ 0264-410X ] ; 2008.

RBID : Pascal:08-0166758

Descripteurs français

Pascal (Inist)
- Coronavirus, Virus bronchite infectieuse aviaire, Souche atténuée, Vaccin, Mutation, Vaccination, Adaptation, Epidémiologie moléculaire, Génotype, Séquence nucléotide, Bronchite infectieuse aviaire, Sérotype, Quasi-espèce.

English descriptors

KwdEn :
- Adaptation, Attenuated strain, Avian infectious bronchitis, Avian infectious bronchitis virus, Coronavirus, Genotype, Molecular epidemiology, Mutation, Nucleotide sequence, Quasispecies, Serotype, Vaccination, Vaccine.

Abstract

In this study, we were interested in determining if high titered egg adapted modified live infectious bronchitis virus (IBV) vaccines contain spike gene related quasispecies that undergo selection in chickens, following vaccination. We sequenced the spike glycoprotein of 12 IBV vaccines (5 different serotypes from 3 different manufacturers) directly from the vaccine vial, then compared that sequence with reisolated viruses from vaccinated and contact-exposed birds over time. We found differences in the S1 sequence within the same vaccine serotype from different manufacturers, differences in S1 sequence between different vaccine serials from the same manufacturer, and intra-vaccine differences or quasispecies. Comparing the sequence data of the reisolated viruses with the original vaccine virus, we were able to identify in vivo selection of viral subpopulations as well as mutations. To our knowledge, this is the first report showing selection of a more fit virus subpopulation as well as mutations associated with replication of modified live IBV vaccine viruses in chickens. This information is important for our understanding of how attenuated virus vaccines, including potential vaccines against the SARS-CoV, can ensure long-term survival of the virus and can lead to changes in pathogenesis and emergence of new viral pathogens. This information is also valuable for the development of safer modified live coronavirus vaccines.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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Format Inist (serveur)

NO :	PASCAL 08-0166758 INIST
ET :	Avian coronavirus infectious bronchitis attenuated live vaccines undergo selection of subpopulations and mutations following vaccination
AU :	MCKINLEY (Enid T.); HILT (Deborah A.); JACKWOOD (Mark W.)
AF :	College of Veterinary Medicine, Department of Population Health, Poultry Diagnostic and Research Center, 953 College Station Road, University of Georgia/Athens, GA 30602/Etats-Unis (1 aut., 2 aut., 3 aut.)
DT :	Publication en série; Niveau analytique
SO :	Vaccine; ISSN 0264-410X; Coden VACCDE; Royaume-Uni; Da. 2008; Vol. 26; No. 10; Pp. 1274-1284; Bibl. 24 ref.
LA :	Anglais
EA :	In this study, we were interested in determining if high titered egg adapted modified live infectious bronchitis virus (IBV) vaccines contain spike gene related quasispecies that undergo selection in chickens, following vaccination. We sequenced the spike glycoprotein of 12 IBV vaccines (5 different serotypes from 3 different manufacturers) directly from the vaccine vial, then compared that sequence with reisolated viruses from vaccinated and contact-exposed birds over time. We found differences in the S1 sequence within the same vaccine serotype from different manufacturers, differences in S1 sequence between different vaccine serials from the same manufacturer, and intra-vaccine differences or quasispecies. Comparing the sequence data of the reisolated viruses with the original vaccine virus, we were able to identify in vivo selection of viral subpopulations as well as mutations. To our knowledge, this is the first report showing selection of a more fit virus subpopulation as well as mutations associated with replication of modified live IBV vaccine viruses in chickens. This information is important for our understanding of how attenuated virus vaccines, including potential vaccines against the SARS-CoV, can ensure long-term survival of the virus and can lead to changes in pathogenesis and emergence of new viral pathogens. This information is also valuable for the development of safer modified live coronavirus vaccines.
CC :	002A05C10; 002A05F04
FD :	Coronavirus; Virus bronchite infectieuse aviaire; Souche atténuée; Vaccin; Mutation; Vaccination; Adaptation; Epidémiologie moléculaire; Génotype; Séquence nucléotide; Bronchite infectieuse aviaire; Sérotype; Quasi-espèce
FG :	Coronaviridae; Nidovirales; Virus; Vétérinaire; Virose; Infection
ED :	Coronavirus; Avian infectious bronchitis virus; Attenuated strain; Vaccine; Mutation; Vaccination; Adaptation; Molecular epidemiology; Genotype; Nucleotide sequence; Avian infectious bronchitis; Serotype; Quasispecies
EG :	Coronaviridae; Nidovirales; Virus; Veterinary; Viral disease; Infection
SD :	Coronavirus; Avian infectious bronchitis virus; Cepa atenuada; Vacuna; Mutación; Vacunación; Adaptación; Epidemiología molecular; Genotipo; Secuencia nucleótido; Bronquitis infecciosa aviar; Serotipo; Cuasiespecie
LO :	INIST-20289.354000175174190020
ID :	08-0166758

Links to Exploration step

Pascal:08-0166758

Le document en format XML

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<fC03 i1="07" i2="X" l="FRE"><s0>Adaptation</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Adaptation</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Adaptación</s0>
<s5>09</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Epidémiologie moléculaire</s0>
<s5>10</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Molecular epidemiology</s0>
<s5>10</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Epidemiología molecular</s0>
<s5>10</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Génotype</s0>
<s5>11</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Genotype</s0>
<s5>11</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Genotipo</s0>
<s5>11</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Séquence nucléotide</s0>
<s5>12</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Nucleotide sequence</s0>
<s5>12</s5>
</fC03>
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<s5>12</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Bronchite infectieuse aviaire</s0>
<s5>14</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Avian infectious bronchitis</s0>
<s5>14</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Bronquitis infecciosa aviar</s0>
<s5>14</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Sérotype</s0>
<s5>67</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Serotype</s0>
<s5>67</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Serotipo</s0>
<s5>67</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Quasi-espèce</s0>
<s5>68</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Quasispecies</s0>
<s5>68</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>Cuasiespecie</s0>
<s5>68</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Vétérinaire</s0>
<s5>13</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Veterinary</s0>
<s5>13</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Veterinario</s0>
<s5>13</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Virose</s0>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Viral disease</s0>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Virosis</s0>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Infection</s0>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Infection</s0>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Infección</s0>
</fC07>
<fN21><s1>105</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
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<server><NO>PASCAL 08-0166758 INIST</NO>
<ET>Avian coronavirus infectious bronchitis attenuated live vaccines undergo selection of subpopulations and mutations following vaccination</ET>
<AU>MCKINLEY (Enid T.); HILT (Deborah A.); JACKWOOD (Mark W.)</AU>
<AF>College of Veterinary Medicine, Department of Population Health, Poultry Diagnostic and Research Center, 953 College Station Road, University of Georgia/Athens, GA 30602/Etats-Unis (1 aut., 2 aut., 3 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Vaccine; ISSN 0264-410X; Coden VACCDE; Royaume-Uni; Da. 2008; Vol. 26; No. 10; Pp. 1274-1284; Bibl. 24 ref.</SO>
<LA>Anglais</LA>
<EA>In this study, we were interested in determining if high titered egg adapted modified live infectious bronchitis virus (IBV) vaccines contain spike gene related quasispecies that undergo selection in chickens, following vaccination. We sequenced the spike glycoprotein of 12 IBV vaccines (5 different serotypes from 3 different manufacturers) directly from the vaccine vial, then compared that sequence with reisolated viruses from vaccinated and contact-exposed birds over time. We found differences in the S1 sequence within the same vaccine serotype from different manufacturers, differences in S1 sequence between different vaccine serials from the same manufacturer, and intra-vaccine differences or quasispecies. Comparing the sequence data of the reisolated viruses with the original vaccine virus, we were able to identify in vivo selection of viral subpopulations as well as mutations. To our knowledge, this is the first report showing selection of a more fit virus subpopulation as well as mutations associated with replication of modified live IBV vaccine viruses in chickens. This information is important for our understanding of how attenuated virus vaccines, including potential vaccines against the SARS-CoV, can ensure long-term survival of the virus and can lead to changes in pathogenesis and emergence of new viral pathogens. This information is also valuable for the development of safer modified live coronavirus vaccines.</EA>
<CC>002A05C10; 002A05F04</CC>
<FD>Coronavirus; Virus bronchite infectieuse aviaire; Souche atténuée; Vaccin; Mutation; Vaccination; Adaptation; Epidémiologie moléculaire; Génotype; Séquence nucléotide; Bronchite infectieuse aviaire; Sérotype; Quasi-espèce</FD>
<FG>Coronaviridae; Nidovirales; Virus; Vétérinaire; Virose; Infection</FG>
<ED>Coronavirus; Avian infectious bronchitis virus; Attenuated strain; Vaccine; Mutation; Vaccination; Adaptation; Molecular epidemiology; Genotype; Nucleotide sequence; Avian infectious bronchitis; Serotype; Quasispecies</ED>
<EG>Coronaviridae; Nidovirales; Virus; Veterinary; Viral disease; Infection</EG>
<SD>Coronavirus; Avian infectious bronchitis virus; Cepa atenuada; Vacuna; Mutación; Vacunación; Adaptación; Epidemiología molecular; Genotipo; Secuencia nucleótido; Bronquitis infecciosa aviar; Serotipo; Cuasiespecie</SD>
<LO>INIST-20289.354000175174190020</LO>
<ID>08-0166758</ID>
</server>
</inist>
</record>

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Avian coronavirus infectious bronchitis attenuated live vaccines undergo selection of subpopulations and mutations following vaccination

Avian coronavirus infectious bronchitis attenuated live vaccines undergo selection of subpopulations and mutations following vaccination

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