SrasV1, PascalFrancis, Corpus, bibRecord, 000247

Polymorphisms in the C-type lectin genes cluster in chromosome 19 and predisposition to severe acute respiratory syndrome coronavirus (SARS-CoV) infection

Identifieur interne : 000247 ( PascalFrancis/Corpus ); précédent : 000246; suivant : 000248

Polymorphisms in the C-type lectin genes cluster in chromosome 19 and predisposition to severe acute respiratory syndrome coronavirus (SARS-CoV) infection

Auteurs : H. Li ; N. L.-S. Tang ; P. K.-S. Chan ; C.-Y. Wang ; D. S.-C. Hui ; C. Luk ; R. Kwok ; W. Huang ; J. J.-Y. Sung ; Q.-P. Kong ; Y.-P. Zhang

Source :

Journal of medical genetics [ 0022-2593 ] ; 2008.

RBID : Pascal:08-0510355

Descripteurs français

Pascal (Inist)
- Infection, Polymorphisme, Lectine, Batterie gène, Chromosome F19, Pathogénie, Déterminisme génétique, Prédisposition, Syndrome respiratoire aigu sévère, Coronavirus, Génétique, Homme.

English descriptors

KwdEn :
- Chromosome F19, Coronavirus, Gene cluster, Genetic determinism, Genetics, Human, Infection, Lectin, Pathogenesis, Polymorphism, Predisposition, Severe acute respiratory syndrome.

Abstract

Background: Polymorphisms of CLEC4M have been associated with predisposition for infection by the severe acute respiratory syndrome coronavirus (SARS-CoV). DC-SIGNR, a C-type lectin encoded by CLEC4M, is a receptor for the virus. A variable number tandem repeat (VNTR) polymorphism in its neck region was recently associated with susceptibility to SARS infection. However, this association was controversial and was not supported by subsequent studies. Two explanations may account for this discrepancy: (1) there may be an unknown predisposition polymorphism located in the proximity which is linked to the VNTR; or (2) it was a spurious association due to unrecognised population structure in the VNTR. Methods: We performed a comprehensively genetic association study on this C-type lectin gene cluster (FCER2, CLEC4G, CD209, and CLEC4M) at 19p13.3 by a tagging single nucleotide polymorphisms (SNPs) approach. Results: 23 tagSNPs were genotyped in 181 SARS patients and 172 population controls. No significant association with disease predisposition was detected. Genetic variations in this cluster also did not predict disease prognosis. However, we detected a population stratification of the VNTR alleles in a sample of 1145 Han Chinese collected from different parts of China. Conclusion: The results indicated that the genetic predisposition allele was not found in this lectin gene cluster and population stratification might cause the previous positive association.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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C01	`01`		`ENG`	@0 Background: Polymorphisms of CLEC4M have been associated with predisposition for infection by the severe acute respiratory syndrome coronavirus (SARS-CoV). DC-SIGNR, a C-type lectin encoded by CLEC4M, is a receptor for the virus. A variable number tandem repeat (VNTR) polymorphism in its neck region was recently associated with susceptibility to SARS infection. However, this association was controversial and was not supported by subsequent studies. Two explanations may account for this discrepancy: (1) there may be an unknown predisposition polymorphism located in the proximity which is linked to the VNTR; or (2) it was a spurious association due to unrecognised population structure in the VNTR. Methods: We performed a comprehensively genetic association study on this C-type lectin gene cluster (FCER2, CLEC4G, CD209, and CLEC4M) at 19p13.3 by a tagging single nucleotide polymorphisms (SNPs) approach. Results: 23 tagSNPs were genotyped in 181 SARS patients and 172 population controls. No significant association with disease predisposition was detected. Genetic variations in this cluster also did not predict disease prognosis. However, we detected a population stratification of the VNTR alleles in a sample of 1145 Han Chinese collected from different parts of China. Conclusion: The results indicated that the genetic predisposition allele was not found in this lectin gene cluster and population stratification might cause the previous positive association.
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Format Inist (serveur)

NO :	PASCAL 08-0510355 INIST
ET :	Polymorphisms in the C-type lectin genes cluster in chromosome 19 and predisposition to severe acute respiratory syndrome coronavirus (SARS-CoV) infection
AU :	LI (H.); TANG (N. L.-S.); CHAN (P. K.-S.); WANG (C.-Y.); HUI (D. S.-C.); LUK (C.); KWOK (R.); HUANG (W.); SUNG (J. J.-Y.); KONG (Q.-P.); ZHANG (Y.-P.)
AF :	State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences/Kunming/Chine (1 aut., 4 aut., 10 aut., 11 aut.); Laboratory for Conservation and Utilization of Bio-resource, Yunnan University/Kunming/Chine (1 aut., 4 aut., 10 aut., 11 aut.); Graduate University of the Chinese Academy of Sciences/Beijing/Chine (1 aut., 4 aut.); KIZ/ CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases/Kunming/Chine (1 aut., 2 aut., 4 aut., 8 aut., 10 aut., 11 aut.); Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong/Hong-Kong (2 aut., 8 aut.); Departments of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong/Hong-Kong (2 aut., 6 aut., 7 aut., 8 aut.); Departments of Microbiology, The Chinese University of Hong Kong/Hong-Kong (3 aut., 9 aut.); Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong/Hong-Kong (3 aut., 5 aut., 9 aut.); Departments of Medicine &t Therapeutics, The Chinese University of Hong Kong/Hong-Kong (5 aut.)
DT :	Publication en série; Niveau analytique
SO :	Journal of medical genetics; ISSN 0022-2593; Coden JMDGAE; Royaume-Uni; Da. 2008; Vol. 45; No. 11; Pp. 752-758; Bibl. 31 ref.
LA :	Anglais
EA :	Background: Polymorphisms of CLEC4M have been associated with predisposition for infection by the severe acute respiratory syndrome coronavirus (SARS-CoV). DC-SIGNR, a C-type lectin encoded by CLEC4M, is a receptor for the virus. A variable number tandem repeat (VNTR) polymorphism in its neck region was recently associated with susceptibility to SARS infection. However, this association was controversial and was not supported by subsequent studies. Two explanations may account for this discrepancy: (1) there may be an unknown predisposition polymorphism located in the proximity which is linked to the VNTR; or (2) it was a spurious association due to unrecognised population structure in the VNTR. Methods: We performed a comprehensively genetic association study on this C-type lectin gene cluster (FCER2, CLEC4G, CD209, and CLEC4M) at 19p13.3 by a tagging single nucleotide polymorphisms (SNPs) approach. Results: 23 tagSNPs were genotyped in 181 SARS patients and 172 population controls. No significant association with disease predisposition was detected. Genetic variations in this cluster also did not predict disease prognosis. However, we detected a population stratification of the VNTR alleles in a sample of 1145 Han Chinese collected from different parts of China. Conclusion: The results indicated that the genetic predisposition allele was not found in this lectin gene cluster and population stratification might cause the previous positive association.
CC :	002A04; 002A07; 002B23A; 002B05C02C
FD :	Infection; Polymorphisme; Lectine; Batterie gène; Chromosome F19; Pathogénie; Déterminisme génétique; Prédisposition; Syndrome respiratoire aigu sévère; Coronavirus; Génétique; Homme
FG :	Virose; Coronaviridae; Nidovirales; Virus; Pathologie de l'appareil respiratoire; Pathologie des poumons
ED :	Infection; Polymorphism; Lectin; Gene cluster; Chromosome F19; Pathogenesis; Genetic determinism; Predisposition; Severe acute respiratory syndrome; Coronavirus; Genetics; Human
EG :	Viral disease; Coronaviridae; Nidovirales; Virus; Respiratory disease; Lung disease
SD :	Infección; Polimorfismo; Lectina; Agregado gen; Cromosoma F19; Patogenia; Determinismo genético; Predisposición; Síndrome respiratorio agudo severo; Coronavirus; Genética; Hombre
LO :	INIST-12125.354000184446700090
ID :	08-0510355

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<affiliation><inist:fA14 i1="02"><s1>Laboratory for Conservation and Utilization of Bio-resource, Yunnan University</s1>
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<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
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<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
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<sZ>8 aut.</sZ>
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<author><name sortKey="Zhang, Y P" sort="Zhang, Y P" uniqKey="Zhang Y" first="Y.-P." last="Zhang">Y.-P. Zhang</name>
<affiliation><inist:fA14 i1="01"><s1>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences</s1>
<s2>Kunming</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
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<affiliation><inist:fA14 i1="02"><s1>Laboratory for Conservation and Utilization of Bio-resource, Yunnan University</s1>
<s2>Kunming</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="04"><s1>KIZ/ CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases</s1>
<s2>Kunming</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
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<idno type="inist">08-0510355</idno>
<date when="2008">2008</date>
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<idno type="RBID">Pascal:08-0510355</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000247</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Polymorphisms in the C-type lectin genes cluster in chromosome 19 and predisposition to severe acute respiratory syndrome coronavirus (SARS-CoV) infection</title>
<author><name sortKey="Li, H" sort="Li, H" uniqKey="Li H" first="H." last="Li">H. Li</name>
<affiliation><inist:fA14 i1="01"><s1>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences</s1>
<s2>Kunming</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
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<affiliation><inist:fA14 i1="02"><s1>Laboratory for Conservation and Utilization of Bio-resource, Yunnan University</s1>
<s2>Kunming</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="03"><s1>Graduate University of the Chinese Academy of Sciences</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="04"><s1>KIZ/ CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases</s1>
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<s3>CHN</s3>
<sZ>1 aut.</sZ>
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<author><name sortKey="Tang, N L S" sort="Tang, N L S" uniqKey="Tang N" first="N. L.-S." last="Tang">N. L.-S. Tang</name>
<affiliation><inist:fA14 i1="04"><s1>KIZ/ CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases</s1>
<s2>Kunming</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
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<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
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<affiliation><inist:fA14 i1="06"><s1>Departments of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong</s1>
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<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
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<affiliation><inist:fA14 i1="07"><s1>Departments of Microbiology, The Chinese University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>3 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
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<affiliation><inist:fA14 i1="08"><s1>Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
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<author><name sortKey="Wang, C Y" sort="Wang, C Y" uniqKey="Wang C" first="C.-Y." last="Wang">C.-Y. Wang</name>
<affiliation><inist:fA14 i1="01"><s1>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences</s1>
<s2>Kunming</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
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<affiliation><inist:fA14 i1="02"><s1>Laboratory for Conservation and Utilization of Bio-resource, Yunnan University</s1>
<s2>Kunming</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="03"><s1>Graduate University of the Chinese Academy of Sciences</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="04"><s1>KIZ/ CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases</s1>
<s2>Kunming</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
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<author><name sortKey="Hui, D S C" sort="Hui, D S C" uniqKey="Hui D" first="D. S.-C." last="Hui">D. S.-C. Hui</name>
<affiliation><inist:fA14 i1="08"><s1>Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
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<affiliation><inist:fA14 i1="09"><s1>Departments of Medicine &t Therapeutics, The Chinese University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Luk, C" sort="Luk, C" uniqKey="Luk C" first="C." last="Luk">C. Luk</name>
<affiliation><inist:fA14 i1="06"><s1>Departments of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
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<author><name sortKey="Kwok, R" sort="Kwok, R" uniqKey="Kwok R" first="R." last="Kwok">R. Kwok</name>
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<s3>HKG</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
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<author><name sortKey="Huang, W" sort="Huang, W" uniqKey="Huang W" first="W." last="Huang">W. Huang</name>
<affiliation><inist:fA14 i1="04"><s1>KIZ/ CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases</s1>
<s2>Kunming</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
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<affiliation><inist:fA14 i1="05"><s1>Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong</s1>
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<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="06"><s1>Departments of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong</s1>
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<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
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<author><name sortKey="Sung, J J Y" sort="Sung, J J Y" uniqKey="Sung J" first="J. J.-Y." last="Sung">J. J.-Y. Sung</name>
<affiliation><inist:fA14 i1="07"><s1>Departments of Microbiology, The Chinese University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>3 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="08"><s1>Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Kong, Q P" sort="Kong, Q P" uniqKey="Kong Q" first="Q.-P." last="Kong">Q.-P. Kong</name>
<affiliation><inist:fA14 i1="01"><s1>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences</s1>
<s2>Kunming</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="02"><s1>Laboratory for Conservation and Utilization of Bio-resource, Yunnan University</s1>
<s2>Kunming</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="04"><s1>KIZ/ CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases</s1>
<s2>Kunming</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Zhang, Y P" sort="Zhang, Y P" uniqKey="Zhang Y" first="Y.-P." last="Zhang">Y.-P. Zhang</name>
<affiliation><inist:fA14 i1="01"><s1>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences</s1>
<s2>Kunming</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="02"><s1>Laboratory for Conservation and Utilization of Bio-resource, Yunnan University</s1>
<s2>Kunming</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
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<affiliation><inist:fA14 i1="04"><s1>KIZ/ CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases</s1>
<s2>Kunming</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
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<sZ>8 aut.</sZ>
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</analytic>
<series><title level="j" type="main">Journal of medical genetics</title>
<title level="j" type="abbreviated">J. med. genet.</title>
<idno type="ISSN">0022-2593</idno>
<imprint><date when="2008">2008</date>
</imprint>
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<seriesStmt><title level="j" type="main">Journal of medical genetics</title>
<title level="j" type="abbreviated">J. med. genet.</title>
<idno type="ISSN">0022-2593</idno>
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</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Chromosome F19</term>
<term>Coronavirus</term>
<term>Gene cluster</term>
<term>Genetic determinism</term>
<term>Genetics</term>
<term>Human</term>
<term>Infection</term>
<term>Lectin</term>
<term>Pathogenesis</term>
<term>Polymorphism</term>
<term>Predisposition</term>
<term>Severe acute respiratory syndrome</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Infection</term>
<term>Polymorphisme</term>
<term>Lectine</term>
<term>Batterie gène</term>
<term>Chromosome F19</term>
<term>Pathogénie</term>
<term>Déterminisme génétique</term>
<term>Prédisposition</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Coronavirus</term>
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<front><div type="abstract" xml:lang="en">Background: Polymorphisms of CLEC4M have been associated with predisposition for infection by the severe acute respiratory syndrome coronavirus (SARS-CoV). DC-SIGNR, a C-type lectin encoded by CLEC4M, is a receptor for the virus. A variable number tandem repeat (VNTR) polymorphism in its neck region was recently associated with susceptibility to SARS infection. However, this association was controversial and was not supported by subsequent studies. Two explanations may account for this discrepancy: (1) there may be an unknown predisposition polymorphism located in the proximity which is linked to the VNTR; or (2) it was a spurious association due to unrecognised population structure in the VNTR. Methods: We performed a comprehensively genetic association study on this C-type lectin gene cluster (FCER2, CLEC4G, CD209, and CLEC4M) at 19p13.3 by a tagging single nucleotide polymorphisms (SNPs) approach. Results: 23 tagSNPs were genotyped in 181 SARS patients and 172 population controls. No significant association with disease predisposition was detected. Genetic variations in this cluster also did not predict disease prognosis. However, we detected a population stratification of the VNTR alleles in a sample of 1145 Han Chinese collected from different parts of China. Conclusion: The results indicated that the genetic predisposition allele was not found in this lectin gene cluster and population stratification might cause the previous positive association.</div>
</front>
</TEI>
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<fA02 i1="01"><s0>JMDGAE</s0>
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<fA03 i2="1"><s0>J. med. genet.</s0>
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<fA05><s2>45</s2>
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<fA06><s2>11</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Polymorphisms in the C-type lectin genes cluster in chromosome 19 and predisposition to severe acute respiratory syndrome coronavirus (SARS-CoV) infection</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>LI (H.)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>TANG (N. L.-S.)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>CHAN (P. K.-S.)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>WANG (C.-Y.)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>HUI (D. S.-C.)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>LUK (C.)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>KWOK (R.)</s1>
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<fA11 i1="08" i2="1"><s1>HUANG (W.)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>SUNG (J. J.-Y.)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>KONG (Q.-P.)</s1>
</fA11>
<fA11 i1="11" i2="1"><s1>ZHANG (Y.-P.)</s1>
</fA11>
<fA14 i1="01"><s1>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences</s1>
<s2>Kunming</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Laboratory for Conservation and Utilization of Bio-resource, Yunnan University</s1>
<s2>Kunming</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Graduate University of the Chinese Academy of Sciences</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>KIZ/ CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases</s1>
<s2>Kunming</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>Departments of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="07"><s1>Departments of Microbiology, The Chinese University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>3 aut.</sZ>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="08"><s1>Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="09"><s1>Departments of Medicine &t Therapeutics, The Chinese University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>5 aut.</sZ>
</fA14>
<fA20><s1>752-758</s1>
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<fA43 i1="01"><s1>INIST</s1>
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<s1>© 2008 INIST-CNRS. All rights reserved.</s1>
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<fA45><s0>31 ref.</s0>
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<fA47 i1="01" i2="1"><s0>08-0510355</s0>
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<fA60><s1>P</s1>
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<fA61><s0>A</s0>
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<fA64 i1="01" i2="1"><s0>Journal of medical genetics</s0>
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<fA66 i1="01"><s0>GBR</s0>
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<fC01 i1="01" l="ENG"><s0>Background: Polymorphisms of CLEC4M have been associated with predisposition for infection by the severe acute respiratory syndrome coronavirus (SARS-CoV). DC-SIGNR, a C-type lectin encoded by CLEC4M, is a receptor for the virus. A variable number tandem repeat (VNTR) polymorphism in its neck region was recently associated with susceptibility to SARS infection. However, this association was controversial and was not supported by subsequent studies. Two explanations may account for this discrepancy: (1) there may be an unknown predisposition polymorphism located in the proximity which is linked to the VNTR; or (2) it was a spurious association due to unrecognised population structure in the VNTR. Methods: We performed a comprehensively genetic association study on this C-type lectin gene cluster (FCER2, CLEC4G, CD209, and CLEC4M) at 19p13.3 by a tagging single nucleotide polymorphisms (SNPs) approach. Results: 23 tagSNPs were genotyped in 181 SARS patients and 172 population controls. No significant association with disease predisposition was detected. Genetic variations in this cluster also did not predict disease prognosis. However, we detected a population stratification of the VNTR alleles in a sample of 1145 Han Chinese collected from different parts of China. Conclusion: The results indicated that the genetic predisposition allele was not found in this lectin gene cluster and population stratification might cause the previous positive association.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002A04</s0>
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<fC02 i1="02" i2="X"><s0>002A07</s0>
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<fC02 i1="04" i2="X"><s0>002B05C02C</s0>
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<fC03 i1="01" i2="X" l="FRE"><s0>Infection</s0>
<s5>01</s5>
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<fC03 i1="01" i2="X" l="ENG"><s0>Infection</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Infección</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Polymorphisme</s0>
<s5>09</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Polymorphism</s0>
<s5>09</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Polimorfismo</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Lectine</s0>
<s5>10</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Lectin</s0>
<s5>10</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Lectina</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Batterie gène</s0>
<s5>11</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Gene cluster</s0>
<s5>11</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Agregado gen</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Chromosome F19</s0>
<s5>12</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Chromosome F19</s0>
<s5>12</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Cromosoma F19</s0>
<s5>12</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Pathogénie</s0>
<s5>13</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Pathogenesis</s0>
<s5>13</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Patogenia</s0>
<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Déterminisme génétique</s0>
<s5>14</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Genetic determinism</s0>
<s5>14</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Determinismo genético</s0>
<s5>14</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Prédisposition</s0>
<s5>15</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Predisposition</s0>
<s5>15</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Predisposición</s0>
<s5>15</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Syndrome respiratoire aigu sévère</s0>
<s2>NM</s2>
<s5>16</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Severe acute respiratory syndrome</s0>
<s2>NM</s2>
<s5>16</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Síndrome respiratorio agudo severo</s0>
<s2>NM</s2>
<s5>16</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>17</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>17</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>17</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Génétique</s0>
<s5>18</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Genetics</s0>
<s5>18</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Genética</s0>
<s5>18</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Homme</s0>
<s5>19</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Human</s0>
<s5>19</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Hombre</s0>
<s5>19</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Virose</s0>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Viral disease</s0>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Virosis</s0>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Pathologie de l'appareil respiratoire</s0>
<s5>37</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>37</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Pathologie des poumons</s0>
<s5>38</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Lung disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Pulmón patología</s0>
<s5>38</s5>
</fC07>
<fN21><s1>336</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 08-0510355 INIST</NO>
<ET>Polymorphisms in the C-type lectin genes cluster in chromosome 19 and predisposition to severe acute respiratory syndrome coronavirus (SARS-CoV) infection</ET>
<AU>LI (H.); TANG (N. L.-S.); CHAN (P. K.-S.); WANG (C.-Y.); HUI (D. S.-C.); LUK (C.); KWOK (R.); HUANG (W.); SUNG (J. J.-Y.); KONG (Q.-P.); ZHANG (Y.-P.)</AU>
<AF>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences/Kunming/Chine (1 aut., 4 aut., 10 aut., 11 aut.); Laboratory for Conservation and Utilization of Bio-resource, Yunnan University/Kunming/Chine (1 aut., 4 aut., 10 aut., 11 aut.); Graduate University of the Chinese Academy of Sciences/Beijing/Chine (1 aut., 4 aut.); KIZ/ CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases/Kunming/Chine (1 aut., 2 aut., 4 aut., 8 aut., 10 aut., 11 aut.); Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong/Hong-Kong (2 aut., 8 aut.); Departments of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong/Hong-Kong (2 aut., 6 aut., 7 aut., 8 aut.); Departments of Microbiology, The Chinese University of Hong Kong/Hong-Kong (3 aut., 9 aut.); Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong/Hong-Kong (3 aut., 5 aut., 9 aut.); Departments of Medicine &t Therapeutics, The Chinese University of Hong Kong/Hong-Kong (5 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Journal of medical genetics; ISSN 0022-2593; Coden JMDGAE; Royaume-Uni; Da. 2008; Vol. 45; No. 11; Pp. 752-758; Bibl. 31 ref.</SO>
<LA>Anglais</LA>
<EA>Background: Polymorphisms of CLEC4M have been associated with predisposition for infection by the severe acute respiratory syndrome coronavirus (SARS-CoV). DC-SIGNR, a C-type lectin encoded by CLEC4M, is a receptor for the virus. A variable number tandem repeat (VNTR) polymorphism in its neck region was recently associated with susceptibility to SARS infection. However, this association was controversial and was not supported by subsequent studies. Two explanations may account for this discrepancy: (1) there may be an unknown predisposition polymorphism located in the proximity which is linked to the VNTR; or (2) it was a spurious association due to unrecognised population structure in the VNTR. Methods: We performed a comprehensively genetic association study on this C-type lectin gene cluster (FCER2, CLEC4G, CD209, and CLEC4M) at 19p13.3 by a tagging single nucleotide polymorphisms (SNPs) approach. Results: 23 tagSNPs were genotyped in 181 SARS patients and 172 population controls. No significant association with disease predisposition was detected. Genetic variations in this cluster also did not predict disease prognosis. However, we detected a population stratification of the VNTR alleles in a sample of 1145 Han Chinese collected from different parts of China. Conclusion: The results indicated that the genetic predisposition allele was not found in this lectin gene cluster and population stratification might cause the previous positive association.</EA>
<CC>002A04; 002A07; 002B23A; 002B05C02C</CC>
<FD>Infection; Polymorphisme; Lectine; Batterie gène; Chromosome F19; Pathogénie; Déterminisme génétique; Prédisposition; Syndrome respiratoire aigu sévère; Coronavirus; Génétique; Homme</FD>
<FG>Virose; Coronaviridae; Nidovirales; Virus; Pathologie de l'appareil respiratoire; Pathologie des poumons</FG>
<ED>Infection; Polymorphism; Lectin; Gene cluster; Chromosome F19; Pathogenesis; Genetic determinism; Predisposition; Severe acute respiratory syndrome; Coronavirus; Genetics; Human</ED>
<EG>Viral disease; Coronaviridae; Nidovirales; Virus; Respiratory disease; Lung disease</EG>
<SD>Infección; Polimorfismo; Lectina; Agregado gen; Cromosoma F19; Patogenia; Determinismo genético; Predisposición; Síndrome respiratorio agudo severo; Coronavirus; Genética; Hombre</SD>
<LO>INIST-12125.354000184446700090</LO>
<ID>08-0510355</ID>
</server>
</inist>
</record>

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Polymorphisms in the C-type lectin genes cluster in chromosome 19 and predisposition to severe acute respiratory syndrome coronavirus (SARS-CoV) infection

Polymorphisms in the C-type lectin genes cluster in chromosome 19 and predisposition to severe acute respiratory syndrome coronavirus (SARS-CoV) infection

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