SrasV1, PascalFrancis, Corpus, bibRecord, 000177

The antiviral action of common household disinfectants and antiseptics against murine hepatitis virus, a potential surrogate for SARS coronavirus

Identifieur interne : 000177 ( PascalFrancis/Corpus ); précédent : 000176; suivant : 000178

The antiviral action of common household disinfectants and antiseptics against murine hepatitis virus, a potential surrogate for SARS coronavirus

Auteurs : Christine Dellanno ; Quinn Vega ; Diane Boesenberg

Source :

American journal of infection control [ 0196-6553 ] ; 2009.

RBID : Pascal:09-0465400

Descripteurs français

Pascal (Inist)
- Syndrome respiratoire aigu sévère, Antiviral, Désinfectant, Antiseptique, Virus hépatite murine, Contrôle.

English descriptors

KwdEn :
- Antiseptic, Antiviral, Check, Disinfecting agent, Murine hepatitis virus, Severe acute respiratory syndrome.

Abstract

Background: The 2003 outbreak of severe acute respiratory syndrome (SARS) infected over 8000 people and killed 774. Transmission of SARS occurred through direct and indirect contact and large droplet nuclei. The World Health Organization recommended the use of household disinfectants, which have not been previously tested against SARS coronavirus (SARS-CoV), to disinfect potentially contaminated environmental surfaces. There is a need for a surrogate test system given the limited availability of the SARS-CoV for testing and biosafety requirements necessary to safely handle it. In this study, the antiviral activity of standard household products was assayed against murine hepatitis virus (MHV), as a potential surrogate for SARS-CoV Methods: A surface test method, which involves drying an amount of virus on a surface and then applying the product for a specific contact time, was used to determine the virucidal activity. The virus titers and log reductions were determined by the Reed and Muench tissue culture infective dose (TCID)₅₀ end point method. Results: When tested as directed, common household disinfectants or antiseptics, containing either 0.050 % of triclosan, 0.12 % of PCMX, 0.21 % of sodium hypochlorite, 0.23 % of pine oil, or 0.10% of a quaternary compound with 79% of ethanol, demonstrated a 3-log reduction or better against MHV without any virus recovered in a 30-second contact time. Conclusion: Common household disinfectants and antiseptics were effective at inactivating MHV, a possible surrogate for SARS-CoV, from surfaces when used as directed. In an outbreak caused by novel agents, it is important to know the effectiveness of disinfectants and antiseptics to prevent or reduce the possibility of human-to-human transmission via surfaces.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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Format Inist (serveur)

NO :	PASCAL 09-0465400 INIST
ET :	The antiviral action of common household disinfectants and antiseptics against murine hepatitis virus, a potential surrogate for SARS coronavirus
AU :	DELLANNO (Christine); VEGA (Quinn); BOESENBERG (Diane)
AF :	Reckitt Benckiser/Montvale, NJ/Etats-Unis (1 aut., 3 aut.); Department of Biology and Molecular Biology Montclair State University/Upper Montclair, NJ/Etats-Unis (2 aut.)
DT :	Publication en série; Niveau analytique
SO :	American journal of infection control; ISSN 0196-6553; Etats-Unis; Da. 2009; Vol. 37; No. 8; Pp. 649-652; Bibl. 12 ref.
LA :	Anglais
EA :	Background: The 2003 outbreak of severe acute respiratory syndrome (SARS) infected over 8000 people and killed 774. Transmission of SARS occurred through direct and indirect contact and large droplet nuclei. The World Health Organization recommended the use of household disinfectants, which have not been previously tested against SARS coronavirus (SARS-CoV), to disinfect potentially contaminated environmental surfaces. There is a need for a surrogate test system given the limited availability of the SARS-CoV for testing and biosafety requirements necessary to safely handle it. In this study, the antiviral activity of standard household products was assayed against murine hepatitis virus (MHV), as a potential surrogate for SARS-CoV Methods: A surface test method, which involves drying an amount of virus on a surface and then applying the product for a specific contact time, was used to determine the virucidal activity. The virus titers and log reductions were determined by the Reed and Muench tissue culture infective dose (TCID)₅₀ end point method. Results: When tested as directed, common household disinfectants or antiseptics, containing either 0.050 % of triclosan, 0.12 % of PCMX, 0.21 % of sodium hypochlorite, 0.23 % of pine oil, or 0.10% of a quaternary compound with 79% of ethanol, demonstrated a 3-log reduction or better against MHV without any virus recovered in a 30-second contact time. Conclusion: Common household disinfectants and antiseptics were effective at inactivating MHV, a possible surrogate for SARS-CoV, from surfaces when used as directed. In an outbreak caused by novel agents, it is important to know the effectiveness of disinfectants and antiseptics to prevent or reduce the possibility of human-to-human transmission via surfaces.
CC :	002B05A02; 002B02S05; 002B02S03
FD :	Syndrome respiratoire aigu sévère; Antiviral; Désinfectant; Antiseptique; Virus hépatite murine; Contrôle
FG :	Virose; Infection; Coronavirus; Coronaviridae; Nidovirales; Virus; Pathologie de l'appareil respiratoire; Pathologie des poumons; Prévention
ED :	Severe acute respiratory syndrome; Antiviral; Disinfecting agent; Antiseptic; Murine hepatitis virus; Check
EG :	Viral disease; Infection; Coronavirus; Coronaviridae; Nidovirales; Virus; Respiratory disease; Lung disease; Prevention
SD :	Síndrome respiratorio agudo severo; Antiviral; Desinfectante; Antiséptico; Murine hepatitis virus; Control
LO :	INIST-19097.354000170137160080
ID :	09-0465400

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Pascal:09-0465400

Le document en format XML

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<front><div type="abstract" xml:lang="en">Background: The 2003 outbreak of severe acute respiratory syndrome (SARS) infected over 8000 people and killed 774. Transmission of SARS occurred through direct and indirect contact and large droplet nuclei. The World Health Organization recommended the use of household disinfectants, which have not been previously tested against SARS coronavirus (SARS-CoV), to disinfect potentially contaminated environmental surfaces. There is a need for a surrogate test system given the limited availability of the SARS-CoV for testing and biosafety requirements necessary to safely handle it. In this study, the antiviral activity of standard household products was assayed against murine hepatitis virus (MHV), as a potential surrogate for SARS-CoV Methods: A surface test method, which involves drying an amount of virus on a surface and then applying the product for a specific contact time, was used to determine the virucidal activity. The virus titers and log reductions were determined by the Reed and Muench tissue culture infective dose (TCID)<sub>50</sub>
 end point method. Results: When tested as directed, common household disinfectants or antiseptics, containing either 0.050 % of triclosan, 0.12 % of PCMX, 0.21 % of sodium hypochlorite, 0.23 % of pine oil, or 0.10% of a quaternary compound with 79% of ethanol, demonstrated a 3-log reduction or better against MHV without any virus recovered in a 30-second contact time. Conclusion: Common household disinfectants and antiseptics were effective at inactivating MHV, a possible surrogate for SARS-CoV, from surfaces when used as directed. In an outbreak caused by novel agents, it is important to know the effectiveness of disinfectants and antiseptics to prevent or reduce the possibility of human-to-human transmission via surfaces.</div>
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<fC01 i1="01" l="ENG"><s0>Background: The 2003 outbreak of severe acute respiratory syndrome (SARS) infected over 8000 people and killed 774. Transmission of SARS occurred through direct and indirect contact and large droplet nuclei. The World Health Organization recommended the use of household disinfectants, which have not been previously tested against SARS coronavirus (SARS-CoV), to disinfect potentially contaminated environmental surfaces. There is a need for a surrogate test system given the limited availability of the SARS-CoV for testing and biosafety requirements necessary to safely handle it. In this study, the antiviral activity of standard household products was assayed against murine hepatitis virus (MHV), as a potential surrogate for SARS-CoV Methods: A surface test method, which involves drying an amount of virus on a surface and then applying the product for a specific contact time, was used to determine the virucidal activity. The virus titers and log reductions were determined by the Reed and Muench tissue culture infective dose (TCID)<sub>50</sub>
 end point method. Results: When tested as directed, common household disinfectants or antiseptics, containing either 0.050 % of triclosan, 0.12 % of PCMX, 0.21 % of sodium hypochlorite, 0.23 % of pine oil, or 0.10% of a quaternary compound with 79% of ethanol, demonstrated a 3-log reduction or better against MHV without any virus recovered in a 30-second contact time. Conclusion: Common household disinfectants and antiseptics were effective at inactivating MHV, a possible surrogate for SARS-CoV, from surfaces when used as directed. In an outbreak caused by novel agents, it is important to know the effectiveness of disinfectants and antiseptics to prevent or reduce the possibility of human-to-human transmission via surfaces.</s0>
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<server><NO>PASCAL 09-0465400 INIST</NO>
<ET>The antiviral action of common household disinfectants and antiseptics against murine hepatitis virus, a potential surrogate for SARS coronavirus</ET>
<AU>DELLANNO (Christine); VEGA (Quinn); BOESENBERG (Diane)</AU>
<AF>Reckitt Benckiser/Montvale, NJ/Etats-Unis (1 aut., 3 aut.); Department of Biology and Molecular Biology Montclair State University/Upper Montclair, NJ/Etats-Unis (2 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>American journal of infection control; ISSN 0196-6553; Etats-Unis; Da. 2009; Vol. 37; No. 8; Pp. 649-652; Bibl. 12 ref.</SO>
<LA>Anglais</LA>
<EA>Background: The 2003 outbreak of severe acute respiratory syndrome (SARS) infected over 8000 people and killed 774. Transmission of SARS occurred through direct and indirect contact and large droplet nuclei. The World Health Organization recommended the use of household disinfectants, which have not been previously tested against SARS coronavirus (SARS-CoV), to disinfect potentially contaminated environmental surfaces. There is a need for a surrogate test system given the limited availability of the SARS-CoV for testing and biosafety requirements necessary to safely handle it. In this study, the antiviral activity of standard household products was assayed against murine hepatitis virus (MHV), as a potential surrogate for SARS-CoV Methods: A surface test method, which involves drying an amount of virus on a surface and then applying the product for a specific contact time, was used to determine the virucidal activity. The virus titers and log reductions were determined by the Reed and Muench tissue culture infective dose (TCID)<sub>50</sub>
 end point method. Results: When tested as directed, common household disinfectants or antiseptics, containing either 0.050 % of triclosan, 0.12 % of PCMX, 0.21 % of sodium hypochlorite, 0.23 % of pine oil, or 0.10% of a quaternary compound with 79% of ethanol, demonstrated a 3-log reduction or better against MHV without any virus recovered in a 30-second contact time. Conclusion: Common household disinfectants and antiseptics were effective at inactivating MHV, a possible surrogate for SARS-CoV, from surfaces when used as directed. In an outbreak caused by novel agents, it is important to know the effectiveness of disinfectants and antiseptics to prevent or reduce the possibility of human-to-human transmission via surfaces.</EA>
<CC>002B05A02; 002B02S05; 002B02S03</CC>
<FD>Syndrome respiratoire aigu sévère; Antiviral; Désinfectant; Antiseptique; Virus hépatite murine; Contrôle</FD>
<FG>Virose; Infection; Coronavirus; Coronaviridae; Nidovirales; Virus; Pathologie de l'appareil respiratoire; Pathologie des poumons; Prévention</FG>
<ED>Severe acute respiratory syndrome; Antiviral; Disinfecting agent; Antiseptic; Murine hepatitis virus; Check</ED>
<EG>Viral disease; Infection; Coronavirus; Coronaviridae; Nidovirales; Virus; Respiratory disease; Lung disease; Prevention</EG>
<SD>Síndrome respiratorio agudo severo; Antiviral; Desinfectante; Antiséptico; Murine hepatitis virus; Control</SD>
<LO>INIST-19097.354000170137160080</LO>
<ID>09-0465400</ID>
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The antiviral action of common household disinfectants and antiseptics against murine hepatitis virus, a potential surrogate for SARS coronavirus

The antiviral action of common household disinfectants and antiseptics against murine hepatitis virus, a potential surrogate for SARS coronavirus

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