Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents
Identifieur interne : 000052 ( PascalFrancis/Corpus ); précédent : 000051; suivant : 000053Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents
Auteurs : Li-Jun Wang ; Chang-An Geng ; Yun-Bao Ma ; Xiao-Yan Huang ; JIE LUO ; HAO CHEN ; Xue-Mei Zhang ; Ji-Jun ChenSource :
- Bioorganic & medicinal chemistry letters : (Print) [ 0960-894X ] ; 2012.
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- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Fifty-seven derivatives of glycyrrhetinic acid (GA) were synthesized, and their anti-hepatitis B virus (HBV) activity was evaluated in HepG 2.2.15 cells. Among them, sixteen compounds showed greater anti-HBV activity than GA, especially, compounds 29, 32, 35, 41 exhibited significantly inhibitory activities against HBV DNA replication with IC50 values of 5.71, 5.36, 8.90 and 9.08 μM, respectively. The structure-activity relationships (SARs) of GA derivatives were discussed for exploring novel anti-HBV agents.
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Format Inist (serveur)
NO : | PASCAL 12-0355115 INIST |
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ET : | Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents |
AU : | WANG (Li-Jun); GENG (Chang-An); MA (Yun-Bao); HUANG (Xiao-Yan); JIE LUO; HAO CHEN; ZHANG (Xue-Mei); CHEN (Ji-Jun) |
AF : | State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences/Kunming 650201/Chine (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut., 8 aut.); Graduate University of the Chinese Academy of Sciences/Beijing 100049/Chine (1 aut., 6 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Bioorganic & medicinal chemistry letters : (Print); ISSN 0960-894X; Pays-Bas; Da. 2012; Vol. 22; No. 10; Pp. 3473-3479; Bibl. 41 ref. |
LA : | Anglais |
EA : | Fifty-seven derivatives of glycyrrhetinic acid (GA) were synthesized, and their anti-hepatitis B virus (HBV) activity was evaluated in HepG 2.2.15 cells. Among them, sixteen compounds showed greater anti-HBV activity than GA, especially, compounds 29, 32, 35, 41 exhibited significantly inhibitory activities against HBV DNA replication with IC50 values of 5.71, 5.36, 8.90 and 9.08 μM, respectively. The structure-activity relationships (SARs) of GA derivatives were discussed for exploring novel anti-HBV agents. |
CC : | 002B02S05 |
FD : | Synthèse chimique; Activité biologique; Relation structure activité; Enoxolone; Antiviral; Virus hépatite B; Antiinflammatoire; Dérivé de l'oléanane; Triterpène; Terpénoïde |
FG : | Orthohepadnavirus; Hepadnaviridae; Virus |
ED : | Chemical synthesis; Biological activity; Structure activity relation; Enoxolone; Antiviral; Hepatitis B virus; Antiinflammatory agent; Oleanane derivatives; Triterpene; Terpenoid |
EG : | Orthohepadnavirus; Hepadnaviridae; Virus |
SD : | Síntesis química; Actividad biológica; Relación estructura actividad; Enoxolona; Antiviral; Hepatitis B virus; Antiinflamatorio; Oleanano derivado; Triterpeno; Terpenoide |
LO : | INIST-22446.354000507721860170 |
ID : | 12-0355115 |
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Pascal:12-0355115Le document en format XML
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<front><div type="abstract" xml:lang="en">Fifty-seven derivatives of glycyrrhetinic acid (GA) were synthesized, and their anti-hepatitis B virus (HBV) activity was evaluated in HepG 2.2.15 cells. Among them, sixteen compounds showed greater anti-HBV activity than GA, especially, compounds 29, 32, 35, 41 exhibited significantly inhibitory activities against HBV DNA replication with IC<sub>50</sub>
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<fC03 i1="04" i2="X" l="SPA"><s0>Enoxolona</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Antiviral</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Antiviral</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Antiviral</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Virus hépatite B</s0>
<s2>NW</s2>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Hepatitis B virus</s0>
<s2>NW</s2>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Hepatitis B virus</s0>
<s2>NW</s2>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Antiinflammatoire</s0>
<s5>23</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Antiinflammatory agent</s0>
<s5>23</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Antiinflamatorio</s0>
<s5>23</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Dérivé de l'oléanane</s0>
<s2>NK</s2>
<s5>24</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Oleanane derivatives</s0>
<s2>NK</s2>
<s5>24</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Oleanano derivado</s0>
<s2>NK</s2>
<s5>24</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Triterpène</s0>
<s5>25</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Triterpene</s0>
<s5>25</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Triterpeno</s0>
<s5>25</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Terpénoïde</s0>
<s2>FX</s2>
<s5>26</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Terpenoid</s0>
<s2>FX</s2>
<s5>26</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Terpenoide</s0>
<s2>FX</s2>
<s5>26</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Orthohepadnavirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Orthohepadnavirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Orthohepadnavirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Hepadnaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Hepadnaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Hepadnaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fN21><s1>275</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 12-0355115 INIST</NO>
<ET>Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents</ET>
<AU>WANG (Li-Jun); GENG (Chang-An); MA (Yun-Bao); HUANG (Xiao-Yan); JIE LUO; HAO CHEN; ZHANG (Xue-Mei); CHEN (Ji-Jun)</AU>
<AF>State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences/Kunming 650201/Chine (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut., 8 aut.); Graduate University of the Chinese Academy of Sciences/Beijing 100049/Chine (1 aut., 6 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Bioorganic & medicinal chemistry letters : (Print); ISSN 0960-894X; Pays-Bas; Da. 2012; Vol. 22; No. 10; Pp. 3473-3479; Bibl. 41 ref.</SO>
<LA>Anglais</LA>
<EA>Fifty-seven derivatives of glycyrrhetinic acid (GA) were synthesized, and their anti-hepatitis B virus (HBV) activity was evaluated in HepG 2.2.15 cells. Among them, sixteen compounds showed greater anti-HBV activity than GA, especially, compounds 29, 32, 35, 41 exhibited significantly inhibitory activities against HBV DNA replication with IC<sub>50</sub>
values of 5.71, 5.36, 8.90 and 9.08 μM, respectively. The structure-activity relationships (SARs) of GA derivatives were discussed for exploring novel anti-HBV agents.</EA>
<CC>002B02S05</CC>
<FD>Synthèse chimique; Activité biologique; Relation structure activité; Enoxolone; Antiviral; Virus hépatite B; Antiinflammatoire; Dérivé de l'oléanane; Triterpène; Terpénoïde</FD>
<FG>Orthohepadnavirus; Hepadnaviridae; Virus</FG>
<ED>Chemical synthesis; Biological activity; Structure activity relation; Enoxolone; Antiviral; Hepatitis B virus; Antiinflammatory agent; Oleanane derivatives; Triterpene; Terpenoid</ED>
<EG>Orthohepadnavirus; Hepadnaviridae; Virus</EG>
<SD>Síntesis química; Actividad biológica; Relación estructura actividad; Enoxolona; Antiviral; Hepatitis B virus; Antiinflamatorio; Oleanano derivado; Triterpeno; Terpenoide</SD>
<LO>INIST-22446.354000507721860170</LO>
<ID>12-0355115</ID>
</server>
</inist>
</record>
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