SrasV1, PascalFrancis, Corpus, bibRecord, 000041

Integrating Silicon Nanowire Field Effect Transistor, Microfluidics and Air Sampling Techniques For Real-Time Monitoring Biological Aerosols

Identifieur interne : 000041 ( PascalFrancis/Corpus ); précédent : 000040; suivant : 000042

Integrating Silicon Nanowire Field Effect Transistor, Microfluidics and Air Sampling Techniques For Real-Time Monitoring Biological Aerosols

Auteurs : FANGXIA SHEN ; MIAOMIAO TAN ; ZHENXING WANG ; MAOSHENG YAO ; ZHENQIANG XU ; YAN WU ; JINDONG WANG ; XUEFENG GUO ; TONG ZHU

Source :

Environmental science & technology [ 0013-936X ] ; 2011.

RBID : Pascal:12-0430651

Descripteurs français

Pascal (Inist)
- Transistor effet champ, Microfluidique, Echantillonnage, Prélèvement, Système temps réel, Surveillance biologique, Mesure air ambiant, Bioaérosol, Influenzavirus A(H1N1), Nanomatériau.

English descriptors

KwdEn :
- Ambient air measurement, Bioaerosol, Biological monitoring, Field effect transistor, Microfluidics, Nanostructured materials, Real time system, Sampling, Samplings.

Abstract

Numerous threats from biological aerosol exposures, such as those from H1N1 influenza, SARS, bird flu, and bioterrorism activities necessitate the development of a real-time bioaerosol sensing system, which however is a long-standing challenge in the field. Here, we developed a real-time monitoring system for airborne influenza H3N2 viruses by integrating electronically addressable silicon nanowire (SiNW) sensor devices, microfluidics and bioaerosol-to-hydrosol air sampling techniques. When airborne influenza H3N2 virus samples were collected and delivered to antibody-modified SiNW devices, discrete nanowire conductance changes were observed within seconds. In contrast, the conductance levels remained relatively unchanged when indoor air or clean air samples were delivered. A 10-fold increase in virus concentration was found to give rise to about 20-30% increase in the sensor response. The selectivity of the sensing device was successfully demonstrated using H1N1 viruses and house dust allergens. From the simulated aerosol release to the detection, we observed a time scale of 1-2 min. Quantitative polymerase chain reaction (qPCR) tests revealed that higher virus concentrations in the air samples generally corresponded to higher conductance levels in the SiNW devices. In addition, the display of detection data on remote platforms such as cell phone and computer was also successfully demonstrated with a wireless module. The work here is expected to lead to innovative methods for biological aerosol monitoring, and further improvements in each of the integrated elements could extend the system to real world applications.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

A01	`01`	`1`		`@0 0013-936X`
A02	`01`			`@0 ESTHAG`
A03		`1`		`@0 Environ. sci. technol.`
A05				`@2 45`
A06				`@2 17`
A08	`01`	`1`	`ENG`	`@1 Integrating Silicon Nanowire Field Effect Transistor, Microfluidics and Air Sampling Techniques For Real-Time Monitoring Biological Aerosols`
A11	`01`	`1`		`@1 FANGXIA SHEN`
A11	`02`	`1`		`@1 MIAOMIAO TAN`
A11	`03`	`1`		`@1 ZHENXING WANG`
A11	`04`	`1`		`@1 MAOSHENG YAO`
A11	`05`	`1`		`@1 ZHENQIANG XU`
A11	`06`	`1`		`@1 YAN WU`
A11	`07`	`1`		`@1 JINDONG WANG`
A11	`08`	`1`		`@1 XUEFENG GUO`
A11	`09`	`1`		`@1 TONG ZHU`
A14	`01`			`@1 State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, Peking University @2 Beijing 100871 @3 CHN @Z 1 aut. @Z 2 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut. @Z 9 aut.`
A14	`02`			`@1 Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University @2 Beijing 100871 @3 CHN @Z 3 aut. @Z 7 aut. @Z 8 aut.`
A20				`@1 7473-7480`
A21				`@1 2011`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 13615 @5 354000508985690540`
A44				`@0 0000 @1 © 2012 INIST-CNRS. All rights reserved.`
A45				`@0 21 ref.`
A47	`01`	`1`		`@0 12-0430651`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Environmental science & technology`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 Numerous threats from biological aerosol exposures, such as those from H1N1 influenza, SARS, bird flu, and bioterrorism activities necessitate the development of a real-time bioaerosol sensing system, which however is a long-standing challenge in the field. Here, we developed a real-time monitoring system for airborne influenza H3N2 viruses by integrating electronically addressable silicon nanowire (SiNW) sensor devices, microfluidics and bioaerosol-to-hydrosol air sampling techniques. When airborne influenza H3N2 virus samples were collected and delivered to antibody-modified SiNW devices, discrete nanowire conductance changes were observed within seconds. In contrast, the conductance levels remained relatively unchanged when indoor air or clean air samples were delivered. A 10-fold increase in virus concentration was found to give rise to about 20-30% increase in the sensor response. The selectivity of the sensing device was successfully demonstrated using H1N1 viruses and house dust allergens. From the simulated aerosol release to the detection, we observed a time scale of 1-2 min. Quantitative polymerase chain reaction (qPCR) tests revealed that higher virus concentrations in the air samples generally corresponded to higher conductance levels in the SiNW devices. In addition, the display of detection data on remote platforms such as cell phone and computer was also successfully demonstrated with a wireless module. The work here is expected to lead to innovative methods for biological aerosol monitoring, and further improvements in each of the integrated elements could extend the system to real world applications.
C02	`01`	`X`		`@0 001D16`
C03	`01`	`X`	`FRE`	`@0 Transistor effet champ @5 02`
C03	`01`	`X`	`ENG`	`@0 Field effect transistor @5 02`
C03	`01`	`X`	`SPA`	`@0 Transistor efecto campo @5 02`
C03	`02`	`X`	`FRE`	`@0 Microfluidique @5 03`
C03	`02`	`X`	`ENG`	`@0 Microfluidics @5 03`
C03	`02`	`X`	`SPA`	`@0 Microfluidic @5 03`
C03	`03`	`X`	`FRE`	`@0 Echantillonnage @5 05`
C03	`03`	`X`	`ENG`	`@0 Sampling @5 05`
C03	`03`	`X`	`SPA`	`@0 Muestreo @5 05`
C03	`04`	`X`	`FRE`	`@0 Prélèvement @5 06`
C03	`04`	`X`	`ENG`	`@0 Samplings @5 06`
C03	`04`	`X`	`SPA`	`@0 Toma de muestra @5 06`
C03	`05`	`X`	`FRE`	`@0 Système temps réel @5 08`
C03	`05`	`X`	`ENG`	`@0 Real time system @5 08`
C03	`05`	`X`	`SPA`	`@0 Sistema tiempo real @5 08`
C03	`06`	`X`	`FRE`	`@0 Surveillance biologique @5 11`
C03	`06`	`X`	`ENG`	`@0 Biological monitoring @5 11`
C03	`06`	`X`	`SPA`	`@0 Vigilancia biológica @5 11`
C03	`07`	`X`	`FRE`	`@0 Mesure air ambiant @5 12`
C03	`07`	`X`	`ENG`	`@0 Ambient air measurement @5 12`
C03	`07`	`X`	`SPA`	`@0 Medida aire ambiental @5 12`
C03	`08`	`X`	`FRE`	`@0 Bioaérosol @5 16`
C03	`08`	`X`	`ENG`	`@0 Bioaerosol @5 16`
C03	`08`	`X`	`SPA`	`@0 Bioaerosol @5 16`
C03	`09`	`X`	`FRE`	`@0 Influenzavirus A(H1N1) @4 INC @5 86`
C03	`10`	`X`	`FRE`	`@0 Nanomatériau @4 CD @5 96`
C03	`10`	`X`	`ENG`	`@0 Nanostructured materials @4 CD @5 96`
C07	`01`	`X`	`FRE`	`@0 Mécanique fluide`
C07	`01`	`X`	`ENG`	`@0 Fluid mechanics`
C07	`01`	`X`	`SPA`	`@0 Mecánica flúido`
N21				`@1 331`

Format Inist (serveur)

NO :	PASCAL 12-0430651 INIST
ET :	Integrating Silicon Nanowire Field Effect Transistor, Microfluidics and Air Sampling Techniques For Real-Time Monitoring Biological Aerosols
AU :	FANGXIA SHEN; MIAOMIAO TAN; ZHENXING WANG; MAOSHENG YAO; ZHENQIANG XU; YAN WU; JINDONG WANG; XUEFENG GUO; TONG ZHU
AF :	State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, Peking University/Beijing 100871/Chine (1 aut., 2 aut., 4 aut., 5 aut., 6 aut., 9 aut.); Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University/Beijing 100871/Chine (3 aut., 7 aut., 8 aut.)
DT :	Publication en série; Niveau analytique
SO :	Environmental science & technology; ISSN 0013-936X; Coden ESTHAG; Etats-Unis; Da. 2011; Vol. 45; No. 17; Pp. 7473-7480; Bibl. 21 ref.
LA :	Anglais
EA :	Numerous threats from biological aerosol exposures, such as those from H1N1 influenza, SARS, bird flu, and bioterrorism activities necessitate the development of a real-time bioaerosol sensing system, which however is a long-standing challenge in the field. Here, we developed a real-time monitoring system for airborne influenza H3N2 viruses by integrating electronically addressable silicon nanowire (SiNW) sensor devices, microfluidics and bioaerosol-to-hydrosol air sampling techniques. When airborne influenza H3N2 virus samples were collected and delivered to antibody-modified SiNW devices, discrete nanowire conductance changes were observed within seconds. In contrast, the conductance levels remained relatively unchanged when indoor air or clean air samples were delivered. A 10-fold increase in virus concentration was found to give rise to about 20-30% increase in the sensor response. The selectivity of the sensing device was successfully demonstrated using H1N1 viruses and house dust allergens. From the simulated aerosol release to the detection, we observed a time scale of 1-2 min. Quantitative polymerase chain reaction (qPCR) tests revealed that higher virus concentrations in the air samples generally corresponded to higher conductance levels in the SiNW devices. In addition, the display of detection data on remote platforms such as cell phone and computer was also successfully demonstrated with a wireless module. The work here is expected to lead to innovative methods for biological aerosol monitoring, and further improvements in each of the integrated elements could extend the system to real world applications.
CC :	001D16
FD :	Transistor effet champ; Microfluidique; Echantillonnage; Prélèvement; Système temps réel; Surveillance biologique; Mesure air ambiant; Bioaérosol; Influenzavirus A(H1N1); Nanomatériau
FG :	Mécanique fluide
ED :	Field effect transistor; Microfluidics; Sampling; Samplings; Real time system; Biological monitoring; Ambient air measurement; Bioaerosol; Nanostructured materials
EG :	Fluid mechanics
SD :	Transistor efecto campo; Microfluidic; Muestreo; Toma de muestra; Sistema tiempo real; Vigilancia biológica; Medida aire ambiental; Bioaerosol
LO :	INIST-13615.354000508985690540
ID :	12-0430651

Links to Exploration step

Pascal:12-0430651

Le document en format XML

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<front><div type="abstract" xml:lang="en">Numerous threats from biological aerosol exposures, such as those from H1N1 influenza, SARS, bird flu, and bioterrorism activities necessitate the development of a real-time bioaerosol sensing system, which however is a long-standing challenge in the field. Here, we developed a real-time monitoring system for airborne influenza H3N2 viruses by integrating electronically addressable silicon nanowire (SiNW) sensor devices, microfluidics and bioaerosol-to-hydrosol air sampling techniques. When airborne influenza H3N2 virus samples were collected and delivered to antibody-modified SiNW devices, discrete nanowire conductance changes were observed within seconds. In contrast, the conductance levels remained relatively unchanged when indoor air or clean air samples were delivered. A 10-fold increase in virus concentration was found to give rise to about 20-30% increase in the sensor response. The selectivity of the sensing device was successfully demonstrated using H1N1 viruses and house dust allergens. From the simulated aerosol release to the detection, we observed a time scale of 1-2 min. Quantitative polymerase chain reaction (qPCR) tests revealed that higher virus concentrations in the air samples generally corresponded to higher conductance levels in the SiNW devices. In addition, the display of detection data on remote platforms such as cell phone and computer was also successfully demonstrated with a wireless module. The work here is expected to lead to innovative methods for biological aerosol monitoring, and further improvements in each of the integrated elements could extend the system to real world applications.</div>
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<fA03 i2="1"><s0>Environ. sci. technol.</s0>
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<fA05><s2>45</s2>
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<fA06><s2>17</s2>
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<fA08 i1="01" i2="1" l="ENG"><s1>Integrating Silicon Nanowire Field Effect Transistor, Microfluidics and Air Sampling Techniques For Real-Time Monitoring Biological Aerosols</s1>
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<fA11 i1="01" i2="1"><s1>FANGXIA SHEN</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>MIAOMIAO TAN</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>ZHENXING WANG</s1>
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<fA11 i1="04" i2="1"><s1>MAOSHENG YAO</s1>
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<fA11 i1="05" i2="1"><s1>ZHENQIANG XU</s1>
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<fA11 i1="06" i2="1"><s1>YAN WU</s1>
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<fA11 i1="07" i2="1"><s1>JINDONG WANG</s1>
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<fA11 i1="08" i2="1"><s1>XUEFENG GUO</s1>
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<fA11 i1="09" i2="1"><s1>TONG ZHU</s1>
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<fA14 i1="01"><s1>State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, Peking University</s1>
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<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University</s1>
<s2>Beijing 100871</s2>
<s3>CHN</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
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<fA20><s1>7473-7480</s1>
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<fC01 i1="01" l="ENG"><s0>Numerous threats from biological aerosol exposures, such as those from H1N1 influenza, SARS, bird flu, and bioterrorism activities necessitate the development of a real-time bioaerosol sensing system, which however is a long-standing challenge in the field. Here, we developed a real-time monitoring system for airborne influenza H3N2 viruses by integrating electronically addressable silicon nanowire (SiNW) sensor devices, microfluidics and bioaerosol-to-hydrosol air sampling techniques. When airborne influenza H3N2 virus samples were collected and delivered to antibody-modified SiNW devices, discrete nanowire conductance changes were observed within seconds. In contrast, the conductance levels remained relatively unchanged when indoor air or clean air samples were delivered. A 10-fold increase in virus concentration was found to give rise to about 20-30% increase in the sensor response. The selectivity of the sensing device was successfully demonstrated using H1N1 viruses and house dust allergens. From the simulated aerosol release to the detection, we observed a time scale of 1-2 min. Quantitative polymerase chain reaction (qPCR) tests revealed that higher virus concentrations in the air samples generally corresponded to higher conductance levels in the SiNW devices. In addition, the display of detection data on remote platforms such as cell phone and computer was also successfully demonstrated with a wireless module. The work here is expected to lead to innovative methods for biological aerosol monitoring, and further improvements in each of the integrated elements could extend the system to real world applications.</s0>
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<fC03 i1="01" i2="X" l="FRE"><s0>Transistor effet champ</s0>
<s5>02</s5>
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<s5>02</s5>
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<s5>05</s5>
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<s5>05</s5>
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<s5>05</s5>
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<s5>06</s5>
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<s5>06</s5>
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<fC03 i1="06" i2="X" l="SPA"><s0>Vigilancia biológica</s0>
<s5>11</s5>
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<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Nanostructured materials</s0>
<s4>CD</s4>
<s5>96</s5>
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<fC07 i1="01" i2="X" l="FRE"><s0>Mécanique fluide</s0>
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<fC07 i1="01" i2="X" l="ENG"><s0>Fluid mechanics</s0>
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<server><NO>PASCAL 12-0430651 INIST</NO>
<ET>Integrating Silicon Nanowire Field Effect Transistor, Microfluidics and Air Sampling Techniques For Real-Time Monitoring Biological Aerosols</ET>
<AU>FANGXIA SHEN; MIAOMIAO TAN; ZHENXING WANG; MAOSHENG YAO; ZHENQIANG XU; YAN WU; JINDONG WANG; XUEFENG GUO; TONG ZHU</AU>
<AF>State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, Peking University/Beijing 100871/Chine (1 aut., 2 aut., 4 aut., 5 aut., 6 aut., 9 aut.); Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University/Beijing 100871/Chine (3 aut., 7 aut., 8 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Environmental science & technology; ISSN 0013-936X; Coden ESTHAG; Etats-Unis; Da. 2011; Vol. 45; No. 17; Pp. 7473-7480; Bibl. 21 ref.</SO>
<LA>Anglais</LA>
<EA>Numerous threats from biological aerosol exposures, such as those from H1N1 influenza, SARS, bird flu, and bioterrorism activities necessitate the development of a real-time bioaerosol sensing system, which however is a long-standing challenge in the field. Here, we developed a real-time monitoring system for airborne influenza H3N2 viruses by integrating electronically addressable silicon nanowire (SiNW) sensor devices, microfluidics and bioaerosol-to-hydrosol air sampling techniques. When airborne influenza H3N2 virus samples were collected and delivered to antibody-modified SiNW devices, discrete nanowire conductance changes were observed within seconds. In contrast, the conductance levels remained relatively unchanged when indoor air or clean air samples were delivered. A 10-fold increase in virus concentration was found to give rise to about 20-30% increase in the sensor response. The selectivity of the sensing device was successfully demonstrated using H1N1 viruses and house dust allergens. From the simulated aerosol release to the detection, we observed a time scale of 1-2 min. Quantitative polymerase chain reaction (qPCR) tests revealed that higher virus concentrations in the air samples generally corresponded to higher conductance levels in the SiNW devices. In addition, the display of detection data on remote platforms such as cell phone and computer was also successfully demonstrated with a wireless module. The work here is expected to lead to innovative methods for biological aerosol monitoring, and further improvements in each of the integrated elements could extend the system to real world applications.</EA>
<CC>001D16</CC>
<FD>Transistor effet champ; Microfluidique; Echantillonnage; Prélèvement; Système temps réel; Surveillance biologique; Mesure air ambiant; Bioaérosol; Influenzavirus A(H1N1); Nanomatériau</FD>
<FG>Mécanique fluide</FG>
<ED>Field effect transistor; Microfluidics; Sampling; Samplings; Real time system; Biological monitoring; Ambient air measurement; Bioaerosol; Nanostructured materials</ED>
<EG>Fluid mechanics</EG>
<SD>Transistor efecto campo; Microfluidic; Muestreo; Toma de muestra; Sistema tiempo real; Vigilancia biológica; Medida aire ambiental; Bioaerosol</SD>
<LO>INIST-13615.354000508985690540</LO>
<ID>12-0430651</ID>
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Integrating Silicon Nanowire Field Effect Transistor, Microfluidics and Air Sampling Techniques For Real-Time Monitoring Biological Aerosols

Integrating Silicon Nanowire Field Effect Transistor, Microfluidics and Air Sampling Techniques For Real-Time Monitoring Biological Aerosols

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