Identification of two neutralizing regions on the severe acute respiratory syndrome coronavirus Spike glycoprotein produced from the mammalian expression system
Identifieur interne : 000631 ( PascalFrancis/Checkpoint ); précédent : 000630; suivant : 000632Identification of two neutralizing regions on the severe acute respiratory syndrome coronavirus Spike glycoprotein produced from the mammalian expression system
Auteurs : SHIXIA WANG [États-Unis] ; Te-Hui W. Chou [États-Unis] ; Pavlo V. Sakhatskyy [États-Unis] ; SONG HUANG [États-Unis] ; John M. Lawrence [États-Unis] ; HONG CAO [États-Unis] ; XIAOYUN HUANG [États-Unis] ; SHAN LU [États-Unis]Source :
- Journal of virology [ 0022-538X ] ; 2005.
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Abstract
The Spike (S) protein of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) plays important roles in viral pathogenesis and potentially in the development of an effective vaccine against this virulent infectious disease. In this study, the codon-optimized S gene of SARS-CoV was synthesized to construct DNA vaccine plasmids expressing either the full-length or segments of the S protein. High titer S-specific immunoglobulin G antibody responses were elicited in rabbits immunized with DNA against various segments of the S protein. Two neutralizing domains were identified on the S protein, one at the N terminus (Ser12-Thr535) and the other near the C terminus (Arg797-Ile1192).
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<front><div type="abstract" xml:lang="en">The Spike (S) protein of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) plays important roles in viral pathogenesis and potentially in the development of an effective vaccine against this virulent infectious disease. In this study, the codon-optimized S gene of SARS-CoV was synthesized to construct DNA vaccine plasmids expressing either the full-length or segments of the S protein. High titer S-specific immunoglobulin G antibody responses were elicited in rabbits immunized with DNA against various segments of the S protein. Two neutralizing domains were identified on the S protein, one at the N terminus (Ser12-Thr535) and the other near the C terminus (Arg797-Ile1192).</div>
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<s2>NW</s2>
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<fC07 i1="01" i2="X" l="SPA"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Appareil respiratoire pathologie</s0>
<s5>13</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>13</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0>
<s5>13</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Virose</s0>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Viral disease</s0>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Virosis</s0>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Infection</s0>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Infection</s0>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Infección</s0>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Poumon pathologie</s0>
<s5>16</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Lung disease</s0>
<s5>16</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Pulmón patología</s0>
<s5>16</s5>
</fC07>
<fN21><s1>087</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Massachusetts</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Shixia Wang" sort="Shixia Wang" uniqKey="Shixia Wang" last="Shixia Wang">SHIXIA WANG</name>
</region>
<name sortKey="Chou, Te Hui W" sort="Chou, Te Hui W" uniqKey="Chou T" first="Te-Hui W." last="Chou">Te-Hui W. Chou</name>
<name sortKey="Hong Cao" sort="Hong Cao" uniqKey="Hong Cao" last="Hong Cao">HONG CAO</name>
<name sortKey="Lawrence, John M" sort="Lawrence, John M" uniqKey="Lawrence J" first="John M." last="Lawrence">John M. Lawrence</name>
<name sortKey="Sakhatskyy, Pavlo V" sort="Sakhatskyy, Pavlo V" uniqKey="Sakhatskyy P" first="Pavlo V." last="Sakhatskyy">Pavlo V. Sakhatskyy</name>
<name sortKey="Shan Lu" sort="Shan Lu" uniqKey="Shan Lu" last="Shan Lu">SHAN LU</name>
<name sortKey="Song Huang" sort="Song Huang" uniqKey="Song Huang" last="Song Huang">SONG HUANG</name>
<name sortKey="Xiaoyun Huang" sort="Xiaoyun Huang" uniqKey="Xiaoyun Huang" last="Xiaoyun Huang">XIAOYUN HUANG</name>
</country>
</tree>
</affiliations>
</record>
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