Identification of two neutralizing regions on the severe acute respiratory syndrome coronavirus Spike glycoprotein produced from the mammalian expression system
Identifieur interne : 000631 ( PascalFrancis/Checkpoint ); précédent : 000630; suivant : 000632Identification of two neutralizing regions on the severe acute respiratory syndrome coronavirus Spike glycoprotein produced from the mammalian expression system
Auteurs : SHIXIA WANG [États-Unis] ; Te-Hui W. Chou [États-Unis] ; Pavlo V. Sakhatskyy [États-Unis] ; SONG HUANG [États-Unis] ; John M. Lawrence [États-Unis] ; HONG CAO [États-Unis] ; XIAOYUN HUANG [États-Unis] ; SHAN LU [États-Unis]Source :
- Journal of virology [ 0022-538X ] ; 2005.
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Abstract
The Spike (S) protein of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) plays important roles in viral pathogenesis and potentially in the development of an effective vaccine against this virulent infectious disease. In this study, the codon-optimized S gene of SARS-CoV was synthesized to construct DNA vaccine plasmids expressing either the full-length or segments of the S protein. High titer S-specific immunoglobulin G antibody responses were elicited in rabbits immunized with DNA against various segments of the S protein. Two neutralizing domains were identified on the S protein, one at the N terminus (Ser12-Thr535) and the other near the C terminus (Arg797-Ile1192).
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Identification of two neutralizing regions on the severe acute respiratory syndrome coronavirus Spike glycoprotein produced from the mammalian expression system</title><author><name sortKey="Shixia Wang" sort="Shixia Wang" uniqKey="Shixia Wang" last="Shixia Wang">SHIXIA WANG</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Laboratory of Nucleic Acid Vaccines, Department of Medicine, University of Massachusetts Medical School</s1><s2>Worcester, Massachusetts</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Chou, Te Hui W" sort="Chou, Te Hui W" uniqKey="Chou T" first="Te-Hui W." last="Chou">Te-Hui W. 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Sakhatskyy</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Laboratory of Nucleic Acid Vaccines, Department of Medicine, University of Massachusetts Medical School</s1><s2>Worcester, Massachusetts</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Song Huang" sort="Song Huang" uniqKey="Song Huang" last="Song Huang">SONG HUANG</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Laboratory of Nucleic Acid Vaccines, Department of Medicine, University of Massachusetts Medical School</s1><s2>Worcester, Massachusetts</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Lawrence, John M" sort="Lawrence, John M" uniqKey="Lawrence J" first="John M." last="Lawrence">John M. Lawrence</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Laboratory of Nucleic Acid Vaccines, Department of Medicine, University of Massachusetts Medical School</s1><s2>Worcester, Massachusetts</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Hong Cao" sort="Hong Cao" uniqKey="Hong Cao" last="Hong Cao">HONG CAO</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Laboratory of Nucleic Acid Vaccines, Department of Medicine, University of Massachusetts Medical School</s1><s2>Worcester, Massachusetts</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Xiaoyun Huang" sort="Xiaoyun Huang" uniqKey="Xiaoyun Huang" last="Xiaoyun Huang">XIAOYUN HUANG</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Laboratory of Nucleic Acid Vaccines, Department of Medicine, University of Massachusetts Medical School</s1><s2>Worcester, Massachusetts</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Shan Lu" sort="Shan Lu" uniqKey="Shan Lu" last="Shan Lu">SHAN LU</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Laboratory of Nucleic Acid Vaccines, Department of Medicine, University of Massachusetts Medical School</s1><s2>Worcester, Massachusetts</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">05-0133038</idno><date when="2005">2005</date><idno type="stanalyst">PASCAL 05-0133038 INIST</idno><idno type="RBID">Pascal:05-0133038</idno><idno type="wicri:Area/PascalFrancis/Corpus">000720</idno><idno type="wicri:Area/PascalFrancis/Curation">000270</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000631</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000631</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Identification of two neutralizing regions on the severe acute respiratory syndrome coronavirus Spike glycoprotein produced from the mammalian expression system</title><author><name sortKey="Shixia Wang" sort="Shixia Wang" uniqKey="Shixia Wang" last="Shixia Wang">SHIXIA WANG</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Laboratory of Nucleic Acid Vaccines, Department of Medicine, University of Massachusetts Medical School</s1><s2>Worcester, Massachusetts</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Chou, Te Hui W" sort="Chou, Te Hui W" uniqKey="Chou T" first="Te-Hui W." last="Chou">Te-Hui W. Chou</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Laboratory of Nucleic Acid Vaccines, Department of Medicine, University of Massachusetts Medical School</s1><s2>Worcester, Massachusetts</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Sakhatskyy, Pavlo V" sort="Sakhatskyy, Pavlo V" uniqKey="Sakhatskyy P" first="Pavlo V." last="Sakhatskyy">Pavlo V. Sakhatskyy</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Laboratory of Nucleic Acid Vaccines, Department of Medicine, University of Massachusetts Medical School</s1><s2>Worcester, Massachusetts</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Song Huang" sort="Song Huang" uniqKey="Song Huang" last="Song Huang">SONG HUANG</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Laboratory of Nucleic Acid Vaccines, Department of Medicine, University of Massachusetts Medical School</s1><s2>Worcester, Massachusetts</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Lawrence, John M" sort="Lawrence, John M" uniqKey="Lawrence J" first="John M." last="Lawrence">John M. Lawrence</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Laboratory of Nucleic Acid Vaccines, Department of Medicine, University of Massachusetts Medical School</s1><s2>Worcester, Massachusetts</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Hong Cao" sort="Hong Cao" uniqKey="Hong Cao" last="Hong Cao">HONG CAO</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Laboratory of Nucleic Acid Vaccines, Department of Medicine, University of Massachusetts Medical School</s1><s2>Worcester, Massachusetts</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Xiaoyun Huang" sort="Xiaoyun Huang" uniqKey="Xiaoyun Huang" last="Xiaoyun Huang">XIAOYUN HUANG</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Laboratory of Nucleic Acid Vaccines, Department of Medicine, University of Massachusetts Medical School</s1><s2>Worcester, Massachusetts</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Shan Lu" sort="Shan Lu" uniqKey="Shan Lu" last="Shan Lu">SHAN LU</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Laboratory of Nucleic Acid Vaccines, Department of Medicine, University of Massachusetts Medical School</s1><s2>Worcester, Massachusetts</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Journal of virology</title><title level="j" type="abbreviated">J. virol.</title><idno type="ISSN">0022-538X</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of virology</title><title level="j" type="abbreviated">J. virol.</title><idno type="ISSN">0022-538X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Coronavirus</term><term>Glycoprotein</term><term>Identification</term><term>Mammalia</term><term>Microbiology</term><term>Severe acute respiratory syndrome</term><term>Virology</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Coronavirus</term><term>Mammalia</term><term>Identification</term><term>Glycoprotéine</term><term>Microbiologie</term><term>Virologie</term><term>Syndrome respiratoire aigu sévère</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The Spike (S) protein of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) plays important roles in viral pathogenesis and potentially in the development of an effective vaccine against this virulent infectious disease. In this study, the codon-optimized S gene of SARS-CoV was synthesized to construct DNA vaccine plasmids expressing either the full-length or segments of the S protein. High titer S-specific immunoglobulin G antibody responses were elicited in rabbits immunized with DNA against various segments of the S protein. Two neutralizing domains were identified on the S protein, one at the N terminus (Ser12-Thr535) and the other near the C terminus (Arg797-Ile1192).</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0022-538X</s0></fA01><fA03 i2="1"><s0>J. virol.</s0></fA03><fA05><s2>79</s2></fA05><fA06><s2>3</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Identification of two neutralizing regions on the severe acute respiratory syndrome coronavirus Spike glycoprotein produced from the mammalian expression system</s1></fA08><fA11 i1="01" i2="1"><s1>SHIXIA WANG</s1></fA11><fA11 i1="02" i2="1"><s1>CHOU (Te-Hui W.)</s1></fA11><fA11 i1="03" i2="1"><s1>SAKHATSKYY (Pavlo V.)</s1></fA11><fA11 i1="04" i2="1"><s1>SONG HUANG</s1></fA11><fA11 i1="05" i2="1"><s1>LAWRENCE (John M.)</s1></fA11><fA11 i1="06" i2="1"><s1>HONG CAO</s1></fA11><fA11 i1="07" i2="1"><s1>XIAOYUN HUANG</s1></fA11><fA11 i1="08" i2="1"><s1>SHAN LU</s1></fA11><fA14 i1="01"><s1>Laboratory of Nucleic Acid Vaccines, Department of Medicine, University of Massachusetts Medical School</s1><s2>Worcester, Massachusetts</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></fA14><fA20><s1>1906-1910</s1></fA20><fA21><s1>2005</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>13592</s2><s5>354000127060900550</s5></fA43><fA44><s0>0000</s0><s1>© 2005 INIST-CNRS. 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Chou</name><name sortKey="Hong Cao" sort="Hong Cao" uniqKey="Hong Cao" last="Hong Cao">HONG CAO</name><name sortKey="Lawrence, John M" sort="Lawrence, John M" uniqKey="Lawrence J" first="John M." last="Lawrence">John M. Lawrence</name><name sortKey="Sakhatskyy, Pavlo V" sort="Sakhatskyy, Pavlo V" uniqKey="Sakhatskyy P" first="Pavlo V." last="Sakhatskyy">Pavlo V. Sakhatskyy</name><name sortKey="Shan Lu" sort="Shan Lu" uniqKey="Shan Lu" last="Shan Lu">SHAN LU</name><name sortKey="Song Huang" sort="Song Huang" uniqKey="Song Huang" last="Song Huang">SONG HUANG</name><name sortKey="Xiaoyun Huang" sort="Xiaoyun Huang" uniqKey="Xiaoyun Huang" last="Xiaoyun Huang">XIAOYUN HUANG</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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