Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus
Identifieur interne : 000603 ( PascalFrancis/Checkpoint ); précédent : 000602; suivant : 000604Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus
Auteurs : Sara Akerström [Suède] ; Mehrdad Mousavi-Jazi [Suède] ; Jonas Klingström [Suède] ; Mikael Leijon [Suède] ; Ake Lundkvist [Suède] ; Ali Mirazimi [Suède]Source :
- Journal of virology [ 0022-538X ] ; 2005.
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- Pascal (Inist)
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Abstract
Nitric oxide (NO) is an important signaling molecule between cells which has been shown to have an inhibitory effect on some virus infections. The purpose of this study was to examine whether NO inhibits the replication cycle of the severe acute respiratory syndrome coronavirus (SARS CoV) in vitro. We found that an organic NO donor, S-nitroso-N-acetylpenicillamine, significantly inhibited the replication cycle of SARS CoV in a concentration-dependent manner. We also show here that NO inhibits viral protein and RNA synthesis. Furthermore, we demonstrate that NO generated by inducible nitric oxide synthase, an enzyme that produces NO, inhibits the SARS CoV replication cycle.
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aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>LightUp Technologies</wicri:noRegion></affiliation></author><author><name sortKey="Klingstrom, Jonas" sort="Klingstrom, Jonas" uniqKey="Klingstrom J" first="Jonas" last="Klingström">Jonas Klingström</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Center for Microbiological Preparedness, Swedish Institute for Infectious Disease Control</s1><s2>Solna</s2><s3>SWE</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Solna</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>MTC/Karolinska Institutet</s1><s2>Stockholm</s2><s3>SWE</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Leijon, Mikael" sort="Leijon, Mikael" uniqKey="Leijon M" first="Mikael" last="Leijon">Mikael Leijon</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>LightUp Technologies</s1><s2>Huddinge</s2><s3>SWE</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>LightUp Technologies</wicri:noRegion></affiliation></author><author><name sortKey="Lundkvist, Ake" sort="Lundkvist, Ake" uniqKey="Lundkvist A" first="Ake" last="Lundkvist">Ake Lundkvist</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Center for Microbiological Preparedness, Swedish Institute for Infectious Disease Control</s1><s2>Solna</s2><s3>SWE</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Solna</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>MTC/Karolinska Institutet</s1><s2>Stockholm</s2><s3>SWE</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Mirazimi, Ali" sort="Mirazimi, Ali" uniqKey="Mirazimi A" first="Ali" last="Mirazimi">Ali Mirazimi</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Center for Microbiological Preparedness, Swedish Institute for Infectious Disease Control</s1><s2>Solna</s2><s3>SWE</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Solna</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Journal of virology</title><title level="j" type="abbreviated">J. virol.</title><idno type="ISSN">0022-538X</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of virology</title><title level="j" type="abbreviated">J. virol.</title><idno type="ISSN">0022-538X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Coronavirus</term><term>Microbiology</term><term>Nitric oxide</term><term>Replication</term><term>Severe acute respiratory syndrome</term><term>Virology</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Coronavirus</term><term>Azote monoxyde</term><term>Réplication</term><term>Microbiologie</term><term>Virologie</term><term>Syndrome respiratoire aigu sévère</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Nitric oxide (NO) is an important signaling molecule between cells which has been shown to have an inhibitory effect on some virus infections. The purpose of this study was to examine whether NO inhibits the replication cycle of the severe acute respiratory syndrome coronavirus (SARS CoV) in vitro. We found that an organic NO donor, S-nitroso-N-acetylpenicillamine, significantly inhibited the replication cycle of SARS CoV in a concentration-dependent manner. We also show here that NO inhibits viral protein and RNA synthesis. Furthermore, we demonstrate that NO generated by inducible nitric oxide synthase, an enzyme that produces NO, inhibits the SARS CoV replication cycle.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0022-538X</s0></fA01><fA03 i2="1"><s0>J. virol.</s0></fA03><fA05><s2>79</s2></fA05><fA06><s2>3</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus</s1></fA08><fA11 i1="01" i2="1"><s1>AKERSTRÖM (Sara)</s1></fA11><fA11 i1="02" i2="1"><s1>MOUSAVI-JAZI (Mehrdad)</s1></fA11><fA11 i1="03" i2="1"><s1>KLINGSTRÖM (Jonas)</s1></fA11><fA11 i1="04" i2="1"><s1>LEIJON (Mikael)</s1></fA11><fA11 i1="05" i2="1"><s1>LUNDKVIST (Ake)</s1></fA11><fA11 i1="06" i2="1"><s1>MIRAZIMI (Ali)</s1></fA11><fA14 i1="01"><s1>Center for Microbiological Preparedness, Swedish Institute for Infectious Disease Control</s1><s2>Solna</s2><s3>SWE</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></fA14><fA14 i1="02"><s1>LightUp Technologies</s1><s2>Huddinge</s2><s3>SWE</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ></fA14><fA14 i1="03"><s1>MTC/Karolinska Institutet</s1><s2>Stockholm</s2><s3>SWE</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ></fA14><fA20><s1>1966-1969</s1></fA20><fA21><s1>2005</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>13592</s2><s5>354000127060900660</s5></fA43><fA44><s0>0000</s0><s1>© 2005 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>34 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>05-0134586</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Journal of virology</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Nitric oxide (NO) is an important signaling molecule between cells which has been shown to have an inhibitory effect on some virus infections. The purpose of this study was to examine whether NO inhibits the replication cycle of the severe acute respiratory syndrome coronavirus (SARS CoV) in vitro. We found that an organic NO donor, S-nitroso-N-acetylpenicillamine, significantly inhibited the replication cycle of SARS CoV in a concentration-dependent manner. We also show here that NO inhibits viral protein and RNA synthesis. 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