Significance of the Myxovirus Resistance A (MxA) Gene -123C>A Single-Nucleotide Polymorphism in Suppressed Interferon β Induction of Severe Acute Respiratory Syndrome Coronavirus Infection
Identifieur interne : 000131 ( PascalFrancis/Checkpoint ); précédent : 000130; suivant : 000132Significance of the Myxovirus Resistance A (MxA) Gene -123C>A Single-Nucleotide Polymorphism in Suppressed Interferon β Induction of Severe Acute Respiratory Syndrome Coronavirus Infection
Auteurs : Johannes Chi-Yun Ching [Hong Kong] ; Kelvin Yuen Kwong Chan [Hong Kong] ; Eric Hing Leung Lee [Hong Kong] ; Mei-Shu Xu [Hong Kong] ; Campbell Kam Po Ting [Hong Kong] ; Thomas M. K. So [Hong Kong] ; Pak C. Sham [Hong Kong] ; Gabriel M. Leung [Hong Kong] ; Joseph S. M. Peiris [Hong Kong] ; Ui-Soon Khoo [Hong Kong]Source :
- The Journal of infectious diseases [ 0022-1899 ] ; 2010.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Myxovirus resistance A (MxA) is an antiviral protein induced by interferon α and β (IFN-α, If-β) that can inhibit viral replication. The minor alleles of the -88G>T and -123C>A MxA promoter single-nucleotide polymorphisms (SNPs) are associated with increased promoter activity and altered response to IFN-α and IFN-β treatment. Here, we demonstrate that the -123A minor allele provided stronger binding affinity to nuclear proteins extracted from IFN-β-untreated cells than did the wild-type allele, whereas the -88T allele showed preferential binding after IFN-β stimulation. Endogenous IFN-α and IFN-β induction can be suppressed in severe acute respiratory syndrome (SARS) coronavirus infection. In support of our in vitro findings, a large case-control genetic-association study for SARS coronavirus infection confirmed that the -123A minor-allele carriers were significantly associated with lower risk of SARS coronavirus infection, whereas the -88T minor-allele carriers were insignificant after adjustment for confounding effects. This suggests that -123C>A plays a more important role in modulating basal MxA expression, thus contributing more significantly to innate immune response against viral infections that suppress endogenous IFN-α and IFN-β induction such as SARS coronavirus.
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
Pascal:10-0302334Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Significance of the Myxovirus Resistance A (MxA) Gene -123C>A Single-Nucleotide Polymorphism in Suppressed Interferon β Induction of Severe Acute Respiratory Syndrome Coronavirus Infection</title>
<author><name sortKey="Ching, Johannes Chi Yun" sort="Ching, Johannes Chi Yun" uniqKey="Ching J" first="Johannes Chi-Yun" last="Ching">Johannes Chi-Yun Ching</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Pathology, University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Pathology, University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yuen Kwong Chan, Kelvin" sort="Yuen Kwong Chan, Kelvin" uniqKey="Yuen Kwong Chan K" first="Kelvin" last="Yuen Kwong Chan">Kelvin Yuen Kwong Chan</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Pathology, University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Pathology, University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hing Leung Lee, Eric" sort="Hing Leung Lee, Eric" uniqKey="Hing Leung Lee E" first="Eric" last="Hing Leung Lee">Eric Hing Leung Lee</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Pathology, University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Pathology, University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xu, Mei Shu" sort="Xu, Mei Shu" uniqKey="Xu M" first="Mei-Shu" last="Xu">Mei-Shu Xu</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Pathology, University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Pathology, University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kam Po Ting, Campbell" sort="Kam Po Ting, Campbell" uniqKey="Kam Po Ting C" first="Campbell" last="Kam Po Ting">Campbell Kam Po Ting</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Pathology, University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Pathology, University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="So, Thomas M K" sort="So, Thomas M K" uniqKey="So T" first="Thomas M. K." last="So">Thomas M. K. So</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Medicine and Geriatrics, Princess Margaret Hospital</s1>
<s3>HKG</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Medicine and Geriatrics, Princess Margaret Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sham, Pak C" sort="Sham, Pak C" uniqKey="Sham P" first="Pak C." last="Sham">Pak C. Sham</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Psychiatry, University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Psychiatry, University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Leung, Gabriel M" sort="Leung, Gabriel M" uniqKey="Leung G" first="Gabriel M." last="Leung">Gabriel M. Leung</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Community Medicine, University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Community Medicine, University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Peiris, Joseph S M" sort="Peiris, Joseph S M" uniqKey="Peiris J" first="Joseph S. M." last="Peiris">Joseph S. M. Peiris</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Microbiology, University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Microbiology, University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Khoo, Ui Soon" sort="Khoo, Ui Soon" uniqKey="Khoo U" first="Ui-Soon" last="Khoo">Ui-Soon Khoo</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Pathology, University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Pathology, University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">10-0302334</idno>
<date when="2010">2010</date>
<idno type="stanalyst">PASCAL 10-0302334 INIST</idno>
<idno type="RBID">Pascal:10-0302334</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000152</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000836</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000131</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000131</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Significance of the Myxovirus Resistance A (MxA) Gene -123C>A Single-Nucleotide Polymorphism in Suppressed Interferon β Induction of Severe Acute Respiratory Syndrome Coronavirus Infection</title>
<author><name sortKey="Ching, Johannes Chi Yun" sort="Ching, Johannes Chi Yun" uniqKey="Ching J" first="Johannes Chi-Yun" last="Ching">Johannes Chi-Yun Ching</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Pathology, University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Pathology, University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yuen Kwong Chan, Kelvin" sort="Yuen Kwong Chan, Kelvin" uniqKey="Yuen Kwong Chan K" first="Kelvin" last="Yuen Kwong Chan">Kelvin Yuen Kwong Chan</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Pathology, University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Pathology, University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hing Leung Lee, Eric" sort="Hing Leung Lee, Eric" uniqKey="Hing Leung Lee E" first="Eric" last="Hing Leung Lee">Eric Hing Leung Lee</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Pathology, University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Pathology, University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xu, Mei Shu" sort="Xu, Mei Shu" uniqKey="Xu M" first="Mei-Shu" last="Xu">Mei-Shu Xu</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Pathology, University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Pathology, University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kam Po Ting, Campbell" sort="Kam Po Ting, Campbell" uniqKey="Kam Po Ting C" first="Campbell" last="Kam Po Ting">Campbell Kam Po Ting</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Pathology, University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Pathology, University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="So, Thomas M K" sort="So, Thomas M K" uniqKey="So T" first="Thomas M. K." last="So">Thomas M. K. So</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Medicine and Geriatrics, Princess Margaret Hospital</s1>
<s3>HKG</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Medicine and Geriatrics, Princess Margaret Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sham, Pak C" sort="Sham, Pak C" uniqKey="Sham P" first="Pak C." last="Sham">Pak C. Sham</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Psychiatry, University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Psychiatry, University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Leung, Gabriel M" sort="Leung, Gabriel M" uniqKey="Leung G" first="Gabriel M." last="Leung">Gabriel M. Leung</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Community Medicine, University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Community Medicine, University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Peiris, Joseph S M" sort="Peiris, Joseph S M" uniqKey="Peiris J" first="Joseph S. M." last="Peiris">Joseph S. M. Peiris</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Microbiology, University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Microbiology, University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Khoo, Ui Soon" sort="Khoo, Ui Soon" uniqKey="Khoo U" first="Ui-Soon" last="Khoo">Ui-Soon Khoo</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Pathology, University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Pathology, University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">The Journal of infectious diseases</title>
<title level="j" type="abbreviated">J. infect. dis.</title>
<idno type="ISSN">0022-1899</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">The Journal of infectious diseases</title>
<title level="j" type="abbreviated">J. infect. dis.</title>
<idno type="ISSN">0022-1899</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Beta interferon</term>
<term>Coronavirus</term>
<term>Gene</term>
<term>Infection</term>
<term>Resistance</term>
<term>Severe acute respiratory syndrome</term>
<term>Single nucleotide polymorphism</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Coronavirus</term>
<term>Résistance</term>
<term>Gène</term>
<term>Polymorphisme mononucléotide</term>
<term>Infection</term>
<term>Interféron bêta</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Myxovirus resistance A (MxA) is an antiviral protein induced by interferon α and β (IFN-α, If-β) that can inhibit viral replication. The minor alleles of the -88G>T and -123C>A MxA promoter single-nucleotide polymorphisms (SNPs) are associated with increased promoter activity and altered response to IFN-α and IFN-β treatment. Here, we demonstrate that the -123A minor allele provided stronger binding affinity to nuclear proteins extracted from IFN-β-untreated cells than did the wild-type allele, whereas the -88T allele showed preferential binding after IFN-β stimulation. Endogenous IFN-α and IFN-β induction can be suppressed in severe acute respiratory syndrome (SARS) coronavirus infection. In support of our in vitro findings, a large case-control genetic-association study for SARS coronavirus infection confirmed that the -123A minor-allele carriers were significantly associated with lower risk of SARS coronavirus infection, whereas the -88T minor-allele carriers were insignificant after adjustment for confounding effects. This suggests that -123C>A plays a more important role in modulating basal MxA expression, thus contributing more significantly to innate immune response against viral infections that suppress endogenous IFN-α and IFN-β induction such as SARS coronavirus.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0022-1899</s0>
</fA01>
<fA02 i1="01"><s0>JIDIAQ</s0>
</fA02>
<fA03 i2="1"><s0>J. infect. dis.</s0>
</fA03>
<fA05><s2>201</s2>
</fA05>
<fA06><s2>12</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Significance of the Myxovirus Resistance A (MxA) Gene -123C>A Single-Nucleotide Polymorphism in Suppressed Interferon β Induction of Severe Acute Respiratory Syndrome Coronavirus Infection</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>CHING (Johannes Chi-Yun)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>YUEN KWONG CHAN (Kelvin)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>HING LEUNG LEE (Eric)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>XU (Mei-Shu)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>KAM PO TING (Campbell)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>SO (Thomas M. K.)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>SHAM (Pak C.)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>LEUNG (Gabriel M.)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>PEIRIS (Joseph S. M.)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>KHOO (Ui-Soon)</s1>
</fA11>
<fA14 i1="01"><s1>Department of Pathology, University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Department of Psychiatry, University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Department of Community Medicine, University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Department of Microbiology, University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Department of Medicine and Geriatrics, Princess Margaret Hospital</s1>
<s3>HKG</s3>
<sZ>6 aut.</sZ>
</fA14>
<fA20><s1>1899-1908</s1>
</fA20>
<fA21><s1>2010</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>2052</s2>
<s5>354000193044770160</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2010 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>42 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>10-0302334</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>The Journal of infectious diseases</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Myxovirus resistance A (MxA) is an antiviral protein induced by interferon α and β (IFN-α, If-β) that can inhibit viral replication. The minor alleles of the -88G>T and -123C>A MxA promoter single-nucleotide polymorphisms (SNPs) are associated with increased promoter activity and altered response to IFN-α and IFN-β treatment. Here, we demonstrate that the -123A minor allele provided stronger binding affinity to nuclear proteins extracted from IFN-β-untreated cells than did the wild-type allele, whereas the -88T allele showed preferential binding after IFN-β stimulation. Endogenous IFN-α and IFN-β induction can be suppressed in severe acute respiratory syndrome (SARS) coronavirus infection. In support of our in vitro findings, a large case-control genetic-association study for SARS coronavirus infection confirmed that the -123A minor-allele carriers were significantly associated with lower risk of SARS coronavirus infection, whereas the -88T minor-allele carriers were insignificant after adjustment for confounding effects. This suggests that -123C>A plays a more important role in modulating basal MxA expression, thus contributing more significantly to innate immune response against viral infections that suppress endogenous IFN-α and IFN-β induction such as SARS coronavirus.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002A05C10</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B05</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Résistance</s0>
<s5>05</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Resistance</s0>
<s5>05</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Resistencia</s0>
<s5>05</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Gène</s0>
<s5>06</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Gene</s0>
<s5>06</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Gen</s0>
<s5>06</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Polymorphisme mononucléotide</s0>
<s5>07</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Single nucleotide polymorphism</s0>
<s5>07</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Polimorfismo mononucleótido</s0>
<s5>07</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Infection</s0>
<s5>08</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Infection</s0>
<s5>08</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Infección</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Interféron bêta</s0>
<s2>FR</s2>
<s5>14</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Beta interferon</s0>
<s2>FR</s2>
<s5>14</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Interferón beta</s0>
<s2>FR</s2>
<s5>14</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Syndrome respiratoire aigu sévère</s0>
<s2>NM</s2>
<s5>15</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Severe acute respiratory syndrome</s0>
<s2>NM</s2>
<s5>15</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Síndrome respiratorio agudo severo</s0>
<s2>NM</s2>
<s5>15</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Cytokine</s0>
<s5>13</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Cytokine</s0>
<s5>13</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Citoquina</s0>
<s5>13</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Virose</s0>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Viral disease</s0>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Virosis</s0>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Pathologie de l'appareil respiratoire</s0>
<s5>16</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>16</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0>
<s5>16</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Pathologie des poumons</s0>
<s5>17</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Lung disease</s0>
<s5>17</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Pulmón patología</s0>
<s5>17</s5>
</fC07>
<fN21><s1>193</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
<affiliations><list><country><li>Hong Kong</li>
</country>
</list>
<tree><country name="Hong Kong"><noRegion><name sortKey="Ching, Johannes Chi Yun" sort="Ching, Johannes Chi Yun" uniqKey="Ching J" first="Johannes Chi-Yun" last="Ching">Johannes Chi-Yun Ching</name>
</noRegion>
<name sortKey="Hing Leung Lee, Eric" sort="Hing Leung Lee, Eric" uniqKey="Hing Leung Lee E" first="Eric" last="Hing Leung Lee">Eric Hing Leung Lee</name>
<name sortKey="Kam Po Ting, Campbell" sort="Kam Po Ting, Campbell" uniqKey="Kam Po Ting C" first="Campbell" last="Kam Po Ting">Campbell Kam Po Ting</name>
<name sortKey="Khoo, Ui Soon" sort="Khoo, Ui Soon" uniqKey="Khoo U" first="Ui-Soon" last="Khoo">Ui-Soon Khoo</name>
<name sortKey="Leung, Gabriel M" sort="Leung, Gabriel M" uniqKey="Leung G" first="Gabriel M." last="Leung">Gabriel M. Leung</name>
<name sortKey="Peiris, Joseph S M" sort="Peiris, Joseph S M" uniqKey="Peiris J" first="Joseph S. M." last="Peiris">Joseph S. M. Peiris</name>
<name sortKey="Sham, Pak C" sort="Sham, Pak C" uniqKey="Sham P" first="Pak C." last="Sham">Pak C. Sham</name>
<name sortKey="So, Thomas M K" sort="So, Thomas M K" uniqKey="So T" first="Thomas M. K." last="So">Thomas M. K. So</name>
<name sortKey="Xu, Mei Shu" sort="Xu, Mei Shu" uniqKey="Xu M" first="Mei-Shu" last="Xu">Mei-Shu Xu</name>
<name sortKey="Yuen Kwong Chan, Kelvin" sort="Yuen Kwong Chan, Kelvin" uniqKey="Yuen Kwong Chan K" first="Kelvin" last="Yuen Kwong Chan">Kelvin Yuen Kwong Chan</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/PascalFrancis/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000131 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Checkpoint/biblio.hfd -nk 000131 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= PascalFrancis |étape= Checkpoint |type= RBID |clé= Pascal:10-0302334 |texte= Significance of the Myxovirus Resistance A (MxA) Gene -123C>A Single-Nucleotide Polymorphism in Suppressed Interferon β Induction of Severe Acute Respiratory Syndrome Coronavirus Infection }}
This area was generated with Dilib version V0.6.33. |