SrasV1, PascalFrancis, Checkpoint, bibRecord, 000019

Proteolytic activation of the SARS-coronavirus spike protein: Cutting enzymes at the cutting edge of antiviral research

Identifieur interne : 000019 ( PascalFrancis/Checkpoint ); précédent : 000018; suivant : 000020

Proteolytic activation of the SARS-coronavirus spike protein: Cutting enzymes at the cutting edge of antiviral research

Auteurs : Graham Simmons [États-Unis] ; Pawel Zmora [Allemagne] ; Stefanie Gierer [Allemagne] ; Adeline Heurich [Allemagne] ; Stefan Pöhlmann [Allemagne]

Source :

Antiviral research [ 0166-3542 ] ; 2013.

RBID : Pascal:14-0035479

Descripteurs français

Pascal (Inist)
- Activation, Virus syndrome respiratoire aigu sévère, Protéine, Enzyme, Antiviral, Relation structure activité, Syndrome respiratoire aigu sévère, Cathepsin L, Protéine S, Protéolyse, Transmembrane protease serine 2, Syndrome respiratoire du Moyen-Orient.
Wicri :
- topic : Enzyme.

English descriptors

KwdEn :
- Activation, Antiviral, Cathepsin L, Enzyme, Middle East respiratory syndrome, Protein, Protein S, Proteolysis, Severe acute respiratory syndrome, Severe acute respiratory syndrome virus, Structure activity relation.

Abstract

The severe acute respiratory syndrome (SARS) pandemic revealed that zoonotic transmission of animal coronaviruses (CoV) to humans poses a significant threat to public health and warrants surveillance and the development of countermeasures. The activity of host cell proteases, which cleave and activate the SARS-CoV spike (S) protein, is essential for viral infectivity and constitutes a target for intervention. However, the identities of the proteases involved have been unclear. Pioneer studies identified cathepsins and type II transmembrane serine proteases as cellular activators of SARS-CoV and demonstrated that several emerging viruses might exploit these enzymes to promote their spread. Here, we will review the proteolytic systems hijacked by SARS-CoV for S protein activation, we will discuss their contribution to viral spread in the host and we will outline antiviral strategies targeting these enzymes. This paper forms part of a series of invited articles in Antiviral Research on "From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses."

Affiliations:

Links toward previous steps (curation, corpus...)

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Links to Exploration step

Pascal:14-0035479

Le document en format XML

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<s2>FE</s2>
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<fC03 i1="07" i2="X" l="SPA"><s0>Síndrome respiratorio agudo severo</s0>
<s2>NM</s2>
<s5>07</s5>
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<fC03 i1="08" i2="X" l="FRE"><s0>Cathepsin L</s0>
<s2>FE</s2>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Cathepsin L</s0>
<s2>FE</s2>
<s5>08</s5>
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<fC03 i1="08" i2="X" l="SPA"><s0>Cathepsin L</s0>
<s2>FE</s2>
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<s5>10</s5>
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<fC03 i1="09" i2="X" l="ENG"><s0>Protein S</s0>
<s5>10</s5>
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<fC03 i1="09" i2="X" l="SPA"><s0>Proteína S</s0>
<s5>10</s5>
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<s5>11</s5>
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<s5>11</s5>
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<fC03 i1="10" i2="X" l="SPA"><s0>Proteolisis</s0>
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<fC07 i1="02" i2="X" l="SPA"><s0>Coronaviridae</s0>
<s2>NW</s2>
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<s2>NW</s2>
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<fC07 i1="03" i2="X" l="ENG"><s0>Nidovirales</s0>
<s2>NW</s2>
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<fC07 i1="03" i2="X" l="SPA"><s0>Nidovirales</s0>
<s2>NW</s2>
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<fC07 i1="04" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
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<s2>FE</s2>
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<s2>FE</s2>
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<fC07 i1="08" i2="X" l="ENG"><s0>Peptidases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Peptidases</s0>
<s2>FE</s2>
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<fC07 i1="09" i2="X" l="FRE"><s0>Hydrolases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Hydrolases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Hydrolases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="10" i2="X" l="FRE"><s0>Régulation</s0>
<s5>37</s5>
</fC07>
<fC07 i1="10" i2="X" l="ENG"><s0>Regulation(control)</s0>
<s5>37</s5>
</fC07>
<fC07 i1="10" i2="X" l="SPA"><s0>Regulación</s0>
<s5>37</s5>
</fC07>
<fC07 i1="11" i2="X" l="FRE"><s0>Pathologie de l'appareil respiratoire</s0>
<s5>38</s5>
</fC07>
<fC07 i1="11" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="11" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="12" i2="X" l="FRE"><s0>Pathologie des poumons</s0>
<s5>39</s5>
</fC07>
<fC07 i1="12" i2="X" l="ENG"><s0>Lung disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="12" i2="X" l="SPA"><s0>Pulmón patología</s0>
<s5>39</s5>
</fC07>
<fN21><s1>041</s1>
</fN21>
</pA>
</standard>
</inist>
<affiliations><list><country><li>Allemagne</li>
<li>États-Unis</li>
</country>
<region><li>Basse-Saxe</li>
<li>Californie</li>
</region>
<settlement><li>Göttingen</li>
</settlement>
</list>
<tree><country name="États-Unis"><region name="Californie"><name sortKey="Simmons, Graham" sort="Simmons, Graham" uniqKey="Simmons G" first="Graham" last="Simmons">Graham Simmons</name>
</region>
</country>
<country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Zmora, Pawel" sort="Zmora, Pawel" uniqKey="Zmora P" first="Pawel" last="Zmora">Pawel Zmora</name>
</region>
<name sortKey="Gierer, Stefanie" sort="Gierer, Stefanie" uniqKey="Gierer S" first="Stefanie" last="Gierer">Stefanie Gierer</name>
<name sortKey="Heurich, Adeline" sort="Heurich, Adeline" uniqKey="Heurich A" first="Adeline" last="Heurich">Adeline Heurich</name>
<name sortKey="Pohlmann, Stefan" sort="Pohlmann, Stefan" uniqKey="Pohlmann S" first="Stefan" last="Pöhlmann">Stefan Pöhlmann</name>
</country>
</tree>
</affiliations>
</record>

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   |texte=   Proteolytic activation of the SARS-coronavirus spike protein: Cutting enzymes at the cutting edge of antiviral research
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Proteolytic activation of the SARS-coronavirus spike protein: Cutting enzymes at the cutting edge of antiviral research

Proteolytic activation of the SARS-coronavirus spike protein: Cutting enzymes at the cutting edge of antiviral research

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