SrasV1, PascalFrancis, Checkpoint, bibRecord, 000016

Accessory proteins of SARS-CoV and other coronaviruses

Identifieur interne : 000016 ( PascalFrancis/Checkpoint ); précédent : 000015; suivant : 000017

Accessory proteins of SARS-CoV and other coronaviruses

Auteurs : DING XIANG LIU [Singapour] ; TO SING FUNG [Singapour] ; Kelvin Kian-Long Chong [Singapour] ; Aditi Shukla [Allemagne] ; Rolf Hilgenfeld [Allemagne]

Source :

Antiviral research [ 0166-3542 ] ; 2014.

RBID : Pascal:14-0232439

Descripteurs français

Pascal (Inist)
- Protéine, Virus syndrome respiratoire aigu sévère, Structure.

English descriptors

KwdEn :
- Protein, Severe acute respiratory syndrome virus, Structure.

Abstract

The huge RNA genome of SARS coronavirus comprises a number of open reading frames that code for a total of eight accessory proteins. Although none of these are essential for virus replication, some appear to have a role in virus pathogenesis. Notably, some SARS-CoV accessory proteins have been shown to modulate the interferon signaling pathways and the production of pro-inflammatory cytokines. The structural information on these proteins is also limited, with only two (p7a and p9b) having their structures determined by X-ray crystallography. This review makes an attempt to summarize the published knowledge on SARS-CoV accessory proteins, with an emphasis on their involvement in virus-host interaction. The accessory proteins of other coronaviruses are also briefly discussed. This paper forms part of a series of invited articles in Antiviral Research on "From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses" (see Introduction by Hilgenfeld and Peiris (2013)).

Affiliations:

Allemagne, Singapour

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Pascal:14-0232439

Le document en format XML

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<front><div type="abstract" xml:lang="en">The huge RNA genome of SARS coronavirus comprises a number of open reading frames that code for a total of eight accessory proteins. Although none of these are essential for virus replication, some appear to have a role in virus pathogenesis. Notably, some SARS-CoV accessory proteins have been shown to modulate the interferon signaling pathways and the production of pro-inflammatory cytokines. The structural information on these proteins is also limited, with only two (p7a and p9b) having their structures determined by X-ray crystallography. This review makes an attempt to summarize the published knowledge on SARS-CoV accessory proteins, with an emphasis on their involvement in virus-host interaction. The accessory proteins of other coronaviruses are also briefly discussed. This paper forms part of a series of invited articles in Antiviral Research on "From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses" (see Introduction by Hilgenfeld and Peiris (2013)).</div>
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Accessory proteins of SARS-CoV and other coronaviruses

Accessory proteins of SARS-CoV and other coronaviruses

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Descripteurs français

English descriptors

Abstract

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