Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An overview of viral structure and host response
Identifieur interne : 004050 ( Ncbi/Merge ); précédent : 004049; suivant : 004051Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An overview of viral structure and host response
Auteurs : Indwiani AstutiSource :
- Diabetes & Metabolic Syndrome [ 1871-4021 ] ; 2020.
Abstract
As a result of its rapid spread in various countries around the world, on March 11, 2020, WHO issued an announcement of the change in coronavirus disease 2019 status from epidemic to pandemic disease. The virus that causes this disease is indicated originating from animals traded in a live animal market in Wuhan, China. Severe Acute Respiratory Syndrome Coronavirus 2 can attack lung cells because there are many conserved receptor entries, namely Angiotensin Converting Enzyme-2. The presence of this virus in host cells will initiate various protective responses leading to pneumonia and Acute Respiratory Distress Syndrome. This review aimed to provide an overview related to this virus and examine the body's responses and possible therapies.
We searched PubMed databases for Severe Acute Respiratory Syndrome Coronavirus-2, Middle East respiratory syndrome-related coronavirus and Severe Acute Respiratory Syndrome Coronavirus. Full texts were retrieved, analyzed and developed into an easy-to-understand review.
We provide a complete review related to structure, origin, and how the body responds to this virus infection and explain the possibility of an immune system over-reaction or cytokine storm. We also include an explanation of how this virus creates modes of avoidance to evade immune system attacks. We further explain the therapeutic approaches that can be taken in the treatment and prevention of this viral infection.
In summary, based on the structural and immune-evasion system of coronavirus, we suggest several approaches to treat the disease.
Url:
DOI: 10.1016/j.dsx.2020.04.020
PubMed: NONE
PubMed Central: 7165108
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An overview of viral structure and host response</title><author><name sortKey="Astuti, Indwiani" sort="Astuti, Indwiani" uniqKey="Astuti I" first="Indwiani" last="Astuti">Indwiani Astuti</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">7165108</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165108</idno><idno type="RBID">PMC:7165108</idno><idno type="doi">10.1016/j.dsx.2020.04.020</idno><idno type="pmid">NONE</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000F22</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000F22</idno><idno type="wicri:Area/Pmc/Curation">000F22</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000F22</idno><idno type="wicri:Area/Pmc/Checkpoint">000073</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000073</idno><idno type="wicri:Area/Ncbi/Merge">004050</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An overview of viral structure and host response</title><author><name sortKey="Astuti, Indwiani" sort="Astuti, Indwiani" uniqKey="Astuti I" first="Indwiani" last="Astuti">Indwiani Astuti</name></author></analytic><series><title level="j">Diabetes & Metabolic Syndrome</title><idno type="ISSN">1871-4021</idno><idno type="eISSN">1878-0334</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background and aim</title><p>As a result of its rapid spread in various countries around the world, on March 11, 2020, WHO issued an announcement of the change in coronavirus disease 2019 status from epidemic to pandemic disease. The virus that causes this disease is indicated originating from animals traded in a live animal market in Wuhan, China. Severe Acute Respiratory Syndrome Coronavirus 2 can attack lung cells because there are many conserved receptor entries, namely Angiotensin Converting Enzyme-2. The presence of this virus in host cells will initiate various protective responses leading to pneumonia and Acute Respiratory Distress Syndrome. This review aimed to provide an overview related to this virus and examine the body's responses and possible therapies.</p></sec><sec><title>Method</title><p>We searched PubMed databases for Severe Acute Respiratory Syndrome Coronavirus-2, Middle East respiratory syndrome-related coronavirus and Severe Acute Respiratory Syndrome Coronavirus. Full texts were retrieved, analyzed and developed into an easy-to-understand review.</p></sec><sec><title>Results</title><p>We provide a complete review related to structure, origin, and how the body responds to this virus infection and explain the possibility of an immune system over-reaction or cytokine storm. We also include an explanation of how this virus creates modes of avoidance to evade immune system attacks. We further explain the therapeutic approaches that can be taken in the treatment and prevention of this viral infection.</p></sec><sec><title>Conclusion</title><p>In summary, based on the structural and immune-evasion system of coronavirus, we suggest several approaches to treat the disease.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Li, Q" uniqKey="Li Q">Q. Li</name></author><author><name sortKey="Guan, X" uniqKey="Guan X">X. Guan</name></author><author><name sortKey="Wu, P" uniqKey="Wu P">P. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Diabetes Metab Syndr</journal-id><journal-id journal-id-type="iso-abbrev">Diabetes Metab Syndr</journal-id><journal-title-group><journal-title>Diabetes & Metabolic Syndrome</journal-title></journal-title-group><issn pub-type="ppub">1871-4021</issn><issn pub-type="epub">1878-0334</issn><publisher><publisher-name>Published by Elsevier Ltd on behalf of Diabetes India.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmc">7165108</article-id><article-id pub-id-type="publisher-id">S1871-4021(20)30084-9</article-id><article-id pub-id-type="doi">10.1016/j.dsx.2020.04.020</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An overview of viral structure and host response</article-title></title-group><contrib-group><contrib contrib-type="author" id="au1"><name><surname>Astuti</surname><given-names>Indwiani</given-names></name><email>Indwiani@gmail.com</email><xref rid="cor1" ref-type="corresp">∗</xref></contrib><contrib contrib-type="author" id="au2"><name><surname>Ysrafil</surname></name></contrib></contrib-group><aff id="aff1">Department of Pharmacology and Therapy, Faculty of Medicine, Public Health and Nurses, Universitas Gadjah Mada, Yogyakarta, Indonesia</aff><author-notes><corresp id="cor1"><label>∗</label>Corresponding author. Department of Pharmacology and Therapy, Faculty of Medicine, Public Health and Nurses, Universitas Gadjah Mada, Yogyakarta, 55281, Indonesia. <email>Indwiani@gmail.com</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>18</day><month>4</month><year>2020</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="epub"><day>18</day><month>4</month><year>2020</year></pub-date><history><date date-type="received"><day>7</day><month>4</month><year>2020</year></date><date date-type="rev-recd"><day>13</day><month>4</month><year>2020</year></date><date date-type="accepted"><day>13</day><month>4</month><year>2020</year></date></history><permissions><copyright-statement>© 2020 Published by Elsevier Ltd on behalf of Diabetes India.</copyright-statement><copyright-year>2020</copyright-year><copyright-holder></copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract id="abs0010"><sec><title>Background and aim</title><p>As a result of its rapid spread in various countries around the world, on March 11, 2020, WHO issued an announcement of the change in coronavirus disease 2019 status from epidemic to pandemic disease. The virus that causes this disease is indicated originating from animals traded in a live animal market in Wuhan, China. Severe Acute Respiratory Syndrome Coronavirus 2 can attack lung cells because there are many conserved receptor entries, namely Angiotensin Converting Enzyme-2. The presence of this virus in host cells will initiate various protective responses leading to pneumonia and Acute Respiratory Distress Syndrome. This review aimed to provide an overview related to this virus and examine the body's responses and possible therapies.</p></sec><sec><title>Method</title><p>We searched PubMed databases for Severe Acute Respiratory Syndrome Coronavirus-2, Middle East respiratory syndrome-related coronavirus and Severe Acute Respiratory Syndrome Coronavirus. Full texts were retrieved, analyzed and developed into an easy-to-understand review.</p></sec><sec><title>Results</title><p>We provide a complete review related to structure, origin, and how the body responds to this virus infection and explain the possibility of an immune system over-reaction or cytokine storm. We also include an explanation of how this virus creates modes of avoidance to evade immune system attacks. We further explain the therapeutic approaches that can be taken in the treatment and prevention of this viral infection.</p></sec><sec><title>Conclusion</title><p>In summary, based on the structural and immune-evasion system of coronavirus, we suggest several approaches to treat the disease.</p></sec></abstract><abstract abstract-type="author-highlights" id="abs0015"><title>Highlights</title><p><list list-type="simple" id="ulist0010"><list-item id="u0010"><label>•</label><p id="p0010">In this review, we provide a complete review and detailed description of the infection process explaining how the virus replicates in the host cell through the study of several previous articles.</p></list-item><list-item id="u0015"><label>•</label><p id="p0015">We also highlight the crucial role of type II transmembrane serine protease in the process of virus entry, and some approaches to treating coronavirus related diseases that target this enzyme in this review.</p></list-item><list-item id="u0020"><label>•</label><p id="p0020">We also describe several immuno evasion strategies done by coronavirus in this review.</p></list-item><list-item id="u0025"><label>•</label><p id="p0025">We explain the sequence of immune responses and their linkages with the severity of disease and provide a graphic display of cellular level processes in this review.</p></list-item></list></p></abstract><kwd-group id="kwrds0010"><title>Keywords</title><kwd>COVID-19</kwd><kwd>SARS-CoV-2</kwd><kwd>Pandemic</kwd><kwd>ACE2</kwd><kwd>Wuhan</kwd></kwd-group><kwd-group id="kwrds0015"><title>Abbreviations</title><kwd>MDA5, (Melanoma differentiation associated protein 5)</kwd><kwd>DMVs, (double-membrane vesicles)</kwd><kwd>MT, (Methyltransferase)</kwd></kwd-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Astuti, Indwiani" sort="Astuti, Indwiani" uniqKey="Astuti I" first="Indwiani" last="Astuti">Indwiani Astuti</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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