Diversity of Coronavirus Spikes: Relationship to Pathogen Entry and Dissemination
Identifieur interne : 003E09 ( Ncbi/Merge ); précédent : 003E08; suivant : 003E10Diversity of Coronavirus Spikes: Relationship to Pathogen Entry and Dissemination
Auteurs :Source :
- Viral Membrane Proteins: Structure, Function, and Drug Design ; 2005.
Abstract
Coronaviruses are widespread in the environment, infecting humans, domesticated and wild mammals, and birds. Infections cause a variety of diseases including bronchitis, gastroenteritis, hepatitis, and encephalitis, with symptoms ranging from being nearly undetectable to rapidly fatal. A combination of interacting variables determine the pattern and severity of coronavirus-induced disease, including the infecting virus strain, its transmission strategy, and the age and immune status of the infected host. Coronavirus pathogenesis is best understood by discerning how each of these variables dictates clinical outcomes. This chapter focuses on variabilities amongst the spike (S) proteins of infecting virus strains. Diversity of coronavirus surface proteins likely contributes to epidemic disease, an important and timely topic given the recent emergence of the human SARS coronavirus.
Url:
DOI: 10.1007/0-387-28146-0_4
PubMed: NONE
PubMed Central: 7121885
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Diversity of Coronavirus Spikes: Relationship to Pathogen Entry and Dissemination</title></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">7121885</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121885</idno><idno type="RBID">PMC:7121885</idno><idno type="doi">10.1007/0-387-28146-0_4</idno><idno type="pmid">NONE</idno><date when="2005">2005</date><idno type="wicri:Area/Pmc/Corpus">000073</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000073</idno><idno type="wicri:Area/Pmc/Curation">000073</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000073</idno><idno type="wicri:Area/Pmc/Checkpoint">001353</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001353</idno><idno type="wicri:Area/Ncbi/Merge">003E09</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Diversity of Coronavirus Spikes: Relationship to Pathogen Entry and Dissemination</title></analytic><series><title level="j">Viral Membrane Proteins: Structure, Function, and Drug Design</title><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Coronaviruses are widespread in the environment, infecting humans, domesticated and wild mammals, and birds. Infections cause a variety of diseases including bronchitis, gastroenteritis, hepatitis, and encephalitis, with symptoms ranging from being nearly undetectable to rapidly fatal. A combination of interacting variables determine the pattern and severity of coronavirus-induced disease, including the infecting virus strain, its transmission strategy, and the age and immune status of the infected host. Coronavirus pathogenesis is best understood by discerning how each of these variables dictates clinical outcomes. This chapter focuses on variabilities amongst the spike (S) proteins of infecting virus strains. Diversity of coronavirus surface proteins likely contributes to epidemic disease, an important and timely topic given the recent emergence of the human SARS coronavirus.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Almazan, F" uniqKey="Almazan F">F. 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<front><journal-meta><journal-id journal-id-type="publisher-id">978-0-387-28146-9</journal-id><journal-id journal-id-type="doi">10.1007/0-387-28146-0</journal-id><journal-id journal-id-type="nlm-ta">Viral Membrane Proteins: Structure, Function, and Drug Design</journal-id><journal-title-group><journal-title>Viral Membrane Proteins: Structure, Function, and Drug Design</journal-title></journal-title-group><isbn publication-format="print">978-0-306-48495-7</isbn><isbn publication-format="electronic">978-0-387-28146-9</isbn></journal-meta><article-meta><article-id pub-id-type="pmc">7121885</article-id><article-id pub-id-type="publisher-id">4</article-id><article-id pub-id-type="doi">10.1007/0-387-28146-0_4</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Diversity of Coronavirus Spikes: Relationship to Pathogen Entry and Dissemination</article-title></title-group><contrib-group content-type="book editors"><contrib contrib-type="editor"><name><surname>Fischer</surname><given-names>Wolfgang B.</given-names></name><xref ref-type="aff" rid="Aff7"></xref></contrib><aff id="Aff7"><institution-wrap><institution-id institution-id-type="GRID">grid.4991.5</institution-id><institution-id institution-id-type="ISNI">0000000419368948</institution-id><institution>Department of Biochemistry,</institution><institution>University of Oxford,</institution></institution-wrap>UK</aff></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Thorp</surname><given-names>Edward B.</given-names></name><xref ref-type="aff" rid="Aff8"></xref></contrib><contrib contrib-type="author"><name><surname>Gallagher</surname><given-names>Thomas M.</given-names></name><xref ref-type="aff" rid="Aff8"></xref></contrib><aff id="Aff8"><institution-wrap><institution-id institution-id-type="GRID">grid.411451.4</institution-id><institution-id institution-id-type="ISNI">0000000122150876</institution-id><institution>Department of Microbiology and Immunology,</institution><institution>Loyola University Medical Center,</institution></institution-wrap>Maywood, IL USA</aff></contrib-group><pub-date pub-type="ppub"><year>2005</year></pub-date><volume>1</volume><fpage>49</fpage><lpage>63</lpage><permissions><copyright-statement>© Kluwer Academic/Plenum Publishers, New York 2005</copyright-statement><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p></license></permissions><abstract id="Abs1"><p>Coronaviruses are widespread in the environment, infecting humans, domesticated and wild mammals, and birds. Infections cause a variety of diseases including bronchitis, gastroenteritis, hepatitis, and encephalitis, with symptoms ranging from being nearly undetectable to rapidly fatal. A combination of interacting variables determine the pattern and severity of coronavirus-induced disease, including the infecting virus strain, its transmission strategy, and the age and immune status of the infected host. Coronavirus pathogenesis is best understood by discerning how each of these variables dictates clinical outcomes. This chapter focuses on variabilities amongst the spike (S) proteins of infecting virus strains. Diversity of coronavirus surface proteins likely contributes to epidemic disease, an important and timely topic given the recent emergence of the human SARS coronavirus.</p></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>Membrane Fusion</kwd><kwd>Infectious Bronchitis Virus</kwd><kwd>Severe Acute Respiratory Syndrome</kwd><kwd>Heptad Repeat</kwd><kwd>Mouse Hepatitis Virus</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© Kluwer Academic/Plenum Publishers, New York 2005</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list></list><tree></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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