CT imaging and clinical course of asymptomatic cases with COVID-19 pneumonia at admission in Wuhan, China
Identifieur interne : 003D37 ( Ncbi/Merge ); précédent : 003D36; suivant : 003D38CT imaging and clinical course of asymptomatic cases with COVID-19 pneumonia at admission in Wuhan, China
Auteurs : Heng Meng [République populaire de Chine] ; Rui Xiong [République populaire de Chine] ; Ruyuan He [République populaire de Chine] ; Weichen Lin [République populaire de Chine] ; Bo Hao [République populaire de Chine] ; Lin Zhang [République populaire de Chine] ; Zilong Lu [République populaire de Chine] ; Xiaokang Shen [République populaire de Chine] ; Tao Fan [République populaire de Chine] ; Wenyang Jiang [République populaire de Chine] ; Wenbin Yang [République populaire de Chine] ; Tao Li [République populaire de Chine] ; Jun Chen [République populaire de Chine] ; Geng Qing [République populaire de Chine]Source :
- The Journal of Infection [ 0163-4453 ] ; 2020.
Abstract
Aimed to characterize the CT imaging and clinical course of asymptomatic cases with COVID-19 pneumonia.
Asymptomatic cases with COVID-19 pneumonia confirmed by SARS-COV-2 nucleic acid testing in Renmin Hospital of Wuhan University were retrospectively enrolled. The characteristics of CT imaging and clinical feature were collected and analyzed.
58 asymptomatic cases with COVID-19 pneumonia admitted to our hospital between Jan 1, 2020 and Feb 23, 2020 were enrolled. All patients had history of exposure to SARS-CoV-2. On admission, patients had no symptoms and laboratory findings were normal. The predominant feature of CT findings in this cohort was ground glass opacity (GGO) (55, 94.8%) with peripheral (44, 75.9%) distribution, unilateral location (34, 58.6%) and mostly involving one or two lobes (38, 65.5%), often accompanied by characteristic signs. After short-term follow-up, 16 patients (27.6%) presented symptoms with lower lymphocyte count and higher CRP, mainly including fever, cough and fatigue. The evolution of lesions on CT imaging were observed in 10 patients (17.2%). The average days of hospitalization was19.80±10.82 days, and was significantly longer in progression patients (28.60±7.55 day).
CT imaging of asymptomatic cases with COVID-19 pneumonia has definite characteristics. Since asymptomatic infections as “covert transmitter”, and some patients can progress rapidly in the short term. It is essential to pay attention to the surveillance of asymptomatic patients with COVID-19. CT scan has great value in screening and detecting patients with COVID-19 pneumonia, especially in the highly suspicious, asymptomatic cases with negative nucleic acid testing.
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DOI: 10.1016/j.jinf.2020.04.004
PubMed: NONE
PubMed Central: 7152865
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surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Thoracic surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060</wicri:regionArea><wicri:noRegion>430060</wicri:noRegion></affiliation></author><author><name sortKey="Hao, Bo" sort="Hao, Bo" uniqKey="Hao B" first="Bo" last="Hao">Bo Hao</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Thoracic surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Thoracic surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060</wicri:regionArea><wicri:noRegion>430060</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Lin" sort="Zhang, Lin" uniqKey="Zhang L" first="Lin" last="Zhang">Lin Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Thoracic surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Thoracic surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060</wicri:regionArea><wicri:noRegion>430060</wicri:noRegion></affiliation></author><author><name sortKey="Lu, Zilong" sort="Lu, Zilong" uniqKey="Lu Z" first="Zilong" last="Lu">Zilong Lu</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Thoracic surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Thoracic surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060</wicri:regionArea><wicri:noRegion>430060</wicri:noRegion></affiliation></author><author><name sortKey="Shen, Xiaokang" sort="Shen, Xiaokang" uniqKey="Shen X" first="Xiaokang" last="Shen">Xiaokang Shen</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Thoracic surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Thoracic surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060</wicri:regionArea><wicri:noRegion>430060</wicri:noRegion></affiliation></author><author><name sortKey="Fan, Tao" sort="Fan, Tao" uniqKey="Fan T" first="Tao" last="Fan">Tao Fan</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Thoracic surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Thoracic surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060</wicri:regionArea><wicri:noRegion>430060</wicri:noRegion></affiliation></author><author><name sortKey="Jiang, Wenyang" sort="Jiang, Wenyang" uniqKey="Jiang W" first="Wenyang" last="Jiang">Wenyang Jiang</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Thoracic surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Thoracic surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060</wicri:regionArea><wicri:noRegion>430060</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Wenbin" sort="Yang, Wenbin" uniqKey="Yang W" first="Wenbin" last="Yang">Wenbin Yang</name><affiliation wicri:level="1"><nlm:aff id="aff0002">Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060</wicri:regionArea><wicri:noRegion>430060</wicri:noRegion></affiliation></author><author><name sortKey="Li, Tao" sort="Li, Tao" uniqKey="Li T" first="Tao" last="Li">Tao Li</name><affiliation wicri:level="1"><nlm:aff id="aff0002">Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060</wicri:regionArea><wicri:noRegion>430060</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Jun" sort="Chen, Jun" uniqKey="Chen J" first="Jun" last="Chen">Jun Chen</name><affiliation wicri:level="1"><nlm:aff id="aff0002">Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, China</nlm:aff><country 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type="doi">10.1016/j.jinf.2020.04.004</idno><idno type="pmid">NONE</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">001178</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001178</idno><idno type="wicri:Area/Pmc/Curation">001178</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001178</idno><idno type="wicri:Area/Pmc/Checkpoint">000355</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000355</idno><idno type="wicri:Area/Ncbi/Merge">003D37</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">CT imaging and clinical course of asymptomatic cases with COVID-19 pneumonia at admission in Wuhan, China</title><author><name sortKey="Meng, Heng" sort="Meng, Heng" uniqKey="Meng H" first="Heng" last="Meng">Heng Meng</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Thoracic surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Thoracic surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060</wicri:regionArea><wicri:noRegion>430060</wicri:noRegion></affiliation></author><author><name sortKey="Xiong, Rui" sort="Xiong, Rui" uniqKey="Xiong R" first="Rui" last="Xiong">Rui Xiong</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Thoracic surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Thoracic surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060</wicri:regionArea><wicri:noRegion>430060</wicri:noRegion></affiliation></author><author><name sortKey="He, Ruyuan" sort="He, Ruyuan" uniqKey="He R" first="Ruyuan" last="He">Ruyuan He</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Thoracic surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Thoracic surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060</wicri:regionArea><wicri:noRegion>430060</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Weichen" sort="Lin, Weichen" uniqKey="Lin W" first="Weichen" last="Lin">Weichen Lin</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Thoracic surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Thoracic surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060</wicri:regionArea><wicri:noRegion>430060</wicri:noRegion></affiliation></author><author><name sortKey="Hao, Bo" sort="Hao, Bo" uniqKey="Hao B" first="Bo" last="Hao">Bo Hao</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Thoracic surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Thoracic surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060</wicri:regionArea><wicri:noRegion>430060</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Lin" sort="Zhang, Lin" uniqKey="Zhang L" first="Lin" last="Zhang">Lin Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Thoracic surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Thoracic surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060</wicri:regionArea><wicri:noRegion>430060</wicri:noRegion></affiliation></author><author><name sortKey="Lu, Zilong" sort="Lu, Zilong" uniqKey="Lu Z" first="Zilong" last="Lu">Zilong Lu</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Thoracic surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Thoracic surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060</wicri:regionArea><wicri:noRegion>430060</wicri:noRegion></affiliation></author><author><name sortKey="Shen, Xiaokang" sort="Shen, Xiaokang" uniqKey="Shen X" first="Xiaokang" last="Shen">Xiaokang Shen</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Thoracic surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Thoracic surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060</wicri:regionArea><wicri:noRegion>430060</wicri:noRegion></affiliation></author><author><name sortKey="Fan, Tao" sort="Fan, Tao" uniqKey="Fan T" first="Tao" last="Fan">Tao Fan</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Thoracic surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Thoracic surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060</wicri:regionArea><wicri:noRegion>430060</wicri:noRegion></affiliation></author><author><name sortKey="Jiang, Wenyang" sort="Jiang, Wenyang" uniqKey="Jiang W" first="Wenyang" last="Jiang">Wenyang Jiang</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Thoracic surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Thoracic surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060</wicri:regionArea><wicri:noRegion>430060</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Wenbin" sort="Yang, Wenbin" uniqKey="Yang W" first="Wenbin" last="Yang">Wenbin Yang</name><affiliation wicri:level="1"><nlm:aff id="aff0002">Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060</wicri:regionArea><wicri:noRegion>430060</wicri:noRegion></affiliation></author><author><name sortKey="Li, Tao" sort="Li, Tao" uniqKey="Li T" first="Tao" last="Li">Tao Li</name><affiliation wicri:level="1"><nlm:aff id="aff0002">Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060</wicri:regionArea><wicri:noRegion>430060</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Jun" sort="Chen, Jun" uniqKey="Chen J" first="Jun" last="Chen">Jun Chen</name><affiliation wicri:level="1"><nlm:aff id="aff0002">Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060</wicri:regionArea><wicri:noRegion>430060</wicri:noRegion></affiliation></author><author><name sortKey="Qing, Geng" sort="Qing, Geng" uniqKey="Qing G" first="Geng" last="Qing">Geng Qing</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Thoracic surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Thoracic surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060</wicri:regionArea><wicri:noRegion>430060</wicri:noRegion></affiliation></author></analytic><series><title level="j">The Journal of Infection</title><idno type="ISSN">0163-4453</idno><idno type="eISSN">1532-2742</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose</title><p>Aimed to characterize the CT imaging and clinical course of asymptomatic cases with COVID-19 pneumonia.</p></sec><sec><title>Methods</title><p>Asymptomatic cases with COVID-19 pneumonia confirmed by SARS-COV-2 nucleic acid testing in Renmin Hospital of Wuhan University were retrospectively enrolled. The characteristics of CT imaging and clinical feature were collected and analyzed.</p></sec><sec><title>Results</title><p>58 asymptomatic cases with COVID-19 pneumonia admitted to our hospital between Jan 1, 2020 and Feb 23, 2020 were enrolled. All patients had history of exposure to SARS-CoV-2. On admission, patients had no symptoms and laboratory findings were normal. The predominant feature of CT findings in this cohort was ground glass opacity (GGO) (55, 94.8%) with peripheral (44, 75.9%) distribution, unilateral location (34, 58.6%) and mostly involving one or two lobes (38, 65.5%), often accompanied by characteristic signs. After short-term follow-up, 16 patients (27.6%) presented symptoms with lower lymphocyte count and higher CRP, mainly including fever, cough and fatigue. The evolution of lesions on CT imaging were observed in 10 patients (17.2%). The average days of hospitalization was19.80±10.82 days, and was significantly longer in progression patients (28.60±7.55 day).</p></sec><sec><title>Conclusion</title><p>CT imaging of asymptomatic cases with COVID-19 pneumonia has definite characteristics. Since asymptomatic infections as “covert transmitter”, and some patients can progress rapidly in the short term. It is essential to pay attention to the surveillance of asymptomatic patients with COVID-19. CT scan has great value in screening and detecting patients with COVID-19 pneumonia, especially in the highly suspicious, asymptomatic cases with negative nucleic acid testing.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Lu, R" uniqKey="Lu R">R. Lu</name></author><author><name sortKey="Zhao, X" uniqKey="Zhao X">X. Zhao</name></author><author><name sortKey="Li, J" uniqKey="Li J">J. Li</name></author><author><name sortKey="Niu, P" uniqKey="Niu P">P. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Infect</journal-id><journal-id journal-id-type="iso-abbrev">J. Infect</journal-id><journal-title-group><journal-title>The Journal of Infection</journal-title></journal-title-group><issn pub-type="ppub">0163-4453</issn><issn pub-type="epub">1532-2742</issn><publisher><publisher-name>Published by Elsevier Ltd on behalf of The British Infection Association.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmc">7152865</article-id><article-id pub-id-type="publisher-id">S0163-4453(20)30211-5</article-id><article-id pub-id-type="doi">10.1016/j.jinf.2020.04.004</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>CT imaging and clinical course of asymptomatic cases with COVID-19 pneumonia at admission in Wuhan, China</article-title></title-group><contrib-group><contrib contrib-type="author" id="au0001"><name><surname>Meng</surname><given-names>Heng</given-names></name><xref rid="aff0001" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au0002"><name><surname>Xiong</surname><given-names>Rui</given-names></name><xref rid="aff0001" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au0003"><name><surname>He</surname><given-names>Ruyuan</given-names></name><xref rid="aff0001" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au0004"><name><surname>Lin</surname><given-names>Weichen</given-names></name><xref rid="aff0001" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au0005"><name><surname>Hao</surname><given-names>Bo</given-names></name><xref rid="aff0001" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au0006"><name><surname>Zhang</surname><given-names>Lin</given-names></name><xref rid="aff0001" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au0007"><name><surname>Lu</surname><given-names>Zilong</given-names></name><xref rid="aff0001" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au0008"><name><surname>Shen</surname><given-names>Xiaokang</given-names></name><xref rid="aff0001" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au0009"><name><surname>Fan</surname><given-names>Tao</given-names></name><xref rid="aff0001" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au0010"><name><surname>Jiang</surname><given-names>Wenyang</given-names></name><xref rid="aff0001" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au0011"><name><surname>Yang</surname><given-names>Wenbin</given-names></name><xref rid="aff0002" ref-type="aff">b</xref></contrib><contrib contrib-type="author" id="au0012"><name><surname>Li</surname><given-names>Tao</given-names></name><xref rid="aff0002" ref-type="aff">b</xref></contrib><contrib contrib-type="author" id="au0013"><name><surname>Chen</surname><given-names>Jun</given-names></name><xref rid="aff0002" ref-type="aff">b</xref></contrib><contrib contrib-type="author" id="au0014"><name><surname>Qing</surname><given-names>Geng</given-names></name><email>gengqingwhu@whu.edu.cn</email><xref rid="aff0001" ref-type="aff">a</xref><xref rid="cor0001" ref-type="corresp">⁎</xref></contrib></contrib-group><aff id="aff0001"><label>a</label>Department of Thoracic surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, China</aff><aff id="aff0002"><label>b</label>Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, China</aff><author-notes><corresp id="cor0001"><label>⁎</label>Corresponding author: Qing Geng, Department of Thoracic surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 410060, China <email>gengqingwhu@whu.edu.cn</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>12</day><month>4</month><year>2020</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="epub"><day>12</day><month>4</month><year>2020</year></pub-date><permissions><copyright-statement>© 2020 Published by Elsevier Ltd on behalf of The British Infection Association.</copyright-statement><copyright-year>2020</copyright-year><copyright-holder></copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract id="abs0001"><sec><title>Purpose</title><p>Aimed to characterize the CT imaging and clinical course of asymptomatic cases with COVID-19 pneumonia.</p></sec><sec><title>Methods</title><p>Asymptomatic cases with COVID-19 pneumonia confirmed by SARS-COV-2 nucleic acid testing in Renmin Hospital of Wuhan University were retrospectively enrolled. The characteristics of CT imaging and clinical feature were collected and analyzed.</p></sec><sec><title>Results</title><p>58 asymptomatic cases with COVID-19 pneumonia admitted to our hospital between Jan 1, 2020 and Feb 23, 2020 were enrolled. All patients had history of exposure to SARS-CoV-2. On admission, patients had no symptoms and laboratory findings were normal. The predominant feature of CT findings in this cohort was ground glass opacity (GGO) (55, 94.8%) with peripheral (44, 75.9%) distribution, unilateral location (34, 58.6%) and mostly involving one or two lobes (38, 65.5%), often accompanied by characteristic signs. After short-term follow-up, 16 patients (27.6%) presented symptoms with lower lymphocyte count and higher CRP, mainly including fever, cough and fatigue. The evolution of lesions on CT imaging were observed in 10 patients (17.2%). The average days of hospitalization was19.80±10.82 days, and was significantly longer in progression patients (28.60±7.55 day).</p></sec><sec><title>Conclusion</title><p>CT imaging of asymptomatic cases with COVID-19 pneumonia has definite characteristics. Since asymptomatic infections as “covert transmitter”, and some patients can progress rapidly in the short term. It is essential to pay attention to the surveillance of asymptomatic patients with COVID-19. CT scan has great value in screening and detecting patients with COVID-19 pneumonia, especially in the highly suspicious, asymptomatic cases with negative nucleic acid testing.</p></sec></abstract><kwd-group id="keys0001"><title>Keywords</title><kwd>SARS-CoV-2</kwd><kwd>Coronavirus Disease 2019(COVID-19)</kwd><kwd>Asymptomatic</kwd><kwd>Computed Tomography</kwd><kwd>Ground Glass Opacity</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Meng, Heng" sort="Meng, Heng" uniqKey="Meng H" first="Heng" last="Meng">Heng Meng</name></noRegion><name sortKey="Chen, Jun" sort="Chen, Jun" uniqKey="Chen J" first="Jun" last="Chen">Jun Chen</name><name sortKey="Fan, Tao" sort="Fan, Tao" uniqKey="Fan T" first="Tao" last="Fan">Tao Fan</name><name sortKey="Hao, Bo" sort="Hao, Bo" uniqKey="Hao B" first="Bo" last="Hao">Bo Hao</name><name sortKey="He, Ruyuan" sort="He, Ruyuan" uniqKey="He R" first="Ruyuan" last="He">Ruyuan He</name><name sortKey="Jiang, Wenyang" sort="Jiang, Wenyang" uniqKey="Jiang W" first="Wenyang" last="Jiang">Wenyang Jiang</name><name sortKey="Li, Tao" sort="Li, Tao" uniqKey="Li T" first="Tao" last="Li">Tao Li</name><name sortKey="Lin, Weichen" sort="Lin, Weichen" uniqKey="Lin W" first="Weichen" last="Lin">Weichen Lin</name><name sortKey="Lu, Zilong" sort="Lu, Zilong" uniqKey="Lu Z" first="Zilong" last="Lu">Zilong Lu</name><name sortKey="Qing, Geng" sort="Qing, Geng" uniqKey="Qing G" first="Geng" last="Qing">Geng Qing</name><name sortKey="Shen, Xiaokang" sort="Shen, Xiaokang" uniqKey="Shen X" first="Xiaokang" last="Shen">Xiaokang Shen</name><name sortKey="Xiong, Rui" sort="Xiong, Rui" uniqKey="Xiong R" first="Rui" last="Xiong">Rui Xiong</name><name sortKey="Yang, Wenbin" sort="Yang, Wenbin" uniqKey="Yang W" first="Wenbin" last="Yang">Wenbin Yang</name><name sortKey="Zhang, Lin" sort="Zhang, Lin" uniqKey="Zhang L" first="Lin" last="Zhang">Lin Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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