Is the sialic acid binding activity of the S protein involved in the enteropathogenicity of transmissible gastroenteritis virus?
Identifieur interne : 003C67 ( Ncbi/Merge ); précédent : 003C66; suivant : 003C68Is the sialic acid binding activity of the S protein involved in the enteropathogenicity of transmissible gastroenteritis virus?
Auteurs : C. Krempl [Allemagne] ; H. Laude ; G. HerrlerSource :
- Advances in experimental medicine and biology [ 0065-2598 ] ; 1998.
Descripteurs français
- KwdFr :
- Acide N-acétyl-neuraminique (métabolisme), Animaux, Gastroentérite (médecine vétérinaire), Gastroentérite (virologie), Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (génétique), Glycoprotéines membranaires (métabolisme), Maladies des porcs (virologie), Protéines de l'enveloppe virale (génétique), Protéines de l'enveloppe virale (métabolisme), Suidae, Virus de la gastroentérite transmissible (métabolisme), Virus de la gastroentérite transmissible (pathogénicité).
- MESH :
- génétique : Glycoprotéines membranaires, Protéines de l'enveloppe virale.
- médecine vétérinaire : Gastroentérite.
- métabolisme : Acide N-acétyl-neuraminique, Glycoprotéines membranaires, Protéines de l'enveloppe virale, Virus de la gastroentérite transmissible.
- pathogénicité : Virus de la gastroentérite transmissible.
- virologie : Gastroentérite, Maladies des porcs.
- Animaux, Glycoprotéine de spicule des coronavirus, Suidae.
English descriptors
- KwdEn :
- Animals, Gastroenteritis (veterinary), Gastroenteritis (virology), Membrane Glycoproteins (genetics), Membrane Glycoproteins (metabolism), N-Acetylneuraminic Acid (metabolism), Spike Glycoprotein, Coronavirus, Swine, Swine Diseases (virology), Transmissible gastroenteritis virus (metabolism), Transmissible gastroenteritis virus (pathogenicity), Viral Envelope Proteins (genetics), Viral Envelope Proteins (metabolism).
- MESH :
- chemical , genetics : Membrane Glycoproteins, Viral Envelope Proteins.
- chemical , metabolism : Membrane Glycoproteins, N-Acetylneuraminic Acid, Viral Envelope Proteins.
- metabolism : Transmissible gastroenteritis virus.
- pathogenicity : Transmissible gastroenteritis virus.
- veterinary : Gastroenteritis.
- virology : Gastroenteritis, Swine Diseases.
- Animals, Spike Glycoprotein, Coronavirus, Swine.
Abstract
Transmissible gastroenteritis virus (TGEV) is able to recognize sialic acid on sialo-glycoconjugates. Analysis of mutants indicated that single point mutations in the S protein (around amino acids 145-155) of TGEV may result both in the loss of the sialic acid binding activity and in a drastic reduction of the enteropathogenicity. From this observation we conclude that the sialic acid binding activity is involved in the enteropathogenicity of TGEV. On the basis of our recent results we propose that binding of sialylated macromolecules to the virions surface may increase virus stability. This in turn would explain how TGEV as an enveloped virus can survive the gastrointestinal passage and cause intestinal infections.
DOI: 10.1007/978-1-4615-5331-1_72
PubMed: 9782329
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 003486
- to stream PubMed, to step Curation: 003486
- to stream PubMed, to step Checkpoint: 003377
Links to Exploration step
pubmed:9782329Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Is the sialic acid binding activity of the S protein involved in the enteropathogenicity of transmissible gastroenteritis virus?</title>
<author><name sortKey="Krempl, C" sort="Krempl, C" uniqKey="Krempl C" first="C" last="Krempl">C. Krempl</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut für Virologie Philipps-Universität Marburg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institut für Virologie Philipps-Universität Marburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Laude, H" sort="Laude, H" uniqKey="Laude H" first="H" last="Laude">H. Laude</name>
</author>
<author><name sortKey="Herrler, G" sort="Herrler, G" uniqKey="Herrler G" first="G" last="Herrler">G. Herrler</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="1998">1998</date>
<idno type="RBID">pubmed:9782329</idno>
<idno type="pmid">9782329</idno>
<idno type="doi">10.1007/978-1-4615-5331-1_72</idno>
<idno type="wicri:Area/PubMed/Corpus">003486</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003486</idno>
<idno type="wicri:Area/PubMed/Curation">003486</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003486</idno>
<idno type="wicri:Area/PubMed/Checkpoint">003377</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003377</idno>
<idno type="wicri:Area/Ncbi/Merge">003C67</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Is the sialic acid binding activity of the S protein involved in the enteropathogenicity of transmissible gastroenteritis virus?</title>
<author><name sortKey="Krempl, C" sort="Krempl, C" uniqKey="Krempl C" first="C" last="Krempl">C. Krempl</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut für Virologie Philipps-Universität Marburg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institut für Virologie Philipps-Universität Marburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Laude, H" sort="Laude, H" uniqKey="Laude H" first="H" last="Laude">H. Laude</name>
</author>
<author><name sortKey="Herrler, G" sort="Herrler, G" uniqKey="Herrler G" first="G" last="Herrler">G. Herrler</name>
</author>
</analytic>
<series><title level="j">Advances in experimental medicine and biology</title>
<idno type="ISSN">0065-2598</idno>
<imprint><date when="1998" type="published">1998</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Gastroenteritis (veterinary)</term>
<term>Gastroenteritis (virology)</term>
<term>Membrane Glycoproteins (genetics)</term>
<term>Membrane Glycoproteins (metabolism)</term>
<term>N-Acetylneuraminic Acid (metabolism)</term>
<term>Spike Glycoprotein, Coronavirus</term>
<term>Swine</term>
<term>Swine Diseases (virology)</term>
<term>Transmissible gastroenteritis virus (metabolism)</term>
<term>Transmissible gastroenteritis virus (pathogenicity)</term>
<term>Viral Envelope Proteins (genetics)</term>
<term>Viral Envelope Proteins (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Acide N-acétyl-neuraminique (métabolisme)</term>
<term>Animaux</term>
<term>Gastroentérite (médecine vétérinaire)</term>
<term>Gastroentérite (virologie)</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Glycoprotéines membranaires (génétique)</term>
<term>Glycoprotéines membranaires (métabolisme)</term>
<term>Maladies des porcs (virologie)</term>
<term>Protéines de l'enveloppe virale (génétique)</term>
<term>Protéines de l'enveloppe virale (métabolisme)</term>
<term>Suidae</term>
<term>Virus de la gastroentérite transmissible (métabolisme)</term>
<term>Virus de la gastroentérite transmissible (pathogénicité)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Membrane Glycoproteins</term>
<term>Viral Envelope Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Membrane Glycoproteins</term>
<term>N-Acetylneuraminic Acid</term>
<term>Viral Envelope Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glycoprotéines membranaires</term>
<term>Protéines de l'enveloppe virale</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Transmissible gastroenteritis virus</term>
</keywords>
<keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Gastroentérite</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Acide N-acétyl-neuraminique</term>
<term>Glycoprotéines membranaires</term>
<term>Protéines de l'enveloppe virale</term>
<term>Virus de la gastroentérite transmissible</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Transmissible gastroenteritis virus</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus de la gastroentérite transmissible</term>
</keywords>
<keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Gastroenteritis</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Gastroentérite</term>
<term>Maladies des porcs</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Gastroenteritis</term>
<term>Swine Diseases</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Spike Glycoprotein, Coronavirus</term>
<term>Swine</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Suidae</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Transmissible gastroenteritis virus (TGEV) is able to recognize sialic acid on sialo-glycoconjugates. Analysis of mutants indicated that single point mutations in the S protein (around amino acids 145-155) of TGEV may result both in the loss of the sialic acid binding activity and in a drastic reduction of the enteropathogenicity. From this observation we conclude that the sialic acid binding activity is involved in the enteropathogenicity of TGEV. On the basis of our recent results we propose that binding of sialylated macromolecules to the virions surface may increase virus stability. This in turn would explain how TGEV as an enveloped virus can survive the gastrointestinal passage and cause intestinal infections.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">9782329</PMID>
<DateCompleted><Year>1999</Year>
<Month>01</Month>
<Day>13</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>04</Month>
<Day>15</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0065-2598</ISSN>
<JournalIssue CitedMedium="Print"><Volume>440</Volume>
<PubDate><Year>1998</Year>
</PubDate>
</JournalIssue>
<Title>Advances in experimental medicine and biology</Title>
<ISOAbbreviation>Adv. Exp. Med. Biol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Is the sialic acid binding activity of the S protein involved in the enteropathogenicity of transmissible gastroenteritis virus?</ArticleTitle>
<Pagination><MedlinePgn>557-61</MedlinePgn>
</Pagination>
<Abstract><AbstractText>Transmissible gastroenteritis virus (TGEV) is able to recognize sialic acid on sialo-glycoconjugates. Analysis of mutants indicated that single point mutations in the S protein (around amino acids 145-155) of TGEV may result both in the loss of the sialic acid binding activity and in a drastic reduction of the enteropathogenicity. From this observation we conclude that the sialic acid binding activity is involved in the enteropathogenicity of TGEV. On the basis of our recent results we propose that binding of sialylated macromolecules to the virions surface may increase virus stability. This in turn would explain how TGEV as an enveloped virus can survive the gastrointestinal passage and cause intestinal infections.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Krempl</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Institut für Virologie Philipps-Universität Marburg, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Laude</LastName>
<ForeName>H</ForeName>
<Initials>H</Initials>
</Author>
<Author ValidYN="Y"><LastName>Herrler</LastName>
<ForeName>G</ForeName>
<Initials>G</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Adv Exp Med Biol</MedlineTA>
<NlmUniqueID>0121103</NlmUniqueID>
<ISSNLinking>0065-2598</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C578553">MHV surface projection glycoprotein</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D008562">Membrane Glycoproteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D064370">Spike Glycoprotein, Coronavirus</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014759">Viral Envelope Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C578557">spike glycoprotein, SARS-CoV</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>GZP2782OP0</RegistryNumber>
<NameOfSubstance UI="D019158">N-Acetylneuraminic Acid</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005759" MajorTopicYN="N">Gastroenteritis</DescriptorName>
<QualifierName UI="Q000662" MajorTopicYN="Y">veterinary</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008562" MajorTopicYN="N">Membrane Glycoproteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019158" MajorTopicYN="N">N-Acetylneuraminic Acid</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D064370" MajorTopicYN="N">Spike Glycoprotein, Coronavirus</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013552" MajorTopicYN="N">Swine</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013553" MajorTopicYN="N">Swine Diseases</DescriptorName>
<QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005760" MajorTopicYN="N">Transmissible gastroenteritis virus</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014759" MajorTopicYN="N">Viral Envelope Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1998</Year>
<Month>10</Month>
<Day>23</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>1998</Year>
<Month>10</Month>
<Day>23</Day>
<Hour>0</Hour>
<Minute>1</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>1998</Year>
<Month>10</Month>
<Day>23</Day>
<Hour>0</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">9782329</ArticleId>
<ArticleId IdType="doi">10.1007/978-1-4615-5331-1_72</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Allemagne</li>
</country>
</list>
<tree><noCountry><name sortKey="Herrler, G" sort="Herrler, G" uniqKey="Herrler G" first="G" last="Herrler">G. Herrler</name>
<name sortKey="Laude, H" sort="Laude, H" uniqKey="Laude H" first="H" last="Laude">H. Laude</name>
</noCountry>
<country name="Allemagne"><noRegion><name sortKey="Krempl, C" sort="Krempl, C" uniqKey="Krempl C" first="C" last="Krempl">C. Krempl</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003C67 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 003C67 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= Ncbi |étape= Merge |type= RBID |clé= pubmed:9782329 |texte= Is the sialic acid binding activity of the S protein involved in the enteropathogenicity of transmissible gastroenteritis virus? }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:9782329" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \ | NlmPubMed2Wicri -a SrasV1
This area was generated with Dilib version V0.6.33. |