Middle East respiratory syndrome: pathogenesis and therapeutic developments.
Identifieur interne : 003478 ( Ncbi/Merge ); précédent : 003477; suivant : 003479Middle East respiratory syndrome: pathogenesis and therapeutic developments.
Auteurs : Hani Choudhry [Arabie saoudite] ; Muhammed A. Bakhrebah [Arabie saoudite] ; Wesam H. Abdulaal [Arabie saoudite] ; Mazin A. Zamzami [Arabie saoudite] ; Othman A. Baothman [Arabie saoudite] ; Mohammed A. Hassan [Arabie saoudite] ; Mustafa Zeyadi [Arabie saoudite] ; Nawal Helmi [Arabie saoudite] ; Faisal Alzahrani ; Ashraf Ali ; Mohammad Khalid Zakaria [Royaume-Uni] ; Mohammad Azhar Kamal [Arabie saoudite] ; Mohiuddin Khan Warsi [Royaume-Uni] ; Firoz Ahmed [Royaume-Uni] ; Mahmood Rasool [Arabie saoudite] ; Mohammad Sarwar JamalSource :
- Future virology [ 1746-0794 ] ; 2019.
Abstract
The first case of Middle East respiratory syndrome coronavirus (MERS-CoV) was identified in the year 2012, which spread rapidly and increased to more than 2200 in 2018. This highly pathogenic virus with high mortality rate is among one of the major public health concerns. Saudi Arabia remains to be the most affected region with the majority of MERS-CoV cases, and currently, no effective drugs and vaccines are available for prevention and treatment. A large amount of information is now available regarding the virus, its structure, route of transmission and its pathophysiology. Therefore, this review summarizes the current understanding of MERS-CoV's pathogenesis, treatment options and recent scientific advancements in vaccine and other therapeutic developments, and the major steps taken for MERS prevention control.
DOI: 10.2217/fvl-2018-0201
PubMed: 32201499
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<front><div type="abstract" xml:lang="en">The first case of Middle East respiratory syndrome coronavirus (MERS-CoV) was identified in the year 2012, which spread rapidly and increased to more than 2200 in 2018. This highly pathogenic virus with high mortality rate is among one of the major public health concerns. Saudi Arabia remains to be the most affected region with the majority of MERS-CoV cases, and currently, no effective drugs and vaccines are available for prevention and treatment. A large amount of information is now available regarding the virus, its structure, route of transmission and its pathophysiology. Therefore, this review summarizes the current understanding of MERS-CoV's pathogenesis, treatment options and recent scientific advancements in vaccine and other therapeutic developments, and the major steps taken for MERS prevention control.</div>
</front>
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<DateRevised><Year>2020</Year>
<Month>03</Month>
<Day>26</Day>
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<Title>Future virology</Title>
<ISOAbbreviation>Future Virol</ISOAbbreviation>
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<ArticleTitle>Middle East respiratory syndrome: pathogenesis and therapeutic developments.</ArticleTitle>
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<Abstract><AbstractText>The first case of Middle East respiratory syndrome coronavirus (MERS-CoV) was identified in the year 2012, which spread rapidly and increased to more than 2200 in 2018. This highly pathogenic virus with high mortality rate is among one of the major public health concerns. Saudi Arabia remains to be the most affected region with the majority of MERS-CoV cases, and currently, no effective drugs and vaccines are available for prevention and treatment. A large amount of information is now available regarding the virus, its structure, route of transmission and its pathophysiology. Therefore, this review summarizes the current understanding of MERS-CoV's pathogenesis, treatment options and recent scientific advancements in vaccine and other therapeutic developments, and the major steps taken for MERS prevention control.</AbstractText>
<CopyrightInformation>© 2019 Future Medicine Ltd.</CopyrightInformation>
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<AffiliationInfo><Affiliation>Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</Affiliation>
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<Month>04</Month>
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<Keyword MajorTopicYN="N">MERS</Keyword>
<Keyword MajorTopicYN="N">SARS</Keyword>
<Keyword MajorTopicYN="N">Saudi Arabia</Keyword>
<Keyword MajorTopicYN="N">WHO</Keyword>
<Keyword MajorTopicYN="N">coronavirus</Keyword>
<Keyword MajorTopicYN="N">global</Keyword>
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<Keyword MajorTopicYN="N">therapeutic</Keyword>
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<CoiStatement>Financial & competing interests disclosure This work was supported by King Abdulaziz City for Science and Technology and Deanship of Scientific Research, King Abdulaziz University. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. Medical writing support was provided by Scidra Consulting, INC and was funded by the authors.</CoiStatement>
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<affiliations><list><country><li>Arabie saoudite</li>
<li>Royaume-Uni</li>
</country>
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<name sortKey="Alzahrani, Faisal" sort="Alzahrani, Faisal" uniqKey="Alzahrani F" first="Faisal" last="Alzahrani">Faisal Alzahrani</name>
<name sortKey="Jamal, Mohammad Sarwar" sort="Jamal, Mohammad Sarwar" uniqKey="Jamal M" first="Mohammad Sarwar" last="Jamal">Mohammad Sarwar Jamal</name>
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</noRegion>
<name sortKey="Abdulaal, Wesam H" sort="Abdulaal, Wesam H" uniqKey="Abdulaal W" first="Wesam H" last="Abdulaal">Wesam H. Abdulaal</name>
<name sortKey="Bakhrebah, Muhammed A" sort="Bakhrebah, Muhammed A" uniqKey="Bakhrebah M" first="Muhammed A" last="Bakhrebah">Muhammed A. Bakhrebah</name>
<name sortKey="Baothman, Othman A" sort="Baothman, Othman A" uniqKey="Baothman O" first="Othman A" last="Baothman">Othman A. Baothman</name>
<name sortKey="Hassan, Mohammed A" sort="Hassan, Mohammed A" uniqKey="Hassan M" first="Mohammed A" last="Hassan">Mohammed A. Hassan</name>
<name sortKey="Helmi, Nawal" sort="Helmi, Nawal" uniqKey="Helmi N" first="Nawal" last="Helmi">Nawal Helmi</name>
<name sortKey="Kamal, Mohammad Azhar" sort="Kamal, Mohammad Azhar" uniqKey="Kamal M" first="Mohammad Azhar" last="Kamal">Mohammad Azhar Kamal</name>
<name sortKey="Rasool, Mahmood" sort="Rasool, Mahmood" uniqKey="Rasool M" first="Mahmood" last="Rasool">Mahmood Rasool</name>
<name sortKey="Zamzami, Mazin A" sort="Zamzami, Mazin A" uniqKey="Zamzami M" first="Mazin A" last="Zamzami">Mazin A. Zamzami</name>
<name sortKey="Zeyadi, Mustafa" sort="Zeyadi, Mustafa" uniqKey="Zeyadi M" first="Mustafa" last="Zeyadi">Mustafa Zeyadi</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Zakaria, Mohammad Khalid" sort="Zakaria, Mohammad Khalid" uniqKey="Zakaria M" first="Mohammad Khalid" last="Zakaria">Mohammad Khalid Zakaria</name>
</noRegion>
<name sortKey="Ahmed, Firoz" sort="Ahmed, Firoz" uniqKey="Ahmed F" first="Firoz" last="Ahmed">Firoz Ahmed</name>
<name sortKey="Warsi, Mohiuddin Khan" sort="Warsi, Mohiuddin Khan" uniqKey="Warsi M" first="Mohiuddin Khan" last="Warsi">Mohiuddin Khan Warsi</name>
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