Middle East respiratory syndrome: pathogenesis and therapeutic developments.
Identifieur interne : 003478 ( Ncbi/Merge ); précédent : 003477; suivant : 003479Middle East respiratory syndrome: pathogenesis and therapeutic developments.
Auteurs : Hani Choudhry [Arabie saoudite] ; Muhammed A. Bakhrebah [Arabie saoudite] ; Wesam H. Abdulaal [Arabie saoudite] ; Mazin A. Zamzami [Arabie saoudite] ; Othman A. Baothman [Arabie saoudite] ; Mohammed A. Hassan [Arabie saoudite] ; Mustafa Zeyadi [Arabie saoudite] ; Nawal Helmi [Arabie saoudite] ; Faisal Alzahrani ; Ashraf Ali ; Mohammad Khalid Zakaria [Royaume-Uni] ; Mohammad Azhar Kamal [Arabie saoudite] ; Mohiuddin Khan Warsi [Royaume-Uni] ; Firoz Ahmed [Royaume-Uni] ; Mahmood Rasool [Arabie saoudite] ; Mohammad Sarwar JamalSource :
- Future virology [ 1746-0794 ] ; 2019.
Abstract
The first case of Middle East respiratory syndrome coronavirus (MERS-CoV) was identified in the year 2012, which spread rapidly and increased to more than 2200 in 2018. This highly pathogenic virus with high mortality rate is among one of the major public health concerns. Saudi Arabia remains to be the most affected region with the majority of MERS-CoV cases, and currently, no effective drugs and vaccines are available for prevention and treatment. A large amount of information is now available regarding the virus, its structure, route of transmission and its pathophysiology. Therefore, this review summarizes the current understanding of MERS-CoV's pathogenesis, treatment options and recent scientific advancements in vaccine and other therapeutic developments, and the major steps taken for MERS prevention control.
DOI: 10.2217/fvl-2018-0201
PubMed: 32201499
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21589</wicri:regionArea><wicri:noRegion>Jeddah 21589</wicri:noRegion></affiliation></author><author><name sortKey="Alzahrani, Faisal" sort="Alzahrani, Faisal" uniqKey="Alzahrani F" first="Faisal" last="Alzahrani">Faisal Alzahrani</name><affiliation><nlm:affiliation>Hematology Lab Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</nlm:affiliation><wicri:noCountry code="subField"> Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Ali, Ashraf" sort="Ali, Ashraf" uniqKey="Ali A" first="Ashraf" last="Ali">Ashraf Ali</name><affiliation><nlm:affiliation>Hematology Lab Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</nlm:affiliation><wicri:noCountry code="subField"> Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Zakaria, Mohammad Khalid" sort="Zakaria, Mohammad Khalid" uniqKey="Zakaria M" first="Mohammad Khalid" last="Zakaria">Mohammad Khalid 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Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah 21589</wicri:regionArea><wicri:noRegion>Jeddah 21589</wicri:noRegion></affiliation></author><author><name sortKey="Jamal, Mohammad Sarwar" sort="Jamal, Mohammad Sarwar" uniqKey="Jamal M" first="Mohammad Sarwar" last="Jamal">Mohammad Sarwar Jamal</name><affiliation><nlm:affiliation>Hematology Lab Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</nlm:affiliation><wicri:noCountry code="subField"> Saudi Arabia</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:32201499</idno><idno type="pmid">32201499</idno><idno type="doi">10.2217/fvl-2018-0201</idno><idno 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21589, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589</wicri:regionArea><wicri:noRegion>Jeddah 21589</wicri:noRegion></affiliation></author><author><name sortKey="Bakhrebah, Muhammed A" sort="Bakhrebah, Muhammed A" uniqKey="Bakhrebah M" first="Muhammed A" last="Bakhrebah">Muhammed A. Bakhrebah</name><affiliation wicri:level="1"><nlm:affiliation>Life Science & environment Research Institute, National Center for Genome Technology, King Abdulaziz City for Science and Technology (KACST), Riyadh 12371, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Life Science & environment Research Institute, National Center for Genome Technology, King Abdulaziz City for Science and Technology (KACST), Riyadh 12371</wicri:regionArea><wicri:noRegion>Riyadh 12371</wicri:noRegion></affiliation></author><author><name sortKey="Abdulaal, Wesam H" sort="Abdulaal, Wesam H" uniqKey="Abdulaal W" first="Wesam H" last="Abdulaal">Wesam H. Abdulaal</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589</wicri:regionArea><wicri:noRegion>Jeddah 21589</wicri:noRegion></affiliation></author><author><name sortKey="Zamzami, Mazin A" sort="Zamzami, Mazin A" uniqKey="Zamzami M" first="Mazin A" last="Zamzami">Mazin A. Zamzami</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589</wicri:regionArea><wicri:noRegion>Jeddah 21589</wicri:noRegion></affiliation></author><author><name sortKey="Baothman, Othman A" sort="Baothman, Othman A" uniqKey="Baothman O" first="Othman A" last="Baothman">Othman A. Baothman</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589</wicri:regionArea><wicri:noRegion>Jeddah 21589</wicri:noRegion></affiliation></author><author><name sortKey="Hassan, Mohammed A" sort="Hassan, Mohammed A" uniqKey="Hassan M" first="Mohammed A" last="Hassan">Mohammed A. Hassan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589</wicri:regionArea><wicri:noRegion>Jeddah 21589</wicri:noRegion></affiliation></author><author><name sortKey="Zeyadi, Mustafa" sort="Zeyadi, Mustafa" uniqKey="Zeyadi M" first="Mustafa" last="Zeyadi">Mustafa Zeyadi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589</wicri:regionArea><wicri:noRegion>Jeddah 21589</wicri:noRegion></affiliation></author><author><name sortKey="Helmi, Nawal" sort="Helmi, Nawal" uniqKey="Helmi N" first="Nawal" last="Helmi">Nawal Helmi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589</wicri:regionArea><wicri:noRegion>Jeddah 21589</wicri:noRegion></affiliation></author><author><name sortKey="Alzahrani, Faisal" sort="Alzahrani, Faisal" uniqKey="Alzahrani F" first="Faisal" last="Alzahrani">Faisal Alzahrani</name><affiliation><nlm:affiliation>Hematology Lab Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</nlm:affiliation><wicri:noCountry code="subField"> Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Ali, Ashraf" sort="Ali, Ashraf" uniqKey="Ali A" first="Ashraf" last="Ali">Ashraf Ali</name><affiliation><nlm:affiliation>Hematology Lab Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</nlm:affiliation><wicri:noCountry code="subField"> Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Zakaria, Mohammad Khalid" sort="Zakaria, Mohammad Khalid" uniqKey="Zakaria M" first="Mohammad Khalid" last="Zakaria">Mohammad Khalid Zakaria</name><affiliation wicri:level="1"><nlm:affiliation>The Pirbright Institute, Ash Road, GU240NF, Surrey, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Pirbright Institute, Ash Road, GU240NF, Surrey</wicri:regionArea><wicri:noRegion>Surrey</wicri:noRegion></affiliation></author><author><name sortKey="Kamal, Mohammad Azhar" sort="Kamal, Mohammad Azhar" uniqKey="Kamal M" first="Mohammad Azhar" last="Kamal">Mohammad Azhar Kamal</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, University of Jeddah, Jeddah 23890, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Biochemistry, University of Jeddah, Jeddah 23890</wicri:regionArea><wicri:noRegion>Jeddah 23890</wicri:noRegion></affiliation></author><author><name sortKey="Warsi, Mohiuddin Khan" sort="Warsi, Mohiuddin Khan" uniqKey="Warsi M" first="Mohiuddin Khan" last="Warsi">Mohiuddin Khan Warsi</name><affiliation wicri:level="1"><nlm:affiliation>The Pirbright Institute, Ash Road, GU240NF, Surrey, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Pirbright Institute, Ash Road, GU240NF, Surrey</wicri:regionArea><wicri:noRegion>Surrey</wicri:noRegion></affiliation></author><author><name sortKey="Ahmed, Firoz" sort="Ahmed, Firoz" uniqKey="Ahmed F" first="Firoz" last="Ahmed">Firoz Ahmed</name><affiliation wicri:level="1"><nlm:affiliation>The Pirbright Institute, Ash Road, GU240NF, Surrey, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Pirbright Institute, Ash Road, GU240NF, Surrey</wicri:regionArea><wicri:noRegion>Surrey</wicri:noRegion></affiliation></author><author><name sortKey="Rasool, Mahmood" sort="Rasool, Mahmood" uniqKey="Rasool M" first="Mahmood" last="Rasool">Mahmood Rasool</name><affiliation wicri:level="1"><nlm:affiliation>Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah 21589</wicri:regionArea><wicri:noRegion>Jeddah 21589</wicri:noRegion></affiliation></author><author><name sortKey="Jamal, Mohammad Sarwar" sort="Jamal, Mohammad Sarwar" uniqKey="Jamal M" first="Mohammad Sarwar" last="Jamal">Mohammad Sarwar Jamal</name><affiliation><nlm:affiliation>Hematology Lab Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</nlm:affiliation><wicri:noCountry code="subField"> Saudi Arabia</wicri:noCountry></affiliation></author></analytic><series><title level="j">Future virology</title><idno type="ISSN">1746-0794</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The first case of Middle East respiratory syndrome coronavirus (MERS-CoV) was identified in the year 2012, which spread rapidly and increased to more than 2200 in 2018. This highly pathogenic virus with high mortality rate is among one of the major public health concerns. Saudi Arabia remains to be the most affected region with the majority of MERS-CoV cases, and currently, no effective drugs and vaccines are available for prevention and treatment. A large amount of information is now available regarding the virus, its structure, route of transmission and its pathophysiology. Therefore, this review summarizes the current understanding of MERS-CoV's pathogenesis, treatment options and recent scientific advancements in vaccine and other therapeutic developments, and the major steps taken for MERS prevention control.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32201499</PMID><DateRevised><Year>2020</Year><Month>03</Month><Day>26</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">1746-0794</ISSN><JournalIssue CitedMedium="Print"><Volume>14</Volume><Issue>4</Issue><PubDate><Year>2019</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Future virology</Title><ISOAbbreviation>Future Virol</ISOAbbreviation></Journal><ArticleTitle>Middle East respiratory syndrome: pathogenesis and therapeutic developments.</ArticleTitle><Pagination><MedlinePgn>237-246</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.2217/fvl-2018-0201</ELocationID><Abstract><AbstractText>The first case of Middle East respiratory syndrome coronavirus (MERS-CoV) was identified in the year 2012, which spread rapidly and increased to more than 2200 in 2018. This highly pathogenic virus with high mortality rate is among one of the major public health concerns. Saudi Arabia remains to be the most affected region with the majority of MERS-CoV cases, and currently, no effective drugs and vaccines are available for prevention and treatment. A large amount of information is now available regarding the virus, its structure, route of transmission and its pathophysiology. Therefore, this review summarizes the current understanding of MERS-CoV's pathogenesis, treatment options and recent scientific advancements in vaccine and other therapeutic developments, and the major steps taken for MERS prevention control.</AbstractText><CopyrightInformation>© 2019 Future Medicine Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Choudhry</LastName><ForeName>Hani</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bakhrebah</LastName><ForeName>Muhammed A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Life Science & environment Research Institute, National Center for Genome Technology, King Abdulaziz City for Science and Technology (KACST), Riyadh 12371, Saudi Arabia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Life Science & environment Research Institute, National Center for Genome Technology, King Abdulaziz City for Science and Technology (KACST), Riyadh 12371, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Abdulaal</LastName><ForeName>Wesam H</ForeName><Initials>WH</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zamzami</LastName><ForeName>Mazin A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baothman</LastName><ForeName>Othman A</ForeName><Initials>OA</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hassan</LastName><ForeName>Mohammed A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Basic Medical Sciences, College of Medicine & Health Sciences, Hadhramout University, Yemen.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Basic Medical Sciences, College of Medicine & Health Sciences, Hadhramout University, Yemen.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zeyadi</LastName><ForeName>Mustafa</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Helmi</LastName><ForeName>Nawal</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alzahrani</LastName><ForeName>Faisal</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Hematology Lab Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Hematology Lab Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ali</LastName><ForeName>Ashraf</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Hematology Lab Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Science of Agriculture, Food and Environment (SAFE), University of Foggia, Via Napoli, 25 - 71122, Foggia, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Hematology Lab Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Science of Agriculture, Food and Environment (SAFE), University of Foggia, Via Napoli, 25 - 71122, Foggia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zakaria</LastName><ForeName>Mohammad Khalid</ForeName><Initials>MK</Initials><AffiliationInfo><Affiliation>The Pirbright Institute, Ash Road, GU240NF, Surrey, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Pirbright Institute, Ash Road, GU240NF, Surrey, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kamal</LastName><ForeName>Mohammad Azhar</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, University of Jeddah, Jeddah 23890, Saudi Arabia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biochemistry, University of Jeddah, Jeddah 23890, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Warsi</LastName><ForeName>Mohiuddin Khan</ForeName><Initials>MK</Initials><AffiliationInfo><Affiliation>The Pirbright Institute, Ash Road, GU240NF, Surrey, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Pirbright Institute, Ash Road, GU240NF, Surrey, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ahmed</LastName><ForeName>Firoz</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>The Pirbright Institute, Ash Road, GU240NF, Surrey, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Pirbright Institute, Ash Road, GU240NF, Surrey, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rasool</LastName><ForeName>Mahmood</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jamal</LastName><ForeName>Mohammad Sarwar</ForeName><Initials>MS</Initials><AffiliationInfo><Affiliation>Hematology Lab Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Hematology Lab Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>04</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Future Virol</MedlineTA><NlmUniqueID>101278124</NlmUniqueID><ISSNLinking>1746-0794</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Arabian Peninsula</Keyword><Keyword MajorTopicYN="N">MERS</Keyword><Keyword MajorTopicYN="N">SARS</Keyword><Keyword MajorTopicYN="N">Saudi Arabia</Keyword><Keyword MajorTopicYN="N">WHO</Keyword><Keyword MajorTopicYN="N">coronavirus</Keyword><Keyword MajorTopicYN="N">global</Keyword><Keyword MajorTopicYN="N">macrophages</Keyword><Keyword MajorTopicYN="N">therapeutic</Keyword><Keyword MajorTopicYN="N">vaccine</Keyword></KeywordList><CoiStatement>Financial & competing interests disclosure This work was supported by King Abdulaziz City for Science and Technology and Deanship of Scientific Research, King Abdulaziz University. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. Medical writing support was provided by Scidra Consulting, INC and was funded by the authors.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>11</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>03</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>3</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>3</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>3</Month><Day>24</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32201499</ArticleId><ArticleId IdType="doi">10.2217/fvl-2018-0201</ArticleId><ArticleId IdType="pmc">PMC7080179</ArticleId></ArticleIdList><pmc-dir>pmcsd</pmc-dir>
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Abdulaal</name><name sortKey="Bakhrebah, Muhammed A" sort="Bakhrebah, Muhammed A" uniqKey="Bakhrebah M" first="Muhammed A" last="Bakhrebah">Muhammed A. Bakhrebah</name><name sortKey="Baothman, Othman A" sort="Baothman, Othman A" uniqKey="Baothman O" first="Othman A" last="Baothman">Othman A. Baothman</name><name sortKey="Hassan, Mohammed A" sort="Hassan, Mohammed A" uniqKey="Hassan M" first="Mohammed A" last="Hassan">Mohammed A. Hassan</name><name sortKey="Helmi, Nawal" sort="Helmi, Nawal" uniqKey="Helmi N" first="Nawal" last="Helmi">Nawal Helmi</name><name sortKey="Kamal, Mohammad Azhar" sort="Kamal, Mohammad Azhar" uniqKey="Kamal M" first="Mohammad Azhar" last="Kamal">Mohammad Azhar Kamal</name><name sortKey="Rasool, Mahmood" sort="Rasool, Mahmood" uniqKey="Rasool M" first="Mahmood" last="Rasool">Mahmood Rasool</name><name sortKey="Zamzami, Mazin A" sort="Zamzami, Mazin A" uniqKey="Zamzami M" first="Mazin A" last="Zamzami">Mazin A. Zamzami</name><name sortKey="Zeyadi, Mustafa" sort="Zeyadi, Mustafa" uniqKey="Zeyadi M" first="Mustafa" last="Zeyadi">Mustafa Zeyadi</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Zakaria, Mohammad Khalid" sort="Zakaria, Mohammad Khalid" uniqKey="Zakaria M" first="Mohammad Khalid" last="Zakaria">Mohammad Khalid Zakaria</name></noRegion><name sortKey="Ahmed, Firoz" sort="Ahmed, Firoz" uniqKey="Ahmed F" first="Firoz" last="Ahmed">Firoz Ahmed</name><name sortKey="Warsi, Mohiuddin Khan" sort="Warsi, Mohiuddin Khan" uniqKey="Warsi M" first="Mohiuddin Khan" last="Warsi">Mohiuddin Khan Warsi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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