Natural small molecules as inhibitors of coronavirus lipid-dependent attachment to host cells: a possible strategy for reducing SARS-COV-2 infectivity?
Identifieur interne : 003432 ( Ncbi/Merge ); précédent : 003431; suivant : 003433Natural small molecules as inhibitors of coronavirus lipid-dependent attachment to host cells: a possible strategy for reducing SARS-COV-2 infectivity?
Auteurs : Mirko Baglivo [Italie] ; Manuela Baronio [Italie] ; Giuseppe Natalini [Italie] ; Tommaso Beccari [Italie] ; Pietro Chiurazzi [Italie] ; Ezio Fulcheri [Italie] ; Paolo Pietro Petralia [Italie] ; Sandro Michelini [Italie] ; Giovanni Fiorentini [Italie] ; Giacinto Abele Miggiano [Italie] ; Assunta Morresi [Italie] ; Gerolamo Tonini [Italie] ; Matteo Bertelli [Italie]Source :
- Acta bio-medica : Atenei Parmensis [ 2531-6745 ] ; 2020.
Descripteurs français
- KwdFr :
- Animaux, Antiviraux (), Antiviraux (pharmacologie), Antiviraux (usage thérapeutique), Attachement viral (), Bibliothèques de petites molécules (pharmacologie), Bibliothèques de petites molécules (usage thérapeutique), Humains, Infections à coronavirus (traitement médicamenteux), Lipides, Pneumopathie virale (traitement médicamenteux).
- MESH :
- pharmacologie : Antiviraux, Bibliothèques de petites molécules.
- traitement médicamenteux : Infections à coronavirus, Pneumopathie virale.
- usage thérapeutique : Antiviraux, Bibliothèques de petites molécules.
- Animaux, Antiviraux, Attachement viral, Humains, Lipides.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Antiviral Agents (therapeutic use), Betacoronavirus (drug effects), Betacoronavirus (physiology), Coronavirus Infections (drug therapy), Humans, Lipids, Pneumonia, Viral (drug therapy), Small Molecule Libraries (pharmacology), Small Molecule Libraries (therapeutic use), Virus Attachment (drug effects).
- MESH :
- chemical , chemistry : Antiviral Agents.
- chemical , pharmacology : Antiviral Agents, Small Molecule Libraries.
- chemical , therapeutic use : Antiviral Agents, Small Molecule Libraries.
- drug effects : Betacoronavirus, Virus Attachment.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- physiology : Betacoronavirus.
- Animals, Humans, Lipids.
Abstract
Viral infectivity depends on interactions between components of the host cell plasma membrane and the virus envelope. Here we review strategies that could help stem the advance of the SARS-COV-2 epidemic.
DOI: 10.23750/abm.v91i1.9402
PubMed: 32191676
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000582
- to stream PubMed, to step Curation: 000582
- to stream PubMed, to step Checkpoint: 000378
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pubmed:32191676Le document en format XML
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Gemelli" IRCCS, Rome, Italy. pietro.chiurazzi@unicatt.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Genomic Medicine, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Fulcheri, Ezio" sort="Fulcheri, Ezio" uniqKey="Fulcheri E" first="Ezio" last="Fulcheri">Ezio Fulcheri</name><affiliation wicri:level="1"><nlm:affiliation>Pathology Division of Anatomic Pathology Dept. of Surgical and Diagnostic Sciences (DISC) University of Genova, Italy; UOSD Fetal Pathology and Ginecology IRCCS . Istituto Giannina Gaslini, Genova, Italy. ezio.fulcheri@unige.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pathology Division of Anatomic Pathology Dept. of Surgical and Diagnostic Sciences (DISC) University of Genova, Italy; UOSD Fetal Pathology and Ginecology IRCCS . Istituto Giannina Gaslini, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation></author><author><name sortKey="Petralia, Paolo Pietro" sort="Petralia, Paolo Pietro" uniqKey="Petralia P" first="Paolo Pietro" last="Petralia">Paolo Pietro Petralia</name><affiliation wicri:level="1"><nlm:affiliation>Institute G. Gaslini, Children's Hospital, Genova, Italy. paolo.petralia@anspi.net.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute G. Gaslini, Children's Hospital, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation></author><author><name sortKey="Michelini, Sandro" sort="Michelini, Sandro" uniqKey="Michelini S" first="Sandro" last="Michelini">Sandro Michelini</name><affiliation wicri:level="3"><nlm:affiliation>Department of Vascular Rehabilitation, San Giovanni Battista Hospital, Rome, Italy. s.michelini@acismom.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Vascular Rehabilitation, San Giovanni Battista Hospital, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Fiorentini, Giovanni" sort="Fiorentini, Giovanni" uniqKey="Fiorentini G" first="Giovanni" last="Fiorentini">Giovanni Fiorentini</name><affiliation wicri:level="1"><nlm:affiliation>Pharmacy Fiorentini, Brescia, Italy. mirko.baglivo@assomagi.org.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pharmacy Fiorentini, Brescia</wicri:regionArea><wicri:noRegion>Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Miggiano, Giacinto Abele" sort="Miggiano, Giacinto Abele" uniqKey="Miggiano G" first="Giacinto Abele" last="Miggiano">Giacinto Abele Miggiano</name><affiliation wicri:level="3"><nlm:affiliation>Human Nutrition Research Center, Sacro Cuore Catholic University, Rome, Italy. GiacintoAbele.Miggiano@unicatt.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Human Nutrition Research Center, Sacro Cuore Catholic University, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Morresi, Assunta" sort="Morresi, Assunta" uniqKey="Morresi A" first="Assunta" last="Morresi">Assunta Morresi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy. assunta.morresi@unipg.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia</wicri:regionArea><wicri:noRegion>Perugia</wicri:noRegion></affiliation></author><author><name sortKey="Tonini, Gerolamo" sort="Tonini, Gerolamo" uniqKey="Tonini G" first="Gerolamo" last="Tonini">Gerolamo Tonini</name><affiliation wicri:level="1"><nlm:affiliation>Department of Surgery, Fondazione Poliambulanza, Brescia, Italy. gerolamotonini@libero.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Surgery, Fondazione Poliambulanza, Brescia</wicri:regionArea><wicri:noRegion>Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Bertelli, Matteo" sort="Bertelli, Matteo" uniqKey="Bertelli M" first="Matteo" last="Bertelli">Matteo Bertelli</name><affiliation wicri:level="1"><nlm:affiliation>MAGI-Euregio, Bolzano, Italy; EBTNA-Lab, Rovereto (TN), Italy. matteo.bertelli@assomagi.org.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>MAGI-Euregio, Bolzano, Italy; EBTNA-Lab, Rovereto (TN)</wicri:regionArea><wicri:noRegion>Rovereto (TN)</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32191676</idno><idno type="pmid">32191676</idno><idno type="doi">10.23750/abm.v91i1.9402</idno><idno type="wicri:Area/PubMed/Corpus">000582</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000582</idno><idno type="wicri:Area/PubMed/Curation">000582</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000582</idno><idno type="wicri:Area/PubMed/Checkpoint">000378</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000378</idno><idno type="wicri:Area/Ncbi/Merge">003432</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Natural small molecules as inhibitors of coronavirus lipid-dependent attachment to host cells: a possible strategy for reducing SARS-COV-2 infectivity?</title><author><name sortKey="Baglivo, Mirko" sort="Baglivo, Mirko" uniqKey="Baglivo M" first="Mirko" last="Baglivo">Mirko Baglivo</name><affiliation wicri:level="1"><nlm:affiliation>MAGI-Euregio, Bolzano, Italy. mirko.baglivo@assomagi.org.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>MAGI-Euregio, Bolzano</wicri:regionArea><wicri:noRegion>Bolzano</wicri:noRegion></affiliation></author><author><name sortKey="Baronio, Manuela" sort="Baronio, Manuela" uniqKey="Baronio M" first="Manuela" last="Baronio">Manuela Baronio</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anaesthesia and Intensive Care, Fondazione Poliambulanza, Brescia, Italy. manubaro@aol.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Anaesthesia and Intensive Care, Fondazione Poliambulanza, Brescia</wicri:regionArea><wicri:noRegion>Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Natalini, Giuseppe" sort="Natalini, Giuseppe" uniqKey="Natalini G" first="Giuseppe" last="Natalini">Giuseppe Natalini</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anaesthesia and Intensive Care, Fondazione Poliambulanza, Brescia, Italy. Giuseppe.natalini@poliambulanza.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Anaesthesia and Intensive Care, Fondazione Poliambulanza, Brescia</wicri:regionArea><wicri:noRegion>Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Beccari, Tommaso" sort="Beccari, Tommaso" uniqKey="Beccari T" first="Tommaso" last="Beccari">Tommaso Beccari</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy. tommaso.beccari@unipg.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Pharmaceutical Sciences, University of Perugia, Perugia</wicri:regionArea><wicri:noRegion>Perugia</wicri:noRegion></affiliation></author><author><name sortKey="Chiurazzi, Pietro" sort="Chiurazzi, Pietro" uniqKey="Chiurazzi P" first="Pietro" last="Chiurazzi">Pietro Chiurazzi</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Genomic Medicine, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy. pietro.chiurazzi@unicatt.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Genomic Medicine, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Fulcheri, Ezio" sort="Fulcheri, Ezio" uniqKey="Fulcheri E" first="Ezio" last="Fulcheri">Ezio Fulcheri</name><affiliation wicri:level="1"><nlm:affiliation>Pathology Division of Anatomic Pathology Dept. of Surgical and Diagnostic Sciences (DISC) University of Genova, Italy; UOSD Fetal Pathology and Ginecology IRCCS . Istituto Giannina Gaslini, Genova, Italy. ezio.fulcheri@unige.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pathology Division of Anatomic Pathology Dept. of Surgical and Diagnostic Sciences (DISC) University of Genova, Italy; UOSD Fetal Pathology and Ginecology IRCCS . Istituto Giannina Gaslini, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation></author><author><name sortKey="Petralia, Paolo Pietro" sort="Petralia, Paolo Pietro" uniqKey="Petralia P" first="Paolo Pietro" last="Petralia">Paolo Pietro Petralia</name><affiliation wicri:level="1"><nlm:affiliation>Institute G. Gaslini, Children's Hospital, Genova, Italy. paolo.petralia@anspi.net.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute G. Gaslini, Children's Hospital, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation></author><author><name sortKey="Michelini, Sandro" sort="Michelini, Sandro" uniqKey="Michelini S" first="Sandro" last="Michelini">Sandro Michelini</name><affiliation wicri:level="3"><nlm:affiliation>Department of Vascular Rehabilitation, San Giovanni Battista Hospital, Rome, Italy. s.michelini@acismom.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Vascular Rehabilitation, San Giovanni Battista Hospital, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Fiorentini, Giovanni" sort="Fiorentini, Giovanni" uniqKey="Fiorentini G" first="Giovanni" last="Fiorentini">Giovanni Fiorentini</name><affiliation wicri:level="1"><nlm:affiliation>Pharmacy Fiorentini, Brescia, Italy. mirko.baglivo@assomagi.org.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pharmacy Fiorentini, Brescia</wicri:regionArea><wicri:noRegion>Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Miggiano, Giacinto Abele" sort="Miggiano, Giacinto Abele" uniqKey="Miggiano G" first="Giacinto Abele" last="Miggiano">Giacinto Abele Miggiano</name><affiliation wicri:level="3"><nlm:affiliation>Human Nutrition Research Center, Sacro Cuore Catholic University, Rome, Italy. GiacintoAbele.Miggiano@unicatt.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Human Nutrition Research Center, Sacro Cuore Catholic University, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Morresi, Assunta" sort="Morresi, Assunta" uniqKey="Morresi A" first="Assunta" last="Morresi">Assunta Morresi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy. assunta.morresi@unipg.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia</wicri:regionArea><wicri:noRegion>Perugia</wicri:noRegion></affiliation></author><author><name sortKey="Tonini, Gerolamo" sort="Tonini, Gerolamo" uniqKey="Tonini G" first="Gerolamo" last="Tonini">Gerolamo Tonini</name><affiliation wicri:level="1"><nlm:affiliation>Department of Surgery, Fondazione Poliambulanza, Brescia, Italy. gerolamotonini@libero.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Surgery, Fondazione Poliambulanza, Brescia</wicri:regionArea><wicri:noRegion>Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Bertelli, Matteo" sort="Bertelli, Matteo" uniqKey="Bertelli M" first="Matteo" last="Bertelli">Matteo Bertelli</name><affiliation wicri:level="1"><nlm:affiliation>MAGI-Euregio, Bolzano, Italy; EBTNA-Lab, Rovereto (TN), Italy. matteo.bertelli@assomagi.org.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>MAGI-Euregio, Bolzano, Italy; EBTNA-Lab, Rovereto (TN)</wicri:regionArea><wicri:noRegion>Rovereto (TN)</wicri:noRegion></affiliation></author></analytic><series><title level="j">Acta bio-medica : Atenei Parmensis</title><idno type="eISSN">2531-6745</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral Agents (chemistry)</term><term>Antiviral Agents (pharmacology)</term><term>Antiviral Agents (therapeutic use)</term><term>Betacoronavirus (drug effects)</term><term>Betacoronavirus (physiology)</term><term>Coronavirus Infections (drug therapy)</term><term>Humans</term><term>Lipids</term><term>Pneumonia, Viral (drug therapy)</term><term>Small Molecule Libraries (pharmacology)</term><term>Small Molecule Libraries (therapeutic use)</term><term>Virus Attachment (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antiviraux ()</term><term>Antiviraux (pharmacologie)</term><term>Antiviraux (usage thérapeutique)</term><term>Attachement viral ()</term><term>Bibliothèques de petites molécules (pharmacologie)</term><term>Bibliothèques de petites molécules (usage thérapeutique)</term><term>Humains</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Lipides</term><term>Pneumopathie virale (traitement médicamenteux)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Small Molecule Libraries</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term><term>Small Molecule Libraries</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Betacoronavirus</term><term>Virus Attachment</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term><term>Bibliothèques de petites molécules</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term><term>Bibliothèques de petites molécules</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Lipids</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Antiviraux</term><term>Attachement viral</term><term>Humains</term><term>Lipides</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Viral infectivity depends on interactions between components of the host cell plasma membrane and the virus envelope. Here we review strategies that could help stem the advance of the SARS-COV-2 epidemic.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32191676</PMID><DateCompleted><Year>2020</Year><Month>03</Month><Day>24</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>20</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2531-6745</ISSN><JournalIssue CitedMedium="Internet"><Volume>91</Volume><Issue>1</Issue><PubDate><Year>2020</Year><Month>03</Month><Day>19</Day></PubDate></JournalIssue><Title>Acta bio-medica : Atenei Parmensis</Title><ISOAbbreviation>Acta Biomed</ISOAbbreviation></Journal><ArticleTitle>Natural small molecules as inhibitors of coronavirus lipid-dependent attachment to host cells: a possible strategy for reducing SARS-COV-2 infectivity?</ArticleTitle><Pagination><MedlinePgn>161-164</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.23750/abm.v91i1.9402</ELocationID><Abstract><AbstractText Label="BACKGROUND">Viral infectivity depends on interactions between components of the host cell plasma membrane and the virus envelope. Here we review strategies that could help stem the advance of the SARS-COV-2 epidemic.</AbstractText><AbstractText Label="METHODS AND RESULTS">We focus on the role of lipid structures, such as lipid rafts and cholesterol, involved in the process, mediated by endocytosis, by which viruses attach to and infect cells. Previous studies have shown that many naturally derived substances, such as cyclodextrin and sterols, could reduce the infectivity of many types of viruses, including the coronavirus family, through interference with lipid-dependent attachment to human host cells.</AbstractText><AbstractText Label="CONCLUSIONS">Certain molecules prove able to reduce the infectivity of some coronaviruses, possibly by inhibiting viral lipid-dependent attachment to host cells. More research into these molecules and methods would be worthwhile as it could provide insights the mechanism of transmission of SARS-COV-2 and, into how they could become a basis for new antiviral strategies.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Baglivo</LastName><ForeName>Mirko</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>MAGI-Euregio, Bolzano, Italy. mirko.baglivo@assomagi.org.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baronio</LastName><ForeName>Manuela</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Anaesthesia and Intensive Care, Fondazione Poliambulanza, Brescia, Italy. manubaro@aol.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Natalini</LastName><ForeName>Giuseppe</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Anaesthesia and Intensive Care, Fondazione Poliambulanza, Brescia, Italy. Giuseppe.natalini@poliambulanza.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beccari</LastName><ForeName>Tommaso</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy. tommaso.beccari@unipg.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chiurazzi</LastName><ForeName>Pietro</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Institute of Genomic Medicine, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy. pietro.chiurazzi@unicatt.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fulcheri</LastName><ForeName>Ezio</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Pathology Division of Anatomic Pathology Dept. of Surgical and Diagnostic Sciences (DISC) University of Genova, Italy; UOSD Fetal Pathology and Ginecology IRCCS . Istituto Giannina Gaslini, Genova, Italy. ezio.fulcheri@unige.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Petralia</LastName><ForeName>Paolo Pietro</ForeName><Initials>PP</Initials><AffiliationInfo><Affiliation>Institute G. Gaslini, Children's Hospital, Genova, Italy. paolo.petralia@anspi.net.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Michelini</LastName><ForeName>Sandro</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Vascular Rehabilitation, San Giovanni Battista Hospital, Rome, Italy. s.michelini@acismom.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fiorentini</LastName><ForeName>Giovanni</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Pharmacy Fiorentini, Brescia, Italy. mirko.baglivo@assomagi.org.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Miggiano</LastName><ForeName>Giacinto Abele</ForeName><Initials>GA</Initials><AffiliationInfo><Affiliation>Human Nutrition Research Center, Sacro Cuore Catholic University, Rome, Italy. GiacintoAbele.Miggiano@unicatt.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morresi</LastName><ForeName>Assunta</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy. assunta.morresi@unipg.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tonini</LastName><ForeName>Gerolamo</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Surgery, Fondazione Poliambulanza, Brescia, Italy. gerolamotonini@libero.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bertelli</LastName><ForeName>Matteo</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>MAGI-Euregio, Bolzano, Italy; EBTNA-Lab, Rovereto (TN), Italy. matteo.bertelli@assomagi.org.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>03</Month><Day>19</Day></ArticleDate></Article><MedlineJournalInfo><Country>Italy</Country><MedlineTA>Acta Biomed</MedlineTA><NlmUniqueID>101295064</NlmUniqueID><ISSNLinking>0392-4203</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008055">Lipids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D054852">Small Molecule Libraries</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Protocol" UI="C000705127">COVID-19 drug treatment</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="Y">Antiviral Agents</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008055" MajorTopicYN="N">Lipids</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D054852" MajorTopicYN="Y">Small Molecule Libraries</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053585" MajorTopicYN="N">Virus Attachment</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>03</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>03</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>3</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>3</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>3</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32191676</ArticleId><ArticleId IdType="doi">10.23750/abm.v91i1.9402</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Italie</li></country><region><li>Latium</li></region><settlement><li>Rome</li></settlement></list><tree><country name="Italie"><noRegion><name sortKey="Baglivo, Mirko" sort="Baglivo, Mirko" uniqKey="Baglivo M" first="Mirko" last="Baglivo">Mirko Baglivo</name></noRegion><name sortKey="Baronio, Manuela" sort="Baronio, Manuela" uniqKey="Baronio M" first="Manuela" last="Baronio">Manuela Baronio</name><name sortKey="Beccari, Tommaso" sort="Beccari, Tommaso" uniqKey="Beccari T" first="Tommaso" last="Beccari">Tommaso Beccari</name><name sortKey="Bertelli, Matteo" sort="Bertelli, Matteo" uniqKey="Bertelli M" first="Matteo" last="Bertelli">Matteo Bertelli</name><name sortKey="Chiurazzi, Pietro" sort="Chiurazzi, Pietro" uniqKey="Chiurazzi P" first="Pietro" last="Chiurazzi">Pietro Chiurazzi</name><name sortKey="Fiorentini, Giovanni" sort="Fiorentini, Giovanni" uniqKey="Fiorentini G" first="Giovanni" last="Fiorentini">Giovanni Fiorentini</name><name sortKey="Fulcheri, Ezio" sort="Fulcheri, Ezio" uniqKey="Fulcheri E" first="Ezio" last="Fulcheri">Ezio Fulcheri</name><name sortKey="Michelini, Sandro" sort="Michelini, Sandro" uniqKey="Michelini S" first="Sandro" last="Michelini">Sandro Michelini</name><name sortKey="Miggiano, Giacinto Abele" sort="Miggiano, Giacinto Abele" uniqKey="Miggiano G" first="Giacinto Abele" last="Miggiano">Giacinto Abele Miggiano</name><name sortKey="Morresi, Assunta" sort="Morresi, Assunta" uniqKey="Morresi A" first="Assunta" last="Morresi">Assunta Morresi</name><name sortKey="Natalini, Giuseppe" sort="Natalini, Giuseppe" uniqKey="Natalini G" first="Giuseppe" last="Natalini">Giuseppe Natalini</name><name sortKey="Petralia, Paolo Pietro" sort="Petralia, Paolo Pietro" uniqKey="Petralia P" first="Paolo Pietro" last="Petralia">Paolo Pietro Petralia</name><name sortKey="Tonini, Gerolamo" sort="Tonini, Gerolamo" uniqKey="Tonini G" first="Gerolamo" last="Tonini">Gerolamo Tonini</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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