Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms.
Identifieur interne : 003370 ( Ncbi/Merge ); précédent : 003369; suivant : 003371Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms.
Auteurs : Abdul Mannan Baig [Pakistan] ; Areeba Khaleeq [Pakistan] ; Usman Ali [Pakistan] ; Hira Syeda [Pakistan]Source :
- ACS chemical neuroscience [ 1948-7193 ] ; 2020.
Descripteurs français
- KwdFr :
- Humains, Infections à coronavirus (immunologie), Infections à coronavirus (physiopathologie), Interactions hôte-pathogène, Pandémies, Peptidyl-Dipeptidase A, Pneumopathie virale (immunologie), Pneumopathie virale (physiopathologie), Récepteurs viraux (métabolisme), Répartition dans les tissus, Système nerveux central (physiopathologie), Système nerveux central (virologie).
- MESH :
- immunologie : Infections à coronavirus, Pneumopathie virale.
- métabolisme : Récepteurs viraux.
- physiopathologie : Infections à coronavirus, Pneumopathie virale, Système nerveux central.
- virologie : Système nerveux central.
- Humains, Interactions hôte-pathogène, Pandémies, Peptidyl-Dipeptidase A, Répartition dans les tissus.
English descriptors
- KwdEn :
- Betacoronavirus (physiology), Central Nervous System (physiopathology), Central Nervous System (virology), Coronavirus Infections (immunology), Coronavirus Infections (physiopathology), Host-Pathogen Interactions, Humans, Pandemics, Peptidyl-Dipeptidase A, Pneumonia, Viral (immunology), Pneumonia, Viral (physiopathology), Receptors, Virus (metabolism), Tissue Distribution.
- MESH :
- chemical , metabolism : Receptors, Virus.
- chemical : Peptidyl-Dipeptidase A.
- immunology : Coronavirus Infections, Pneumonia, Viral.
- physiology : Betacoronavirus.
- physiopathology : Central Nervous System, Coronavirus Infections, Pneumonia, Viral.
- virology : Central Nervous System.
- Host-Pathogen Interactions, Humans, Pandemics, Tissue Distribution.
Abstract
The recent outbreak of coronavirus infectious disease 2019 (COVID-19) has gripped the world with apprehension and has evoked a scare of epic proportion regarding its potential to spread and infect humans worldwide. As we are in the midst of an ongoing pandemic of COVID-19, scientists are struggling to understand how it resembles and differs from the severe acute respiratory syndrome coronavirus (SARS-CoV) at the genomic and transcriptomic level. In a short time following the outbreak, it has been shown that, similar to SARS-CoV, COVID-19 virus exploits the angiotensin-converting enzyme 2 (ACE2) receptor to gain entry inside the cells. This finding raises the curiosity of investigating the expression of ACE2 in neurological tissue and determining the possible contribution of neurological tissue damage to the morbidity and mortality caused by COIVD-19. Here, we investigate the density of the expression levels of ACE2 in the CNS, the host-virus interaction and relate it to the pathogenesis and complications seen in the recent cases resulting from the COVID-19 outbreak. Also, we debate the need for a model for staging COVID-19 based on neurological tissue involvement.
DOI: 10.1021/acschemneuro.0c00122
PubMed: 32167747
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000635
- to stream PubMed, to step Curation: 000635
- to stream PubMed, to step Checkpoint: 000520
Links to Exploration step
pubmed:32167747Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms.</title><author><name sortKey="Baig, Abdul Mannan" sort="Baig, Abdul Mannan" uniqKey="Baig A" first="Abdul Mannan" last="Baig">Abdul Mannan Baig</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological and Biomedical Sciences, Aga Khan University, Karachi 74800, Pakistan.</nlm:affiliation><country xml:lang="fr">Pakistan</country><wicri:regionArea>Department of Biological and Biomedical Sciences, Aga Khan University, Karachi 74800</wicri:regionArea><wicri:noRegion>Karachi 74800</wicri:noRegion></affiliation></author><author><name sortKey="Khaleeq, Areeba" sort="Khaleeq, Areeba" uniqKey="Khaleeq A" first="Areeba" last="Khaleeq">Areeba Khaleeq</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological and Biomedical Sciences, Aga Khan University, Karachi 74800, Pakistan.</nlm:affiliation><country xml:lang="fr">Pakistan</country><wicri:regionArea>Department of Biological and Biomedical Sciences, Aga Khan University, Karachi 74800</wicri:regionArea><wicri:noRegion>Karachi 74800</wicri:noRegion></affiliation></author><author><name sortKey="Ali, Usman" sort="Ali, Usman" uniqKey="Ali U" first="Usman" last="Ali">Usman Ali</name><affiliation wicri:level="1"><nlm:affiliation>Medical College, Aga Khan University, Karachi 74800, Pakistan.</nlm:affiliation><country xml:lang="fr">Pakistan</country><wicri:regionArea>Medical College, Aga Khan University, Karachi 74800</wicri:regionArea><wicri:noRegion>Karachi 74800</wicri:noRegion></affiliation></author><author><name sortKey="Syeda, Hira" sort="Syeda, Hira" uniqKey="Syeda H" first="Hira" last="Syeda">Hira Syeda</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biosciences, Mohammad Ali Jinnah University, Karachi 75400, Pakistan.</nlm:affiliation><country xml:lang="fr">Pakistan</country><wicri:regionArea>Department of Biosciences, Mohammad Ali Jinnah University, Karachi 75400</wicri:regionArea><wicri:noRegion>Karachi 75400</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32167747</idno><idno type="pmid">32167747</idno><idno type="doi">10.1021/acschemneuro.0c00122</idno><idno type="wicri:Area/PubMed/Corpus">000635</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000635</idno><idno type="wicri:Area/PubMed/Curation">000635</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000635</idno><idno type="wicri:Area/PubMed/Checkpoint">000520</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000520</idno><idno type="wicri:Area/Ncbi/Merge">003370</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms.</title><author><name sortKey="Baig, Abdul Mannan" sort="Baig, Abdul Mannan" uniqKey="Baig A" first="Abdul Mannan" last="Baig">Abdul Mannan Baig</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological and Biomedical Sciences, Aga Khan University, Karachi 74800, Pakistan.</nlm:affiliation><country xml:lang="fr">Pakistan</country><wicri:regionArea>Department of Biological and Biomedical Sciences, Aga Khan University, Karachi 74800</wicri:regionArea><wicri:noRegion>Karachi 74800</wicri:noRegion></affiliation></author><author><name sortKey="Khaleeq, Areeba" sort="Khaleeq, Areeba" uniqKey="Khaleeq A" first="Areeba" last="Khaleeq">Areeba Khaleeq</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological and Biomedical Sciences, Aga Khan University, Karachi 74800, Pakistan.</nlm:affiliation><country xml:lang="fr">Pakistan</country><wicri:regionArea>Department of Biological and Biomedical Sciences, Aga Khan University, Karachi 74800</wicri:regionArea><wicri:noRegion>Karachi 74800</wicri:noRegion></affiliation></author><author><name sortKey="Ali, Usman" sort="Ali, Usman" uniqKey="Ali U" first="Usman" last="Ali">Usman Ali</name><affiliation wicri:level="1"><nlm:affiliation>Medical College, Aga Khan University, Karachi 74800, Pakistan.</nlm:affiliation><country xml:lang="fr">Pakistan</country><wicri:regionArea>Medical College, Aga Khan University, Karachi 74800</wicri:regionArea><wicri:noRegion>Karachi 74800</wicri:noRegion></affiliation></author><author><name sortKey="Syeda, Hira" sort="Syeda, Hira" uniqKey="Syeda H" first="Hira" last="Syeda">Hira Syeda</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biosciences, Mohammad Ali Jinnah University, Karachi 75400, Pakistan.</nlm:affiliation><country xml:lang="fr">Pakistan</country><wicri:regionArea>Department of Biosciences, Mohammad Ali Jinnah University, Karachi 75400</wicri:regionArea><wicri:noRegion>Karachi 75400</wicri:noRegion></affiliation></author></analytic><series><title level="j">ACS chemical neuroscience</title><idno type="eISSN">1948-7193</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Betacoronavirus (physiology)</term><term>Central Nervous System (physiopathology)</term><term>Central Nervous System (virology)</term><term>Coronavirus Infections (immunology)</term><term>Coronavirus Infections (physiopathology)</term><term>Host-Pathogen Interactions</term><term>Humans</term><term>Pandemics</term><term>Peptidyl-Dipeptidase A</term><term>Pneumonia, Viral (immunology)</term><term>Pneumonia, Viral (physiopathology)</term><term>Receptors, Virus (metabolism)</term><term>Tissue Distribution</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Humains</term><term>Infections à coronavirus (immunologie)</term><term>Infections à coronavirus (physiopathologie)</term><term>Interactions hôte-pathogène</term><term>Pandémies</term><term>Peptidyl-Dipeptidase A</term><term>Pneumopathie virale (immunologie)</term><term>Pneumopathie virale (physiopathologie)</term><term>Récepteurs viraux (métabolisme)</term><term>Répartition dans les tissus</term><term>Système nerveux central (physiopathologie)</term><term>Système nerveux central (virologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Receptors, Virus</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Peptidyl-Dipeptidase A</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Récepteurs viraux</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term><term>Système nerveux central</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Central Nervous System</term><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Système nerveux central</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Central Nervous System</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Host-Pathogen Interactions</term><term>Humans</term><term>Pandemics</term><term>Tissue Distribution</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Interactions hôte-pathogène</term><term>Pandémies</term><term>Peptidyl-Dipeptidase A</term><term>Répartition dans les tissus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The recent outbreak of coronavirus infectious disease 2019 (COVID-19) has gripped the world with apprehension and has evoked a scare of epic proportion regarding its potential to spread and infect humans worldwide. As we are in the midst of an ongoing pandemic of COVID-19, scientists are struggling to understand how it resembles and differs from the severe acute respiratory syndrome coronavirus (SARS-CoV) at the genomic and transcriptomic level. In a short time following the outbreak, it has been shown that, similar to SARS-CoV, COVID-19 virus exploits the angiotensin-converting enzyme 2 (ACE2) receptor to gain entry inside the cells. This finding raises the curiosity of investigating the expression of ACE2 in neurological tissue and determining the possible contribution of neurological tissue damage to the morbidity and mortality caused by COIVD-19. Here, we investigate the density of the expression levels of ACE2 in the CNS, the host-virus interaction and relate it to the pathogenesis and complications seen in the recent cases resulting from the COVID-19 outbreak. Also, we debate the need for a model for staging COVID-19 based on neurological tissue involvement.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32167747</PMID><DateCompleted><Year>2020</Year><Month>04</Month><Day>08</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>08</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1948-7193</ISSN><JournalIssue CitedMedium="Internet"><Volume>11</Volume><Issue>7</Issue><PubDate><Year>2020</Year><Month>04</Month><Day>01</Day></PubDate></JournalIssue><Title>ACS chemical neuroscience</Title><ISOAbbreviation>ACS Chem Neurosci</ISOAbbreviation></Journal><ArticleTitle>Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms.</ArticleTitle><Pagination><MedlinePgn>995-998</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1021/acschemneuro.0c00122</ELocationID><Abstract><AbstractText>The recent outbreak of coronavirus infectious disease 2019 (COVID-19) has gripped the world with apprehension and has evoked a scare of epic proportion regarding its potential to spread and infect humans worldwide. As we are in the midst of an ongoing pandemic of COVID-19, scientists are struggling to understand how it resembles and differs from the severe acute respiratory syndrome coronavirus (SARS-CoV) at the genomic and transcriptomic level. In a short time following the outbreak, it has been shown that, similar to SARS-CoV, COVID-19 virus exploits the angiotensin-converting enzyme 2 (ACE2) receptor to gain entry inside the cells. This finding raises the curiosity of investigating the expression of ACE2 in neurological tissue and determining the possible contribution of neurological tissue damage to the morbidity and mortality caused by COIVD-19. Here, we investigate the density of the expression levels of ACE2 in the CNS, the host-virus interaction and relate it to the pathogenesis and complications seen in the recent cases resulting from the COVID-19 outbreak. Also, we debate the need for a model for staging COVID-19 based on neurological tissue involvement.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Baig</LastName><ForeName>Abdul Mannan</ForeName><Initials>AM</Initials><Identifier Source="ORCID">0000-0003-0626-216X</Identifier><AffiliationInfo><Affiliation>Department of Biological and Biomedical Sciences, Aga Khan University, Karachi 74800, Pakistan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khaleeq</LastName><ForeName>Areeba</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Biological and Biomedical Sciences, Aga Khan University, Karachi 74800, Pakistan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ali</LastName><ForeName>Usman</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Medical College, Aga Khan University, Karachi 74800, Pakistan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Syeda</LastName><ForeName>Hira</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Biosciences, Mohammad Ali Jinnah University, Karachi 75400, Pakistan.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>03</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>ACS Chem Neurosci</MedlineTA><NlmUniqueID>101525337</NlmUniqueID><ISSNLinking>1948-7193</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011991">Receptors, Virus</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.15.1</RegistryNumber><NameOfSubstance UI="D007703">Peptidyl-Dipeptidase A</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.17.-</RegistryNumber><NameOfSubstance UI="C413524">angiotensin converting enzyme 2</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>ACS Chem Neurosci. 2020 Apr 15;11(8):1192-1194</RefSource><PMID Version="1">32233443</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002490" MajorTopicYN="N">Central Nervous System</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D054884" MajorTopicYN="Y">Host-Pathogen Interactions</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007703" MajorTopicYN="N">Peptidyl-Dipeptidase A</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011991" MajorTopicYN="N">Receptors, Virus</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014018" MajorTopicYN="N">Tissue Distribution</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">ACE2 tissue distribution</Keyword><Keyword MajorTopicYN="Y">COVID-19</Keyword><Keyword MajorTopicYN="Y">Coronavirus</Keyword><Keyword MajorTopicYN="Y">SARS-CoV-2</Keyword><Keyword MajorTopicYN="Y">host−virus interaction</Keyword><Keyword MajorTopicYN="Y">spike protein</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>3</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>4</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>3</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32167747</ArticleId><ArticleId IdType="doi">10.1021/acschemneuro.0c00122</ArticleId><ArticleId IdType="pmc">PMC7094171</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Pakistan</li></country></list><tree><country name="Pakistan"><noRegion><name sortKey="Baig, Abdul Mannan" sort="Baig, Abdul Mannan" uniqKey="Baig A" first="Abdul Mannan" last="Baig">Abdul Mannan Baig</name></noRegion><name sortKey="Ali, Usman" sort="Ali, Usman" uniqKey="Ali U" first="Usman" last="Ali">Usman Ali</name><name sortKey="Khaleeq, Areeba" sort="Khaleeq, Areeba" uniqKey="Khaleeq A" first="Areeba" last="Khaleeq">Areeba Khaleeq</name><name sortKey="Syeda, Hira" sort="Syeda, Hira" uniqKey="Syeda H" first="Hira" last="Syeda">Hira Syeda</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003370 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 003370 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Ncbi
|étape= Merge
|type= RBID
|clé= pubmed:32167747
|texte= Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:32167747" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |