An exclusive 42 amino acid signature in pp1ab protein provides insights into the evolutive history of the 2019 novel human-pathogenic coronavirus (SARS-CoV-2).
Identifieur interne : 003368 ( Ncbi/Merge ); précédent : 003367; suivant : 003369An exclusive 42 amino acid signature in pp1ab protein provides insights into the evolutive history of the 2019 novel human-pathogenic coronavirus (SARS-CoV-2).
Auteurs : Yair Cárdenas-Conejo [Mexique] ; Andr Meda Li An-Rico [Mexique] ; Daniel Alejandro García-Rodríguez [Mexique] ; Sara Centeno-Leija [Mexique] ; Hugo Serrano-Posada [Mexique]Source :
- Journal of medical virology [ 1096-9071 ] ; 2020.
Abstract
The city of Wuhan, Hubei province, China, was the origin of a severe pneumonia outbreak in December 2019, attributed to a novel coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]), causing a total of 2761 deaths and 81109 cases (25 February 2020). SARS-CoV-2 belongs to genus Betacoronavirus, subgenus Sarbecovirus. The polyprotein 1ab (pp1ab) remains unstudied thoroughly since it is similar to other sarbecoviruses. In this short communication, we performed phylogenetic-structural sequence analysis of pp1ab protein of SARS-CoV-2. The analysis showed that the viral pp1ab has not changed in most isolates throughout the outbreak time, but interestingly a deletion of 8 aa in the virulence factor nonstructural protein 1 was found in a virus isolated from a Japanese patient that did not display critical symptoms. While comparing pp1ab protein with other betacoronaviruses, we found a 42 amino acid signature that is only present in SARS-CoV-2 (AS-SCoV2). Members from clade 2 of sarbecoviruses have traces of this signature. The AS-SCoV2 located in the acidic-domain of papain-like protein of SARS-CoV-2 and bat-SL-CoV-RatG13 guided us to suggest that the novel 2019 coronavirus probably emerged by genetic drift from bat-SL-CoV-RaTG13. The implication of this amino acid signature in papain-like protein structure arrangement and function is something worth to be explored.
DOI: 10.1002/jmv.25758
PubMed: 32167166
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000637
- to stream PubMed, to step Curation: 000637
- to stream PubMed, to step Checkpoint: 000793
Links to Exploration step
pubmed:32167166Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">An exclusive 42 amino acid signature in pp1ab protein provides insights into the evolutive history of the 2019 novel human-pathogenic coronavirus (SARS-CoV-2).</title>
<author><name sortKey="Cardenas Conejo, Yair" sort="Cardenas Conejo, Yair" uniqKey="Cardenas Conejo Y" first="Yair" last="Cárdenas-Conejo">Yair Cárdenas-Conejo</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory of Agrobiotechnology, National Council of Science and Technology (CONACYT)-University of Colima, Colima, Colima, Mexico.</nlm:affiliation>
<country xml:lang="fr">Mexique</country>
<wicri:regionArea>Laboratory of Agrobiotechnology, National Council of Science and Technology (CONACYT)-University of Colima, Colima, Colima</wicri:regionArea>
<wicri:noRegion>Colima</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Li An Rico, Andr Meda" sort="Li An Rico, Andr Meda" uniqKey="Li An Rico A" first="Andr Meda" last="Li An-Rico">Andr Meda Li An-Rico</name>
<affiliation wicri:level="1"><nlm:affiliation>University Center for Biomedical Research, National Council of Science and Technology (CONACYT)-University of Colima, Colima, Colima, Mexico.</nlm:affiliation>
<country xml:lang="fr">Mexique</country>
<wicri:regionArea>University Center for Biomedical Research, National Council of Science and Technology (CONACYT)-University of Colima, Colima, Colima</wicri:regionArea>
<wicri:noRegion>Colima</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Garcia Rodriguez, Daniel Alejandro" sort="Garcia Rodriguez, Daniel Alejandro" uniqKey="Garcia Rodriguez D" first="Daniel Alejandro" last="García-Rodríguez">Daniel Alejandro García-Rodríguez</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory of Agrobiotechnology, University of Colima, Colima, Colima, Mexico.</nlm:affiliation>
<country xml:lang="fr">Mexique</country>
<wicri:regionArea>Laboratory of Agrobiotechnology, University of Colima, Colima, Colima</wicri:regionArea>
<wicri:noRegion>Colima</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Centeno Leija, Sara" sort="Centeno Leija, Sara" uniqKey="Centeno Leija S" first="Sara" last="Centeno-Leija">Sara Centeno-Leija</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory of Agrobiotechnology, National Council of Science and Technology (CONACYT)-University of Colima, Colima, Colima, Mexico.</nlm:affiliation>
<country xml:lang="fr">Mexique</country>
<wicri:regionArea>Laboratory of Agrobiotechnology, National Council of Science and Technology (CONACYT)-University of Colima, Colima, Colima</wicri:regionArea>
<wicri:noRegion>Colima</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Serrano Posada, Hugo" sort="Serrano Posada, Hugo" uniqKey="Serrano Posada H" first="Hugo" last="Serrano-Posada">Hugo Serrano-Posada</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory of Agrobiotechnology, National Council of Science and Technology (CONACYT)-University of Colima, Colima, Colima, Mexico.</nlm:affiliation>
<country xml:lang="fr">Mexique</country>
<wicri:regionArea>Laboratory of Agrobiotechnology, National Council of Science and Technology (CONACYT)-University of Colima, Colima, Colima</wicri:regionArea>
<wicri:noRegion>Colima</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2020">2020</date>
<idno type="RBID">pubmed:32167166</idno>
<idno type="pmid">32167166</idno>
<idno type="doi">10.1002/jmv.25758</idno>
<idno type="wicri:Area/PubMed/Corpus">000637</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000637</idno>
<idno type="wicri:Area/PubMed/Curation">000637</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000637</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000793</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000793</idno>
<idno type="wicri:Area/Ncbi/Merge">003368</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">An exclusive 42 amino acid signature in pp1ab protein provides insights into the evolutive history of the 2019 novel human-pathogenic coronavirus (SARS-CoV-2).</title>
<author><name sortKey="Cardenas Conejo, Yair" sort="Cardenas Conejo, Yair" uniqKey="Cardenas Conejo Y" first="Yair" last="Cárdenas-Conejo">Yair Cárdenas-Conejo</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory of Agrobiotechnology, National Council of Science and Technology (CONACYT)-University of Colima, Colima, Colima, Mexico.</nlm:affiliation>
<country xml:lang="fr">Mexique</country>
<wicri:regionArea>Laboratory of Agrobiotechnology, National Council of Science and Technology (CONACYT)-University of Colima, Colima, Colima</wicri:regionArea>
<wicri:noRegion>Colima</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Li An Rico, Andr Meda" sort="Li An Rico, Andr Meda" uniqKey="Li An Rico A" first="Andr Meda" last="Li An-Rico">Andr Meda Li An-Rico</name>
<affiliation wicri:level="1"><nlm:affiliation>University Center for Biomedical Research, National Council of Science and Technology (CONACYT)-University of Colima, Colima, Colima, Mexico.</nlm:affiliation>
<country xml:lang="fr">Mexique</country>
<wicri:regionArea>University Center for Biomedical Research, National Council of Science and Technology (CONACYT)-University of Colima, Colima, Colima</wicri:regionArea>
<wicri:noRegion>Colima</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Garcia Rodriguez, Daniel Alejandro" sort="Garcia Rodriguez, Daniel Alejandro" uniqKey="Garcia Rodriguez D" first="Daniel Alejandro" last="García-Rodríguez">Daniel Alejandro García-Rodríguez</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory of Agrobiotechnology, University of Colima, Colima, Colima, Mexico.</nlm:affiliation>
<country xml:lang="fr">Mexique</country>
<wicri:regionArea>Laboratory of Agrobiotechnology, University of Colima, Colima, Colima</wicri:regionArea>
<wicri:noRegion>Colima</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Centeno Leija, Sara" sort="Centeno Leija, Sara" uniqKey="Centeno Leija S" first="Sara" last="Centeno-Leija">Sara Centeno-Leija</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory of Agrobiotechnology, National Council of Science and Technology (CONACYT)-University of Colima, Colima, Colima, Mexico.</nlm:affiliation>
<country xml:lang="fr">Mexique</country>
<wicri:regionArea>Laboratory of Agrobiotechnology, National Council of Science and Technology (CONACYT)-University of Colima, Colima, Colima</wicri:regionArea>
<wicri:noRegion>Colima</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Serrano Posada, Hugo" sort="Serrano Posada, Hugo" uniqKey="Serrano Posada H" first="Hugo" last="Serrano-Posada">Hugo Serrano-Posada</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory of Agrobiotechnology, National Council of Science and Technology (CONACYT)-University of Colima, Colima, Colima, Mexico.</nlm:affiliation>
<country xml:lang="fr">Mexique</country>
<wicri:regionArea>Laboratory of Agrobiotechnology, National Council of Science and Technology (CONACYT)-University of Colima, Colima, Colima</wicri:regionArea>
<wicri:noRegion>Colima</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of medical virology</title>
<idno type="eISSN">1096-9071</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The city of Wuhan, Hubei province, China, was the origin of a severe pneumonia outbreak in December 2019, attributed to a novel coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]), causing a total of 2761 deaths and 81109 cases (25 February 2020). SARS-CoV-2 belongs to genus Betacoronavirus, subgenus Sarbecovirus. The polyprotein 1ab (pp1ab) remains unstudied thoroughly since it is similar to other sarbecoviruses. In this short communication, we performed phylogenetic-structural sequence analysis of pp1ab protein of SARS-CoV-2. The analysis showed that the viral pp1ab has not changed in most isolates throughout the outbreak time, but interestingly a deletion of 8 aa in the virulence factor nonstructural protein 1 was found in a virus isolated from a Japanese patient that did not display critical symptoms. While comparing pp1ab protein with other betacoronaviruses, we found a 42 amino acid signature that is only present in SARS-CoV-2 (AS-SCoV2). Members from clade 2 of sarbecoviruses have traces of this signature. The AS-SCoV2 located in the acidic-domain of papain-like protein of SARS-CoV-2 and bat-SL-CoV-RatG13 guided us to suggest that the novel 2019 coronavirus probably emerged by genetic drift from bat-SL-CoV-RaTG13. The implication of this amino acid signature in papain-like protein structure arrangement and function is something worth to be explored.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32167166</PMID>
<DateRevised><Year>2020</Year>
<Month>03</Month>
<Day>20</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1096-9071</ISSN>
<JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year>
<Month>Mar</Month>
<Day>13</Day>
</PubDate>
</JournalIssue>
<Title>Journal of medical virology</Title>
<ISOAbbreviation>J. Med. Virol.</ISOAbbreviation>
</Journal>
<ArticleTitle>An exclusive 42 amino acid signature in pp1ab protein provides insights into the evolutive history of the 2019 novel human-pathogenic coronavirus (SARS-CoV-2).</ArticleTitle>
<ELocationID EIdType="doi" ValidYN="Y">10.1002/jmv.25758</ELocationID>
<Abstract><AbstractText>The city of Wuhan, Hubei province, China, was the origin of a severe pneumonia outbreak in December 2019, attributed to a novel coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]), causing a total of 2761 deaths and 81109 cases (25 February 2020). SARS-CoV-2 belongs to genus Betacoronavirus, subgenus Sarbecovirus. The polyprotein 1ab (pp1ab) remains unstudied thoroughly since it is similar to other sarbecoviruses. In this short communication, we performed phylogenetic-structural sequence analysis of pp1ab protein of SARS-CoV-2. The analysis showed that the viral pp1ab has not changed in most isolates throughout the outbreak time, but interestingly a deletion of 8 aa in the virulence factor nonstructural protein 1 was found in a virus isolated from a Japanese patient that did not display critical symptoms. While comparing pp1ab protein with other betacoronaviruses, we found a 42 amino acid signature that is only present in SARS-CoV-2 (AS-SCoV2). Members from clade 2 of sarbecoviruses have traces of this signature. The AS-SCoV2 located in the acidic-domain of papain-like protein of SARS-CoV-2 and bat-SL-CoV-RatG13 guided us to suggest that the novel 2019 coronavirus probably emerged by genetic drift from bat-SL-CoV-RaTG13. The implication of this amino acid signature in papain-like protein structure arrangement and function is something worth to be explored.</AbstractText>
<CopyrightInformation>© 2020 Wiley Periodicals, Inc.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cárdenas-Conejo</LastName>
<ForeName>Yair</ForeName>
<Initials>Y</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-0190-244X</Identifier>
<AffiliationInfo><Affiliation>Laboratory of Agrobiotechnology, National Council of Science and Technology (CONACYT)-University of Colima, Colima, Colima, Mexico.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liñan-Rico</LastName>
<ForeName>Andrómeda</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>University Center for Biomedical Research, National Council of Science and Technology (CONACYT)-University of Colima, Colima, Colima, Mexico.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>García-Rodríguez</LastName>
<ForeName>Daniel Alejandro</ForeName>
<Initials>DA</Initials>
<AffiliationInfo><Affiliation>Laboratory of Agrobiotechnology, University of Colima, Colima, Colima, Mexico.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Centeno-Leija</LastName>
<ForeName>Sara</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Laboratory of Agrobiotechnology, National Council of Science and Technology (CONACYT)-University of Colima, Colima, Colima, Mexico.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Serrano-Posada</LastName>
<ForeName>Hugo</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Laboratory of Agrobiotechnology, National Council of Science and Technology (CONACYT)-University of Colima, Colima, Colima, Mexico.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>APN-2015-01-741 to Yair Cárdenas-Conejo</GrantID>
<Agency>Consejo Nacional de Ciencia y Tecnología</Agency>
<Country></Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>03</Month>
<Day>13</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>J Med Virol</MedlineTA>
<NlmUniqueID>7705876</NlmUniqueID>
<ISSNLinking>0146-6615</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">SARS</Keyword>
<Keyword MajorTopicYN="N">SARS-CoV-2</Keyword>
<Keyword MajorTopicYN="N">Wuhan</Keyword>
<Keyword MajorTopicYN="N">coronavirus</Keyword>
<Keyword MajorTopicYN="N">pp1ab protein</Keyword>
<Keyword MajorTopicYN="N">virus</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year>
<Month>02</Month>
<Day>26</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>03</Month>
<Day>09</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>3</Month>
<Day>14</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>3</Month>
<Day>14</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>3</Month>
<Day>14</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>aheadofprint</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">32167166</ArticleId>
<ArticleId IdType="doi">10.1002/jmv.25758</ArticleId>
</ArticleIdList>
<ReferenceList><Title>REFERENCES</Title>
<Reference><Citation>Wu F, Zhao S, Yu B, et al. A new coronavirus associated with human respiratory disease in China. Nature. 2020;579:265-269. https://doi.org/10.1038/s41586-020-2008-3</Citation>
</Reference>
<Reference><Citation>Ji W, Wang W, Zhao X, Zai J, Li X. Homologous recombination within the spike glycoprotein of the newly identified coronavirus may boost cross-species transmission from snake to human. J Med Virol. 2020;92:433-440. https://doi.org/10.1002/jmv.25682</Citation>
</Reference>
<Reference><Citation>Chan JF-W, Kok K-H, Zhu Z, et al. Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. Emerg Microbes Infect. 2020;9:221-236. https://doi.org/10.1080/22221751.2020.1719902</Citation>
</Reference>
<Reference><Citation>Zhu N, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382:727-733. https://doi.org/10.1056/NEJMoa2001017</Citation>
</Reference>
<Reference><Citation>Lu R, Zhao X, Li J, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2020;395:565-574. https://doi.org/10.1016/S0140-6736(20)30251-8</Citation>
</Reference>
<Reference><Citation>Zhou P, Yang X-L, Wang X-G, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;579:270-273. https://doi.org/10.1038/s41586-020-2012-7</Citation>
</Reference>
<Reference><Citation>Báez-Santos YM St., John SE, Mesecar AD. The SARS-coronavirus papain-like protease: structure, function, and inhibition by designed antiviral compounds. Antiviral Res. Elsevier B.V. 115, 2020:21-38. https://doi.org/10.1016/j.antiviral.2014.12.015</Citation>
</Reference>
<Reference><Citation>Argüello-Astorga G, Herrera-Estrella L. Evolution of light-regulated plant promoters. Annu Rev Plant Physiol Plant Mol Biol. 1998;9:525-555. https://doi.org/10.1146/annurev.arplant.49.1.525</Citation>
</Reference>
<Reference><Citation>Hagemeijer MC, Rottier PJM, Haan CAM. Biogenesis and dynamics of the coronavirus replicative structures. Viruses. 2012;4:3245-3269. https://doi.org/10.3390/v4113245</Citation>
</Reference>
<Reference><Citation>Züst R, Cervantes-Barragán L, Kuri T, et al. Coronavirus non-structural protein 1 Is a major pathogenicity factor: implications for the rational design of coronavirus vaccines. PLoS Pathog. 2007;3:e109. https://doi.org/10.1371/journal.ppat.0030109</Citation>
</Reference>
<Reference><Citation>Serrano P, Johnson MA, Almeida MS, et al. Nuclear magnetic resonance structure of the N-terminal domain of nonstructural protein 3 from the severe acute respiratory syndrome coronavirus. J Virol. 2007;81:12049-12060. https://doi.org/10.1128/JVI.00969-07</Citation>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Mexique</li>
</country>
</list>
<tree><country name="Mexique"><noRegion><name sortKey="Cardenas Conejo, Yair" sort="Cardenas Conejo, Yair" uniqKey="Cardenas Conejo Y" first="Yair" last="Cárdenas-Conejo">Yair Cárdenas-Conejo</name>
</noRegion>
<name sortKey="Centeno Leija, Sara" sort="Centeno Leija, Sara" uniqKey="Centeno Leija S" first="Sara" last="Centeno-Leija">Sara Centeno-Leija</name>
<name sortKey="Garcia Rodriguez, Daniel Alejandro" sort="Garcia Rodriguez, Daniel Alejandro" uniqKey="Garcia Rodriguez D" first="Daniel Alejandro" last="García-Rodríguez">Daniel Alejandro García-Rodríguez</name>
<name sortKey="Li An Rico, Andr Meda" sort="Li An Rico, Andr Meda" uniqKey="Li An Rico A" first="Andr Meda" last="Li An-Rico">Andr Meda Li An-Rico</name>
<name sortKey="Serrano Posada, Hugo" sort="Serrano Posada, Hugo" uniqKey="Serrano Posada H" first="Hugo" last="Serrano-Posada">Hugo Serrano-Posada</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003368 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 003368 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= Ncbi |étape= Merge |type= RBID |clé= pubmed:32167166 |texte= An exclusive 42 amino acid signature in pp1ab protein provides insights into the evolutive history of the 2019 novel human-pathogenic coronavirus (SARS-CoV-2). }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:32167166" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \ | NlmPubMed2Wicri -a SrasV1
This area was generated with Dilib version V0.6.33. |