Escalating infection control response to the rapidly evolving epidemiology of the coronavirus disease 2019 (COVID-19) due to SARS-CoV-2 in Hong Kong
Identifieur interne : 003292 ( Ncbi/Merge ); précédent : 003291; suivant : 003293Escalating infection control response to the rapidly evolving epidemiology of the coronavirus disease 2019 (COVID-19) due to SARS-CoV-2 in Hong Kong
Auteurs : Vincent C. C. Cheng [République populaire de Chine] ; Shuk-Ching Wong [République populaire de Chine] ; Jonathan H. K. Chen [République populaire de Chine] ; Cyril C. Y. Yip [République populaire de Chine] ; Vivien W. M. Chuang [République populaire de Chine] ; Owen T. Y. Tsang [République populaire de Chine] ; Siddharth Sridhar [République populaire de Chine] ; Jasper F. W. Chan [République populaire de Chine] ; Pak-Leung Ho [République populaire de Chine] ; Kwok-Yung Yuen [République populaire de Chine]Source :
- Infection Control and Hospital Epidemiology [ 0899-823X ] ; ????.
Abstract
To describe the infection control preparedness measures undertaken for coronavirus disease (COVID-19) due to SARS-CoV-2 (previously known as 2019 novel coronavirus) in the first 42 days after announcement of a cluster of pneumonia in China, on December 31, 2019 (day 1) in Hong Kong.
A bundled approach of active and enhanced laboratory surveillance, early airborne infection isolation, rapid molecular diagnostic testing, and contact tracing for healthcare workers (HCWs) with unprotected exposure in the hospitals was implemented. Epidemiological characteristics of confirmed cases, environmental samples, and air samples were collected and analyzed.
From day 1 to day 42, 42 of 1,275 patients (3.3%) fulfilling active (n = 29) and enhanced laboratory surveillance (n = 13) were confirmed to have the SARS-CoV-2 infection. The number of locally acquired case significantly increased from 1 of 13 confirmed cases (7.7%, day 22 to day 32) to 27 of 29 confirmed cases (93.1%, day 33 to day 42;
Appropriate hospital infection control measures was able to prevent nosocomial transmission of SARS-CoV-2.
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DOI: 10.1017/ice.2020.58
PubMed: 32131908
PubMed Central: 7137535
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Cheng</name><affiliation wicri:level="1"><nlm:aff id="a1">Department of Microbiology,<institution>Queen Mary Hospital</institution>,<city>Hong Kong Special Administrative Region</city>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2">Infection Control Team,<institution>Queen Mary Hospital</institution>, Hong Kong West Cluster,<city>Hong Kong Special Administrative Region</city>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wong, Shuk Ching" sort="Wong, Shuk Ching" uniqKey="Wong S" first="Shuk-Ching" last="Wong">Shuk-Ching Wong</name><affiliation wicri:level="1"><nlm:aff id="a2">Infection Control Team,<institution>Queen Mary Hospital</institution>, Hong Kong West Cluster,<city>Hong Kong Special Administrative Region</city>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Jonathan H K" sort="Chen, Jonathan H K" uniqKey="Chen J" first="Jonathan H. K." last="Chen">Jonathan H. K. Chen</name><affiliation wicri:level="1"><nlm:aff id="a1">Department of Microbiology,<institution>Queen Mary Hospital</institution>,<city>Hong Kong Special Administrative Region</city>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yip, Cyril C Y" sort="Yip, Cyril C Y" uniqKey="Yip C" first="Cyril C. Y." last="Yip">Cyril C. Y. Yip</name><affiliation wicri:level="1"><nlm:aff id="a1">Department of Microbiology,<institution>Queen Mary Hospital</institution>,<city>Hong Kong Special Administrative Region</city>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chuang, Vivien W M" sort="Chuang, Vivien W M" uniqKey="Chuang V" first="Vivien W. M." last="Chuang">Vivien W. M. Chuang</name><affiliation wicri:level="1"><nlm:aff id="a3">Quality & Safety Division (Infection, Emergency, and Contingency),<institution>Hospital Authority</institution>,<city>Hong Kong Special Administrative Region</city>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tsang, Owen T Y" sort="Tsang, Owen T Y" uniqKey="Tsang O" first="Owen T. Y." last="Tsang">Owen T. Y. Tsang</name><affiliation wicri:level="1"><nlm:aff id="a4">Infectious Disease Center,<institution>Hospital Authority</institution>,<city>Hong Kong Special Administrative Region</city>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sridhar, Siddharth" sort="Sridhar, Siddharth" uniqKey="Sridhar S" first="Siddharth" last="Sridhar">Siddharth Sridhar</name><affiliation wicri:level="1"><nlm:aff id="a5">Department of Microbiology, Li Ka Shing Faculty of Medicine,<institution>The University of Hong Kong</institution>,<city>Hong Kong Special Administrative Region</city>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chan, Jasper F W" sort="Chan, Jasper F W" uniqKey="Chan J" first="Jasper F. W." last="Chan">Jasper F. W. Chan</name><affiliation wicri:level="1"><nlm:aff id="a5">Department of Microbiology, Li Ka Shing Faculty of Medicine,<institution>The University of Hong Kong</institution>,<city>Hong Kong Special Administrative Region</city>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ho, Pak Leung" sort="Ho, Pak Leung" uniqKey="Ho P" first="Pak-Leung" last="Ho">Pak-Leung Ho</name><affiliation wicri:level="1"><nlm:aff id="a5">Department of Microbiology, Li Ka Shing Faculty of Medicine,<institution>The University of Hong Kong</institution>,<city>Hong Kong Special Administrative Region</city>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name><affiliation wicri:level="1"><nlm:aff id="a5">Department of Microbiology, Li Ka Shing Faculty of Medicine,<institution>The University of Hong Kong</institution>,<city>Hong Kong Special Administrative Region</city>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32131908</idno><idno type="pmc">7137535</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137535</idno><idno type="RBID">PMC:7137535</idno><idno type="doi">10.1017/ice.2020.58</idno><date when="????">????</date><idno type="wicri:Area/Pmc/Corpus">001052</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001052</idno><idno type="wicri:Area/Pmc/Curation">001052</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001052</idno><idno type="wicri:Area/Pmc/Checkpoint">001954</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001954</idno><idno type="wicri:Area/Ncbi/Merge">003292</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Escalating infection control response to the rapidly evolving epidemiology of the coronavirus disease 2019 (COVID-19) due to SARS-CoV-2 in Hong Kong</title><author><name sortKey="Cheng, Vincent C C" sort="Cheng, Vincent C C" uniqKey="Cheng V" first="Vincent C. C." last="Cheng">Vincent C. C. Cheng</name><affiliation wicri:level="1"><nlm:aff id="a1">Department of Microbiology,<institution>Queen Mary Hospital</institution>,<city>Hong Kong Special Administrative Region</city>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2">Infection Control Team,<institution>Queen Mary Hospital</institution>, Hong Kong West Cluster,<city>Hong Kong Special Administrative Region</city>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wong, Shuk Ching" sort="Wong, Shuk Ching" uniqKey="Wong S" first="Shuk-Ching" last="Wong">Shuk-Ching Wong</name><affiliation wicri:level="1"><nlm:aff id="a2">Infection Control Team,<institution>Queen Mary Hospital</institution>, Hong Kong West Cluster,<city>Hong Kong Special Administrative Region</city>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Jonathan H K" sort="Chen, Jonathan H K" uniqKey="Chen J" first="Jonathan H. K." last="Chen">Jonathan H. K. Chen</name><affiliation wicri:level="1"><nlm:aff id="a1">Department of Microbiology,<institution>Queen Mary Hospital</institution>,<city>Hong Kong Special Administrative Region</city>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yip, Cyril C Y" sort="Yip, Cyril C Y" uniqKey="Yip C" first="Cyril C. Y." last="Yip">Cyril C. Y. Yip</name><affiliation wicri:level="1"><nlm:aff id="a1">Department of Microbiology,<institution>Queen Mary Hospital</institution>,<city>Hong Kong Special Administrative Region</city>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chuang, Vivien W M" sort="Chuang, Vivien W M" uniqKey="Chuang V" first="Vivien W. M." last="Chuang">Vivien W. M. Chuang</name><affiliation wicri:level="1"><nlm:aff id="a3">Quality & Safety Division (Infection, Emergency, and Contingency),<institution>Hospital Authority</institution>,<city>Hong Kong Special Administrative Region</city>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tsang, Owen T Y" sort="Tsang, Owen T Y" uniqKey="Tsang O" first="Owen T. Y." last="Tsang">Owen T. Y. Tsang</name><affiliation wicri:level="1"><nlm:aff id="a4">Infectious Disease Center,<institution>Hospital Authority</institution>,<city>Hong Kong Special Administrative Region</city>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sridhar, Siddharth" sort="Sridhar, Siddharth" uniqKey="Sridhar S" first="Siddharth" last="Sridhar">Siddharth Sridhar</name><affiliation wicri:level="1"><nlm:aff id="a5">Department of Microbiology, Li Ka Shing Faculty of Medicine,<institution>The University of Hong Kong</institution>,<city>Hong Kong Special Administrative Region</city>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chan, Jasper F W" sort="Chan, Jasper F W" uniqKey="Chan J" first="Jasper F. W." last="Chan">Jasper F. W. Chan</name><affiliation wicri:level="1"><nlm:aff id="a5">Department of Microbiology, Li Ka Shing Faculty of Medicine,<institution>The University of Hong Kong</institution>,<city>Hong Kong Special Administrative Region</city>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ho, Pak Leung" sort="Ho, Pak Leung" uniqKey="Ho P" first="Pak-Leung" last="Ho">Pak-Leung Ho</name><affiliation wicri:level="1"><nlm:aff id="a5">Department of Microbiology, Li Ka Shing Faculty of Medicine,<institution>The University of Hong Kong</institution>,<city>Hong Kong Special Administrative Region</city>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name><affiliation wicri:level="1"><nlm:aff id="a5">Department of Microbiology, Li Ka Shing Faculty of Medicine,<institution>The University of Hong Kong</institution>,<city>Hong Kong Special Administrative Region</city>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Infection Control and Hospital Epidemiology</title><idno type="ISSN">0899-823X</idno><idno type="eISSN">1559-6834</idno><imprint><date when="????">????</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="as1"><title>Objective:</title><p>To describe the infection control preparedness measures undertaken for coronavirus disease (COVID-19) due to SARS-CoV-2 (previously known as 2019 novel coronavirus) in the first 42 days after announcement of a cluster of pneumonia in China, on December 31, 2019 (day 1) in Hong Kong.</p></sec><sec id="as2"><title>Methods:</title><p>A bundled approach of active and enhanced laboratory surveillance, early airborne infection isolation, rapid molecular diagnostic testing, and contact tracing for healthcare workers (HCWs) with unprotected exposure in the hospitals was implemented. Epidemiological characteristics of confirmed cases, environmental samples, and air samples were collected and analyzed.</p></sec><sec id="as3"><title>Results:</title><p>From day 1 to day 42, 42 of 1,275 patients (3.3%) fulfilling active (n = 29) and enhanced laboratory surveillance (n = 13) were confirmed to have the SARS-CoV-2 infection. The number of locally acquired case significantly increased from 1 of 13 confirmed cases (7.7%, day 22 to day 32) to 27 of 29 confirmed cases (93.1%, day 33 to day 42; <italic>P</italic> < .001). Among them, 28 patients (66.6%) came from 8 family clusters. Of 413 HCWs caring for these confirmed cases, 11 (2.7%) had unprotected exposure requiring quarantine for 14 days. None of these was infected, and nosocomial transmission of SARS-CoV-2 was not observed. Environmental surveillance was performed in the room of a patient with viral load of 3.3 × 10<sup>6</sup> copies/mL (pooled nasopharyngeal and throat swabs) and 5.9 × 10<sup>6</sup> copies/mL (saliva), respectively. SARS-CoV-2 was identified in 1 of 13 environmental samples (7.7%) but not in 8 air samples collected at a distance of 10 cm from the patient’s chin with or without wearing a surgical mask.</p></sec><sec id="as4"><title>Conclusion:</title><p>Appropriate hospital infection control measures was able to prevent nosocomial transmission of SARS-CoV-2.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Infect Control Hosp Epidemiol</journal-id><journal-id journal-id-type="iso-abbrev">Infect Control Hosp Epidemiol</journal-id><journal-id journal-id-type="publisher-id">ICE</journal-id><journal-title-group><journal-title>Infection Control and Hospital Epidemiology</journal-title></journal-title-group><issn pub-type="ppub">0899-823X</issn><issn pub-type="epub">1559-6834</issn><publisher><publisher-name>Cambridge University Press</publisher-name><publisher-loc>New York, USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">32131908</article-id><article-id pub-id-type="pmc">7137535</article-id><article-id pub-id-type="doi">10.1017/ice.2020.58</article-id><article-id pub-id-type="publisher-id">S0899823X20000586</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Escalating infection control response to the rapidly evolving epidemiology of the coronavirus disease 2019 (COVID-19) due to SARS-CoV-2 in Hong Kong</article-title></title-group><contrib-group><contrib contrib-type="author" equal-contrib="yes"><name><surname>Cheng</surname><given-names>Vincent C. C.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="a1"><sup>1</sup></xref><xref ref-type="aff" rid="a2"><sup>2</sup></xref><xref ref-type="author-notes" rid="afn1"><sup>a</sup></xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name><surname>Wong</surname><given-names>Shuk-Ching</given-names></name><degrees>MNurs</degrees><xref ref-type="aff" rid="a2"><sup>2</sup></xref><xref ref-type="author-notes" rid="afn1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Jonathan H. K.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="a1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Yip</surname><given-names>Cyril C. Y.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="a1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Chuang</surname><given-names>Vivien W. M.</given-names></name><degrees>FRCPath</degrees><xref ref-type="aff" rid="a3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tsang</surname><given-names>Owen T. Y.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="a4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sridhar</surname><given-names>Siddharth</given-names></name><degrees>FRCPath</degrees><xref ref-type="aff" rid="a5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Chan</surname><given-names>Jasper F. W.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="a5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ho</surname><given-names>Pak-Leung</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="a5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Yuen</surname><given-names>Kwok-Yung</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="a5"><sup>5</sup></xref><xref ref-type="corresp" rid="cor1"></xref></contrib></contrib-group><aff id="a1"><label>1</label>Department of Microbiology,<institution>Queen Mary Hospital</institution>,<city>Hong Kong Special Administrative Region</city>,<country>China</country></aff><aff id="a2"><label>2</label>Infection Control Team,<institution>Queen Mary Hospital</institution>, Hong Kong West Cluster,<city>Hong Kong Special Administrative Region</city>,<country>China</country></aff><aff id="a3"><label>3</label>Quality & Safety Division (Infection, Emergency, and Contingency),<institution>Hospital Authority</institution>,<city>Hong Kong Special Administrative Region</city>,<country>China</country></aff><aff id="a4"><label>4</label>Infectious Disease Center,<institution>Hospital Authority</institution>,<city>Hong Kong Special Administrative Region</city>,<country>China</country></aff><aff id="a5"><label>5</label>Department of Microbiology, Li Ka Shing Faculty of Medicine,<institution>The University of Hong Kong</institution>,<city>Hong Kong Special Administrative Region</city>,<country>China</country></aff><author-notes><corresp id="cor1"><bold>Author for correspondence:</bold> Kwok-Yung Yuen, E-mail: <email>kyyuen@hku.hk</email></corresp><fn id="afn1" fn-type="other"><label>a</label><p>Authors of equal contribution.</p></fn></author-notes><pub-date publication-format="electronic" date-type="pub"><day>05</day><month>3</month><year>2020</year></pub-date><fpage>1</fpage><lpage>6</lpage><history><date date-type="received"><day>14</day><month>2</month><year>2020</year></date><date date-type="rev-recd"><day>18</day><month>2</month><year>2020</year></date><date date-type="accepted"><day>22</day><month>2</month><year>2020</year></date></history><permissions><copyright-statement>© The Society for Healthcare Epidemiology of America 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder>The Society for Healthcare Epidemiology of America</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (<uri xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</uri>), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><self-uri xlink:title="pdf" xlink:href="S0899823X20000586a.pdf"></self-uri><abstract abstract-type="normal"><sec id="as1"><title>Objective:</title><p>To describe the infection control preparedness measures undertaken for coronavirus disease (COVID-19) due to SARS-CoV-2 (previously known as 2019 novel coronavirus) in the first 42 days after announcement of a cluster of pneumonia in China, on December 31, 2019 (day 1) in Hong Kong.</p></sec><sec id="as2"><title>Methods:</title><p>A bundled approach of active and enhanced laboratory surveillance, early airborne infection isolation, rapid molecular diagnostic testing, and contact tracing for healthcare workers (HCWs) with unprotected exposure in the hospitals was implemented. Epidemiological characteristics of confirmed cases, environmental samples, and air samples were collected and analyzed.</p></sec><sec id="as3"><title>Results:</title><p>From day 1 to day 42, 42 of 1,275 patients (3.3%) fulfilling active (n = 29) and enhanced laboratory surveillance (n = 13) were confirmed to have the SARS-CoV-2 infection. The number of locally acquired case significantly increased from 1 of 13 confirmed cases (7.7%, day 22 to day 32) to 27 of 29 confirmed cases (93.1%, day 33 to day 42; <italic>P</italic> < .001). Among them, 28 patients (66.6%) came from 8 family clusters. Of 413 HCWs caring for these confirmed cases, 11 (2.7%) had unprotected exposure requiring quarantine for 14 days. None of these was infected, and nosocomial transmission of SARS-CoV-2 was not observed. Environmental surveillance was performed in the room of a patient with viral load of 3.3 × 10<sup>6</sup> copies/mL (pooled nasopharyngeal and throat swabs) and 5.9 × 10<sup>6</sup> copies/mL (saliva), respectively. SARS-CoV-2 was identified in 1 of 13 environmental samples (7.7%) but not in 8 air samples collected at a distance of 10 cm from the patient’s chin with or without wearing a surgical mask.</p></sec><sec id="as4"><title>Conclusion:</title><p>Appropriate hospital infection control measures was able to prevent nosocomial transmission of SARS-CoV-2.</p></sec></abstract><counts><fig-count count="1"></fig-count><table-count count="2"></table-count><ref-count count="30"></ref-count><page-count count="6"></page-count></counts></article-meta></front></pmc><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Cheng, Vincent C C" sort="Cheng, Vincent C C" uniqKey="Cheng V" first="Vincent C. C." last="Cheng">Vincent C. C. Cheng</name></noRegion><name sortKey="Chan, Jasper F W" sort="Chan, Jasper F W" uniqKey="Chan J" first="Jasper F. W." last="Chan">Jasper F. W. Chan</name><name sortKey="Chen, Jonathan H K" sort="Chen, Jonathan H K" uniqKey="Chen J" first="Jonathan H. K." last="Chen">Jonathan H. K. Chen</name><name sortKey="Cheng, Vincent C C" sort="Cheng, Vincent C C" uniqKey="Cheng V" first="Vincent C. C." last="Cheng">Vincent C. C. Cheng</name><name sortKey="Chuang, Vivien W M" sort="Chuang, Vivien W M" uniqKey="Chuang V" first="Vivien W. M." last="Chuang">Vivien W. M. Chuang</name><name sortKey="Ho, Pak Leung" sort="Ho, Pak Leung" uniqKey="Ho P" first="Pak-Leung" last="Ho">Pak-Leung Ho</name><name sortKey="Sridhar, Siddharth" sort="Sridhar, Siddharth" uniqKey="Sridhar S" first="Siddharth" last="Sridhar">Siddharth Sridhar</name><name sortKey="Tsang, Owen T Y" sort="Tsang, Owen T Y" uniqKey="Tsang O" first="Owen T. Y." last="Tsang">Owen T. Y. Tsang</name><name sortKey="Wong, Shuk Ching" sort="Wong, Shuk Ching" uniqKey="Wong S" first="Shuk-Ching" last="Wong">Shuk-Ching Wong</name><name sortKey="Yip, Cyril C Y" sort="Yip, Cyril C Y" uniqKey="Yip C" first="Cyril C. Y." last="Yip">Cyril C. Y. Yip</name><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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