Renin-Angiotensin System Inhibition in Cardiovascular Patients at the Time of COVID19: Much Ado for Nothing? A Statement of Activity from the Directors of the Board and the Scientific Directors of the Italian Society of Hypertension
Identifieur interne : 003117 ( Ncbi/Merge ); précédent : 003116; suivant : 003118Renin-Angiotensin System Inhibition in Cardiovascular Patients at the Time of COVID19: Much Ado for Nothing? A Statement of Activity from the Directors of the Board and the Scientific Directors of the Italian Society of Hypertension
Auteurs : Guido Iaccarino [Italie] ; Claudio Borghi [Italie] ; Arrigo F. G. Cicero [Italie] ; Claudio Ferri [Italie] ; Pietro Minuz [Italie] ; Maria Lorenza Muiesan [Italie] ; Paolo Mulatero [Italie] ; Giuseppe Mulè [Italie] ; Giacomo Pucci [Italie] ; Massimo Salvetti [Italie] ; Carmine Savoia [Italie] ; Leonardo Alberto Sechi [Italie] ; Massimo Volpe [Italie] ; Guido Grassi [Italie]Source :
- High Blood Pressure & Cardiovascular Prevention [ 1120-9879 ] ; 2020.
Abstract
Cardiovascular diseases, in particular hypertension, as well as the cardiovascular treatment with Renin–Angiotensin System inhibitors such as Angiotensin Converting Enzyme (ACE) inhibitors and Angiotensin Receptor Blockers (ARBs), are claimed once again as mechanisms of Severe Acute Respiratory Syndrome (SARS) during the COVID-19 outbreak due to Cov-2 epidemics. In vitro studies are available to support the eventual role of ACE inhibitors and ARBs in both the promotion and antagonism of the disease. The available literature, indeed, presents contrasting results, all concentrated in experimental models. Evidence in humans is lacking that those mechanisms are actually occurring in the present COVID-19 outbreak. Here we present the reasoned statement of the Italian Society of Hypertension to maintain ongoing antihypertensive treatments. Furthermore, the Italian Society of Hypertension presents its own initiative to investigate the issue using an online questionnaire to collect relevant data in human disease.
Url:
DOI: 10.1007/s40292-020-00380-3
PubMed: 31925708
PubMed Central: 7138256
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xml:lang="fr">Italie</country><wicri:regionArea>Milan</wicri:regionArea></affiliation></author></analytic><series><title level="j">High Blood Pressure & Cardiovascular Prevention</title><idno type="ISSN">1120-9879</idno><idno type="eISSN">1179-1985</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">Cardiovascular diseases, in particular hypertension, as well as the cardiovascular treatment with Renin–Angiotensin System inhibitors such as Angiotensin Converting Enzyme (ACE) inhibitors and Angiotensin Receptor Blockers (ARBs), are claimed once again as mechanisms of Severe Acute Respiratory Syndrome (SARS) during the COVID-19 outbreak due to Cov-2 epidemics. In vitro studies are available to support the eventual role of ACE inhibitors and ARBs in both the promotion and antagonism of the disease. The available literature, indeed, presents contrasting results, all concentrated in experimental models. Evidence in humans is lacking that those mechanisms are actually occurring in the present COVID-19 outbreak. Here we present the reasoned statement of the Italian Society of Hypertension to maintain ongoing antihypertensive treatments. Furthermore, the Italian Society of Hypertension presents its own initiative to investigate the issue using an online questionnaire to collect relevant data in human disease.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Assiri, A" uniqKey="Assiri A">A Assiri</name></author><author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name></author><author><name sortKey="Al Rabeeah, Aa" uniqKey="Al Rabeeah A">AA Al-Rabeeah</name></author><author><name sortKey="Al Rabiah, Fa" uniqKey="Al Rabiah F">FA Al-Rabiah</name></author><author><name sortKey="Al Hajjar, S" uniqKey="Al Hajjar S">S Al-Hajjar</name></author><author><name sortKey="Al Barrak, A" uniqKey="Al Barrak A">A Al-Barrak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leung, Gm" uniqKey="Leung G">GM Leung</name></author><author><name sortKey="Hedley, Aj" uniqKey="Hedley A">AJ Hedley</name></author><author><name sortKey="Ho, Lm" uniqKey="Ho L">LM Ho</name></author><author><name sortKey="Chau, P" uniqKey="Chau P">P Chau</name></author><author><name sortKey="Wong, Io" uniqKey="Wong I">IO Wong</name></author><author><name sortKey="Thach, Tq" uniqKey="Thach T">TQ Thach</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Menachery, Vd" uniqKey="Menachery V">VD Menachery</name></author><author><name sortKey="Yount, Bl" uniqKey="Yount B">BL Yount</name></author><author><name sortKey="Debbink, K" uniqKey="Debbink K">K Debbink</name></author><author><name sortKey="Agnihothram, S" uniqKey="Agnihothram S">S Agnihothram</name></author><author><name sortKey="Gralinski, Le" uniqKey="Gralinski L">LE Gralinski</name></author><author><name sortKey="Plante, Ja" uniqKey="Plante J">JA Plante</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zisman, Ls" uniqKey="Zisman L">LS Zisman</name></author><author><name sortKey="Meixell, Ge" uniqKey="Meixell G">GE Meixell</name></author><author><name sortKey="Bristow, Mr" uniqKey="Bristow M">MR Bristow</name></author><author><name sortKey="Canver, Cc" uniqKey="Canver C">CC Canver</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ferrario, Cm" uniqKey="Ferrario C">CM Ferrario</name></author><author><name sortKey="Jessup, J" uniqKey="Jessup J">J Jessup</name></author><author><name sortKey="Chappell, Mc" uniqKey="Chappell M">MC Chappell</name></author><author><name sortKey="Averill, Db" uniqKey="Averill D">DB Averill</name></author><author><name sortKey="Brosnihan, Kb" uniqKey="Brosnihan K">KB Brosnihan</name></author><author><name sortKey="Tallant, Ea" uniqKey="Tallant E">EA Tallant</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, N" uniqKey="Chen N">N Chen</name></author><author><name sortKey="Zhou, M" uniqKey="Zhou M">M Zhou</name></author><author><name sortKey="Dong, X" uniqKey="Dong X">X Dong</name></author><author><name sortKey="Qu, J" uniqKey="Qu J">J Qu</name></author><author><name sortKey="Gong, F" uniqKey="Gong F">F Gong</name></author><author><name sortKey="Han, Y" uniqKey="Han Y">Y Han</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Onder, G" uniqKey="Onder G">G Onder</name></author><author><name sortKey="Rezza, G" uniqKey="Rezza G">G Rezza</name></author><author><name sortKey="Brusaferro, S" uniqKey="Brusaferro S">S Brusaferro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clerkin, Kj" uniqKey="Clerkin K">KJ Clerkin</name></author><author><name sortKey="Fried, Ja" uniqKey="Fried J">JA Fried</name></author><author><name sortKey="Raikhelkar, J" uniqKey="Raikhelkar J">J Raikhelkar</name></author><author><name sortKey="Sayer, G" uniqKey="Sayer G">G Sayer</name></author><author><name sortKey="Griffin, Jm" uniqKey="Griffin J">JM Griffin</name></author><author><name sortKey="Masoumi, A" uniqKey="Masoumi A">A Masoumi</name></author><author><name sortKey="Disease, Coronavirus" uniqKey="Disease C">Coronavirus Disease</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Danser, Ahj" uniqKey="Danser A">AHJ Danser</name></author><author><name sortKey="Epstein, M" uniqKey="Epstein M">M Epstein</name></author><author><name sortKey="Batlle, D" uniqKey="Batlle D">D Batlle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hanff, Tc" uniqKey="Hanff T">TC Hanff</name></author><author><name sortKey="Harhay, Mo" uniqKey="Harhay M">MO Harhay</name></author><author><name sortKey="Brown, Ts" uniqKey="Brown T">TS Brown</name></author><author><name sortKey="Cohen, Jb" uniqKey="Cohen J">JB Cohen</name></author><author><name sortKey="Mohareb, Am" uniqKey="Mohareb A">AM Mohareb</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Glowacka, I" uniqKey="Glowacka I">I Glowacka</name></author><author><name sortKey="Bertram, S" uniqKey="Bertram S">S Bertram</name></author><author><name sortKey="Herzog, P" uniqKey="Herzog P">P Herzog</name></author><author><name sortKey="Pfefferle, S" uniqKey="Pfefferle S">S Pfefferle</name></author><author><name sortKey="Steffen, I" uniqKey="Steffen I">I Steffen</name></author><author><name sortKey="Muench, Mo" uniqKey="Muench M">MO Muench</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Imai, Y" uniqKey="Imai Y">Y Imai</name></author><author><name sortKey="Kuba, K" uniqKey="Kuba K">K Kuba</name></author><author><name sortKey="Rao, S" uniqKey="Rao S">S Rao</name></author><author><name sortKey="Huan, Y" uniqKey="Huan Y">Y Huan</name></author><author><name sortKey="Guo, F" uniqKey="Guo F">F Guo</name></author><author><name sortKey="Guan, B" uniqKey="Guan B">B Guan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gurwitz, D" uniqKey="Gurwitz D">D Gurwitz</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">High Blood Press Cardiovasc Prev</journal-id><journal-id journal-id-type="iso-abbrev">High Blood Press Cardiovasc Prev</journal-id><journal-title-group><journal-title>High Blood Pressure & Cardiovascular Prevention</journal-title></journal-title-group><issn pub-type="ppub">1120-9879</issn><issn pub-type="epub">1179-1985</issn><publisher><publisher-name>Springer International Publishing</publisher-name><publisher-loc>Cham</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31925708</article-id><article-id pub-id-type="pmc">7138256</article-id><article-id pub-id-type="publisher-id">380</article-id><article-id pub-id-type="doi">10.1007/s40292-020-00380-3</article-id><article-categories><subj-group subj-group-type="heading"><subject>Clinical Guidelines and Practice Recommendations</subject></subj-group></article-categories><title-group><article-title>Renin-Angiotensin System Inhibition in Cardiovascular Patients at the Time of COVID19: Much Ado for Nothing? A Statement of Activity from the Directors of the Board and the Scientific Directors of the Italian Society of Hypertension</article-title></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-8997-835X</contrib-id><name><surname>Iaccarino</surname><given-names>Guido</given-names></name><address><email>guiaccar@unina.it</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0001-8039-8781</contrib-id><name><surname>Borghi</surname><given-names>Claudio</given-names></name><address><email>claudio.borghi@unibo.it</email></address><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-4367-3884</contrib-id><name><surname>Cicero</surname><given-names>Arrigo F. G.</given-names></name><address><email>arrrigo.cicero@unibo.it</email></address><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Ferri</surname><given-names>Claudio</given-names></name><address><email>claudio.ferri@cc.univaq.it</email></address><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Minuz</surname><given-names>Pietro</given-names></name><address><email>pietro.minuz@univr.it</email></address><xref ref-type="aff" rid="Aff4">4</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-4007-9441</contrib-id><name><surname>Muiesan</surname><given-names>Maria Lorenza</given-names></name><address><email>marialorenza.muiesan@unibs.it</email></address><xref ref-type="aff" rid="Aff5">5</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-5480-1116</contrib-id><name><surname>Mulatero</surname><given-names>Paolo</given-names></name><address><email>paolo.mulatero@unito.it</email></address><xref ref-type="aff" rid="Aff6">6</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-8500-8671</contrib-id><name><surname>Mulè</surname><given-names>Giuseppe</given-names></name><address><email>giuseppe.mule@unipa.it</email></address><xref ref-type="aff" rid="Aff7">7</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0003-0180-859X</contrib-id><name><surname>Pucci</surname><given-names>Giacomo</given-names></name><address><email>giacomo.pucci@gmail.com</email></address><xref ref-type="aff" rid="Aff8">8</xref></contrib><contrib contrib-type="author"><name><surname>Salvetti</surname><given-names>Massimo</given-names></name><address><email>massimo.salvetti@unibs.it</email></address><xref ref-type="aff" rid="Aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Savoia</surname><given-names>Carmine</given-names></name><address><email>carmine.savoia@uniroma1.it</email></address><xref ref-type="aff" rid="Aff9">9</xref></contrib><contrib contrib-type="author"><name><surname>Sechi</surname><given-names>Leonardo Alberto</given-names></name><address><email>sechi@uniud.it</email></address><xref ref-type="aff" rid="Aff10">10</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-9642-8380</contrib-id><name><surname>Volpe</surname><given-names>Massimo</given-names></name><address><email>massimo.volpe@uniroma1.it</email></address><xref ref-type="aff" rid="Aff11">11</xref><xref ref-type="aff" rid="Aff12">12</xref></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0003-1922-6547</contrib-id><name><surname>Grassi</surname><given-names>Guido</given-names></name><address><email>guido.grassi@unimib.it</email></address><xref ref-type="aff" rid="Aff13">13</xref></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="GRID">grid.4691.a</institution-id><institution-id institution-id-type="ISNI">0000 0001 0790 385X</institution-id><institution>Department of Advanced Biomedical Sciences,</institution><institution>Federico II University,</institution></institution-wrap>Naples, Italy</aff><aff id="Aff2"><label>2</label><institution-wrap><institution-id institution-id-type="GRID">grid.6292.f</institution-id><institution-id institution-id-type="ISNI">0000 0004 1757 1758</institution-id><institution>Department of Medicine and Surgery Sciences,</institution><institution>Alma Mater Studiorum University of Bologna,</institution></institution-wrap>Bologna, Italy</aff><aff id="Aff3"><label>3</label><institution-wrap><institution-id institution-id-type="GRID">grid.158820.6</institution-id><institution-id institution-id-type="ISNI">0000 0004 1757 2611</institution-id><institution>Department of Clinical Medicine, Public Health, Life and Environment Sciences,</institution><institution>University of Aquila,</institution></institution-wrap>L’Aquila, Italy</aff><aff id="Aff4"><label>4</label><institution-wrap><institution-id institution-id-type="GRID">grid.5611.3</institution-id><institution-id institution-id-type="ISNI">0000 0004 1763 1124</institution-id><institution>Department of Medicine,</institution><institution>University of Verona,</institution></institution-wrap>Verona, Italy</aff><aff id="Aff5"><label>5</label><institution-wrap><institution-id institution-id-type="GRID">grid.7637.5</institution-id><institution-id institution-id-type="ISNI">0000000417571846</institution-id><institution>Dept of Clinical & Experimental Sciences,</institution><institution>University of Brescia-Medicina 2,</institution></institution-wrap>ASST Spedali Civili Brescia, Brescia, Italy</aff><aff id="Aff6"><label>6</label><institution-wrap><institution-id institution-id-type="GRID">grid.7605.4</institution-id><institution-id institution-id-type="ISNI">0000 0001 2336 6580</institution-id><institution>Division of Internal Medicine and Hypertension, Department of Medical Sciences,</institution><institution>University of Torino,</institution></institution-wrap>Turin, Italy</aff><aff id="Aff7"><label>7</label><institution-wrap><institution-id institution-id-type="GRID">grid.10776.37</institution-id><institution-id institution-id-type="ISNI">0000 0004 1762 5517</institution-id><institution>Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Unit of Nephrology and Hypertension,</institution><institution>University of Palermo,</institution></institution-wrap>Palermo, Italy</aff><aff id="Aff8"><label>8</label><institution-wrap><institution-id institution-id-type="GRID">grid.9027.c</institution-id><institution-id institution-id-type="ISNI">0000 0004 1757 3630</institution-id><institution>Section of Internal Medicine Terni, Department of Medicine,</institution><institution>University of Perugia,</institution></institution-wrap>Terni, Italy</aff><aff id="Aff9"><label>9</label><institution-wrap><institution-id institution-id-type="GRID">grid.7841.a</institution-id><institution>Clinical and Molecular Medicine Department,</institution><institution>Sapienza University of Rome,</institution></institution-wrap>Rome, Italy</aff><aff id="Aff10"><label>10</label><institution-wrap><institution-id institution-id-type="GRID">grid.5390.f</institution-id><institution-id institution-id-type="ISNI">0000 0001 2113 062X</institution-id><institution>Department of Medical Area,</institution><institution>University of Udine,</institution></institution-wrap>Udine, Italy</aff><aff id="Aff11"><label>11</label><institution-wrap><institution-id institution-id-type="GRID">grid.7841.a</institution-id><institution>Division of Cardiology, Department of Clinical and Molecular Medicine,</institution><institution>University of Rome Sapienza, Sant’Andrea Hospital,</institution></institution-wrap>Rome, Italy</aff><aff id="Aff12"><label>12</label><institution-wrap><institution-id institution-id-type="GRID">grid.419543.e</institution-id><institution-id institution-id-type="ISNI">0000 0004 1760 3561</institution-id><institution>IRCCS Neuromed,</institution></institution-wrap>Pozzilli, IS Italy</aff><aff id="Aff13"><label>13</label><institution-wrap><institution-id institution-id-type="GRID">grid.7563.7</institution-id><institution-id institution-id-type="ISNI">0000 0001 2174 1754</institution-id><institution>Department of Medicine and Surgery,</institution><institution>University of Milano-Bicocca,</institution></institution-wrap>Milan, Italy</aff></contrib-group><pub-date pub-type="epub"><day>7</day><month>4</month><year>2020</year></pub-date><pub-date pub-type="pmc-release"><day>7</day><month>4</month><year>2020</year></pub-date><fpage>1</fpage><lpage>4</lpage><history><date date-type="received"><day>26</day><month>3</month><year>2020</year></date><date date-type="accepted"><day>2</day><month>4</month><year>2020</year></date></history><permissions><copyright-statement>© The Author(s) 2020</copyright-statement><license license-type="OpenAccess"><license-p><bold>Open Access</bold>This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.To view a copy of this licence, visit <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/">http://creativecommons.org/licenses/by-nc/4.0/</ext-link>.</license-p></license></permissions><abstract id="Abs1"><p id="Par1">Cardiovascular diseases, in particular hypertension, as well as the cardiovascular treatment with Renin–Angiotensin System inhibitors such as Angiotensin Converting Enzyme (ACE) inhibitors and Angiotensin Receptor Blockers (ARBs), are claimed once again as mechanisms of Severe Acute Respiratory Syndrome (SARS) during the COVID-19 outbreak due to Cov-2 epidemics. In vitro studies are available to support the eventual role of ACE inhibitors and ARBs in both the promotion and antagonism of the disease. The available literature, indeed, presents contrasting results, all concentrated in experimental models. Evidence in humans is lacking that those mechanisms are actually occurring in the present COVID-19 outbreak. Here we present the reasoned statement of the Italian Society of Hypertension to maintain ongoing antihypertensive treatments. Furthermore, the Italian Society of Hypertension presents its own initiative to investigate the issue using an online questionnaire to collect relevant data in human disease.</p></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>COVID-19</kwd><kwd>hypertension</kwd><kwd>cardiovascular diseases</kwd><kwd>infection</kwd><kwd>outcomes</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Iaccarino, Guido" sort="Iaccarino, Guido" uniqKey="Iaccarino G" first="Guido" last="Iaccarino">Guido Iaccarino</name></noRegion><name sortKey="Borghi, Claudio" sort="Borghi, Claudio" uniqKey="Borghi C" first="Claudio" last="Borghi">Claudio Borghi</name><name sortKey="Cicero, Arrigo F G" sort="Cicero, Arrigo F G" uniqKey="Cicero A" first="Arrigo F. G." last="Cicero">Arrigo F. G. Cicero</name><name sortKey="Ferri, Claudio" sort="Ferri, Claudio" uniqKey="Ferri C" first="Claudio" last="Ferri">Claudio Ferri</name><name sortKey="Grassi, Guido" sort="Grassi, Guido" uniqKey="Grassi G" first="Guido" last="Grassi">Guido Grassi</name><name sortKey="Minuz, Pietro" sort="Minuz, Pietro" uniqKey="Minuz P" first="Pietro" last="Minuz">Pietro Minuz</name><name sortKey="Muiesan, Maria Lorenza" sort="Muiesan, Maria Lorenza" uniqKey="Muiesan M" first="Maria Lorenza" last="Muiesan">Maria Lorenza Muiesan</name><name sortKey="Mulatero, Paolo" sort="Mulatero, Paolo" uniqKey="Mulatero P" first="Paolo" last="Mulatero">Paolo Mulatero</name><name sortKey="Mule, Giuseppe" sort="Mule, Giuseppe" uniqKey="Mule G" first="Giuseppe" last="Mulè">Giuseppe Mulè</name><name sortKey="Pucci, Giacomo" sort="Pucci, Giacomo" uniqKey="Pucci G" first="Giacomo" last="Pucci">Giacomo Pucci</name><name sortKey="Salvetti, Massimo" sort="Salvetti, Massimo" uniqKey="Salvetti M" first="Massimo" last="Salvetti">Massimo Salvetti</name><name sortKey="Savoia, Carmine" sort="Savoia, Carmine" uniqKey="Savoia C" first="Carmine" last="Savoia">Carmine Savoia</name><name sortKey="Sechi, Leonardo Alberto" sort="Sechi, Leonardo Alberto" uniqKey="Sechi L" first="Leonardo Alberto" last="Sechi">Leonardo Alberto Sechi</name><name sortKey="Volpe, Massimo" sort="Volpe, Massimo" uniqKey="Volpe M" first="Massimo" last="Volpe">Massimo Volpe</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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